@article{
3508,
   Author = {Schafer, J. L. and Graham, J. W.},
   Title = {Missing data: our view of the state of the art},
   Journal = {Psychol Methods},
   Volume = {7},
   Number = {2},
   Pages = {147-77},
   Year = {2002} }



@article{
3507,
   Author = {LeWitt, P. A. and Guttman, M. and Tetrud, J. W. and Tuite, P. J. and Mori, A. and Chaikin, P. and Sussman, N. M.},
   Title = {Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005)},
   Journal = {Ann Neurol},
   Volume = {63},
   Number = {3},
   Pages = {295-302},
   Year = {2008} }



@article{
3506,
   Author = {Cieslak, M. and Komoszynski, M. and Wojtczak, A.},
   Title = {Adenosine A(2A) receptors in Parkinson's disease treatment},
   Journal = {Purinergic Signal},
   Volume = {4},
   Number = {4},
   Pages = {305-12},
   Year = {2008} }



@article{
3505,
   Author = {Stacy, M. and Silver, D. and Mendis, T. and Sutton, J. and Mori, A. and Chaikin, P. and Sussman, N. M.},
   Title = {A 12-week, placebo-controlled study (6002-US-006) of istradefylline in Parkinson disease},
   Journal = {Neurology},
   Volume = {70},
   Number = {23},
   Pages = {2233-40},
   Year = {2008} }



@article{
3504,
   Author = {Rao, N. and Dvorchik, B. and Sussman, N. and Wang, H. and Yamamoto, K. and Mori, A. and Uchimura, T. and Chaikin, P.},
   Title = {A study of the pharmacokinetic interaction of istradefylline, a novel therapeutic for Parkinson's disease, and atorvastatin},
   Journal = {J Clin Pharmacol},
   Volume = {48},
   Number = {9},
   Pages = {1092-8},
   Year = {2008} }



@article{
3503,
   Author = {Gottwald, M. D. and Aminoff, M. J.},
   Title = {New frontiers in the pharmacological management of Parkinson's disease},
   Journal = {Drugs Today (Barc)},
   Volume = {44},
   Number = {7},
   Pages = {531-45},
   Year = {2008} }



@article{
3502,
   Author = {Hauser, R. A. and Shulman, L. M. and Trugman, J. M. and Roberts, J. W. and Mori, A. and Ballerini, R. and Sussman, N. M.},
   Title = {Study of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations},
   Journal = {Mov Disord},
   Volume = {23},
   Number = {15},
   Pages = {2177-85},
   Year = {2008} }



@article{
3501,
   Author = {Lopez-Cortes, L. F. and Valera-Bestard, B. and Gutierrez-Valencia, A. and Ruiz-Valderas, R. and Jimenez, L. and Arizcorreta, A. and Terron, A. and Viciana, P.},
   Title = {Role of pegylated interferon-alpha-2a and ribavirin concentrations in sustained viral response in HCV/HIV-coinfected patients},
   Journal = {Clin Pharmacol Ther},
   Volume = {84},
   Number = {5},
   Pages = {573-80},
   Year = {2008} }



@article{
3500,
   Author = {Schoenfeld, D. A.},
   Title = {Sample-size formula for the proportional-hazards regression model},
   Journal = {Biometrics},
   Volume = {39},
   Number = {2},
   Pages = {499-503},
   Year = {1983} }



@article{
3499,
   Author = {Iltz, J. L. and Baker, D. E. and Setter, S. M. and Keith Campbell, R.},
   Title = {Exenatide: an incretin mimetic for the treatment of type 2 diabetes mellitus},
   Journal = {Clin Ther},
   Volume = {28},
   Number = {5},
   Pages = {652-65},
   Year = {2006} }



@article{
3498,
   Author = {Dokoumetzidis, A. and Aarons, L.},
   Title = {Analytical expressions for combining population pharmacokinetic parameters from different studies},
   Journal = {J Biopharm Stat},
   Volume = {18},
   Number = {4},
   Pages = {662-76},
   Year = {2008} }



@article{
3497,
   Author = {Wang, Y.},
   Title = {Derivation of various NONMEM estimation methods},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {34},
   Number = {5},
   Pages = {575-93},
   Year = {2007} }



@article{
3496,
   Author = {Friberg, L. and Vermeulen, A. and Petersson, K. and Karlsson, M.},
   Title = {An Agonist-Antagonist Interaction Model for Prolactin Release Following Risperidone and Paliperidone Treatment},
   Journal = {Clin Pharmacol Ther},
   Year = {2008} }



@article{
3494,
   Author = {Redding, L. E. and Sohn, M. D. and McKone, T. E. and Chen, J. W. and Wang, S. L. and Hsieh, D. P. and Yang, R. S.},
   Title = {Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results},
   Journal = {Environ Health Perspect},
   Volume = {116},
   Number = {12},
   Pages = {1629-35},
   Year = {2008} }



@article{
3493,
   Author = {Austin, P. C.},
   Title = {Using the bootstrap to improve estimation and confidence intervals for regression coefficients selected using backwards variable elimination},
   Journal = {Stat Med},
   Volume = {27},
   Number = {17},
   Pages = {3286-300},
   Year = {2008} }



@article{
3492,
   Author = {Zierhut, M. L. and Gastonguay, M. R. and Martin, S. W. and Vicini, P. and Bekker, P. J. and Holloway, D. and Leese, P. T. and Peterson, M. C.},
   Title = {Population PK-PD model for Fc-osteoprotegerin in healthy postmenopausal women},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {35},
   Number = {4},
   Pages = {379-99},
   Year = {2008} }



@article{
3491,
   Author = {Dai, G. and Pfister, M. and Blackwood-Chirchir, A. and Roy, A.},
   Title = {Importance of characterizing determinants of variability in exposure: application to dasatinib in subjects with chronic myeloid leukemia},
   Journal = {J Clin Pharmacol},
   Volume = {48},
   Number = {11},
   Pages = {1254-69},
   Year = {2008} }



@article{
3490,
   Author = {Marsh, R. E. and Tuszynski, J. A. and Sawyer, M. B. and Vos, K. J.},
   Title = {Emergence of power laws in the pharmacokinetics of paclitaxel due to competing saturable processes},
   Journal = {J Pharm Pharm Sci},
   Volume = {11},
   Number = {3},
   Pages = {77-96},
   Year = {2008} }



@article{
3489,
   Author = {Hogan, J. W. and Lancaster, T.},
   Title = {Instrumental variables and inverse probability weighting for causal inference from longitudinal observational studies},
   Journal = {Stat Methods Med Res},
   Volume = {13},
   Number = {1},
   Pages = {17-48},
   Year = {2004} }



@article{
3488,
   Author = {Hogan, J. W. and Roy, J. and Korkontzelou, C.},
   Title = {Handling drop-out in longitudinal studies},
   Journal = {Stat Med},
   Volume = {23},
   Number = {9},
   Pages = {1455-97},
   Year = {2004} }



@article{
3487,
   Author = {Hogan, J. W. and Lin, X. and Herman, B.},
   Title = {Mixtures of varying coefficient models for longitudinal data with discrete or continuous nonignorable dropout},
   Journal = {Biometrics},
   Volume = {60},
   Number = {4},
   Pages = {854-64},
   Year = {2004} }



@article{
3486,
   Author = {Tsiatis, A.A. and Mehta, C.},
   Title = {On the ineﬃciency of the adaptive design for monitoring 
clinical trials },
   Journal = {Biometrika},
   Volume = {90},
   Number = {2},
   Pages = {367-378},
   Year = {2003} }



@article{
3485,
   Author = {Karlsson, M. O. and Savic, R. M.},
   Title = {Diagnosing model diagnostics},
   Journal = {Clin Pharmacol Ther},
   Volume = {82},
   Number = {1},
   Pages = {17-20},
   Year = {2007} }



@article{
3484,
   Author = {Yin, O. Q. and Wang, Y. and Schran, H.},
   Title = {A mechanism-based population pharmacokinetic model for characterizing time-dependent pharmacokinetics of midostaurin and its metabolites in human subjects},
   Journal = {Clin Pharmacokinet},
   Volume = {47},
   Number = {12},
   Pages = {807-16},
   Year = {2008} }



@article{
3483,
   Author = {Gomeni, R. and Lavergne, A. and Merlo-Pich, E.},
   Title = {Modelling placebo response in depression trials using a longitudinal model with informative dropout},
   Journal = {Eur J Pharm Sci},
   Year = {2008} }



@article{
3482,
   Author = {Di Bisceglie, A. M. and Shiffman, M. L. and Everson, G. T. and Lindsay, K. L. and Everhart, J. E. and Wright, E. C. and Lee, W. M. and Lok, A. S. and Bonkovsky, H. L. and Morgan, T. R. and Ghany, M. G. and Morishima, C. and Snow, K. K. and Dienstag, J. L.},
   Title = {Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon},
   Journal = {N Engl J Med},
   Volume = {359},
   Number = {23},
   Pages = {2429-2441},
   Year = {2008} }



@article{
3481,
   Author = {Salazar, J. C. and Cahn, P. and Yogev, R. and Negra, M. D. and Castelli-Gattinara, G. and Fortuny, C. and Flynn, P. M. and Giaquinto, C. and Ruan, P. K. and Smith, M. E. and Mikl, J. and Jelaska, A.},
   Title = {Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents},
   Journal = {AIDS},
   Volume = {22},
   Number = {14},
   Pages = {1789-98},
   Year = {2008} }



@inproceedings{
3480,
   Title = {Population pharmacokinetic (PK) assessment o systemic steady-state tipranavir (TPV) concentrations for adults administered tipranavir/ritonavir 500/200 mg BID},
   Year = {2005} }



@misc{
3479,
   Title = {National Health and Nutrition Examination Survey (NHANES): 1999-2000},
      Year = {} }



@article{
3478,
   Author = {Lindbom, L. and Pihlgreen, P. and Jonsson, N.},
   Title = {PsN-Toolkit—A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {79},
   Pages = {241-257},
   Year = {2005} }



@inproceedings{
3477,
   Title = {RESIST -1: A Phase 3, randomized, controlled, open label, multicenter trial comparing tipranavir/ritonavir (TPV/r) to an optimized comparator protease inhibitor/r (CPI/r) regimen in antiretroviral (ARV) experienced patients: 24 week data},
   Year = {2004} }



@article{
3476,
   Author = {Cahn, P.},
   Title = {24-week data from RESIST-2: Phase 3 study of the efficacy and safety of background therapy plus tipranavir/ritonavir (TPV/r) or optimized ritonavir-boosted standard-of-care (SOC) comparator PI (CPI) in a large randomized multicenter trial in treatment-experienced HIV+ patients},
   Journal = {Int Cong Drug Therapy HIV},
   Volume = {7: Abstract No. PL14.3},
   Year = {2004} }



@article{
3475,
   Author = {MacGregor, T. R. and Sabo, J. P. and Norris, S. H. and Johnson, P. and Galitz, L. and McCallister, S.},
   Title = {Pharmacokinetic characterization of different dose combinations of coadministered tipranavir and ritonavir in healthy volunteers},
   Journal = {HIV Clin Trials},
   Volume = {5},
   Number = {6},
   Pages = {371-82},
   Year = {2004} }



@article{
3474,
   Author = {Wade, K. C. and Wu, D. and Kaufman, D. A. and Ward, R. M. and Benjamin, D. K., Jr. and Sullivan, J. E. and Ramey, N. and Jayaraman, B. and Hoppu, K. and Adamson, P. C. and Gastonguay, M. R. and Barrett, J. S.},
   Title = {Population pharmacokinetics of fluconazole in young infants},
   Journal = {Antimicrob Agents Chemother},
   Volume = {52},
   Number = {11},
   Pages = {4043-9},
   Year = {2008} }



@article{
3473,
   Author = {Vaeth, M. and Skovlund, E.},
   Title = {A simple approach to power and sample size calculations in logistic regression and Cox regression models},
   Journal = {Stat Med},
   Volume = {23},
   Number = {11},
   Pages = {1781-92},
   Year = {2004} }



@article{
3472,
   Author = {Petain, A. and Kattygnarath, D. and Azard, J. and Chatelut, E. and Delbaldo, C. and Geoerger, B. and Barrois, M. and Seronie-Vivien, S. and LeCesne, A. and Vassal, G.},
   Title = {Population pharmacokinetics and pharmacogenetics of imatinib in children and adults},
   Journal = {Clin Cancer Res},
   Volume = {14},
   Number = {21},
   Pages = {7102-9},
   Year = {2008} }



@article{
3471,
   Author = {Landersdorfer, C. B. and Jusko, W. J.},
   Title = {Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus},
   Journal = {Clin Pharmacokinet},
   Volume = {47},
   Number = {7},
   Pages = {417-48},
   Year = {2008} }



@article{
3470,
   Author = {Ogungbenro, K. and Dokoumetzidis, A. and Aarons, L.},
   Title = {Application of optimal design methodologies in clinical pharmacology experiments},
   Journal = {Pharm Stat},
   Year = {2008} }



@article{
3469,
   Author = {Cui, L. and Hung, H. M. and Wang, S. J.},
   Title = {Modification of sample size in group sequential clinical trials},
   Journal = {Biometrics},
   Volume = {55},
   Number = {3},
   Pages = {853-7},
   Year = {1999} }



@article{
3468,
   Author = {Muller, H. H. and Schafer, H.},
   Title = {Adaptive group sequential designs for clinical trials: combining the advantages of adaptive and of classical group sequential approaches},
   Journal = {Biometrics},
   Volume = {57},
   Number = {3},
   Pages = {886-91},
   Year = {2001} }



@article{
3467,
   Author = {Posch, M. and Koenig, F. and Branson, M. and Brannath, W. and Dunger-Baldauf, C. and Bauer, P.},
   Title = {Testing and estimation in flexible group sequential designs with adaptive treatment selection},
   Journal = {Stat Med},
   Volume = {24},
   Number = {24},
   Pages = {3697-714},
   Year = {2005} }



@book{
3466,
   Title = {Guanfacine package insert},
   Publisher = {Mylan Company},
   Year = {2007} }



@article{
3465,
   Author = {McCrindle, B. W. and Urbina, E. M. and Dennison, B. A. and Jacobson, M. S. and Steinberger, J. and Rocchini, A. P. and Hayman, L. L. and Daniels, S. R.},
   Title = {Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing},
   Journal = {Circulation},
   Volume = {115},
   Number = {14},
   Pages = {1948-67},
   Year = {2007} }



@article{
3464,
   Author = {Rodenburg, J. and Vissers, M. N. and Wiegman, A. and van Trotsenburg, A. S. and van der Graaf, A. and de Groot, E. and Wijburg, F. A. and Kastelein, J. J. and Hutten, B. A.},
   Title = {Statin treatment in children with familial hypercholesterolemia: the younger, the better},
   Journal = {Circulation},
   Volume = {116},
   Number = {6},
   Pages = {664-8},
   Year = {2007} }



@article{
3463,
   Author = {de Jongh, S. and Lilien, M. R. and op't Roodt, J. and Stroes, E. S. and Bakker, H. D. and Kastelein, J. J.},
   Title = {Early statin therapy restores endothelial function in children with familial hypercholesterolemia},
   Journal = {J Am Coll Cardiol},
   Volume = {40},
   Number = {12},
   Pages = {2117-21},
   Year = {2002} }



@article{
3462,
   Author = {Clauss, S. B. and Holmes, K. W. and Hopkins, P. and Stein, E. and Cho, M. and Tate, A. and Johnson-Levonas, A. O. and Kwiterovich, P. O.},
   Title = {Efficacy and safety of lovastatin therapy in adolescent girls with heterozygous familial hypercholesterolemia},
   Journal = {Pediatrics},
   Volume = {116},
   Number = {3},
   Pages = {682-8},
   Year = {2005} }



@article{
3461,
   Author = {Wiegman, A. and Hutten, B. A. and de Groot, E. and Rodenburg, J. and Bakker, H. D. and Buller, H. R. and Sijbrands, E. J. and Kastelein, J. J.},
   Title = {Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial},
   Journal = {JAMA},
   Volume = {292},
   Number = {3},
   Pages = {331-7},
   Year = {2004} }



@article{
3460,
   Author = {McCrindle, B. W. and Ose, L. and Marais, A. D.},
   Title = {Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial},
   Journal = {J Pediatr},
   Volume = {143},
   Number = {1},
   Pages = {74-80},
   Year = {2003} }



@article{
3459,
   Author = {de Jongh, S. and Ose, L. and Szamosi, T. and Gagne, C. and Lambert, M. and Scott, R. and Perron, P. and Dobbelaere, D. and Saborio, M. and Tuohy, M. B. and Stepanavage, M. and Sapre, A. and Gumbiner, B. and Mercuri, M. and van Trotsenburg, A. S. and Bakker, H. D. and Kastelein, J. J.},
   Title = {Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin},
   Journal = {Circulation},
   Volume = {106},
   Number = {17},
   Pages = {2231-7},
   Year = {2002} }



@article{
3458,
   Author = {Stein, E. A. and Illingworth, D. R. and Kwiterovich, P. O., Jr. and Liacouras, C. A. and Siimes, M. A. and Jacobson, M. S. and Brewster, T. G. and Hopkins, P. and Davidson, M. and Graham, K. and Arensman, F. and Knopp, R. H. and DuJovne, C. and Williams, C. L. and Isaacsohn, J. L. and Jacobsen, C. A. and Laskarzewski, P. M. and Ames, S. and Gormley, G. J.},
   Title = {Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial},
   Journal = {JAMA},
   Volume = {281},
   Number = {2},
   Pages = {137-44},
   Year = {1999} }



@article{
3457,
   Author = {Knipscheer, H. C. and Boelen, C. C. and Kastelein, J. J. and van Diermen, D. E. and Groenemeijer, B. E. and van den Ende, A. and Buller, H. R. and Bakker, H. D.},
   Title = {Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia},
   Journal = {Pediatr Res},
   Volume = {39},
   Number = {5},
   Pages = {867-71},
   Year = {1996} }



@article{
3456,
   Title = {American Academy of Pediatrics. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents},
   Journal = {Pediatrics},
   Volume = {89},
   Number = {3 Pt 2},
   Pages = {525-84},
   Year = {1992} }



@article{
3455,
   Author = {Stone, N. J. and Levy, R. I. and Fredrickson, D. S. and Verter, J.},
   Title = {Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia},
   Journal = {Circulation},
   Volume = {49},
   Number = {3},
   Pages = {476-88},
   Year = {1974} }



@article{
3454,
   Author = {Slack, J.},
   Title = {Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states},
   Journal = {Lancet},
   Volume = {2},
   Number = {7635},
   Pages = {1380-2},
   Year = {1969} }



@article{
3453,
   Author = {Wiegman, A. and Rodenburg, J. and de Jongh, S. and Defesche, J. C. and Bakker, H. D. and Kastelein, J. J. and Sijbrands, E. J.},
   Title = {Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children},
   Journal = {Circulation},
   Volume = {107},
   Number = {11},
   Pages = {1473-8},
   Year = {2003} }



@article{
3452,
   Author = {Spengel, F. A. and Kaess, B. and Keller, C. and Kroner, K. K. and Schreiber, M. and Schuster, H. and Zollner, N.},
   Title = {Atherosclerosis of the carotid arteries in young patients with familial hypercholesterolemia},
   Journal = {Klin Wochenschr},
   Volume = {66},
   Number = {2},
   Pages = {65-8},
   Year = {1988} }



@article{
3451,
   Author = {Kwiterovich, P. O., Jr.},
   Title = {Pediatric implications of heterozygous familial hypercholesterolemia. Screening and dietary treatment},
   Journal = {Arteriosclerosis},
   Volume = {9},
   Number = {1 Suppl},
   Pages = {I111-20},
   Year = {1989} }



@article{
3450,
   Title = {Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group},
   Journal = {JAMA},
   Volume = {264},
   Number = {23},
   Pages = {3018-24},
   Year = {1990} }



@article{
3449,
   Author = {Newman, W. P., 3rd and Wattigney, W. and Berenson, G. S.},
   Title = {Autopsy studies in United States children and adolescents. Relationship of risk factors to atherosclerotic lesions},
   Journal = {Ann N Y Acad Sci},
   Volume = {623},
   Pages = {16-25},
   Year = {1991} }



@article{
3448,
   Author = {Berenson, G. S. and Srinivasan, S. R. and Bao, W. and Newman, W. P., 3rd and Tracy, R. E. and Wattigney, W. A.},
   Title = {Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study},
   Journal = {N Engl J Med},
   Volume = {338},
   Number = {23},
   Pages = {1650-6},
   Year = {1998} }



@misc{
3447,
   Title = {Product Information (SmPC): LipitorTM Product Information, 2007, Pfizer Limited},
      Year = {} }



@misc{
3446,
   Title = {Clincal Study Report 981-080: A multicenter, open-label, compassionate-use study to
assess the efficacy and safety of atorvastatin in patients with severe
hypercholesterolemia who have not achieved an adequate response with conventional
lipid-lowering therapy},
      Year = {} }



@misc{
3445,
   Title = {Clincal Study Report 981-147: A 1-year study in children and adolescents with familial
or severe hypercholesterolemia comparing atorvastatin to placebo (6-month double
blind treatment), followed by atorvastatin open-label treatment for 6 months},
      Year = {} }



@misc{
3444,
   Title = {Clincal Study Report 981-336: A 1-year, open-label, randomized parallel group
multicenter study for the comparison of atorvastatin vs colestipol on the treatment of
children and adolescents with familial hypercholesterolemia (FH) and severe
hypercholesterolemia},
      Year = {} }



@incollection{
3443,
   Author = {Brown, Michael S. and Hobbes, Helen H. and Goldstein, Joseph L.},
   Title = {Familial hypercholesterolemia},
   BookTitle = {The metabolic basis of inherited disease. 7th Edition},
   Editor = {Scriver, Charles R. and Beaudet, Arthur L. and Sly, William S. and Valle, David},
   Publisher = {McGraw-Hill},
   Address = {New York, NY},
   Pages = {1215-50},
   Year = {1989} }



@article{
3442,
   Author = {USFDA},
   Title = {Requip/Ropinirole Hydrochloride
SmithKline Beecham
Application No.: 20658
Approval Date: 09/19/1997},
   Journal = {http://www.fda.gov/cder/foi/nda/97/020658_requip_toc.htm},
   Year = {1997} }



@article{
3441,
   Author = {USFDA},
   Title = {Mirapex (Pramipexole Dihydrochloride) Tablets
Company:  Pharmacia & Upjohn, Inc.
Application No.:  020-667
Approval Date: 7/1/1997},
   Journal = {http://www.fda.gov/cder/foi/nda/98/020667.htm},
   Year = {1997} }



@article{
3440,
   Author = {Brooks, D. J.},
   Title = {Dopamine agonists: their role in the treatment of Parkinson's disease},
   Journal = {J Neurol Neurosurg Psychiatry},
   Volume = {68},
   Number = {6},
   Pages = {685-9},
   Year = {2000} }



@article{
3439,
   Author = {Ahn, J. E. and Karlsson, M. O. and Dunne, A. and Ludden, T. M.},
   Title = {Likelihood based approaches to handling data below the quantification limit using NONMEM VI},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {35},
   Number = {4},
   Pages = {401-21},
   Year = {2008} }



@article{
3438,
   Author = {Hamren, B. and Ericsson, H. and Samuelsson, O. and Karlsson, M. O.},
   Title = {Mechanistic modelling of tesaglitazar pharmacokinetic data in subjects with various degrees of renal function--evidence of interconversion},
   Journal = {Br J Clin Pharmacol},
   Volume = {65},
   Number = {6},
   Pages = {855-63},
   Year = {2008} }



@article{
3437,
   Author = {Choi, L. and Caffo, B. and Rohde, C. and Ndovi, T. T. and Hendrix, C. W.},
   Title = {A mechanistic latent variable model for estimating drug concentrations in the male genital tract: a case study in drug kinetics},
   Journal = {Stat Med},
   Volume = {27},
   Number = {14},
   Pages = {2697-714},
   Year = {2008} }



@article{
3436,
   Author = {Barrett, J. and Skolnik, J. and Jayaraman, B. and Patel, D. and Adamson, P.},
   Title = {Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs},
   Journal = {Clin Pharmacol Ther},
   Year = {2008} }



@article{
3435,
   Author = {Shudo, E. and Ribeiro, R. M. and Perelson, A. S.},
   Title = {Modelling hepatitis C virus kinetics during treatment with pegylated interferon alpha-2b: errors in the estimation of viral kinetic parameters},
   Journal = {J Viral Hepat},
   Volume = {15},
   Number = {5},
   Pages = {357-62},
   Year = {2008} }



@article{
3434,
   Author = {Talal, A. H. and Ribeiro, R. M. and Powers, K. A. and Grace, M. and Cullen, C. and Hussain, M. and Markatou, M. and Perelson, A. S.},
   Title = {Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders},
   Journal = {Hepatology},
   Volume = {43},
   Number = {5},
   Pages = {943-53},
   Year = {2006} }



@article{
3433,
   Author = {Schmidli, H. and Bretz, F. and Racine-Poon, A.},
   Title = {Bayesian predictive power for interim adaptation in seamless phase II/III trials where the endpoint is survival up to some specified timepoint},
   Journal = {Stat Med},
   Volume = {26},
   Number = {27},
   Pages = {4925-38},
   Year = {2007} }



@article{
3432,
   Author = {Dmitrienko, A. and Wang, M. D.},
   Title = {Bayesian predictive approach to interim monitoring in clinical trials},
   Journal = {Stat Med},
   Volume = {25},
   Number = {13},
   Pages = {2178-95},
   Year = {2006} }



@article{
3431,
   Author = {Hazra, A. and Pyszczynski, N. A. and DuBois, D. C. and Almon, R. R. and Jusko, W. J.},
   Title = {Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats},
   Journal = {Pharm Res},
   Volume = {25},
   Number = {4},
   Pages = {769-80},
   Year = {2008} }



@article{
3430,
   Author = {Seng, K. Y. and Nestorov, I. and Vicini, P.},
   Title = {Physiologically based pharmacokinetic modeling of drug disposition in rat and human: a fuzzy arithmetic approach},
   Journal = {Pharm Res},
   Volume = {25},
   Number = {8},
   Pages = {1771-81},
   Year = {2008} }



@article{
3429,
   Author = {Rajman, I.},
   Title = {PK/PD modelling and simulations: utility in drug development},
   Journal = {Drug Discov Today},
   Volume = {13},
   Number = {7-8},
   Pages = {341-6},
   Year = {2008} }



@article{
3428,
   Author = {Souza, T. and Kush, R. and Evans, J. P.},
   Title = {Global clinical data interchange standards are here!},
   Journal = {Drug Discov Today},
   Volume = {12},
   Number = {3-4},
   Pages = {174-81},
   Year = {2007} }



@article{
3427,
   Author = {Vyshemirsky, V. and Girolami, M.},
   Title = {BioBayes: a software package for Bayesian inference in systems biology},
   Journal = {Bioinformatics},
   Volume = {24},
   Number = {17},
   Pages = {1933-4},
   Year = {2008} }



@article{
3426,
   Author = {Ferner, R. E.},
   Title = {Post-mortem clinical pharmacology},
   Journal = {Br J Clin Pharmacol},
   Year = {2008} }



@article{
3425,
   Author = {Wang, J. and Weiss, M. and D'Argenio, D. Z.},
   Title = {A note on population analysis of dissolution-absorption models using the inverse Gaussian function},
   Journal = {J Clin Pharmacol},
   Volume = {48},
   Number = {6},
   Pages = {719-25},
   Year = {2008} }



@article{
3424,
   Author = {Fotouhi, A. R.},
   Title = {Modelling overdispersion in longitudinal count data in clinical trials with application to epileptic data},
   Journal = {Contemp Clin Trials},
   Volume = {29},
   Number = {4},
   Pages = {547-54},
   Year = {2008} }



@article{
3423,
   Author = {Mukherjee, A. and Dombi, T. and Wittke, B. and Lalonde, R.},
   Title = {Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period},
   Journal = {Clin Pharmacol Ther},
   Year = {2008} }



@article{
3422,
   Author = {Therneau, T. M. and Hamilton, S. A.},
   Title = {rhDNase as an example of recurrent event analysis},
   Journal = {Stat Med},
   Volume = {16},
   Number = {18},
   Pages = {2029-47},
   Year = {1997} }



@article{
3421,
   Author = {Roe, D. J.},
   Title = {Comparison of population pharmacokinetic modeling methods using simulated data: results from the Population Modeling Workgroup},
   Journal = {Stat Med},
   Volume = {16},
   Number = {11},
   Pages = {1241-57; discussion 1257-62},
   Year = {1997} }



@article{
3420,
   Author = {Sornay-Rendu, E. and Garnero, P. and Munoz, F. and Duboeuf, F. and Delmas, P. D.},
   Title = {Effect of withdrawal of hormone replacement therapy on bone mass and bone turnover: the OFELY study},
   Journal = {Bone},
   Volume = {33},
   Number = {1},
   Pages = {159-66},
   Year = {2003} }



@article{
3419,
   Author = {Martin, A. R. and Sornay-Rendu, E. and Chandler, J. M. and Duboeuf, F. and Girman, C. J. and Delmas, P. D.},
   Title = {The impact of osteoporosis on quality-of-life: the OFELY cohort},
   Journal = {Bone},
   Volume = {31},
   Number = {1},
   Pages = {32-6},
   Year = {2002} }



@article{
3417,
   Author = {Gathe, J. C., Jr. and Pierone, G. and Piliero, P. and Arasteh, K. and Rubio, R. and Lalonde, R. G. and Cooper, D. and Lazzarin, A. and Kohlbrenner, V. M. and Dohnanyi, C. and Sabo, J. and Mayers, D.},
   Title = {Efficacy and safety of three doses of tipranavir boosted with ritonavir in treatment-experienced HIV type-1 infected patients},
   Journal = {AIDS Res Hum Retroviruses},
   Volume = {23},
   Number = {2},
   Pages = {216-23},
   Year = {2007} }



@article{
3416,
   Author = {Campos Moreno, E. and Merino Sanjuan, M. and Merino, V. and Nacher, A. and Martin Algarra, R. V. and Casabo, V. G.},
   Title = {Population modelling to describe pharmacokinetics of amiodarone in rats: relevance of plasma protein and tissue depot binding},
   Journal = {Eur J Pharm Sci},
   Volume = {30},
   Number = {2},
   Pages = {190-7},
   Year = {2007} }



@article{
3415,
   Author = {Gadde, K. M. and Parker, C. B. and Maner, L. G. and Wagner, H. R., 2nd and Logue, E. J. and Drezner, M. K. and Krishnan, K. R.},
   Title = {Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women},
   Journal = {Obes Res},
   Volume = {9},
   Number = {9},
   Pages = {544-51},
   Year = {2001} }



@article{
3414,
   Author = {Anderson, J. W. and Greenway, F. L. and Fujioka, K. and Gadde, K. M. and McKenney, J. and O'Neil, P. M.},
   Title = {Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial},
   Journal = {Obes Res},
   Volume = {10},
   Number = {7},
   Pages = {633-41},
   Year = {2002} }



@article{
3413,
   Author = {Jain, A. K. and Kaplan, R. A. and Gadde, K. M. and Wadden, T. A. and Allison, D. B. and Brewer, E. R. and Leadbetter, R. A. and Richard, N. and Haight, B. and Jamerson, B. D. and Buaron, K. S. and Metz, A.},
   Title = {Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms},
   Journal = {Obes Res},
   Volume = {10},
   Number = {10},
   Pages = {1049-56},
   Year = {2002} }



@article{
3412,
   Author = {Li, Z. and Maglione, M. and Tu, W. and Mojica, W. and Arterburn, D. and Shugarman, L. R. and Hilton, L. and Suttorp, M. and Solomon, V. and Shekelle, P. G. and Morton, S. C.},
   Title = {Meta-analysis: pharmacologic treatment of obesity},
   Journal = {Ann Intern Med},
   Volume = {142},
   Number = {7},
   Pages = {532-46},
   Year = {2005} }



@article{
3410,
   Author = {Dragalin, V. and Hsuan, F. and Padmanabhan, S. K.},
   Title = {Adaptive designs for dose-finding studies based on sigmoid Emax model},
   Journal = {J Biopharm Stat},
   Volume = {17},
   Number = {6},
   Pages = {1051-70},
   Year = {2007} }



@article{
3409,
   Author = {Chow, S. C. and Cheng, B. and Cosmatos, D.},
   Title = {On power and sample size calculation for QT studies with recording replicates at given time point},
   Journal = {J Biopharm Stat},
   Volume = {18},
   Number = {3},
   Pages = {483-93},
   Year = {2008} }



@article{
3408,
   Author = {Wang, S. and Guo, P. and Wang, X. and Zhou, Q. and Gallo, J. M.},
   Title = {Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models},
   Journal = {Mol Cancer Ther},
   Volume = {7},
   Number = {2},
   Pages = {407-17},
   Year = {2008} }



@article{
3407,
   Author = {Shudo, E. and Ribeiro, R. M. and Perelson, A. S.},
   Title = {Modelling the kinetics of hepatitis C virus RNA decline over 4 weeks of treatment with pegylated interferon alpha-2b},
   Journal = {J Viral Hepat},
   Volume = {15},
   Number = {5},
   Pages = {379-82},
   Year = {2008} }



@article{
3406,
   Author = {Ying, G. S. and Heitjan, D. F.},
   Title = {Weibull prediction of event times in clinical trials},
   Journal = {Pharm Stat},
   Volume = {7},
   Number = {2},
   Pages = {107-20},
   Year = {2008} }



@article{
3405,
   Author = {Hong, Y. and Dingemanse, J. and Mager, D. E.},
   Title = {Pharmacokinetic/pharmacodynamic modeling of renin biomarkers in subjects treated with the renin inhibitor aliskiren},
   Journal = {Clin Pharmacol Ther},
   Volume = {84},
   Number = {1},
   Pages = {136-43},
   Year = {2008} }



@article{
3403,
   Author = {Bairagi, N. and Chatterjee, S. and Chattopadhyay, J.},
   Title = {Variability in the secretion of corticotropin-releasing hormone, adrenocorticotropic hormone and cortisol and understandability of the hypothalamic-pituitary-adrenal axis dynamics--a mathematical study based on clinical evidence},
   Journal = {Math Med Biol},
   Volume = {25},
   Number = {1},
   Pages = {37-63},
   Year = {2008} }



@article{
3402,
   Author = {Charles, B. and Touitou, Y. and Selmaoui, B.},
   Title = {A population pharmacokinetic turnover and surge-function model for describing melatonin biological rhythm in healthy male subjects},
   Journal = {J Pharm Sci},
   Year = {2008} }



@article{
3401,
   Author = {Dickinson, L. and Boffito, M. and Khoo, S. H. and Schutz, M. and Aarons, L. J. and Pozniak, A. L. and Back, D. J.},
   Title = {Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing},
   Journal = {J Antimicrob Chemother},
   Volume = {62},
   Number = {1},
   Pages = {161-7},
   Year = {2008} }



@article{
3400,
   Author = {Ballem, P. J. and Segal, G. M. and Stratton, J. R. and Gernsheimer, T. and Adamson, J. W. and Slichter, S. J.},
   Title = {Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance},
   Journal = {J Clin Invest},
   Volume = {80},
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@article{
3399,
   Author = {Harker, L. A. and Roskos, L. K. and Marzec, U. M. and Carter, R. A. and Cherry, J. K. and Sundell, B. and Cheung, E. N. and Terry, D. and Sheridan, W.},
   Title = {Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers},
   Journal = {Blood},
   Volume = {95},
   Number = {8},
   Pages = {2514-22},
   Year = {2000} }



@article{
3398,
   Author = {Schiffer, C. A. and Miller, K. and Larson, R. A. and Amrein, P. C. and Antin, J. H. and Zani, V. J. and Stone, R. M.},
   Title = {A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia},
   Journal = {Blood},
   Volume = {95},
   Number = {8},
   Pages = {2530-5},
   Year = {2000} }



@article{
3397,
   Author = {Perez-Ruixo, J. J. and Krzyzanski, W. and Hing, J.},
   Title = {Pharmacodynamic analysis of recombinant human erythropoietin effect on reticulocyte production rate and age distribution in healthy subjects},
   Journal = {Clin Pharmacokinet},
   Volume = {47},
   Number = {6},
   Pages = {399-415},
   Year = {2008} }



@article{
3396,
   Author = {Krzyzanski, W. and Perez-Ruixo, J. J. and Vermeulen, A.},
   Title = {Basic pharmacodynamic models for agents that alter the lifespan distribution of natural cells},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {35},
   Number = {3},
   Pages = {349-77},
   Year = {2008} }



@article{
3395,
   Author = {Zeuner, A. and Signore, M. and Marinetti, D. and Bartucci, M. and Peshcle, C. and De Maria, R.},
   Title = {Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocite progenitors and can be rescued by stem cell factor},
   Journal = {Cancer Res.},
   Volume = {67},
   Number = {10},
   Pages = {4767-73},
   Year = {2007} }



@article{
3394,
   Author = {Munzenberger, P. J. and McKercher, P.},
   Title = {Pediatric dosing--the pharmacist's dilemma},
   Journal = {Contemp. Pharmacy Prac},
   Volume = {3},
   Pages = {11-14},
   Year = {1980} }



@article{
3393,
   Author = {VanDevanter, D. R.},
   Title = {First bacterial infection as an alternative clinical end point for regulatory approval of agents targeting the primary cystic fibrosis defect},
   Journal = {J Pediatr},
   Volume = {147},
   Number = {3},
   Pages = {332-4},
   Year = {2005} }



@article{
3392,
   Author = {Rabin, H. R. and Butler, S. M. and Wohl, M. E. and Geller, D. E. and Colin, A. A. and Schidlow, D. V. and Johnson, C. A. and Konstan, M. W. and Regelmann, W. E.},
   Title = {Pulmonary exacerbations in cystic fibrosis},
   Journal = {Pediatr Pulmonol},
   Volume = {37},
   Number = {5},
   Pages = {400-6},
   Year = {2004} }



@article{
3391,
   Author = {Hamren, B. and Bjork, E. and Sunzel, M. and Karlsson, M.},
   Title = {Models for plasma glucose, HbA1c, and hemoglobin interrelationships in patients with type 2 diabetes following tesaglitazar treatment},
   Journal = {Clin Pharmacol Ther},
   Volume = {84},
   Number = {2},
   Pages = {228-35},
   Year = {2008} }



@article{
3390,
   Author = {App, E. M. and Tomkiewicz, R. P. and King, M.},
   Title = {Thio-group carrying mucolytic agents inactivate proteases such as human neutrophil elastase (HNE) in vitro.},
   Journal = {Am Rev Respir Dis},
   Volume = {147},
   Pages = {A673},
   Year = {1993} }



@article{
3389,
   Author = {App, E. M. and Hochstrasser, K. and Tomkiewicz, R. P.},
   Title = {Do SH group carrying reducing agents affect the protease-antiprotease balance in bronchial secretions?},
   Journal = {Eur Respir J},
   Volume = {6: Suppl 17},
   Pages = {438S},
   Year = {1993} }



@article{
3388,
   Author = {App, E. M. and Tomkiewicz, R. P. and King, M.},
   Title = {New MDI mucolytic Nacystelyn® (NAL) compared with N-acetyl-cysteine (NAC) and other reducing agents in human sputum rheology and bronchial secretion inhibitor (BSI) activity in vitro},
   Journal = {Eur Respir J},
   Volume = {5},
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@article{
3387,
   Author = {Gillissen, A. and Jaworska, M. and Orth, M. and Coffiner, M. and Maes, P. and App, E. M. and Cantin, A. M. and Schultze-Werninghaus, G.},
   Title = {Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro.},
   Journal = {Respir Med},
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   Number = {3},
   Pages = {159-68},
   Year = {1997} }



@article{
3386,
   Author = {Vanderbist, F. and Maes, P. and Neve, J.},
   Title = {In vitro comparative assessment of the antioxidant activity of Nacystelyn® against three reactive oxygen species},
   Journal = {Arzneimittelforschung },
   Volume = {46},
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@article{
3385,
   Author = {Donaldson, K. and Brown, D. and MacNee, W.},
   Title = {The thiol antioxidant Nacystelyn® reduces pulmonary inflammation cuased by instilled particles or endotoxin},
   Journal = {Am J Respir Crit Care Med},
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@article{
3384,
   Author = {Parmentier, M. and Drost, E. and Hirani, N. and Rahman, I. and Donaldson, K. and MacNee, W. and Antonicelli, F.},
   Title = {Thiol antioxidants inhibit neutrophil chemotaxis by decreasing release of IL-8 from macrophages and pulmonary epithelial cells (abstract)},
   Journal = {Am J Respir Crit Care Med},
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@article{
3383,
   Author = {Tomkiewicz, R. P. and App, E. M. and De Sanctis, G. T. and Coffiner, M. and Maes, P. and Rubin, B. K. and King, M.},
   Title = {A comparison of a new mucolytic N-acetylcysteine L-lysinate with N-actylcysteine: airway epithelial function and mucus changes in dog},
   Journal = {Pulm Pharmacol},
   Volume = {8},
   Number = {6},
   Pages = {259-65},
   Year = {1995} }



@article{
3382,
   Author = {Tomkiewicz, R. P. and App, E. M. and Coffiner, M. and Fossion, J. and Maes, P. and King, M.},
   Title = {Mucolytic treatment with N-acetylcysteine L-lysinate metered dose inhaler in dogs: airway epithelial function changes},
   Journal = {Eur Respir J},
   Volume = {7},
   Pages = {81-7},
   Year = {1994} }



@article{
3381,
   Author = {Marriott, C. and Fossion, J. and Coffiner, M. and Maes, P.},
   Title = {A rheological evaluation of Nacsystelyn using purified mucus gels},
   Journal = {Am Rev Respir Dis},
   Volume = {145},
   Pages = {A618},
   Year = {1992} }



@article{
3380,
   Author = {Marriott, M. and Ingham, S. and Pritchard, K. and Williams, M. and Coffiner, M. and Fossion, J.},
   Title = {The effect of Nacystelyn® on the viscoelastic properties of mucus and frog palate transport rate},
   Journal = {Eur Respir J},
   Volume = {4},
   Pages = {378S},
   Year = {1991} }



@article{
3379,
   Title = {GMR-29716: A study to investigate the bioequivalence of two oral formulations of pantoprazole: Phase III (formulation C) vs. final marketing formulation (formulation E)  [Byk-Gulden Report 159/94; Byk-Gulden Protocol FHP028E]},
   Year = {} }



@article{
3378,
   Author = {Cantin, A. M.},
   Title = {DNase I acutely increases cystic fibrosis sputum elastase activity and its potential to induce lung hemorrhage in mice},
   Journal = {Am J Respir Crit Care Med},
   Volume = {157},
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   Year = {1998} }



@article{
3377,
   Author = {Rochat, T. and Pastore, F. D. and Shchlegel-Haueter, S. E. and Filthuth, I. and Auckenthaler, R. and Belli, D. and Suter, S.},
   Title = {Aerosolized rhDNase in cystic fibrosis: effect on leucocyte proteases in sputum.},
   Journal = {Eur Respir J},
   Volume = {9},
   Number = {11},
   Pages = {2200-6},
   Year = {196} }



@article{
3376,
   Author = {Rao, S. and Wilson, D. B. and Brooks, R. C. and Sproule, B. J.},
   Title = {Acute effects of nebulization of N-acetylcysteine on pulmonary mechanics and gas exchange},
   Journal = {Am Rev Respir Dis},
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@article{
3375,
   Title = {La mucoviscidose},
   Journal = {Le Journal du Medicin},
   Volume = {952},
   Pages = {22},
   Year = {1996} }



@article{
3374,
   Author = {Fitzsimmons, S. C.},
   Title = {The changing epidemiology of cystic fibrosis},
   Journal = {Curr Probl Pediatr},
   Volume = {24},
   Number = {5},
   Pages = {171-9},
   Year = {1993} }



@article{
3373,
   Author = {Davis, P. B. and Drumm, M. and Donstan, M. W.},
   Title = {Cystic fibrosis},
   Journal = {Am J Respir Crit Care Med},
   Volume = {154},
   Pages = {1229-56},
   Year = {1996} }



@misc{
3372,
   Author = {Pulitano, T. A. and Stroshane, R. M.},
   Title = {Determination of pantoprazole in human plasma samples using LC-MS-MS (Protocol 3001A3-337-US ). Wyeth Research RPT-66312},
      Year = {} }



@misc{
3371,
   Author = {Pulitano, T. A. and Stroshane, R. M.},
   Title = {Determination of pantoprazole in human plasma samples using LC-MS-MS (Protocol 3001A3-334-US ). Wyeth Research RPT-62839},
      Year = {} }



@misc{
3370,
   Author = {Pulitano, T. A. and Stroshane, R. M.},
   Title = {Determination of pantoprazole in human plasma samples using LC-MS-MS (Protocol 3001A3-331-US ). Wyeth Research RPT-62842},
      Year = {} }



@misc{
3369,
   Author = {Pulitano, T. A. and Stroshane, R.},
   Title = {Determination of pantoprazole in human plasma samples using LC/MS/MS [Protocol 3001B3-333-WW]. Wyeth Research RPT-62840},
      Year = {} }



@misc{
3368,
   Author = {Pulitano, T. A. and Yanuzzi, M. S.},
   Title = {The validation of an LC/MS/MS method for the determination of pantoprazole in human plasma [Protocol 04_0873]. Wyeth Research RPT-54260},
      Year = {} }



@article{
3367,
   Author = {Goss, C. H. and Burns, J. L.},
   Title = {Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis},
   Journal = {Thorax},
   Volume = {62},
   Number = {4},
   Pages = {360-7},
   Year = {2007} }



@article{
3366,
   Author = {Mitchell, E. A. and Elliott, R. B.},
   Title = {Controlled trial of oral N-acetylcysteine in cystic fibrosis},
   Journal = {Aust Paediatr J},
   Volume = {18},
   Number = {1},
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   Year = {1982} }



@incollection{
3365,
   Author = {Turgeon, M. L.},
   Title = {Chapter 23: Principles of homeostasis and thrombosis},
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3364,
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3356,
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3355,
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@article{
3354,
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3353,
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3352,
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3350,
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@misc{
3338,
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3337,
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3333,
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@misc{
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   Author = {MMWR},
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3319,
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3318,
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3317,
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@article{
3316,
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3315,
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3314,
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3313,
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3311,
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3310,
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3309,
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3308,
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3307,
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@article{
3306,
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@article{
3305,
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   Title = {Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis II: Mechanistic Pharmacodynamic Model for Dexamethasone Effects in Lewis Rats with Collagen-Induced Arthritis},
   Journal = {J Pharmacol Exp Ther},
   Year = {2008} }



@article{
3304,
   Author = {Degon, M. and Chipkin, S. R. and Hollot, C. V. and Zoeller, R. T. and Chait, Y.},
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@article{
3303,
   Author = {Guyton, A. C. and Coleman, T. G. and Granger, H. J.},
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@article{
3302,
   Author = {Dansirikul, C. and Silber, H. E. and Karlsson, M. O.},
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@article{
3301,
   Author = {Marscher, Alan P. and Jorstad, Svetlana G. and D‚ÄôArcangelo, Francesca D. and Smith, Paul S. and Williams, G. Grant and Larionov, Valeri M. and Oh, Haruki and Olmstead, Alice R. and Aller, Margo F. and Aller, Hugh D. and McHardy, Ian M. and L√§hteenm√§ki, Anne and Tornikoski, Merja and Valtaoja, Esko and Hagen-Thorn, Vladimir A. and Kopatskaya, Eugenia N. and Gear, Walter K. and Tosti, Gino and Kurtanidze, Omar and Nikolashvili, Maria},
   Title = {The inner jet of an active galactic nucleus as revealed by a radio-to-Œ≥-ray outburst},
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@article{
3300,
   Author = {Yelland, L. N. and Burns, J. P. and Sims, D. N. and Salter, A. B. and White, J. M.},
   Title = {Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose},
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@article{
3299,
   Author = {Bueno, L. and de Alwis, D. P. and Pitou, C. and Yingling, J. and Lahn, M. and Glatt, S. and Troconiz, I. F.},
   Title = {Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice},
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@article{
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   Author = {Wilkins, J. J. and Savic, R. M. and Karlsson, M. O. and Langdon, G. and McIlleron, H. and Pillai, G. C. and Smith, P. J. and Simonsson, U. S.},
   Title = {Population pharmacokinetics of rifampin in pulmonary tuberculosis patients including a semi-mechanistic model to describe variable absorption},
   Journal = {Antimicrob Agents Chemother},
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@article{
3297,
   Author = {Menon-Andersen, D. and Mondick, J. T. and Jayaraman, B. and Thompson, P. A. and Blaney, S. M. and Bernstein, M. and Bond, M. and Champagne, M. and Fossler, M. J. and Barrett, J. S.},
   Title = {Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults},
   Journal = {Cancer Chemother Pharmacol},
   Year = {2008} }



@article{
3296,
   Author = {Chen, J. and Alemao, E. and Yin, D. and Cook, J.},
   Title = {Development of a diabetes treatment simulation model: with application to assessing alternative treatment intensification strategies on survival and diabetes-related complications},
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   Volume = {10 Suppl 1},
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   Year = {2008} }



@article{
3295,
   Author = {Chow, C. C. and Hall, K. D.},
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@article{
3294,
   Author = {Müllera, P. and Berrya, D. A. and Grieveb, A. P. and Smith, M. and Kramsd, M.},
   Title = {Simulation-Based Sequential Bayesian Design},
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@article{
3293,
   Author = {Smith, M. K. and Jones, I. and Morris, M. F. and Grieve, A. P. and Tan, K.},
   Title = {Implementation of a Bayesian adaptive design in a proof of concept study},
   Journal = {Pharm Stat},
   Volume = {5},
   Number = {1},
   Pages = {39-50},
   Year = {2006} }



@article{
3292,
   Author = {Perez-Ruixo, J. J. and Zannikos, P. and Hirankarn, S. and Stuyckens, K. and Ludwig, E. A. and Soto-Matos, A. and Lopez-Lazaro, L. and Owen, J. S.},
   Title = {Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients},
   Journal = {Clin Pharmacokinet},
   Volume = {46},
   Number = {10},
   Pages = {867-84},
   Year = {2007} }



@article{
3291,
   Author = {Vandenhende, F. and Renard, D. and Nie, Y. and Kumar, A. and Miller, J. and Tauscher, J. and Witcher, J. and Zhou, Y. and Wong, D. F.},
   Title = {Bayesian hierarchical modeling of receptor occupancy in PET trials},
   Journal = {J Biopharm Stat},
   Volume = {18},
   Number = {2},
   Pages = {256-72},
   Year = {2008} }



@article{
3290,
   Author = {Fanta, S. and Niemi, M. and Jonsson, S. and Karlsson, M. O. and Holmberg, C. and Neuvonen, P. J. and Hoppu, K. and Backman, J. T.},
   Title = {Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms},
   Journal = {Pharmacogenet Genomics},
   Volume = {18},
   Number = {2},
   Pages = {77-90},
   Year = {2008} }



@article{
3289,
   Author = {Bies, R. and Gastonguay, M. and Schwartz, S.},
   Title = {Mathematics for Understanding Disease},
   Journal = {Clin Pharmacol Ther},
   Year = {2008} }



@article{
3288,
   Author = {Punyawudho, B. and Ramsay, R. E. and Macias, F. M. and Rowan, A. J. and Collins, J. F. and Brundage, R. C. and Birnbaum, A. K.},
   Title = {Population pharmacokinetics of lamotrigine in elderly patients},
   Journal = {J Clin Pharmacol},
   Volume = {48},
   Number = {4},
   Pages = {455-63},
   Year = {2008} }



@article{
3287,
   Author = {Tod, M. and Jullien, V. and Pons, G.},
   Title = {Facilitation of drug evaluation in children by population methods and modelling},
   Journal = {Clin Pharmacokinet},
   Volume = {47},
   Number = {4},
   Pages = {231-43},
   Year = {2008} }



@article{
3286,
   Author = {Testart-Paillet, D. and Girard, P. and You, B. and Freyer, G. and Pobel, C. and Tranchand, B.},
   Title = {Contribution of modelling chemotherapy-induced hematological toxicity for clinical practice},
   Journal = {Crit Rev Oncol Hematol},
   Volume = {63},
   Number = {1},
   Pages = {1-11},
   Year = {2007} }



@article{
3285,
   Author = {Ikawa, K. and Morikawa, N. and Ikeda, K. and Miki, M. and Nishimura, S. and Kobayashi, M.},
   Title = {Population pharmacokinetics and pharmacodynamics of biapenem in paediatric patients},
   Journal = {J Clin Pharm Ther},
   Volume = {33},
   Number = {2},
   Pages = {203-10},
   Year = {2008} }



@article{
3284,
   Author = {Aitkenhead, A. R. and Lin, E. S. and Achola, K. J.},
   Title = {The pharmacokinetics of oral and intravenous nalbuphine in healthy volunteers},
   Journal = {Br J Clin Pharmacol},
   Volume = {25},
   Number = {2},
   Pages = {264-8},
   Year = {1988} }



@article{
3283,
   Author = {Lehr, T. and Staab, A. and Tillmann, C. and Nielsen, E. O. and Trommeshauser, D. and Schaefer, H. G. and Kloft, C.},
   Title = {Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach},
   Journal = {Br J Pharmacol},
   Volume = {153},
   Number = {1},
   Pages = {164-74},
   Year = {2008} }



@article{
3282,
   Author = {Anderson, B. J. and Woollard, G. A. and Holford, N. H.},
   Title = {Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy},
   Journal = {Eur J Clin Pharmacol},
   Volume = {57},
   Number = {8},
   Pages = {559-69},
   Year = {2001} }



@article{
3280,
   Author = {Barrett, J. S. and Gupta, M. and Mondick, J. T.},
   Title = {Model-based drug development applied to oncology},
   Journal = {Expert.Opin.Drug Discovery},
   Volume = {2},
   Number = {2},
   Pages = {185-209},
   Year = {2007} }



@article{
3278,
   Author = {Semmar, N. and Urien, S. and Bruguerolle, B. and Simon, N.},
   Title = {Independent-model diagnostics for a priori identification and interpretation of outliers from a full pharmacokinetic database: correspondence analysis, Mahalanobis distance and Andrews curves},
   Journal = {J Pharmacokinet Pharmacodyn},
   Year = {2008} }



@article{
3276,
   Author = {Nakade, S. and Ohno, T. and Kitagawa, J. and Hashimoto, Y. and Katayama, M. and Awata, H. and Kodama, Y. and Miyata, Y.},
   Title = {Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting},
   Journal = {Cancer Chemother Pharmacol},
   Year = {2008} }



@article{
3275,
   Author = {Allegaert, K. and van den Anker, J. N. and de Hoon, J. N. and van Schaik, R. H. and Debeer, A. and Tibboel, D. and Naulaers, G. and Anderson, B. J.},
   Title = {Covariates of tramadol disposition in the first months of life},
   Journal = {Br J Anaesth},
   Volume = {100},
   Number = {4},
   Pages = {525-32},
   Year = {2008} }



@article{
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   Author = {Lunn, D. J. and Aarons, L.},
   Title = {The pharmacokinetics of saquinavir: a Markov chain Monte Carlo population analysis},
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   Number = {1},
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@article{
3273,
   Author = {Lunn, D. J. and Wakefield, J. and Racine-Poon, A.},
   Title = {Cumulative logit models for ordinal data: a case study involving allergic rhinitis severity scores},
   Journal = {Stat Med},
   Volume = {20},
   Number = {15},
   Pages = {2261-85},
   Year = {2001} }



@article{
3271,
   Author = {Lunn, D. J. and Whittaker, J. C. and Best, N.},
   Title = {A Bayesian toolkit for genetic association studies},
   Journal = {Genet Epidemiol},
   Volume = {30},
   Number = {3},
   Pages = {231-47},
   Year = {2006} }



@article{
3270,
   Author = {Lunn, D. J.},
   Title = {Automated covariate selection and Bayesian model averaging in population PK/PD models},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {35},
   Number = {1},
   Pages = {85-100},
   Year = {2008} }



@article{
3269,
   Author = {Gupta, P. and Hutmacher, M. M. and Frame, B. and Miller, R.},
   Title = {An alternative method for population pharmacokinetic data analysis under noncompliance},
   Journal = {J Pharmacokinet Pharmacodyn},
   Year = {2008} }



@article{
3268,
   Author = {Isla, A. and Rodriguez-Gascon, A. and Troconiz, I. F. and Bueno, L. and Solinis, M. A. and Maynar, J. and Sanchez-Izquierdo, J. and Pedraz, J. L.},
   Title = {Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy},
   Journal = {Clin Pharmacokinet},
   Volume = {47},
   Number = {3},
   Pages = {173-80},
   Year = {2008} }



@article{
3267,
   Author = {Cortessis, V. and Thomas, D. C.},
   Title = {Toxicokinetic genetics: an approach to gene-environment and gene-gene interactions in complex metabolic pathways},
   Journal = {IARC Sci Publ},
   Number = {157},
   Pages = {127-50},
   Year = {2004} }



@misc{
3266,
   Title = {Forteo teriparitide (rDNA origin) injection Package Insert},
   Publisher = {Eli Lilly and Company},
   Pages = {1-22},
      Year = {2004} }



@book{
3265,
   Author = {Amgen, Inc},
   Title = {SensiparT (cinacalcet HCl) Tablets. Product Information},
   Address = {Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799},
   Year = {2004} }



@article{
3264,
   Author = {Berman, E. and Nicolaides, M. and Maki, R. G. and Fleisher, M. and Chanel, S. and Scheu, K. and Wilson, B. and Heller, G. and Sauter, N. P.},
   Title = {Altered bone and mineral metabolism in patients receiving imatinib mesylate},
   Journal = {N Engl J Med},
   Pages = {2006-2013},
   Year = {2006} }



@techreport{
3263,
   Author = {Center for Drug, Evaluation and Research},
   Title = {Clinical pharmacology and biopharmaceutics review for teriparatide (Forteo) NDA filing (Part 3)},
   Year = {2001} }



@techreport{
3262,
   Author = {Center for Drug, Evaluation and Research},
   Title = {Clinical pharmacology and biopharmaceutics review for teriparatide (Forteo) NDA filing (Part 4) and Medical Safety Review (Part 1)},
   Year = {2001} }



@techreport{
3261,
   Author = {Center for Drug, Evaluation and Research},
   Title = {Clinical pharmacology and biopharmaceutics reviews for teraparatide (Forteo) NDA filing (Part1)},
   Year = {2001} }



@techreport{
3260,
   Author = {Center for Drug, Evaluation and Research},
   Title = {Clinical pharmacology and biopharmaceutics review for teriparatide (Forteo) NDA filing (Part 2)},
   Year = {2001} }



@techreport{
3258,
   Author = {Products, Division of Metabolic Endocrine Drug},
   Title = {Medical safety review for teriparatide (Forteo) NDA filing (Part 2)},
   Year = {2001} }



@misc{
3257,
   Author = {Division of, Metabolic and Endocrine Drug, Products},
   Title = {Medical Review for Teraparatide (Forteo) NDA filing},
      Year = {2001} }



@techreport{
3256,
   Author = {Eli Lily Company},
   Title = {Clinical Study Summary: Study B3D-MC-GHBU},
   Year = {2006} }



@article{
3255,
   Author = {Figueirido, I. M. N.},
   Title = {Approximation of Bone Remodeling Models},
   Journal = {Journal de Math,matiques Pures et Appliqu,es},
   Volume = {84},
   Number = {12},
   Pages = {1794-1812},
   Year = {2005} }



@article{
3254,
   Author = {Fink, E. and Cormier, C. and Steinmetz, P. and Kindermans, C. and LeBouc, Y. and Souberbielle, J. C.},
   Title = {Differences in the Capacity of Several Biochemical Bone Markers to Assess High Bone Turnover in Early Menopause and Response to Alendronate Therapy},
   Journal = {Osteoporosis Int},
   Volume = {11},
   Pages = {295-303},
   Year = {2000} }



@article{
3253,
   Author = {Hernandez, C. J. and Keaveny, T. M.},
   Title = {Review: A biomechanical perspective on bone quality},
   Journal = {Bone},
   Year = {2006} }



@article{
3252,
   Author = {Hernandez, C. J. and Beaupr, G. S. and Carter, D. R.},
   Title = {A theoretical analysis of the changes in basic multicellular unit activity at menopause},
   Journal = {Bone},
   Volume = {32},
   Pages = {357-363},
   Year = {2003} }



@article{
3251,
   Author = {Hernandez, C. J. and Beaupr, G. S. and Marcus, R. and Carter, D. R.},
   Title = {A theoretical analysis of the contributions of remodeling space, mineralization, and bone balance to changes in bone mineral density during alendronate treatment},
   Journal = {Bone},
   Volume = {29},
   Number = {6},
   Pages = {511-516},
   Year = {2001} }



@article{
3250,
   Author = {Baron, R. and Rawadi, G.},
   Title = {Targeting the Wnt/{beta}-catenin Pathway to Regulate Bone Formation in the Adult Skeleton},
   Journal = {Endocrinology},
   Year = {2007} }



@article{
3249,
   Author = {Krishnan, V. and Bryant, H. U. and Macdougald, O. A.},
   Title = {Regulation of bone mass by Wnt signaling},
   Journal = {J Clin Invest},
   Volume = {116},
   Number = {5},
   Pages = {1202-1209},
   Year = {2006} }



@article{
3248,
   Author = {Karsenty, G.},
   Title = {Update on the transcriptional control of osteoblast differentiation},
   Journal = {BoneKEy},
   Volume = {4},
   Number = {6},
   Pages = {164-170},
   Year = {2007} }



@article{
3247,
   Author = {Walser, M.},
   Title = {Protein-binding of inorganic phosphate in plasma of normal subjects and patients with renal disease},
   Journal = {J Clin Invest},
   Volume = {39},
   Number = {3},
   Pages = {501-506},
   Year = {1960} }



@book{
3246,
   Author = {Roche, Pharmaceuticals},
   Title = {ROCALTROLr brand of calcitrol capsules and oral solution. Complete Product Information},
   Address = {Roche Laboratories Inc. 340 Kingsland Street, Nutley, NJ 07110-1199},
   Year = {2004} }



@article{
3245,
   Author = {Bailey, B. J. and Briars, G. L.},
   Title = {Estimating the surface area of the human body},
   Journal = {Stat Med},
   Volume = {15},
   Number = {13},
   Pages = {1325-32},
   Year = {1996} }



@article{
3244,
   Author = {Potter, B. K. and Burns, T. C. and Lacap, A. P. and Granville, R. R. and Gajewski, D. A.},
   Title = {Heterotopic ossification following traumatic and combat-related amputations. Prevalence, risk factors, and preliminary results of excision},
   Journal = {J Bone Joint Surg Am},
   Volume = {89},
   Number = {3},
   Pages = {476-86},
   Year = {2007} }



@article{
3243,
   Author = {Shinoda, S. and Aoyama, T. and Aoyama, Y. and Tomioka, S. and Matsumoto, Y. and Ohe, Y.},
   Title = {Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain},
   Journal = {Biol Pharm Bull},
   Volume = {30},
   Number = {1},
   Pages = {157-61},
   Year = {2007} }



@article{
3242,
   Author = {Forrest, J. A. and Clements, J. A. and Prescott, L. F.},
   Title = {Clinical pharmacokinetics of paracetamol},
   Journal = {Clin Pharmacokinet},
   Volume = {7},
   Number = {2},
   Pages = {93-107},
   Year = {1982} }



@article{
3241,
   Author = {Vrijens, B. and Tousset, E. and Rode, R. and Bertz, R. and Mayer, S. and Urquhart, J.},
   Title = {Successful projection of the time course of drug concentration in plasma during a 1-year period from electronically compiled dosing-time data used as input to individually parameterized pharmacokinetic models},
   Journal = {J Clin Pharmacol},
   Volume = {45},
   Number = {4},
   Pages = {461-7},
   Year = {2005} }



@article{
3240,
   Title = {Pfizer, Inc.  Population Exposure-Blood Pressure Response Report for Torcetrapib (CP-529,414) Phase 1 and 2 Data (Protocols A3071015, A3071016, A3071026, A3071028).  Pfizer internal report. 2007},
   Year = {} }



@article{
3239,
   Title = {Pfizer, Inc.  Phase 3 Torcetrapib Exposure-Blood Pressure Response Population Modeling Analysis.  Pfizer internal report. 2007},
   Year = {} }



@incollection{
3238,
   Author = {Ribeiro, R. M. and Powers, K. A. and Talal, A. H. and Perelson, A. S. and Schinazi, R. F. and Schiff, E. R.},
   Title = {Modeling the viral dynamics of HCV in patients treated with pegylated interferon alpha 2b},
   BookTitle = {Framing the Knowledge of Therapeutics for Viral Hepatitis},
   Publisher = {IHL Press},
   Address = {College Park, GA},
   Volume = {1},
   Pages = {407-420},
   Year = {2006} }



@article{
3237,
   Author = {Hing, J. and Perez-Ruixo, J. J. and Stuyckens, K. and Soto-Matos, A. and Lopez-Lazaro, L. and Zannikos, P.},
   Title = {Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of trabectedin (ET-743, Yondelis) induced neutropenia},
   Journal = {Clin Pharmacol Ther},
   Volume = {83},
   Number = {1},
   Pages = {130-43},
   Year = {2008} }



@article{
3236,
   Author = {Roy, A. and Mould, D. R. and Wang, X. F. and Tay, L. and Raymond, R. and Pfister, M.},
   Title = {Modeling and simulation of abatacept exposure and interleukin-6 response in support of recommended doses for rheumatoid arthritis},
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Number = {11},
   Pages = {1408-20},
   Year = {2007} }



@article{
3235,
   Author = {Geldof, M. and Freijer, J. I. and Peletier, L. A. and van Beijsterveldt, L. and Danhof, M.},
   Title = {Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex},
   Journal = {Eur J Pharm Sci},
   Year = {2007} }



@article{
3234,
   Author = {Baille, P. and Bruno, R. and Schellens, J. H. and Webster, L. K. and Millward, M. and Verweij, J. and Montay, G.},
   Title = {Optimal sampling strategies for bayesian estimation of docetaxel (Taxotere) clearance},
   Journal = {Clin Cancer Res},
   Volume = {3},
   Number = {9},
   Pages = {1535-8},
   Year = {1997} }



@article{
3233,
   Author = {Patterson, S. and Francis, S. and Ireson, M. and Webber, D. and Whitehead, J.},
   Title = {A novel Bayesian decision procedure for early-phase dose-finding studies},
   Journal = {J Biopharm Stat},
   Volume = {9},
   Number = {4},
   Pages = {583-97},
   Year = {1999} }



@article{
3232,
   Author = {Ishizuka, N. and Ohashi, Y.},
   Title = {The continual reassessment method and its applications: a Bayesian methodology for phase I cancer clinical trials},
   Journal = {Stat Med},
   Volume = {20},
   Number = {17-18},
   Pages = {2661-81},
   Year = {2001} }



@article{
3231,
   Author = {Bortot, P. and Thomaseth, K. and Salvan, A.},
   Title = {Population toxicokinetic analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin using Bayesian techniques},
   Journal = {Stat Med},
   Volume = {21},
   Number = {4},
   Pages = {533-47},
   Year = {2002} }



@article{
3230,
   Author = {Miller, G. and Martz, H. F. and Little, T. T. and Guilmette, R.},
   Title = {Bayesian internal dosimetry calculations using Markov Chain Monte Carlo},
   Journal = {Radiat Prot Dosimetry},
   Volume = {98},
   Number = {2},
   Pages = {191-8},
   Year = {2002} }



@article{
3229,
   Author = {Russell, C. D. and Taylor, A. T., Jr. and Dubovsky, E. V.},
   Title = {A Bayesian regression model for plasma clearance},
   Journal = {J Nucl Med},
   Volume = {43},
   Number = {6},
   Pages = {762-6},
   Year = {2002} }



@article{
3228,
   Author = {Kerbusch, T. and Mathot, R. A. and Otten, H. M. and Meesters, E. W. and van Kan, H. J. and Schellens, J. H. and Beijnen, J. H.},
   Title = {Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report},
   Journal = {Pharmacol Toxicol},
   Volume = {90},
   Number = {5},
   Pages = {243-5},
   Year = {2002} }



@article{
3227,
   Author = {Bothtner, U. and Milne, S. E. and Kenny, G. N. and Georgieff, M. and Schraag, S.},
   Title = {Bayesian probabilistic network modeling of remifentanil and propofol interaction on wakeup time after closed-loop controlled anesthesia},
   Journal = {J Clin Monit Comput},
   Volume = {17},
   Number = {1},
   Pages = {31-6},
   Year = {2002} }



@article{
3226,
   Author = {Teramachi, H. and Hatakeyama, H. and Matsushita, R. and Imai, Y. and Miyamoto, K. and Tsuji, A.},
   Title = {Evaluation of predictability for vancomycin dosage regimens by the Bayesian method with Japanese population pharmacokinetic parameters},
   Journal = {Biol Pharm Bull},
   Volume = {25},
   Number = {10},
   Pages = {1333-8},
   Year = {2002} }



@article{
3225,
   Author = {Rousseau, A. and Sabot, C. and Delepine, N. and Delepine, G. and Debord, J. and Lachatre, G. and Marquet, P.},
   Title = {Bayesian estimation of methotrexate pharmacokinetic parameters and area under the curve in children and young adults with localised osteosarcoma},
   Journal = {Clin Pharmacokinet},
   Volume = {41},
   Number = {13},
   Pages = {1095-104},
   Year = {2002} }



@article{
3224,
   Author = {Rousseau, A. and Monchaud, C. and Debord, J. and Vervier, I. and Estenne, M. and Thiry, P. and Marquet, P.},
   Title = {Bayesian forecasting of oral cyclosporin pharmacokinetics in stable lung transplant recipients with and without cystic fibrosis},
   Journal = {Ther Drug Monit},
   Volume = {25},
   Number = {1},
   Pages = {28-35},
   Year = {2003} }



@article{
3223,
   Author = {Monchaud, C. and Rousseau, A. and Leger, F. and David, O. J. and Debord, J. and Dantoine, T. and Marquet, P.},
   Title = {Limited sampling strategies using Bayesian estimation or multilinear regression for cyclosporin AUC(0-12) monitoring in cardiac transplant recipients over the first year post-transplantation},
   Journal = {Eur J Clin Pharmacol},
   Volume = {58},
   Number = {12},
   Pages = {813-20},
   Year = {2003} }



@article{
3222,
   Author = {Cremers, S. C. and Scholten, E. M. and Schoemaker, R. C. and Lentjes, E. G. and Vermeij, P. and Paul, L. C. and den Hartigh, J. and de Fijter, J. W.},
   Title = {A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients},
   Journal = {Nephrol Dial Transplant},
   Volume = {18},
   Number = {6},
   Pages = {1201-8},
   Year = {2003} }



@article{
3221,
   Author = {Climente-Marti, M. and Merino-Sanjuan, M. and Almenar-Cubells, D. and Jimenez-Torres, N. V.},
   Title = {A Bayesian method for predicting 5-fluorouracil pharmacokinetic parameters following short-term infusion in patients with colorectal cancer},
   Journal = {J Pharm Sci},
   Volume = {92},
   Number = {6},
   Pages = {1155-65},
   Year = {2003} }



@article{
3220,
   Author = {Magni, P. and Bellazzi, R. and De Nicolao, G. and Poggesi, I. and Rocchetti, M.},
   Title = {Nonparametric AUC estimation in population studies with incomplete sampling: a Bayesian approach},
   Journal = {J Pharmacokinet Pharmacodyn},
   Volume = {29},
   Number = {5-6},
   Pages = {445-71},
   Year = {2002} }



@article{
3219,
   Author = {Bolon, M. and Bastien, O. and Flamens, C. and Paulus, S. and Salord, F. and Boulieu, R.},
   Title = {Evaluation of the estimation of midazolam concentrations and pharmacokinetic parameters in intensive care patients using a bayesian pharmacokinetic software (PKS) according to sparse sampling approach},
   Journal = {J Pharm Pharmacol},
   Volume = {55},
   Number = {6},
   Pages = {765-71},
   Year = {2003} }



@article{
3218,
   Author = {Russell, C. D.},
   Title = {A Bayesian 3-compartment model for 99mTc-MAG3 clearance},
   Journal = {J Nucl Med},
   Volume = {44},
   Number = {8},
   Pages = {1357-61},
   Year = {2003} }



@article{
3217,
   Author = {Conti, D. V. and Cortessis, V. and Molitor, J. and Thomas, D. C.},
   Title = {Bayesian modeling of complex metabolic pathways},
   Journal = {Hum Hered},
   Volume = {56},
   Number = {1-3},
   Pages = {83-93},
   Year = {2003} }



@article{
3216,
   Author = {Murphy, E. F. and Gilmour, S. G. and Crabbe, M. J.},
   Title = {Efficient and cost-effective experimental determination of kinetic constants and data: the success of a Bayesian systematic approach to drug transport, receptor binding, continuous culture and cell transport kinetics},
   Journal = {FEBS Lett},
   Volume = {556},
   Number = {1-3},
   Pages = {193-8},
   Year = {2004} }



@article{
3215,
   Author = {Peris-Marti, J. F. and Borras-Blasco, J. and Rosique-Robles, J. D. and Gonzalez-Delgado, M.},
   Title = {Evaluation of once daily tobramycin dosing in critically ill patients through Bayesian simulation},
   Journal = {J Clin Pharm Ther},
   Volume = {29},
   Number = {1},
   Pages = {65-70},
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@article{
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@article{
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@article{
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@article{
3208,
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@techreport{
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   Author = {DHHS and FDA},
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   Year = {2006} }



@article{
3145,
   Author = {Lewiecki, E. M. and Miller, P. D. and McClung, M. R. and Cohen, S. B. and Bolognese, M. A. and Liu, Y. and Wang, A. and Siddhanti, S. and Fitzpatrick, L. A.},
   Title = {Two-Year Treatment With Denosumab (AMG 162) in a Randomized Phase 2 Study of Postmenopausal Women With Low BMD},
   Journal = {J.Bone Miner.Res.},
   Volume = {22},
   Number = {12},
   Pages = {1832-1841},
   Year = {2007} }



@article{
3144,
   Author = {Jilka, R. L.},
   Title = {Molecular and cellular mechanisms of the anabolic effect of intermittent PTH},
   Journal = {Bone},
   Volume = {40},
   Number = {6},
   Pages = {1434-1446},
   Year = {2007} }



@misc{
3143,
   Author = {McVicar, C. and Gardiner, T. and Stitt, A.},
   Title = {Human cell-derived epoetin delta is less angiogenic than darbopoetin alfa in vitro},
      Year = {2007} }



@article{
3142,
   Author = {Elliott, S. and Egrie, J. and Browne, J. and Lorenzini, T. and Busse, L. and Rogers, N. and Ponting, I.},
   Title = {Control of rHuEPO biological activity: the role of carbohydrate},
   Journal = {Exp.Hamatol.},
   Volume = {32},
   Number = {12},
   Pages = {1146-1155},
   Year = {2004} }



@article{
3141,
   Author = {Shahrokh, Z. and Flatman, M. and Davies, M.},
   Title = {Erythropoieitn produced by a human cell line has only trace levels of potentially immunogenic N-glycolylneuraminic acid residues},
   Journal = {Haematologica/The Hematology Journal},
   Volume = {91},
   Number = {s1},
   Pages = {208},
   Year = {2006} }



@article{
3140,
   Author = {Peterson, M. and Stouch, B. and Chen, D. and Baughman, S. and Holloway, D. and Bekker, P. and Martin, S.},
   Title = {A population PK/PD model describes the rapid, profound, and sustained suppression of urinary N-telopeptide following administration of AMG 162, a fully human monoclonal antibody against RANKL, to healthy postmenopausal women},
   Journal = {The AAPS Journal},
   Volume = {24},
   Number = {6 Abstract W4340},
   Year = {2004} }



@article{
3139,
   Author = {Parfitt, A. M.},
   Title = {Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone},
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   Volume = {55},
   Number = {3},
   Pages = {273-286},
   Year = {1994} }



@article{
3138,
   Author = {Parfitt, A. M.},
   Title = {The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological and kinetic approaches to bone turnover},
   Journal = {Metabolism},
   Volume = {25},
   Number = {7},
   Pages = {809-844},
   Year = {1976} }



@article{
3137,
   Author = {Koue, T. and Kubo, M. and Funaki, T. and Fukuda, T. and Azuma, J. and Takaai, M. and Kayano, Y. and Hashimoto, Y.},
   Title = {Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {30},
   Number = {11},
   Pages = {2154-2158},
   Year = {2007} }



@article{
3136,
   Author = {El-Masri, H. A.},
   Title = {Experimental and mathematical modeling methods for the investigation of toxicological interactions},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {223},
   Number = {2},
   Pages = {148-154},
   Year = {2007} }



@article{
3135,
   Author = {Albers, S. and Meibohm, B. and Mir, T. S. and Laer, S.},
   Title = {Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure},
   Journal = {Br.J.Clin Pharmacol.},
   Year = {2007} }



@article{
3134,
   Author = {Jilka, R. L. and Weinstein, R. S. and Parfitt, A. M. and Manolagas, S. C.},
   Title = {Quantifying osteoblast and osteocyte apoptosis: challenges and rewards},
   Journal = {J.Bone Miner.Res.},
   Volume = {22},
   Number = {10},
   Pages = {1492-1501},
   Year = {2007} }



@article{
3133,
   Author = {Woo, S. and Krzyzanski, W. and Duliege, A. M. and Stead, R. B. and Jusko, W. J.},
   Title = {Population Pharmacokinetics and Pharmacodynamics of Peptidic Erythropoiesis Receptor Agonist (ERA) in Healthy Volunteers},
   Journal = {J.Clin Pharmacol.},
   Year = {2007} }



@article{
3132,
   Author = {Hennig, S. and Norris, R. and Kirkpatrick, C. M.},
   Title = {Target concentration intervention is needed for tobramycin dosing in paediatric patients with cystic fibrosis - a population pharmacokinetic study},
   Journal = {Br.J.Clin Pharmacol.},
   Year = {2007} }



@article{
3131,
   Author = {Eisenberg, P. and MacKintosh, F. R. and Ritch, P. and Cornett, P. A. and Macciocchi, A.},
   Title = {Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: a dose-ranging clinical study},
   Journal = {Annals of Oncology: Official Journal of the European Society for Medical Oncology},
   Volume = {15},
   Number = {2},
   Pages = {330-337},
   Year = {2004} }



@article{
3130,
   Author = {Smith, W. B. and Pratt, R. D.},
   Title = {Pharmacokinetics and pharmacodynamics of epoetin delta in two studies in healthy volunteers and two studies in patients with chronic kidney disease},
   Journal = {Clin Ther.},
   Volume = {29},
   Pages = {1368-1380},
   Year = {2007} }



@article{
3129,
   Author = {Scott, L. V. and Medbak, S. and Dinan, T. G.},
   Title = {ACTH and cortisol release following intravenous desmopressin: a dose-response study},
   Journal = {Clin.Endocrinol.(Oxf)},
   Volume = {51},
   Number = {5},
   Pages = {653-658},
   Year = {1999} }



@article{
3128,
   Author = {Dinan, T. G. and O'Brien, S. and Lavelle, E. and Scott, L. V.},
   Title = {Further neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression},
   Journal = {Psychol.Med.},
   Volume = {34},
   Number = {1},
   Pages = {169-172},
   Year = {2004} }



@article{
3127,
   Author = {Fetterly, G. J. and Owen, J. S. and Stuyckens, K. and Passarell, J. A. and Zannikos, P. and Soto-Matos, A. and Izquierdo, M. A. and Perez-Ruixo, J. J.},
   Title = {Semimechanistic pharmacokinetic/pharmacodynamic model for hepatoprotective effect of dexamethasone on transient transaminitis after trabectedin (ET-743) treatment},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Year = {2007} }



@article{
3126,
   Author = {Li, L. and Yu, M. and Chin, R. and Lucksiri, A. and Flockhart, D. A. and Hall, S. D.},
   Title = {Drug-drug interaction prediction: a Bayesian meta-analysis approach},
   Journal = {Statistics in Medicine},
   Volume = {26},
   Number = {20},
   Pages = {3700-3721},
   Year = {2007} }



@article{
3125,
   Author = {Parfitt, A. M.},
   Title = {Misconceptions (3): calcium leaves bone only by resorption and enters only by formation},
   Journal = {Bone},
   Volume = {33},
   Number = {3},
   Pages = {259-263},
   Year = {2003} }



@article{
3124,
   Author = {Dunbar, J. L. and Turncliff, R. Z. and Hayes, S. C. and Farrell, C. B.},
   Title = {Population Pharmacokinetics of Extended-Release Injectable Naltrexone (XR-NTX) in Patients With Alcohol Dependence},
   Journal = {J.Stud.Alcohol Drugs},
   Volume = {68},
   Number = {6},
   Pages = {862-870},
   Year = {2007} }



@article{
3123,
   Author = {Ogungbenro, K. and Aarons, L.},
   Title = {Design of population pharmacokinetic experiments using prior information},
   Journal = {Xenobiotica},
   Volume = {37},
   Number = {10},
   Pages = {1311-1330},
   Year = {2007} }



@article{
3122,
   Author = {Masoli, M. and Holt, S. and Weatherall, M. and Beasley, R.},
   Title = {Dose-response relationship of inhaled budesonide in adult asthma: a meta-analysis},
   Journal = {Eur.Respir.J.},
   Volume = {23},
   Number = {4},
   Pages = {552-558},
   Year = {2004} }



@article{
3121,
   Author = {Kleiger, R. E. and Miller, J. P. and Bigger, J. T., Jr. and Moss, A. J.},
   Title = {Decreased heart rate variability and its association with increased mortality after acute myocardial infarction},
   Journal = {The American Journal of Cardiology},
   Volume = {59},
   Number = {4},
   Pages = {256-262},
   Year = {1987} }



@article{
3120,
   Author = {Paradisis, M. and Jiang, X. and McLachlan, A. J. and Evans, N. and Kluckow, M. and Osborn, D.},
   Title = {Population pharmacokinetics and dosing regimen design of milrinone in preterm infants},
   Journal = {Archives of Disease in Childhood.Fetal and Neonatal Edition},
   Volume = {92},
   Number = {3},
   Pages = {F204-F209},
   Year = {2007} }



@incollection{
3119,
   Author = {Gibaldi, M. and Perrier, D.},
   Title = {Multiple dosing},
   BookTitle = {Pharmacokinetics},
   Publisher = {Marcel Dekker, Inc.},
   Address = {New York},
   Volume = {2nd Ed.  },
   Pages = {113-144},
   Year = {1982} }



@article{
3118,
   Author = {Bergstrand, M. and Plan, E. and Kjellsson, M. and Karlsson, M. O.},
   Title = {A comparison of methods for handling of data below the limit of quantification in NONMEM VI},
   Journal = {PAGE.Abstracts of the Annual Meeting of the Population Approach Group in Europe.},
   Volume = {Abstr 1201},
   Year = {2007} }



@techreport{
3117,
   Author = {Short, T. A.},
   Title = {Rpad: open source in action},
   Institution = {Power Engineering Society General Meeting. IEEE},
   Year = {2006} }



@article{
3116,
   Author = {Hirt, D. and Mentre, F. and Tran, A. and Rey, E. and Auleley, S. and Salmon, D. and Duval, X. and Treluyer, J. M.},
   Title = {Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients},
   Journal = {British Journal of Clinical Pharmacology},
   Year = {2007} }



@article{
3115,
   Author = {Fedorov, V. and Leonov, S.},
   Title = {Population pharmacokinetic measures, their estimation and selection of sampling times},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {17},
   Number = {5},
   Pages = {919-941},
   Year = {2007} }



@article{
3114,
   Author = {Li, D. and Lu, W. and Zhu, J. Y. and Gao, J. and Lou, Y. Q. and Zhang, G. L.},
   Title = {Population pharmacokinetics of tacrolimus and CYP3A5, MDR1 and IL-10 polymorphisms in adult liver transplant patients},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {32},
   Number = {5},
   Pages = {505-515},
   Year = {2007} }



@article{
3113,
   Author = {Perez-Ruixo, J. J. and Zannikos, P. and Hirankarn, S. and Stuyckens, K. and Ludwig, E. A. and Soto-Matos, A. and Lopez-Lazaro, L. and Owen, J. S.},
   Title = {Population Pharmacokinetic Meta-Analysis of Trabectedin (ET-743, Yondelis((R))) in Cancer Patients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {46},
   Number = {10},
   Pages = {867-884},
   Year = {2007} }



@article{
3112,
   Author = {Cronenberger, C. and Mould, D. R. and Roethig, H. J. and Sarkar, M.},
   Title = {Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers},
   Journal = {British Journal of Clinical Pharmacology},
   Year = {2007} }



@article{
3111,
   Author = {Duval, V. and Karlsson, M. O.},
   Title = {Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model},
   Journal = {Pharmaceutical Research},
   Volume = {19},
   Number = {12},
   Pages = {1835-1840},
   Year = {2002} }



@article{
3110,
   Author = {Hirt, D. and Urien, S. and Jullien, V. and Firtion, G. and Chappuy, H. and Rey, E. and Pons, G. and Mandelbrot, L. and Treluyer, J. M.},
   Title = {Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {64},
   Number = {5},
   Pages = {634-644},
   Year = {2007} }



@article{
3109,
   Author = {Othman, A. A. and Newman, A. H. and Eddington, N. D.},
   Title = {Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {322},
   Number = {2},
   Pages = {760-769},
   Year = {2007} }



@article{
3108,
   Author = {Rubino, C. M. and Ma, L. and Bhavnani, S. M. and Korth-Bradley, J. and Speth, J. and Ellis-Grosse, E. and Rodvold, K. R. and Ambrose, P. G. and Drusano, G. L.},
   Title = {Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
3107,
   Author = {Tremoulet, A. H. and Capparelli, E. V. and Patel, P. and Acosta, E. P. and Luzuriaga, K. and Bryson, Y. and Wara, D. and Zorrilla, C. and Holland, D. and Mirochnick, M.},
   Title = {Population Pharmacokinetics of Lamivudine in HIV Exposed and Infected Infants},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
3106,
   Author = {Gueorguieva, I. I. and Nestorov, I. A. and Rowland, M.},
   Title = {Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {31},
   Number = {3},
   Pages = {185-213},
   Year = {2004} }



@article{
3105,
   Author = {Jonsson, E. N. and Macintyre, F. and James, I. and Krams, M. and Marshall, S.},
   Title = {Bridging the pharmacokinetics and pharmacodynamics of UK-279,276 across healthy volunteers and stroke patients using a mechanistically based model for target-mediated disposition},
   Journal = {Pharmaceutical Research},
   Volume = {22},
   Number = {8},
   Pages = {1236-1246},
   Year = {2005} }



@misc{
3104,
   Author = {Pratt, R. D. and Dowell, J. A.},
   Title = {Pharmacokinetics of epoetin delta: a new erythropoietin produced by gene activation in a human cell line},
      Year = {2006} }



@article{
3103,
   Author = {Martin, K. J.},
   Title = {The first human cell line-derived erythropoietin, epoetin-delta (Dynepo), in the management of anemia in patients with chronic kidney disease},
   Journal = {Clin.Nephrol.},
   Volume = {68},
   Number = {1},
   Pages = {26-31},
   Year = {2007} }



@article{
3102,
   Author = {Spinowitz, B. S. and Pratt, R. D.},
   Title = {Epoetin delta is effective for the management of anaemia associated with chronic kidney disease},
   Journal = {Curr.Med.Res.Opin.},
   Volume = {22},
   Number = {12},
   Pages = {2507-2513},
   Year = {2006} }



@article{
3101,
   Author = {Kwan, J. T. and Pratt, R. D.},
   Title = {Epoetin delta, erythropoietin produced in a human cell line, in the management of anaemia in predialysis chronic kidney disease patients},
   Journal = {Curr.Med.Res.Opin.},
   Volume = {23},
   Number = {2},
   Pages = {307-311},
   Year = {2007} }



@article{
3100,
   Author = {Smith, M. T.},
   Title = {Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites},
   Journal = {Clin.Exp.Pharmacol.Physiol},
   Volume = {27},
   Number = {7},
   Pages = {524-528},
   Year = {2000} }



@article{
3099,
   Author = {Boyle, W. J. and Simonet, W. S. and Lacey, D. L.},
   Title = {Osteoclast differentiation and activation},
   Journal = {Nature},
   Volume = {423},
   Number = {6937},
   Pages = {337-342},
   Year = {2003} }



@article{
3098,
   Author = {Comte, L. and Vrijens, B. and Tousset, E. and Gerard, P. and Urquhart, J.},
   Title = {Estimation of the comparative therapeutic superiority of QD and BID dosing regimens, based on integrated analysis of dosing history data and pharmacokinetics},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {34},
   Number = {4},
   Pages = {549-558},
   Year = {2007} }



@article{
3097,
   Author = {Lonnebo, A. and Grahnen, A. and Karlsson, M. O.},
   Title = {An integrated model for the effect of budesonide on ACTH and cortisol in healthy volunteers},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {64},
   Number = {2},
   Pages = {125-132},
   Year = {2007} }



@article{
3096,
   Author = {Diago, M. and Crespo, J. and Olveira, A. and Perez, R. and Barcena, R. and Sanchez-Tapias, J. M. and Munoz-Sanchez, M. and Romero-Gomez, M.},
   Title = {Clinical trial: pharmacodynamics and pharmacokinetics of re-treatment with fixed-dose induction of peginterferon alpha-2a in hepatitis C virus genotype 1 true non-responder patients},
   Journal = {Aliment.Pharmacol.Ther.},
   Volume = {26},
   Number = {8},
   Pages = {1131-1138},
   Year = {2007} }



@article{
3095,
   Author = {Pillai, G. and Gieschke, R. and Goggin, T. and Jacqmin, P. and Schimmer, R. C. and Steimer, J. L.},
   Title = {A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {58},
   Number = {6},
   Pages = {618-631},
   Year = {2004} }



@article{
3094,
   Author = {Ambrose, P. G. and Forrest, A. and Craig, W. A. and Rubino, C. M. and Bhavnani, S. M. and Drusano, G. L. and Heine, H. S.},
   Title = {Pharmacokinetics-Pharmacodynamics of Gatifloxacin in a Lethal Murine-Bacillus anthracis Inhalation Infection Model},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
3093,
   Author = {Jiang, D. C. and Wang, L. and Wang, Y. Q. and Li, L. and Lu, W. and Bai, X. R.},
   Title = {Population pharmacokinetics of valproate in Chinese children with epilepsy},
   Journal = {Acta Pharmacol.Sin.},
   Volume = {28},
   Number = {10},
   Pages = {1677-1684},
   Year = {2007} }



@article{
3092,
   Author = {Langers, P. and Cremers, S. C. and den, Hartigh J. and Rijnbeek, E. M. and Ringers, J. and Lamers, C. B. and Hommes, D. W. and Van, Hoek B.},
   Title = {Individualized population pharmacokinetic model with limited sampling for cyclosporine monitoring after liver transplantation in clinical practice: C0+C2?},
   Journal = {Aliment.Pharmacol.Ther.},
   Year = {2007} }



@article{
3091,
   Author = {Snoeck, E. and Jacqmin, P. and Sargentini-Maier, M. L. and Stockis, A.},
   Title = {Modeling and simulation of intravenous levetiracetam pharmacokinetic profiles in children to evaluate dose adaptation rules},
   Journal = {Epilepsy Research},
   Volume = {76},
   Number = {2-3},
   Pages = {140-147},
   Year = {2007} }



@article{
3090,
   Author = {Hazra, A. and DuBois, D. C. and Almon, R. R. and Jusko, W. J.},
   Title = {Assessing the dynamics of nuclear glucocorticoid-receptor complex: adding flexibility to gene expression modeling},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {34},
   Number = {3},
   Pages = {333-354},
   Year = {2007} }



@article{
3089,
   Author = {Dokoumetzidis, A. and Aarons, L.},
   Title = {Bayesian optimal designs for pharmacokinetic models: sensitivity to uncertainty},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {17},
   Number = {5},
   Pages = {851-867},
   Year = {2007} }



@article{
3088,
   Author = {Neumann, A. and Buti, M. and Lurie, Y. and et al.},
   Title = {The second phase HCV decline slope is the best predictor of sustained viral response during treatment of chronic HCV genotype I patients with peg-interferon-a-2b and ribavirin. [AASLD Abrstract 778]},
   Journal = {Hepatology},
   Volume = {36},
   Number = {4 Pt 2 of 2},
   Year = {2002} }



@article{
3087,
   Author = {Fried, M. W. and Shiffman, M. L. and Reddy, K. R. and Smith, C. and Marinos, G. and Goncales, F. L., Jr. and Haussinger, D. and Diago, M. and Carosi, G. and Dhumeaux, D. and Craxi, A. and Lin, A. and Hoffman, J. and Yu, J.},
   Title = {Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection},
   Journal = {The New England Journal of Medicine},
   Volume = {347},
   Number = {13},
   Pages = {975-982},
   Year = {2002} }



@article{
3086,
   Author = {Manns, M. P. and McHutchison, J. G. and Gordon, S. C. and Rustgi, V. K. and Shiffman, M. and Reindollar, R. and Goodman, Z. D. and Koury, K. and Ling, M. and Albrecht, J. K.},
   Title = {Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial},
   Journal = {Lancet},
   Volume = {358},
   Number = {9286},
   Pages = {958-965},
   Year = {2001} }



@article{
3085,
   Author = {Zeuzem, S.},
   Title = {Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: who responds less well?},
   Journal = {Annals of Internal Medicine},
   Volume = {140},
   Number = {5},
   Pages = {370-381},
   Year = {2004} }



@article{
3084,
   Author = {Perelson, A. and Herrmann, E. and Micol, F. and Zeuzem, S.},
   Title = {New kinetic models for the hepatitis C virus},
   Journal = {Hepatology},
   Volume = {42},
   Number = {4},
   Pages = {749-754},
   Year = {2005} }



@article{
3083,
   Author = {Lalonde, R. L. and Kowalski, K. G. and Hutmacher, M. M. and Ewy, W. and Nichols, D. J. and Milligan, P. A. and Corrigan, B. W. and Lockwood, P. A. and Marshall, S. A. and Benincosa, L. J. and Tensfeldt, T. G. and Parivar, K. and Amantea, M. and Glue, P. and Koide, H. and Miller, R.},
   Title = {Model-based drug development},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {82},
   Number = {1},
   Pages = {21-32},
   Year = {2007} }



@article{
3082,
   Author = {Lodise, T. P. and Nau, R. and Kinzig, M. and Drusano, G. L. and Jones, R. N. and Sorgel, F.},
   Title = {Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation},
   Journal = {The Journal of Antimicrobial Chemotherapy},
   Year = {2007} }



@article{
3081,
   Author = {Potts, A. L. and Larsson, P. and Eksborg, S. and Warman, G. and Lonnqvist, P. A. and Anderson, B. J.},
   Title = {Clonidine disposition in children; a population analysis},
   Journal = {Paediatr.Anaesth.},
   Volume = {17},
   Number = {10},
   Pages = {924-933},
   Year = {2007} }



@article{
3080,
   Author = {Panhard, X. and Legrand, M. and Taburet, A. M. and Diquet, B. and Goujard, C. and Mentre, F.},
   Title = {Population pharmacokinetic analysisof lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART},
   Journal = {European Journal of Clinical Pharmacology},
   Year = {2007} }



@article{
3079,
   Author = {He, Y. L. and Sadler, B. M. and Sabo, R. and Balez, S. and Wang, Y. and Campestrini, J. and Laurent, A. and Ligueros-Saylan, M. and Howard, D.},
   Title = {The Absolute Oral Bioavailability and Population-Based Pharmacokinetic Modelling of a Novel Dipeptidylpeptidase-IV Inhibitor, Vildagliptin, in Healthy Volunteers},
   Journal = {Clin Pharmacokinet.},
   Volume = {46},
   Number = {9},
   Pages = {787-802},
   Year = {2007} }



@article{
3078,
   Author = {Agerso, H. and Seiding, Larsen L. and Riis, A. and Lovgren, U. and Karlsson, M. O. and Senderovitz, T.},
   Title = {Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients},
   Journal = {Br.J Clin Pharmacol},
   Volume = {58},
   Number = {4},
   Pages = {352-358},
   Year = {2004} }



@article{
3077,
   Author = {Chevaliez, S. and Pawlotsky, J. M.},
   Title = {Hepatitis C virus: virology, diagnosis and management of antiviral therapy},
   Journal = {World J Gastroenterol.},
   Volume = {13},
   Number = {17},
   Pages = {2461-2466},
   Year = {2007} }



@article{
3076,
   Title = {Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group},
   Journal = {Lancet},
   Volume = {352},
   Number = {9131},
   Pages = {854-865},
   Year = {1998} }



@article{
3075,
   Title = {Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group},
   Journal = {Lancet},
   Volume = {352},
   Number = {9131},
   Pages = {837-853},
   Year = {1998} }



@article{
3074,
   Author = {Stratton, I. M. and Adler, A. I. and Neil, H. A. and Matthews, D. R. and Manley, S. E. and Cull, C. A. and Hadden, D. and Turner, R. C. and Holman, R. R.},
   Title = {Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study},
   Journal = {BMJ},
   Volume = {321},
   Number = {7258},
   Pages = {405-412},
   Year = {2000} }



@article{
3073,
   Author = {Pokela, M. L. and Anttila, E. and Seppala, T. and Olkkola, K. T.},
   Title = {Marked variation in oxycodone pharmacokinetics in infants},
   Journal = {Paediatr.Anaesth.},
   Volume = {15},
   Number = {7},
   Pages = {560-565},
   Year = {2005} }



@article{
3072,
   Author = {Kokki, H. and Lintula, H. and Vanamo, K. and Heiskanen, M. and Eskelinen, M.},
   Title = {Oxycodone vs placebo in children with undifferentiated abdominal pain: a randomized, double-blind clinical trial of the effect of analgesia on diagnostic accuracy},
   Journal = {Arch Pediatr.Adolesc Med},
   Volume = {159},
   Number = {4},
   Pages = {320-325},
   Year = {2005} }



@article{
3071,
   Author = {Kokki, H. and Rasanen, I. and Lasalmi, M. and Lehtola, S. and Ranta, V. P. and Vanamo, K. and Ojanpera, I.},
   Title = {Comparison of oxycodone pharmacokinetics after buccal and sublingual administration in children},
   Journal = {Clin Pharmacokinet.},
   Volume = {45},
   Number = {7},
   Pages = {745-754},
   Year = {2006} }



@article{
3070,
   Author = {Zernikow, B. and Smale, H. and Michel, E. and Hasan, C. and Jorch, N. and Andler, W.},
   Title = {Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study},
   Journal = {Eur.J Pain},
   Volume = {10},
   Number = {7},
   Pages = {587-595},
   Year = {2006} }



@misc{
3069,
   Title = {GNU's Not Unix! - Free Software, Free Society},
   Publisher = {Free Software Foundation, Inc},
   Month = {2007},
      Year = {} }



@misc{
3068,
   Title = {World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects},
      Year = {2000} }



@techreport{
3067,
   Author = {Committee for Medicinal Products for Human, Use},
   Title = {Guideline on reporting the results of population pharmacokinetic analyses},
   Institution = {European Medicines Agency (EMEA)},
   Year = {2007} }



@misc{
3066,
   Title = {NMQual: NONMEM installation utility. Metrum Institute, 2008. http://metruminstitute.org },
   Volume = {2008},
      Year = {} }



@article{
3065,
   Author = {Chan, P. L. and Nutt, J. G. and Holford, N. H.},
   Title = {Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation},
   Journal = {Pharmaceutical Research},
   Volume = {24},
   Number = {4},
   Pages = {791-802},
   Year = {2007} }



@article{
3064,
   Author = {Peeters, M. Y. and Bras, L. J. and DeJongh, J. and Wesselink, R. M. and Aarts, L. P. and Danhof, M. and Knibbe, C. A.},
   Title = {Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients},
   Journal = {Clin Pharmacol Ther.},
   Year = {2007} }



@article{
3063,
   Author = {Herd, D. W. and Anderson, B. J. and Holford, N. H.},
   Title = {Modeling the norketamine metabolite in children and the implications for analgesia},
   Journal = {Paediatr.Anaesth.},
   Volume = {17},
   Number = {9},
   Pages = {831-840},
   Year = {2007} }



@article{
3062,
   Author = {Benedetti, M. S. and Whomsley, R. and Canning, M.},
   Title = {Drug metabolism in the paediatric population and in the elderly},
   Journal = {Drug Metabolism Today},
   Volume = {12},
   Number = {15-16},
   Pages = {599-610},
   Year = {2007} }



@article{
3061,
   Author = {Han, C.},
   Title = {Experimental design for regression analysis when the responses are subject to censoring},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {87},
   Number = {2},
   Pages = {104-111},
   Year = {2007} }



@misc{
3060,
   Author = {Thorn, M. D.},
   Title = {Addendum 01 to the clinical study report PALO-03-11. Protocol No. PALO-03-11},
   Publisher = {Statistical Resources, Inc.},
      Year = {2007} }



@article{
3059,
   Author = {Gibiansky, L.},
   Title = {Precision of parameter estimates: covariance step ($COV) versus bootstrap procedure},
   Journal = {PAGE.Abstracts of the Annual Meeting of the Population Approach Group in Europe.},
   Pages = {Abstr 1106},
   Year = {2007} }



@article{
3058,
   Author = {Dartois, C. and Lemenuel-Diot, A. and Laveille, C. and Tranchand, B. and Tod, M. and Girard, P.},
   Title = {Evaluation of Uncertainty Parameters Estimated by Different Population PK Software and Methods},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {34},
   Number = {3},
   Pages = {289-311},
   Year = {2007} }



@article{
3057,
   Author = {Lopata, R. G. and Backes, W. H. and van den Bosch, P. P. and van Riel, N. A.},
   Title = {On the identifiability of pharmacokinetic parameters in dynamic contrast-enhanced imaging},
   Journal = {Magn Reson.Med},
   Volume = {58},
   Number = {2},
   Pages = {425-429},
   Year = {2007} }



@article{
3056,
   Author = {Savic, R. M. and Jonker, D. M. and Kerbusch, T. and Karlsson, M. O.},
   Title = {Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2007} }



@article{
3055,
   Author = {Herd, D. and Anderson, B. J.},
   Title = {Ketamine disposition in children presenting for procedural sedation and analgesia in a children's emergency department},
   Journal = {Paediatr.Anaesth.},
   Volume = {17},
   Number = {7},
   Pages = {622-629},
   Year = {2007} }



@article{
3054,
   Author = {Puisset, F. and Alexandre, J. and Treluyer, J. M. and Raoul, V. and Roche, H. and Goldwasser, F. and Chatelut, E.},
   Title = {Clinical pharmacodynamic factors in docetaxel toxicity},
   Journal = {Br.J Cancer},
   Year = {2007} }



@article{
3053,
   Author = {Babul, N. and Noveck, R. and Chipman, H. and Roth, S. H. and Gana, T. and Albert, K.},
   Title = {Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee},
   Journal = {J Pain Symptom.Manage.},
   Volume = {28},
   Number = {1},
   Pages = {59-71},
   Year = {2004} }



@article{
3052,
   Author = {Kivitz, A. and Ma, C. and Ahdieh, H. and Galer, B. S.},
   Title = {A 2-week, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase III trial comparing the efficacy of oxymorphone extended release and placebo in adults with pain associated with osteoarthritis of the hip or knee},
   Journal = {Clin Ther.},
   Volume = {28},
   Number = {3},
   Pages = {352-364},
   Year = {2006} }



@article{
3051,
   Author = {Moore, R. A. and McQuay, H. J.},
   Title = {Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids},
   Journal = {Arthritis Res.Ther.},
   Volume = {7},
   Number = {5},
   Pages = {R1046-R1051},
   Year = {2005} }



@article{
3050,
   Author = {Gallagher, R. M. and Welz-Bosna, M. and Gammaitoni, A.},
   Title = {Assessment of dosing frequency of sustained-release opioid preparations in patients with chronic nonmalignant pain},
   Journal = {Pain Med},
   Volume = {8},
   Number = {1},
   Pages = {71-74},
   Year = {2007} }



@article{
3049,
   Author = {Plock, N. and Buerger, C. and Joukhadar, C. and Kljucar, S. and Kloft, C.},
   Title = {Does linezolid inhibit its own metabolism? - Population pharmacokinetics as a tool to explain the observed nonlinearity in both healthy volunteers and septic patients},
   Journal = {Drug Metab Dispos.},
   Year = {2007} }



@article{
3048,
   Author = {Weerakkody, G. J. and Jakubowski, J. A. and Brandt, J. T. and Farid, N. A. and Payne, C. D. and Zhu, J. and Warner, M. R. and Naganuma, H. and Winters, K. J.},
   Title = {Comparison of speed of onset of platelet inhibition after loading doses of clopidogrel versus prasugrel in healthy volunteers and correlation with responder status},
   Journal = {Am J Cardiol.},
   Volume = {100},
   Number = {2},
   Pages = {331-336},
   Year = {2007} }



@article{
3047,
   Author = {Hope, W. W. and Seibel, N. L. and Schwartz, C. L. and Arrieta, A. and Flynn, P. and Shad, A. and Albano, E. and Keirns, J. J. and Buell, D. N. and Gumbo, T. and Drusano, G. L. and Walsh, T. J.},
   Title = {Population Pharmacokinetics of Micafungin in Pediatric Patients and the Implications for Antifungal Dosing},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
3046,
   Author = {Katz, N.},
   Title = {Methodological issues in clinical trials of opioids for chronic pain},
   Journal = {Neurology},
   Volume = {65},
   Number = {12 Suppl 4},
   Pages = {S32-S49},
   Year = {2005} }



@article{
3045,
   Author = {Whitehead, J. and Williamson, D.},
   Title = {Bayesian decision procedures based on logistic regression models for dose-finding studies},
   Journal = {J Biopharm.Stat},
   Volume = {8},
   Number = {3},
   Pages = {445-467},
   Year = {1998} }



@article{
3043,
   Author = {Whitehead, J. and Zhou, Y. and Mander, A. and Ritchie, S. and Sabin, A. and Wright, A.},
   Title = {An evaluation of Bayesian designs for dose-escalation studies in healthy volunteers},
   Journal = {Stat Med},
   Volume = {25},
   Number = {3},
   Pages = {433-445},
   Year = {2006} }



@article{
3042,
   Author = {Whitehead, J. and Patterson, S. and Webber, D. and Francis, S. and Zhou, Y.},
   Title = {Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers},
   Journal = {Biostatistics},
   Volume = {2},
   Number = {1},
   Pages = {47-61},
   Year = {2001} }



@article{
3041,
   Author = {Zhou, Y. and Whitehead, J. and Bonvini, E. and Stevens, J. W.},
   Title = {Bayesian decision procedures for binary and continuous bivariate dose-escalation studies},
   Journal = {Pharm.Stat},
   Volume = {5},
   Number = {2},
   Pages = {125-133},
   Year = {2006} }



@article{
3040,
   Author = {Huang, X. and Biswas, S. and Oki, Y. and Issa, J. P. and Berry, D. A.},
   Title = {A parallel phase I/II clinical trial design for combination therapies},
   Journal = {Biometrics},
   Volume = {e-pub ahead of print},
   Year = {2007} }



@article{
3039,
   Author = {Herring, A. H. and Yang, J.},
   Title = {Bayesian modeling of multiple episode occurrence and severity with a terminating event},
   Journal = {Biometrics},
   Volume = {e-pub ahead of print},
   Year = {2007} }



@article{
3038,
   Author = {Zhou, Y. and Whitehead, J. and Korhonen, P. and Mustonen, M.},
   Title = {Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers},
   Journal = {Biometrics},
   Volume = {e-pub ahead of print.},
   Year = {2007} }



@article{
3037,
   Author = {Blake, M. J. and Gaedigk, A. and Pearce, R. E. and Bomgaars, L. R. and Christensen, M. L. and Stowe, C. and James, L. P. and Wilson, J. T. and Kearns, G. L. and Leeder, J. S.},
   Title = {Ontogeny of dextromethorphan O- and N-demethylation in the first year of life},
   Journal = {Clin Pharmacol Ther.},
   Volume = {81},
   Number = {4},
   Pages = {510-516},
   Year = {2007} }



@article{
3036,
   Author = {Fliss, G. and Staab, A. and Tillmann, C. and Trommeshauser, D. and Schaefer, H. G. and Kloft, C.},
   Title = {Population Pharmacokinetic Data Analysis of Cilobradine, an I(f) Channel Blocker},
   Journal = {Pharmaceutical Research},
   Year = {2007} }



@article{
3035,
   Author = {Ogungbenro, K. and Gueorguieva, I. and Majid, O. and Graham, G. and Aarons, L.},
   Title = {Optimal design for multiresponse pharmacokinetic-pharmacodynamic models - dealing with unbalanced designs},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {34},
   Number = {3},
   Pages = {313-331},
   Year = {2007} }



@article{
3034,
   Author = {Daimon, T. and Goto, M.},
   Title = {Curvature-adjusted optimal design of sampling times for the inference of pharmacokinetic compartment models},
   Journal = {Stat Med},
   Volume = {26},
   Number = {14},
   Pages = {2799-2812},
   Year = {2007} }



@article{
3033,
   Author = {Savic, R. M. and Karlsson, M. O.},
   Title = {Importance of shrinkage in empirical Bayes estimates for diagnostics and estimation: problems and solutions},
   Journal = {PAGE.Abstracts of the Annual Meeting of the Population Approach Group in Europe},
   Year = {2007} }



@techreport{
3032,
   Author = {Cv Therapeutics, Inc},
   Title = {Addendum to the evaluation of the population pharmacokinetics of ranolazine in healthy subjects and in patients with cardiac angina},
   Number = {RACVT118018},
   Year = {2006} }



@techreport{
3031,
   Author = {Cv Therapeutics, Inc},
   Title = {Evaluation of population pharmacokinetics of ranolazine in healthy subjects and in patients with cardiac angina},
   Number = {RACVT00200},
   Year = {2007} }



@article{
3030,
   Author = {McNulty, R.},
   Title = {Are all 5-HT3 receptor antagonists the same?},
   Journal = {J Natl.Compr.Canc.Netw.},
   Volume = {5},
   Number = {1},
   Pages = {35-43},
   Year = {2007} }



@article{
3029,
   Author = {Pham, D. Q. and Cohen, H. and Chu, V.},
   Title = {Inhaled human [rDNA origin] insulin, a novel formulation for diabetes mellitus},
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Number = {7},
   Pages = {890-903},
   Year = {2007} }



@article{
3028,
   Author = {Kshirsagar, S. A. and Blaschke, T. F. and Sheiner, L. B. and Krygowski, M. and Acosta, E. P. and Verotta, D.},
   Title = {Improving data reliability using a non-compliance detection method versus},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {34},
   Number = {1},
   Pages = {35-55},
   Year = {2007} }



@article{
3027,
   Author = {Li, J. and Yang, X. and Wu, Y. and Shoptaw, S.},
   Title = {A random-effects Markov transition model for Poisson-distributed repeated},
   Journal = {Stat Med},
   Volume = {26},
   Number = {12},
   Pages = {2519-2532},
   Year = {2007} }



@techreport{
3026,
   Author = {Syntex, Research},
   Title = {A dose-ranging efficacy, safety, and pharmacokinetic study of single intravenous doses of RS-25259 for prevention of nausea and vomiting in chemotherapy-naive cancer patients receiving highly emetogenic chemotherapy},
   Number = {25259S2330},
   Year = {1995} }



@techreport{
3025,
   Author = {Fisher, J.},
   Title = {Population pharmacokinetic modeling of palonosetron in pediatric patients: Helsinn Healthcare SA Report PALO-07-06},
   Year = {2007} }



@article{
3024,
   Author = {Greenspan, S. L. and Bone, H. G. and Ettinger, M. P. and Hanley, D. A. and Lindsay, R. and Zanchetta, J. R. and Blosch, C. M. and Mathisen, A. L. and Morris, S. A. and Marriott, T. B.},
   Title = {Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial},
   Journal = {Ann.Intern Med},
   Volume = {146},
   Number = {5},
   Pages = {326-339},
   Year = {2007} }



@article{
3023,
   Author = {Black, D. M. and Delmas, P. D. and Eastell, R. and Reid, I. R. and Boonen, S. and Cauley, J. A. and Cosman, F. and Lakatos, P. and Leung, P. C. and Man, Z. and Mautalen, C. and Mesenbrink, P. and Hu, H. and Caminis, J. and Tong, K. and Rosario-Jansen, T. and Krasnow, J. and Hue, T. F. and Sellmeyer, D. and Eriksen, E. F. and Cummings, S. R.},
   Title = {Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis},
   Journal = {N Engl J Med},
   Volume = {356},
   Number = {18},
   Pages = {1809-1822},
   Year = {2007} }



@article{
3022,
   Author = {Bell, B. S. and Morrish, K. and Harrison, F. and Petullo, D. and Thompson, L. and Gray, G.},
   Title = {Times "R" a changing: FDA perspectives on use of "open source"},
   Journal = {FDA CDER Office of Biostatistics Joint Statistics Meeting},
   Year = {2006} }



@article{
3021,
   Author = {Ribbing, J. and Nyberg, J. and Caster, O. and Jonsson, E. N.},
   Title = {The lasso-a novel method for predictive covariate model building in nonlinear mixed effects models},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2007} }



@article{
3020,
   Author = {Othman, A. A. and Newman, A. H. and Eddington, N. D.},
   Title = {Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling},
   Journal = {J Pharmacol Exp.Ther.},
   Year = {2007} }



@article{
3019,
   Author = {Paradisis, M. and Jiang, X. and McLachlan, A. J. and Evans, N. and Kluckow, M. and Osborn, D.},
   Title = {Population pharmacokinetics and dosing regimen design of milrinone in preterm infants},
   Journal = {Arch Dis.Child Fetal Neonatal Ed},
   Volume = {92},
   Number = {3},
   Pages = {F204-F209},
   Year = {2007} }



@article{
3018,
   Title = {Computer modeling of diabetes and its complications: a report on the Fourth Mount Hood Challenge Meeting},
   Journal = {Diabetes Care},
   Volume = {30},
   Number = {6},
   Pages = {1638-1646},
   Year = {2007} }



@article{
3017,
   Author = {Zuideveld, K. P. and Van der Graaf, P. H. and Peletier, L. A. and Danhof, M.},
   Title = {Allometric scaling of pharmacodynamic responses: application to 5-Ht(1A) receptor mediated responses from rat to man},
   Journal = {Pharmaceutical Research},
   Year = {2007} }



@article{
3016,
   Author = {Allegaert, K. and Anderson, B. J. and van den Anker, J. N. and Vanhaesebrouck, S. and de, Zegher F.},
   Title = {Renal drug clearance in preterm neonates: relation to prenatal growth},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {29},
   Number = {3},
   Pages = {284-291},
   Year = {2007} }



@article{
3015,
   Author = {Mangoni, A. A.},
   Title = {The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions},
   Journal = {Expert.Opin.Drug Metab Toxicol.},
   Volume = {3},
   Number = {3},
   Pages = {315-320},
   Year = {2007} }



@article{
3014,
   Author = {Bruno, R. and Vivier, N. and Vergniol, J. C. and De Phillips, S. L. and Montay, G. and Sheiner, L. B.},
   Title = {A population pharmacokinetic model for docetaxel (Taxotere): model building and validation},
   Journal = {J Pharmacokinet.Biopharm.},
   Volume = {24},
   Number = {2},
   Pages = {153-172},
   Year = {1996} }



@article{
3013,
   Author = {Danhof, M. and de, Jongh J. and De Lange, E. C. and Della, Pasqua O. and Ploeger, B. A. and Voskuyl, R. A.},
   Title = {Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis},
   Journal = {Annu.Rev.Pharmacol Toxicol.},
   Volume = {47},
   Pages = {357-400},
   Year = {2007} }



@article{
3012,
   Author = {Dodds, M. G. and Vicini, P.},
   Title = {Assessing convergence of Markov chain Monte Carlo simulations in hierarchical Bayesian models for population pharmacokinetics},
   Journal = {Ann.Biomed.Eng},
   Volume = {32},
   Number = {9},
   Pages = {1300-1313},
   Year = {2004} }



@article{
3011,
   Author = {Abbas, I. and Rovira, J. and Casanovas, J.},
   Title = {Clinical trial optimization: Monte Carlo simulation Markov model for planning clinical trials recruitment},
   Journal = {Contemp.Clin Trials},
   Volume = {28},
   Number = {3},
   Pages = {220-231},
   Year = {2007} }



@article{
3010,
   Author = {Gruwez, B. and Poirier, M. F. and Dauphin, A. and Olie, J. P. and Tod, M.},
   Title = {A kinetic-pharmacodynamic model for clinical trial simulation of antidepressant action: application to clomipramine-lithium interaction},
   Journal = {Contemp.Clin Trials},
   Volume = {28},
   Number = {3},
   Pages = {276-287},
   Year = {2007} }



@article{
3009,
   Author = {Bulitta, J. B. and Duffull, S. B. and Kinzig-Schippers, M. and Holzgrabe, U. and Stephan, U. and Drusano, G. L. and Sorgel, F.},
   Title = {Population pharmacokinetics and pharmacodynamics of piperacillin: systematic comparison of cystic fibrosis patients and healthy volunteers},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
3008,
   Author = {Lodise, T. P. and Kinzig-Schippers, M. and Drusano, G. L. and Loos, U. and Vogel, F. and Bulitta, J. and Hinder, M. and Sorgel, F.},
   Title = {Use of population pharmacokinetic modeling and Monte Carlo simulation to describe the pharmacodynamic profile of cefditoren in plasma and epithelial lining fluid},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@incollection{
3007,
   Author = {Riggs, M. M. and Godfrey, C. J. and Gastonguay, M. and Ette, E. I. and Williams, P. J.},
   Title = {Clinical trial simulation: efficacy trials},
   BookTitle = {Pharmacometrics: the science of quantitative pharmacology},
   Publisher = {Wiley},
   Address = {Hoboken},
   Pages = {881-902},
   Year = {2007} }



@article{
3006,
   Author = {Avramis, V. I. and Spence, S. A.},
   Title = {Clinical pharmacology of asparaginases in the United States: Asparaginase population pharmacokinetic and pharmacodynamic (PK-PD) models (NONMEM) in adult and pediatric ALL patients},
   Journal = {J Pediatr.Hematol.Oncol.},
   Volume = {29},
   Number = {4},
   Pages = {239-247},
   Year = {2007} }



@article{
3005,
   Author = {Nicolau, D. P. and Sutherland, C. A. and Arguedas, A. and Dagan, R. and Pichichero, M. E.},
   Title = {Pharmacokinetics of cefprozil in plasma and middle ear fluid: in children undergoing treatment for acute otitis media},
   Journal = {Paediatr.Drugs},
   Volume = {9},
   Number = {2},
   Pages = {119-123},
   Year = {2007} }



@article{
3004,
   Author = {Bauer, R. J. and Guzy, S. and Ng, C.},
   Title = {A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples},
   Journal = {AAPS J},
   Volume = {9},
   Number = {1},
   Pages = {E60-E83},
   Year = {2007} }



@article{
3003,
   Author = {Krishna, R. and Schaefer, H. G. and Bjerrum, O. J.},
   Title = {Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development},
   Journal = {Eur.J Pharm.Sci.},
   Year = {2007} }



@article{
3002,
   Author = {Dickinson, G. L. and Rezaee, S. and Proctor, N. J. and Lennard, M. S. and Tucker, G. T. and Rostami-Hodjegan, A.},
   Title = {Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphism on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application},
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Number = {2},
   Pages = {175-186},
   Year = {2007} }



@article{
3001,
   Author = {Willmann, S. and Hohn, K. and Edginton, A. and Sevestre, M. and Solodenko, J. and Weiss, W. and Lippert, J. and Schmitt, W.},
   Title = {Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2007} }



@article{
3000,
   Author = {Thall, P. F. and Wooten, L. H. and Logothetis, C. J. and Millikan, R. E. and Tannir, N. M.},
   Title = {Bayesian and frequentist two-stage treatment strategies based on sequential failure times subject to interval censoring},
   Journal = {Stat Med},
   Year = {2007} }



@article{
2999,
   Author = {Hutmacher, M. M. and Nestorov, I. and Ludden, T. and Zitnik, R. and Banfield, C.},
   Title = {Modeling the exposure-response relationship of etanercept in the treatment of patients with chronic moderate to severe plaque psoriasis},
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Number = {2},
   Pages = {238-248},
   Year = {2007} }



@article{
2998,
   Author = {Hamberg, A. K. and Dahl, M. L. and Barban, M. and Scordo, M. G. and Wadelius, M. and Pengo, V. and Padrini, R. and Jonsson, E. N.},
   Title = {A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy},
   Journal = {Clin Pharmacol Ther.},
   Volume = {81},
   Number = {4},
   Pages = {529-538},
   Year = {2007} }



@article{
2997,
   Author = {Bundgaard, C. and Larsen, F. and Jorgensen, M. and Gabrielsson, J.},
   Title = {Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: application to escitalopram-induced effects on brain serotonin levels},
   Journal = {Eur.J Pharm.Sci.},
   Volume = {29},
   Number = {5},
   Pages = {394-404},
   Year = {2006} }



@article{
2996,
   Author = {Strohmer, B. and Schernthaner, C. and Paulweber, B. and Pichler, M.},
   Title = {Gender-specific comparison of five QT correction formulae in middle-aged participants in an atherosclerosis prevention program},
   Journal = {Med Sci.Monit.},
   Volume = {13},
   Number = {4},
   Pages = {CR165-CR171},
   Year = {2007} }



@article{
2995,
   Author = {Vossen, M. and Sevestre, M. and Niederalt, C. and Jang, I. J. and Willmann, S. and Edginton, A. N.},
   Title = {Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models},
   Journal = {Theor.Biol.Med Model.},
   Volume = {4},
   Number = {1},
   Pages = {13},
   Year = {2007} }



@article{
2994,
   Author = {Zhang, X. and Lin, T. and Bertasso, A. and Evans, C. and Dorr, A. and Kolis, S. J. and Salgo, M. and Patel, I.},
   Title = {Population pharmacokinetics of enfuvirtide in HIV-1-infected pediatric patients over 48 weeks of treatment},
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Number = {4},
   Pages = {510-517},
   Year = {2007} }



@misc{
2993,
   Author = {National Center for Health Statistics, Division of Data Services},
   Title = {Clinical growth charts},
   Month = {2007},
      Year = {} }



@article{
2992,
   Author = {Greenblatt, D. J. and Harmatz, J. S. and Karim, A.},
   Title = {Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelton, a hypnotic agent acting via melatonin receptors MT 1  and MT 2 },
   Journal = {J Clin Pharmacol},
   Volume = {47},
   Pages = {485-496},
   Year = {2007} }



@techreport{
2991,
   Author = {Quintiles, Inc},
   Title = {Validation of a manual method to quantify erythropoietin in human serum by an enzyme linked imunosorbent assay - Bioanalytical Method Report HMR4396-P3A},
   Number = {QKAN-1999-0086-BIO},
   Year = {2007} }



@article{
2990,
   Author = {Jonsson, F. and Jonsson, E. N. and Bois, F. Y. and Marshall, S.},
   Title = {The application of a Bayesian approach to the analysis of a complex, mechanistically based model},
   Journal = {J Biopharm.Stat},
   Volume = {17},
   Number = {1},
   Pages = {65-92},
   Year = {2007} }



@article{
2989,
   Author = {Gueorguieva, I. and Ogungbenro, K. and Graham, G. and Glatt, S. and Aarons, L.},
   Title = {A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {86},
   Number = {1},
   Pages = {51-61},
   Year = {2007} }



@article{
2988,
   Author = {Bundgaard, C. and Larsen, F. and Jorgensen, M. and Mork, A.},
   Title = {Pharmacokinetic/Pharmacodynamic feedback modelling of the functional corticosterone response in rats after acute treatment with escitalopram},
   Journal = {Basic Clin Pharmacol Toxicol.},
   Volume = {100},
   Number = {3},
   Pages = {182-189},
   Year = {2007} }



@article{
2987,
   Author = {Krzyzanski, W. and Perez-Ruixo, J. J.},
   Title = {An assessment of recombinant human erythropoietin effect on reticulocyte production rate and lifespan distribution in healthy subjects},
   Journal = {Pharmaceutical Research},
   Year = {2007} }



@article{
2986,
   Author = {Langdon, G. and Gueorguieva, I. and Aarons, L. and Karlsson, M.},
   Title = {Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM},
   Journal = {Eur.J Clin Pharmacol},
   Year = {2007} }



@article{
2984,
   Author = {Okusanya, O. and Forrest, A. and DiFrancesco, R. and Balic, S. and Rosenkranz, S. and Para, M. F. and Adams, E. and Yarasheski, K. E. and Reichman, R. C. and Morse, G. D.},
   Title = {Compartmental pharmacokinetic analysis of oral amprenavir with secondary peaks},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Year = {2007} }



@article{
2983,
   Author = {Cremers, S. and Schoemaker, R. and Scholten, E. and den, Hartigh J. and Konig-Quartel, J. and van, Kan E. and Paul, L. and de, Fijter J.},
   Title = {Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling},
   Journal = {Br.J Clin Pharmacol},
   Volume = {60},
   Number = {3},
   Pages = {249-256},
   Year = {2005} }



@article{
2982,
   Author = {Semmes, R. L. and Shen, D. D.},
   Title = {A reversible clearance model for the enterohepatic circulation of drug and conjugate metabolite pair 2725},
   Journal = {Drug Metab Dispos.},
   Volume = {18},
   Number = {1},
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   Year = {1990} }



@article{
2981,
   Author = {Ruane, P. J. and Luber, A. D. and Wire, M. B. and Lou, Y. and Shelton, M. J. and Lancaster, C. T. and Pappa, K. A.},
   Title = {Plasma amprenavir pharmacokinetics and tolerability following administration of 1,400 milligrams of fosamprenavir once daily in combination with either 100 or 200 milligrams of ritonavir in healthy volunteers},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {51},
   Number = {2},
   Pages = {560-565},
   Year = {2007} }



@article{
2980,
   Author = {Gelman, A. and Bois, F. and Jiang, J.},
   Title = {Physiological pharmacokinetic analysis using population modeling informative prior distributions},
   Journal = {J Am.Stat Assoc.},
   Volume = {91},
   Number = {43},
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@article{
2979,
   Author = {Agbaje, O. F. and Luzio, S. D. and Albarrak, A. I. and Lunn, D. J. and Owens, D. R. and Hovorka, R.},
   Title = {Bayesian hierarchical approach to estimate insulin sensitivity by minimal model},
   Journal = {Clin Sci.(Lond)},
   Volume = {105},
   Number = {5},
   Pages = {551-560},
   Year = {2003} }



@article{
2977,
   Author = {Gurrin, L. C. and Moss, T. J. and Sloboda, D. M. and Hazelton, M. L. and Challis, J. R. and Newnham, J. P.},
   Title = {Using WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids},
   Journal = {J Biopharm.Stat.},
   Volume = {13},
   Number = {1},
   Pages = {117-139},
   Year = {2003} }



@techreport{
2975,
   Author = {Cv Therapeutics, Inc},
   Title = {Validation of a high performance liquid chromatographic-mass spectrometric method for the analysis of CVT-3146 in heparinized human plasma by 96 well solid phase extraction method},
   Number = {Technical Report CVT3146.009-B},
   Month= {4 May, 2004},
   Year = {2004} }



@techreport{
2974,
   Author = {Cv Therapeutics, Inc},
   Title = {A study to evaluate the single-sose pharmacokinetics and pharmacodynamics of regadenoson in patients with renal impairment. Protocol number CVT 5112},
   Year = {2006} }



@article{
2973,
   Author = {Shou, M. and Lu, W. and Kari, P. H. and Xiang, C. and Liang, Y. and Lu, P. and Cui, D. and Emary, W. B. and Michel, K. B. and Adelsberger, J. K. and Brunner, J. E. and Rodrigues, A. D.},
   Title = {Population pharmacokinetic modeling for enterohepatic recirculation in Rhesus monkey},
   Journal = {Eur.J Pharm.Sci.},
   Volume = {26},
   Number = {2},
   Pages = {151-161},
   Year = {2005} }



@article{
2972,
   Author = {Nielsen, E. I. and Viberg, A. and Lowdin, E. and Cars, O. and Karlsson, M. O. and Sandstrom, M.},
   Title = {Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {51},
   Number = {1},
   Pages = {128-136},
   Year = {2007} }



@article{
2971,
   Author = {Freeman, B. B., III and Hinds, P. and Iacono, L. C. and Razzouk, B. I. and Burghen, E. and Stewart, C. F.},
   Title = {Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer},
   Journal = {Pediatr.Blood Cancer},
   Volume = {47},
   Number = {5},
   Pages = {572-579},
   Year = {2006} }



@article{
2970,
   Author = {Olsson-Gisleskog, P. and Jacqmin, P. and Perez-Ruixo, J. J.},
   Title = {Population pharmacokinetics meta-analysis of recombinant human erythropoietin in healthy subjects},
   Journal = {Clin Pharmacokinet.},
   Volume = {46},
   Number = {2},
   Pages = {159-173},
   Year = {2007} }



@article{
2969,
   Author = {Chang, A. K. and Bijur, P. E. and Meyer, R. H. and Kenny, M. K. and Solorzano, C. and Gallagher, E. J.},
   Title = {Safety and efficacy of hydromorphone as an analgesic alternative to morphine in acute pain: a randomized clinical trial},
   Journal = {Ann.Emerg.Med.},
   Volume = {48},
   Number = {2},
   Pages = {164-172},
   Year = {2006} }



@techreport{
2968,
   Author = {Aventis, Pharmaceuticals},
   Title = {Report K970221M; reference standard HMR4396-07},
   Year = {2004} }



@techreport{
2967,
   Author = {Aventis, Pharmaceuticals},
   Title = {Analysis of HMR4396 concentrations in human serum samples collected from protocol HMR4396A/3003},
   Year = {2004} }



@techreport{
2966,
   Author = {Otsuka Maryland Research Institute, Inc},
   Title = {Multicenter, randomized, double-blind, placebo-comtrolled, dose-ranging, efficacy, safety, and pharmacokinetic study of OPC-41061 in hospitalized patients with hyponatremia secondary to liver disease. Protocol No. 156-96-203},
   Year = {2002} }



@techreport{
2965,
   Author = {Otsuka Maryland Research Institute, Inc},
   Title = {International, multicenter, randomized, double-blind, placebo-controlled, efficacy and safety study of the effects of titrated oral tolvaptan tablets in patients with hyponatremia. Protocol No. 156-03-238},
   Year = {2006} }



@techreport{
2964,
   Author = {Otsuka Maryland Research Institute, Inc},
   Title = {Multicenter, randomized, double-blind, placebo-controlled, efficacy and safety study of the effects of titrated oral tolvaptan tablets in patients with hyponatremia. Protocol No. 156-02-235},
   Year = {2006} }



@article{
2963,
   Author = {Yamada, Y. and Sugiura, M. and Higo, K. and Ozeki, T. and Takayanagi, R. and Okuyama, K. and Yamamoto, K. and Satoh, H. and Sawada, Y. and Iga, T.},
   Title = {Receptor occupancy theory-based analysis of antiemetic effects and standard doses of 5-HT3 receptor antagonists in cancer patients},
   Journal = {Cancer Chemother.Pharmacol},
   Volume = {54},
   Number = {2},
   Pages = {185-190},
   Year = {2004} }



@article{
2962,
   Author = {Roila, F. and Ballatori, E. and Tonato, M. and Del, Favero A.},
   Title = {5-HT3 receptor antagonists: differences and similarities},
   Journal = {Eur.J Cancer},
   Volume = {33},
   Number = {9},
   Pages = {1364-1370},
   Year = {1997} }



@article{
2961,
   Author = {Gregory, R. E. and Ettinger, D. S.},
   Title = {5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy},
   Journal = {Drugs},
   Volume = {55},
   Number = {2},
   Pages = {173-189},
   Year = {1998} }



@article{
2960,
   Author = {Bhattaram, V. A. and Bonapace, C. and Chilukuri, D. M. and Duan, J. Z. and Garnett, C. and Gobburu, J. V. S. and Jang, S. H. and Kenna, L. and Lesko, L. J. and Madabushi, R. and Men, Y. and Powell, J. R. and Qiu, W. and Ramchandani, R. P. and Tornoe, C. W. and Wang, Y. and Zheng, J. J.},
   Title = {Impact of pharmacometric reviews on new drug approval and labeling decisions--a survey of 31 new drug applications submitted between 2005 and 2006},
   Journal = {Clin Pharmacol Ther.},
   Volume = {81},
   Number = {2},
   Pages = {213-221},
   Year = {2006} }



@techreport{
2959,
   Author = {Guideline, Ich- E. Harmonized Tripartite},
   Title = {Dose response information to support drug registration},
   Institution = {Food and Drug Administration},
   Month= {November},
   Year = {1994} }



@techreport{
2958,
   Title = {Guidance for Industry. Exposure-response relationships--Study designs, data analysis, and regulatory applications},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
   Month= {April},
   Year = {2003} }



@article{
2956,
   Author = {Fredholm, B. B. and Battig, K. and Holmen, J. and Nehlig, A. and Zvartau, E. E.},
   Title = {Actions of caffeine in the brain with special reference to factors that contribute to its widespread use},
   Journal = {Pharmacological Reviews},
   Volume = {51},
   Number = {1},
   Pages = {83-133},
   Year = {1999} }



@article{
2955,
   Author = {Herxheimer, A.},
   Title = {How much drug in the tablet?},
   Journal = {Lancet},
   Volume = {337},
   Number = {8748},
   Pages = {1042},
   Year = {1991} }



@article{
2954,
   Author = {Lesko, L. J. and Rowland, M. and Peck, C. C. and Blaschke, T. F.},
   Title = {Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans},
   Journal = {J Clin Pharmacol.},
   Volume = {40},
   Number = {8},
   Pages = {803-814},
   Year = {2000} }



@article{
2953,
   Author = {Bush, J. K. and Dai, W. S. and Dieck, G. S. and Hostelley, L. S. and Hassall, T.},
   Title = {The art and science of risk management: a US research-based industry perspective},
   Journal = {Drug Saf},
   Volume = {28},
   Number = {1},
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   Year = {2005} }



@article{
2952,
   Author = {Adelroth, E. and Inman, M. D. and Summers, E. and Pace, D. and Modi, M. and O'Byrne, P. M.},
   Title = {Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast},
   Journal = {J Allergy Clin Immunol.},
   Volume = {99},
   Number = {2},
   Pages = {210-215},
   Year = {1997} }



@book{
2951,
   Author = {Ting, N.},
   Title = {Dose finding in drug development},
   Publisher = {Springer},
   Year = {2006} }



@article{
2950,
   Author = {Gordi, T. and Frohna, P. and Sun, H. and Wolff, A. and Belardinelli, L. and Lieu, H.},
   Title = {A population pharmacokinetic/pharmacodynamic analysis of regadenosonl, an adenosine A 2A -receptor agonist, in healthy male volunteers},
   Journal = {Clin Pharmacokinet.},
   Volume = {45},
   Number = {12},
   Pages = {1201-1212},
   Year = {2006} }



@article{
2949,
   Author = {Jadhav, P. R. and Agerso, H. and Tornoe, C. W. and Gobburu, J. V.},
   Title = {Semi-mechanistic pharmacodynamic modeling for degarelix, a novel gonadotropin releasing hormone (GnRH) blocker},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {5},
   Pages = {609-634},
   Year = {2006} }



@article{
2948,
   Author = {Lemenuel-Diot, A. and Mallet, A. and Laveille, C. and Bruno, R.},
   Title = {Estimating heterogeneity in random effects models for longitudinal data},
   Journal = {Biom.J},
   Volume = {47},
   Number = {3},
   Pages = {329-345},
   Year = {2005} }



@article{
2947,
   Author = {Jînsson, S. and Kjellsson, M. C. and Karlsson, M. O.},
   Title = {Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM and NLMIXED},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {31},
   Number = {4},
   Pages = {299-320},
   Year = {2004} }



@article{
2946,
   Author = {Yafune, A. and Takebe, M. and Ogata, H.},
   Title = {A use of Monte Carlo integration for population pharmacokinetics with multivariate population distribution},
   Journal = {J Pharmacokinet.Biopharm.},
   Volume = {26},
   Number = {1},
   Pages = {103-123},
   Year = {1998} }



@article{
2945,
   Author = {Walker, S.},
   Title = {An EM algorithm for nonlinear random effects models},
   Journal = {Biometrics},
   Volume = {52},
   Number = {3},
   Pages = {934-944},
   Year = {1996} }



@article{
2944,
   Author = {Zandvliet, A. S. and Schellens, J. H. and Copalu, W. and Beijnen, J. H. and Huitema, A. D.},
   Title = {A semi-physiological population pharmacokinetic model describing the},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {5},
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   Year = {2006} }



@article{
2943,
   Author = {Hazra, A. and Krzyzanski, W. and Jusko, W. J.},
   Title = {Mathematical assessment of properties of precursor-dependent indirect},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {6},
   Pages = {683-717},
   Year = {2006} }



@techreport{
2942,
   Author = {GloboMax É, L. L. C.},
   Title = {Population pharmacokinetic and pharmacodynamic modeling of palonosetron},
   Year = {2002} }



@article{
2941,
   Author = {Chou, T. C.},
   Title = {Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies},
   Journal = {Pharmacological Reviews},
   Volume = {58},
   Number = {3},
   Pages = {621-681},
   Year = {2006} }



@article{
2940,
   Author = {Tan, M. and Fang, H. B. and Tian, G. L. and Houghton, P. J.},
   Title = {Experimental design and sample size determination for testing synergism in drug combination studies based on uniform measures},
   Journal = {Statistics in Medicine},
   Volume = {22},
   Number = {13},
   Pages = {2091-2100},
   Year = {2003} }



@article{
2939,
   Author = {Tallarida, R. J.},
   Title = {Drug synergism: its detection and applications},
   Journal = {J Pharmacol.Exp.Ther.},
   Volume = {298},
   Number = {3},
   Pages = {865-872},
   Year = {2001} }



@article{
2938,
   Author = {Tallarida, R. J.},
   Title = {An overview of drug combination analysis with isobolograms},
   Journal = {J Pharmacol.Exp.Ther.},
   Volume = {319},
   Number = {1},
   Pages = {1-7},
   Year = {2006} }



@article{
2937,
   Author = {Kong, M. and Lee, J. J.},
   Title = {A generalized response surface model with varying relative potency for assessing drug interaction},
   Journal = {Biometrics},
   Volume = {62},
   Number = {4},
   Pages = {986-995},
   Year = {2006} }



@techreport{
2936,
   Title = {Guidance for Industry, investigators, and reviewers exploratory IND studies  },
   Year = {2006} }



@techreport{
2935,
   Title = {Guidance for Industry. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers},
   Year = {2006} }



@article{
2934,
   Author = {Kramer, W. G. and Lewis, R. P. and Cobb, T. C. and Forester, W. F., Jr. and Visconti, J. A. and Wanke, L. A. and Boxenbaum, H. G. and Reuning, R. H.},
   Title = {Pharmacokinetics of digoxin: comparison of a two- and a three-compartment model in man},
   Journal = {J Pharmacokinet.Biopharm.},
   Volume = {2},
   Number = {4},
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@article{
2933,
   Author = {Johnston, J. A. and Fiedler-Kelly, J. and Glover, E. D. and Sachs, D. P. and Grasela, T. H. and Veaugh-Geiss, J.},
   Title = {Relationship between drug exposure and the efficacy and safety of bupropion sustained release for smoking cessation},
   Journal = {Nicotine.Tob.Res.},
   Volume = {3},
   Number = {2},
   Pages = {131-140},
   Year = {2001} }



@article{
2932,
   Author = {Booth, B. P. and Rahman, A. and Dagher, R. and Griebel, D. and Lennon, S. and Fuller, D. and Sahajwalla, C. and Mehta, M. and Gobburu, J. V.},
   Title = {Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients},
   Journal = {J Clin.Pharmacol.},
   Volume = {47},
   Number = {1},
   Pages = {101-111},
   Year = {2007} }



@article{
2931,
   Author = {Labellarte, M. J. and Walkup, J. T. and Riddle, M. A.},
   Title = {The new antidepressants. Selective serotonin reuptake inhibitors},
   Journal = {Pediatr.Clin.North Am},
   Volume = {45},
   Number = {5},
   Pages = {1137-55, ix},
   Year = {1998} }



@article{
2930,
   Author = {Kastelic, E. A. and Labellarte, M. J. and Riddle, M. A.},
   Title = {Selective serotonin reuptake inhibitors for children and adolescents},
   Journal = {Curr.Psychiatry Rep.},
   Volume = {2},
   Number = {2},
   Pages = {117-123},
   Year = {2000} }



@techreport{
2929,
   Author = {Helsinn Healthcare, S. A.},
   Title = {A double-blind pediatric study to assess the safety, pharmacokinetcs and efficacy of single IV doses of palonosetron, 3.0Êg/kg or 10.0Êg/kg, in the prevention of chemotherapy-induced nausea and vomiting},
   Year = {2006} }



@book{
2928,
   Title = {Aloxi r  (palenosetron HCl) Intravenous Injection label, NDC Number 58063-797-25},
   Publisher = {Helsinn Healthcare SA},
   Address = {Lugano, Switzerland},
   Year = {2006} }



@techreport{
2927,
   Author = {European Medicines, Agency},
   Title = {Guideline on reporting the results of population pharmacokinetic analyses (DRAFT)},
   Institution = {EMEA},
   Year = {2006} }



@article{
2926,
   Author = {Gao, Z. and Li, Z. and Baker, S. P. and Lasley, R. D. and Meyer, S. and Elzein, E. and Palle, V. and Zablocki, J. A. and Blackburn, B. and Belardinelli, L.},
   Title = {Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists},
   Journal = {J Pharmacol.Exp.Ther.},
   Volume = {298},
   Number = {1},
   Pages = {209-218},
   Year = {2001} }



@book{
2925,
   Author = {Pharma, E. S. P.},
   Title = {Tenexr package insert},
   Year = {2003} }



@misc{
2924,
   Author = {Nchs},
   Title = {Clincal Growth Charts},
      Year = {} }



@misc{
2923,
   Author = {Nchs},
   Title = {NHANES III, Third National Health and Nutrition Examination Survey, 1988-94},
      Year = {} }



@article{
2922,
   Author = {Wernicke, J. F. and Faries, D. and Breitung, R. and Girod, D.},
   Title = {QT correction methods in children and adolescents},
   Journal = {J Cardiovasc.Electrophysiol.},
   Volume = {16},
   Number = {1},
   Pages = {76-81},
   Year = {2005} }



@article{
2921,
   Author = {Mahmood, I.},
   Title = {Prediction of drug clearance in children from adults: a comparison of several allometric methods},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {61},
   Number = {5},
   Pages = {545-557},
   Year = {2006} }



@article{
2920,
   Author = {Hayashi, N. and Tsukamoto, Y. and Sallas, W. M. and Lowe, P. J.},
   Title = {A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab},
   Journal = {Br.J Clin.Pharmacol.},
   Year = {2006} }



@article{
2919,
   Author = {Sprandel, K. A. and Drusano, G. L. and Hecht, D. W. and Rotschafer, J. C. and Danziger, L. H. and Rodvold, K. A.},
   Title = {Population pharmacokinetic modeling and Monte Carlo simulation of varying doses of intravenous metronidazole},
   Journal = {Diagn.Microbiol.Infect.Dis.},
   Volume = {55},
   Number = {4},
   Pages = {303-309},
   Year = {2006} }



@article{
2918,
   Author = {Edginton, A. N. and Schmitt, W. and Willmann, S.},
   Title = {Development and evaluation of a generic physiologically based pharmacokinetic model for children},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {10},
   Pages = {1013-1034},
   Year = {2006} }



@article{
2917,
   Author = {Jones, H. M. and Parrott, N. and Ohlenbusch, G. and Lave, T.},
   Title = {Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {12},
   Pages = {1213-1226},
   Year = {2006} }



@article{
2916,
   Author = {Wade, J. R. and Snoeck, E. and Duff, F. and Lamb, M. and Jorga, K.},
   Title = {Pharmacokinetics of ribavirin in patients with hepatitis C virus},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {62},
   Number = {6},
   Pages = {710-714},
   Year = {2006} }



@article{
2915,
   Author = {Aumente, D. and Santos, Buelga D. and Lukas, J. C. and Gomez, P. and Torres, A. and Garcia, M. J.},
   Title = {Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {12},
   Pages = {1227-1238},
   Year = {2006} }



@article{
2914,
   Author = {Chen, M. and Ma, L. and Drusano, G. L. and Bertino, J. S., Jr. and Nafziger, A. N.},
   Title = {Sex differences in CYP3A activity using intravenous and oral midazolam},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {80},
   Number = {5},
   Pages = {531-538},
   Year = {2006} }



@article{
2913,
   Author = {Peeters, M. Y. and Prins, S. A. and Knibbe, C. A. and DeJongh, J. and Mathot, R. A. and Warris, C. and van Schaik, R. H. and Tibboel, D. and Danhof, M.},
   Title = {Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery},
   Journal = {Anesthesiology},
   Volume = {105},
   Number = {6},
   Pages = {1135-1146},
   Year = {2006} }



@article{
2912,
   Author = {Davies, G. R. and Khoo, S. H. and Aarons, L. J.},
   Title = {Optimal sampling strategies for early pharmacodynamic measures in tuberculosis},
   Journal = {J Antimicrob.Chemother.},
   Volume = {58},
   Number = {3},
   Pages = {594-600},
   Year = {2006} }



@article{
2911,
   Author = {Dokoumetzidis, A. and Aarons, L.},
   Title = {Propagation of population pharmacokinetic information using a Bayesian approach: comparison with meta-analysis},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {32},
   Number = {3-4},
   Pages = {401-418},
   Year = {2005} }



@article{
2910,
   Author = {Yates, J. W.},
   Title = {Structural identifiability of physiologically based pharmacokinetic models},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {4},
   Pages = {421-439},
   Year = {2006} }



@article{
2909,
   Author = {Kang, D. and Schwartz, J. B. and Verotta, D.},
   Title = {Sample size computations for PK/PD population models},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {32},
   Number = {5-6},
   Pages = {685-701},
   Year = {2005} }



@article{
2908,
   Author = {Stark, J. G. and Werner, S. and Homrighausen, S. and Tang, Y. and Krieg, M. and Derendorf, H. and Moellmann, H. and Hochhaus, G.},
   Title = {Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {4},
   Pages = {441-459},
   Year = {2006} }



@article{
2907,
   Author = {Gruwez, B. and Poirier, M. F. and Dauphin, A. and Olie, J. P. and Tod, M.},
   Title = {A kinetic-pharmacodynamic model for clinical trial simulation of antidepressant action: application to clomipramine-lithium interaction},
   Journal = {Contemp.Clin.Trials},
   Year = {2006} }



@article{
2906,
   Author = {Daimon, T. and Goto, M.},
   Title = {Curvature-adjusted optimal design of sampling times for the inference of pharmacokinetic compartment models},
   Journal = {Statistics in Medicine},
   Year = {2006} }



@article{
2905,
   Author = {Lockwood, P. and Ewy, W. and Hermann, D. and Holford, N.},
   Title = {Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease},
   Journal = {Pharmaceutical Research},
   Volume = {23},
   Number = {9},
   Pages = {2050-2059},
   Year = {2006} }



@article{
2904,
   Author = {Hennig, S. and Waterhouse, T. H. and Bell, S. C. and France, M. and Wainwright, C. E. and Miller, H. and Charles, B. G. and Duffull, S. B.},
   Title = {A d-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients},
   Journal = {Br.J Clin.Pharmacol.},
   Year = {2006} }



@article{
2903,
   Author = {Jacqmin, P. and Snoeck, E. and Van Schaick, E. A. and Gieschke, R. and Pillai, P. and Steimer, J. L. and Girard, P.},
   Title = {Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD Model},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2902,
   Author = {Kaila, N. and Straka, R. J. and Brundage, R. C.},
   Title = {Mixture models and subpopulation classification: a pharmacokinetic simulation study and application to metoprolol CYP2D6 phenotype},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2901,
   Author = {Tannenbaum, S. J. and Holford, N. H. and Lee, H. and Peck, C. C. and Mould, D. R.},
   Title = {Simulation of correlated continuous and categorical variables using a single multivariate distribution},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2900,
   Author = {Edginton, A. N. and Schmitt, W. and Voith, B. and Willmann, S.},
   Title = {A mechanistic approach for the scaling of clearance in children},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {7},
   Pages = {683-704},
   Year = {2006} }



@article{
2898,
   Author = {Chien, J. Y. and Mohutsky, M. A. and Wrighton, S. A.},
   Title = {Physiological approaches to the prediction of drug-drug interactions in study populations},
   Journal = {Curr.Drug Metab},
   Volume = {4},
   Number = {5},
   Pages = {347-356},
   Year = {2003} }



@article{
2897,
   Author = {Chien, J. Y. and Lucksiri, A. and Ernest, C. S. and Gorski, J. C. and Wrighton, S. A. and Hall, S. D.},
   Title = {Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole},
   Journal = {Drug Metab Dispos.},
   Volume = {34},
   Number = {7},
   Pages = {1208-1219},
   Year = {2006} }



@article{
2896,
   Author = {Rosenberg, G. and Angel, I. and Kozak, A.},
   Title = {Clinical pharmacology of DP-b99 in healthy volunteers: first administration to humans},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {60},
   Number = {1},
   Pages = {7-16},
   Year = {2005} }



@article{
2895,
   Author = {Kuter, D. J. and Goodnough, L. T. and Romo, J. and DiPersio, J. and Peterson, R. and Tomita, D. and Sheridan, W. and McCullough, J.},
   Title = {Thrombopoietin therapy increases platelet yields in healthy platelet donors},
   Journal = {Blood},
   Volume = {98},
   Number = {5},
   Pages = {1339-1345},
   Year = {2001} }



@article{
2894,
   Author = {Bussel, J. B. and Kuter, D. J. and George, J. N. and McMillan, R. and Aledort, L. M. and Conklin, G. T. and Lichtin, A. E. and Lyons, R. M. and Nieva, J. and Wasser, J. S. and Wiznitzer, I. and Kelly, R. and Chen, C. F. and Nichol, J. L.},
   Title = {AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP},
   Journal = {N.Engl.J Med.},
   Volume = {355},
   Number = {16},
   Pages = {1672-1681},
   Year = {2006} }



@article{
2893,
   Author = {Wang, B. and Nichol, J. L. and Sullivan, J. T.},
   Title = {Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {76},
   Number = {6},
   Pages = {628-638},
   Year = {2004} }



@techreport{
2892,
   Author = {GlaxoSmithKline},
   Title = {A 48 week, Phase II, open-label, multi-cohort, multicenter study to evaluate the safety, tolerability, pharmacokinetics and antiviral activity of fosamprenavir/ritonavir QD and fosamprenavir/ritonavir BID when administered to HIV-1 infected, antiretroviral naive and experienced, pediatric subjects 2 to 18 years old},
   Number = {RM2004/00512/00},
   Year = {2006} }



@techreport{
2891,
   Author = {GlaxoSmithKline},
   Title = {A 48 week Phase II, open-label, 2-cohort, multicenter study to evaluate the pharmacokinetics, safety, tolerability and antiviral activity of GW433908 and GW433908/RTV when administered to HIV-1 infected protease inhibitor (PI) naãve and PI-experienced pediatric subjects aged 4 weeks to <2 years},
   Number = {RM2006/00360/00},
   Year = {2006} }



@techreport{
2890,
   Author = {GlaxoSmithKline},
   Title = {A 48 week, Phase II, non-comparative, open-label, multi-cohort, multicenter study to evaluate the safety, tolerability, pharmacokinetics and antiviral activity of GW433908/ritonavir BID when administered to HIV-1 infected, PI-naive and experienced, pediatric subjects, 2 to 18 years old and of GW433908 BID administered to PI-naive, pediatric subjects 2 to <6 years old (APV29005)},
   Number = {RM2006/00532/00},
   Year = {2006} }



@article{
2889,
   Author = {Cheung, W. and Minton, N. and Gunawardena, K.},
   Title = {Pharmacokinetics and pharmacodynamics of epoetin alfa once weekly and three times weekly},
   Journal = {Eur.J Clin.Pharmacol.},
   Volume = {57},
   Number = {5},
   Pages = {411-418},
   Year = {2001} }



@article{
2888,
   Author = {Cheung, W. K. and Goon, B. L. and Guilfoyle, M. C. and Wacholtz, M. C.},
   Title = {Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {4},
   Pages = {412-423},
   Year = {1998} }



@article{
2887,
   Author = {Lewis, M. J. and Rassi, D. and Short, A. L.},
   Title = {Analysis of the QT interval and its variability in healthy adults during rest and exercise},
   Journal = {Physiol Meas.},
   Volume = {27},
   Number = {11},
   Pages = {1211-1226},
   Year = {2006} }



@article{
2886,
   Author = {Zhou, H.},
   Title = {Population-based assessments of clinical drug-drug interactions: qualitative indices or quantitative measures?},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {11},
   Pages = {1268-1289},
   Year = {2006} }



@article{
2885,
   Author = {Sansom, L. N. and Evans, A. M.},
   Title = {What is the true clinical significance of plasma protein binding displacement interactions?},
   Journal = {Drug Saf},
   Volume = {12},
   Number = {4},
   Pages = {227-233},
   Year = {1995} }



@article{
2884,
   Author = {Rolan, P. E.},
   Title = {Plasma protein binding displacement interactions--why are they still regarded as clinically important?},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {37},
   Number = {2},
   Pages = {125-128},
   Year = {1994} }



@article{
2883,
   Author = {Dale, L. C. and Glover, E. D. and Sachs, D. P. and Schroeder, D. R. and Offord, K. P. and Croghan, I. T. and Hurt, R. D.},
   Title = {Bupropion for smoking cessation : predictors of successful outcome},
   Journal = {Chest},
   Volume = {119},
   Number = {5},
   Pages = {1357-1364},
   Year = {2001} }



@article{
2882,
   Author = {Lima, J. J. and Beasley, B. N. and Parker, R. B. and Johnson, J. A.},
   Title = {A pharmacodynamic model of the effects of controlled-onset extended-release verapamil on 24-hour ambulatory blood pressure},
   Journal = {Int.J Clin.Pharmacol.Ther.},
   Volume = {43},
   Number = {4},
   Pages = {187-194},
   Year = {2005} }



@article{
2881,
   Author = {Yamakawa, T. and Itoh, S. and Onishi, S. and Isobe, K. and Hosoe, A. and Nishimura, Y.},
   Title = {Developmental changes in hepatic esterase activity towards chloramphenicol succinate and its Michaelis-Menten constant of liver, kidney and lung in human},
   Journal = {Developmental Pharmacology and Therapeutics},
   Volume = {7},
   Number = {3},
   Pages = {205-212},
   Year = {1984} }



@misc{
2880,
   Author = {Bell, B. M.},
   Title = {The importance of marginal likelihood estimation applied to mixed-effects modeling},
      Year = {2006} }



@article{
2879,
   Author = {Ternant, D. and Paintaud, G.},
   Title = {Pharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins},
   Journal = {Expert.Opin.Biol.Ther.},
   Volume = {5 Suppl 1},
   Pages = {S37-S47},
   Year = {2005} }



@article{
2878,
   Author = {Ellis, J. M. and Kuti, J. L. and Nicolau, D. P.},
   Title = {Pharmacodynamic evaluation of meropenem and cefotaxime for pediatric meningitis: a report from the OPTAMA program},
   Journal = {Paediatr.Drugs},
   Volume = {8},
   Number = {2},
   Pages = {131-138},
   Year = {2006} }



@article{
2875,
   Author = {Dansirikul, C. and Morris, R. G. and Tett, S. E. and Duffull, S. B.},
   Title = {A Bayesian approach for population pharmacokinetic modelling of sirolimus},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {62},
   Number = {4},
   Pages = {420-434},
   Year = {2006} }



@article{
2874,
   Author = {Kloft, C. and Wallin, J. and Henningsson, A. and Chatelut, E. and Karlsson, M. O.},
   Title = {Population pharmacokinetic-pharmacodynamic model for neutropenia with patient subgroup identification: comparison across anticancer drugs},
   Journal = {Clinical Cancer Research: an official journal of the American Association for Cancer Research},
   Volume = {12},
   Number = {18},
   Pages = {5481-5490},
   Year = {2006} }



@article{
2873,
   Author = {Kshirsagar, S. A. and Blaschke, T. F. and Sheiner, L. B. and Krygowski, M. and Acosta, E. P. and Verotta, D.},
   Title = {Improving data reliability using a non-compliance detection method versus using pharmacokinetic criteria},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2872,
   Author = {Anderson, B. J. and Allegaert, K. and van den Anker, J. N. and Cossey, V. and Holford, N. H.},
   Title = {Vancomycin pharmacokinetics in preterm neonates and the prediction of adult clearance},
   Journal = {Br.J Clin.Pharmacol.},
   Year = {2006} }



@article{
2871,
   Author = {Johnson, T. N. and Rostami-Hodjegan, A. and Tucker, G. T.},
   Title = {Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {9},
   Pages = {931-956},
   Year = {2006} }



@article{
2870,
   Author = {Tam, V. H. and Kabbara, S.},
   Title = {Comparative performance of different stochastic methods to simulate drug exposure and variability in a population},
   Journal = {Diagn.Microbiol.Infect.Dis.},
   Year = {2006} }



@article{
2869,
   Author = {Garrido, M. J. and Habre, W. and Rombout, F. and Troconiz, I. F.},
   Title = {Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics},
   Journal = {Pharmaceutical Research},
   Volume = {23},
   Number = {9},
   Pages = {2014-2023},
   Year = {2006} }



@article{
2868,
   Author = {Zitta, S. and Holzer, H. and Reibnegger, G. and Estelberger, W.},
   Title = {Recalibration of population-based GFR formulae by pharmacokinetic methods},
   Journal = {Nephrol.Dial.Transplant.},
   Year = {2006} }



@article{
2867,
   Author = {Kroll, M. H.},
   Title = {Parathyroid hormone temporal effects on bone formation and resorption},
   Journal = {Bull.Math.Biol.},
   Volume = {62},
   Number = {1},
   Pages = {163-188},
   Year = {2000} }



@article{
2866,
   Author = {Bekele, B. N. and Shen, Y.},
   Title = {A Bayesian approach to jointly modeling toxicity and biomarker expression in a phase I/II dose-finding trial},
   Journal = {Biometrics},
   Volume = {61},
   Number = {2},
   Pages = {343-354},
   Year = {2005} }



@article{
2865,
   Author = {Zohar, S. and Chevret, S.},
   Title = {The continual reassessment method: comparison of Bayesian stopping rules for dose-ranging studies},
   Journal = {Statistics in Medicine},
   Volume = {20},
   Number = {19},
   Pages = {2827-2843},
   Year = {2001} }



@article{
2864,
   Author = {Zohar, S. and Latouche, A. and Taconnet, M. and Chevret, S.},
   Title = {Software to compute and conduct sequential Bayesian phase I or II dose-ranging clinical trials with stopping rules},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {72},
   Number = {2},
   Pages = {117-125},
   Year = {2003} }



@article{
2863,
   Author = {Zohar, S. and Chevret, S.},
   Title = {Phase I (or phase II) dose-ranging clinical trials: proposal of a two-stage Bayesian design},
   Journal = {J Biopharm.Stat.},
   Volume = {13},
   Number = {1},
   Pages = {87-101},
   Year = {2003} }



@article{
2862,
   Author = {Yin, G. and Li, Y. and Ji, Y.},
   Title = {Bayesian dose-finding in phase I/II clinical trials using toxicity and efficacy odds ratios},
   Journal = {Biometrics},
   Volume = {62},
   Number = {3},
   Pages = {777-787},
   Year = {2006} }



@article{
2861,
   Author = {Abbas, I. and Rovira, J. and Casanovas, J.},
   Title = {Clinical trial optimization: Monte Carlo simulation Markov model for planning clinical trials recruitment},
   Journal = {Contemp.Clin.Trials},
   Year = {2006} }



@article{
2860,
   Author = {Troconiz, I. F. and Zsolt, I. and Garrido, M. J. and Valle, M. and Antonijoan, R. M. and Barbanoj, M. J.},
   Title = {Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor},
   Journal = {Pharmaceutical Research},
   Volume = {23},
   Number = {7},
   Pages = {1533-1542},
   Year = {2006} }



@article{
2858,
   Author = {Locklin, R. M. and Khosla, S. and Turner, R. T. and Riggs, B. L.},
   Title = {Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone},
   Journal = {J Cell Biochem.},
   Volume = {89},
   Number = {1},
   Pages = {180-190},
   Year = {2003} }



@article{
2857,
   Author = {O'Hara, T. and Hayes, S. and Davis, J. and Devane, J. and Smart, T. and Dunne, A.},
   Title = {In vivo-in vitro correlation (IVIVC) modeling incorporating a convolution step},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {28},
   Number = {3},
   Pages = {277-298},
   Year = {2001} }



@article{
2856,
   Author = {Stevens, J. C.},
   Title = {New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology},
   Journal = {Drug Discov.Today},
   Volume = {11},
   Number = {9-10},
   Pages = {440-445},
   Year = {2006} }



@article{
2855,
   Author = {Bell, G. D.},
   Title = {Premedication, preparation, and surveillance},
   Journal = {Endoscopy},
   Volume = {34},
   Number = {1},
   Pages = {2-12},
   Year = {2002} }



@article{
2854,
   Author = {Drossman, D. A. and Brandt, L. J. and Sears, C. and Li, Z. and Nat, J. and Bozymski, E. M.},
   Title = {A preliminary study of patients' concerns related to GI endoscopy},
   Journal = {Am J Gastroenterol.},
   Volume = {91},
   Number = {2},
   Pages = {287-291},
   Year = {1996} }



@article{
2853,
   Author = {Morrow, J. B. and Zuccaro, G., Jr. and Conwell, D. L. and Vargo, J. J. and Dumot, J. A. and Karafa, M. and Shay, S. S.},
   Title = {Sedation for colonoscopy using a single bolus is safe, effective, and efficient: a prospective, randomized, double-blind trial},
   Journal = {Am J Gastroenterol.},
   Volume = {95},
   Number = {9},
   Pages = {2242-2247},
   Year = {2000} }



@article{
2852,
   Author = {Sipe, B. W. and Rex, D. K. and Latinovich, D. and Overley, C. and Kinser, K. and Bratcher, L. and Kareken, D.},
   Title = {Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists},
   Journal = {Gastrointest.Endosc.},
   Volume = {55},
   Number = {7},
   Pages = {815-825},
   Year = {2002} }



@article{
2851,
   Author = {Cohen, L. B. and Dubovsky, A. N. and Aisenberg, J. and Miller, K. M.},
   Title = {Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist},
   Journal = {Gastrointest.Endosc.},
   Volume = {58},
   Number = {5},
   Pages = {725-732},
   Year = {2003} }



@article{
2850,
   Author = {Brandt, L. J.},
   Title = {Patients' attitudes and apprehensions about endoscopy: how to calm troubled waters},
   Journal = {Am J Gastroenterol.},
   Volume = {96},
   Number = {2},
   Pages = {280-284},
   Year = {2001} }



@article{
2849,
   Author = {Scheffer, G. J.},
   Title = {Conscious sedation for endoscopic procedures},
   Journal = {Neth.J Med.},
   Volume = {62},
   Number = {1},
   Pages = {1-3},
   Year = {2004} }



@article{
2848,
   Author = {Cotton, P. B. and Connor, P. and McGee, D. and Jowell, P. and Nickl, N. and Schutz, S. and Leung, J. and Lee, J. and Libby, E.},
   Title = {Colonoscopy: practice variation among 69 hospital-based endoscopists},
   Journal = {Gastrointest.Endosc.},
   Volume = {57},
   Number = {3},
   Pages = {352-357},
   Year = {2003} }



@article{
2847,
   Author = {Vicari, J. J.},
   Title = {Sedation and analgesia},
   Journal = {Gastrointest.Endosc.Clin.N.Am},
   Volume = {12},
   Number = {2},
   Pages = {297-311, viii},
   Year = {2002} }



@article{
2846,
   Author = {Kanaan, R. A. and Kanaan, L. A.},
   Title = {Transforming growth factor beta1, bone connection},
   Journal = {Med.Sci.Monit.},
   Volume = {12},
   Number = {8},
   Pages = {RA164-RA169},
   Year = {2006} }



@article{
2845,
   Author = {Karst, M. and Gorny, G. and Galvin, R. J. and Oursler, M. J.},
   Title = {Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation},
   Journal = {J Cell Physiol},
   Volume = {200},
   Number = {1},
   Pages = {99-106},
   Year = {2004} }



@article{
2844,
   Author = {Dale, L. C. and Ebbert, J. O. and Schroeder, D. R. and Croghan, I. T. and Rasmussen, D. F. and Trautman, J. A. and Cox, L. S. and Hurt, R. D.},
   Title = {Bupropion for the treatment of nicotine dependence in spit tobacco users: a pilot study},
   Journal = {Nicotine.Tob.Res.},
   Volume = {4},
   Number = {3},
   Pages = {267-274},
   Year = {2002} }



@article{
2843,
   Author = {Etter, J. F. and Laszlo, E. and Zellweger, J. P. and Perrot, C. and Perneger, T. V.},
   Title = {Nicotine replacement to reduce cigarette consumption in smokers who are unwilling to quit: a randomized trial},
   Journal = {J Clin.Psychopharmacol.},
   Volume = {22},
   Number = {5},
   Pages = {487-495},
   Year = {2002} }



@article{
2842,
   Author = {Bolliger, C. T. and Zellweger, J. P. and Danielsson, T. and van, Biljon X. and Robidou, A. and Westin, A. and Perruchoud, A. P. and Sawe, U.},
   Title = {Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety},
   Journal = {BMJ},
   Volume = {321},
   Number = {7257},
   Pages = {329-333},
   Year = {2000} }



@article{
2841,
   Author = {Jolicoeur, D. G. and Richter, K. P. and Ahluwalia, J. S. and Mosier, M. C. and Resnicow, K.},
   Title = {Smoking cessation, smoking reduction, and delayed quitting among smokers given nicotine patches and a self-help pamphlet},
   Journal = {Subst.Abus.},
   Volume = {24},
   Number = {2},
   Pages = {101-106},
   Year = {2003} }



@article{
2840,
   Author = {Batra, A. and Klingler, K. and Landfeldt, B. and Friederich, H. M. and Westin, A. and Danielsson, T.},
   Title = {Smoking reduction treatment with 4-mg nicotine gum: a double-blind, randomized, placebo-controlled study},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {78},
   Number = {6},
   Pages = {689-696},
   Year = {2005} }



@article{
2839,
   Author = {Hatsukami, D. K. and Rennard, S. and Patel, M. K. and Kotlyar, M. and Malcolm, R. and Nides, M. A. and Dozier, G. and Bars, M. P. and Jamerson, B. D.},
   Title = {Effects of sustained-release bupropion among persons interested in reducing but not quitting smoking},
   Journal = {Am J Med.},
   Volume = {116},
   Number = {3},
   Pages = {151-157},
   Year = {2004} }



@article{
2838,
   Author = {Rennard, S. I. and Glover, E. D. and Leischow, S. and Daughton, D. M. and Glover, P. N. and Muramoto, M. and Franzon, M. and Danielsson, T. and Landfeldt, B. and Westin, A.},
   Title = {Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial},
   Journal = {Nicotine.Tob.Res.},
   Volume = {8},
   Number = {4},
   Pages = {555-564},
   Year = {2006} }



@article{
2837,
   Author = {Garcia, M. and Fernandez, E. and Schiaffino, A. and Peris, M. and Borras, J. M.},
   Title = {Smoking reduction in a population-based cohort},
   Journal = {Prev.Med.},
   Volume = {40},
   Number = {6},
   Pages = {679-684},
   Year = {2005} }



@article{
2836,
   Author = {Haustein, K. O. and Krause, J. and Haustein, H. and Rasmussen, T. and Cort, N.},
   Title = {Comparison of the effects of combined nicotine replacement therapy vs. cigarette smoking in males},
   Journal = {Nicotine.Tob.Res.},
   Volume = {5},
   Number = {2},
   Pages = {195-203},
   Year = {2003} }



@article{
2835,
   Author = {Carpenter, M. J. and Hughes, J. R. and Solomon, L. J. and Callas, P. W.},
   Title = {Both smoking reduction with nicotine replacement therapy and motivational advice increase future cessation among smokers unmotivated to quit},
   Journal = {J Consult Clin.Psychol.},
   Volume = {72},
   Number = {3},
   Pages = {371-381},
   Year = {2004} }



@article{
2834,
   Author = {Alberg, A. J. and Patnaik, J. L. and May, J. W. and Hoffman, S. C. and Gitchelle, J. and Comstock, G. W. and Helzlsouer, K. J.},
   Title = {Nicotine replacement therapy use among a cohort of smokers},
   Journal = {J Addict.Dis.},
   Volume = {24},
   Number = {1},
   Pages = {101-113},
   Year = {2005} }



@article{
2833,
   Author = {van Bezooijen, R. L. and Roelen, B. A. and Visser, A. and van, der Wee-Pals and de, Wilt E. and Karperien, M. and Hamersma, H. and Papapoulos, S. E. and ten, Dijke P. and Lowik, C. W.},
   Title = {Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist},
   Journal = {J Exp.Med.},
   Volume = {199},
   Number = {6},
   Pages = {805-814},
   Year = {2004} }



@article{
2832,
   Author = {van Bezooijen, R. L. and ten, Dijke P. and Papapoulos, S. E. and Lowik, C. W.},
   Title = {SOST/sclerostin, an osteocyte-derived negative regulator of bone formation},
   Journal = {Cytokine Growth Factor Rev.},
   Volume = {16},
   Number = {3},
   Pages = {319-327},
   Year = {2005} }



@article{
2831,
   Author = {van Bezooijen, R. L. and Papapoulos, S. E. and Lowik, C. W.},
   Title = {Bone morphogenetic proteins and their antagonists: the sclerostin paradigm},
   Journal = {J Endocrinol.Invest},
   Volume = {28},
   Number = {8 Suppl},
   Pages = {15-17},
   Year = {2005} }



@article{
2830,
   Author = {Kitano, H.},
   Title = {Cancer as a robust system: implications for anticancer therapy},
   Journal = {Nat.Rev.Cancer},
   Volume = {4},
   Number = {3},
   Pages = {227-235},
   Year = {2004} }



@article{
2829,
   Author = {Kalinski, P. and Moser, M.},
   Title = {Consensual immunity: success-driven development of T-helper-1 and T-helper-2 responses},
   Journal = {Nat.Rev.Immunol.},
   Volume = {5},
   Number = {3},
   Pages = {251-260},
   Year = {2005} }



@article{
2828,
   Author = {Rule, A. D. and Larson, T. S. and Bergstralh, E. J. and Slezak, J. M. and Jacobsen, S. J. and Cosio, F. G.},
   Title = {Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease},
   Journal = {Annals of Internal Medicine},
   Volume = {141},
   Number = {12},
   Pages = {929-937},
   Year = {2004} }



@article{
2827,
   Author = {Stevens, L. A. and Coresh, J. and Greene, T. and Levey, A. S.},
   Title = {Assessing kidney function--measured and estimated glomerular filtration rate},
   Journal = {N.Engl.J Med.},
   Volume = {354},
   Number = {23},
   Pages = {2473-2483},
   Year = {2006} }



@article{
2826,
   Author = {Agoram, B. and Gastonguay, M. R. and Heatherington, A.},
   Title = {Development and evaluation of a population pharmacokinetic-pharmacodynamic model of darbepoetin alfa in patients with non-myeloid malignancies undergoing multicylcle chemotherapy},
   Journal = {The AAPS Journal},
   Volume = {8},
   Number = {3},
   Year = {2006} }



@article{
2825,
   Author = {Yalcinkaya, F. and Tumer, N. and Cakar, N. and Ozkaya, N.},
   Title = {Low-dose erythropoietin is effective and safe in children on continuous ambulatory peritoneal dialysis},
   Journal = {Pediatr.Nephrol.},
   Volume = {11},
   Number = {3},
   Pages = {350-352},
   Year = {1997} }



@article{
2824,
   Author = {van Damme-Lombaerts, R. and Herman, J.},
   Title = {Erythropoietin treatment in children with renal failure},
   Journal = {Pediatr.Nephrol.},
   Volume = {13},
   Number = {2},
   Pages = {148-152},
   Year = {1999} }



@book{
2823,
   Author = {Stoklosa, M. J. and Ansel, H. C.},
   Title = {Pharmaceutical calculations},
   Publisher = {Williams & Wilkins},
   Address = {Baltimore},
   Year = {1996} }



@article{
2822,
   Author = {Sieniawska, M. and Roszkowska-Blaim, M.},
   Title = {Recombinant human erythropoietin dosage in children undergoing hemodialysis and continuous ambulatory peritoneal dialysis},
   Journal = {Pediatr.Nephrol.},
   Volume = {11},
   Number = {5},
   Pages = {628-630},
   Year = {1997} }



@article{
2821,
   Author = {Schwartz, G. J. and Brion, L. P. and Spitzer, A.},
   Title = {The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents},
   Journal = {Pediatr.Clin.North Am},
   Volume = {34},
   Number = {3},
   Pages = {571-590},
   Year = {1987} }



@article{
2820,
   Author = {Ongkingco, J. R. and Ruley, E. J. and Turner, M. E. and Fragale, M. R.},
   Title = {Efficacy of once- versus thrice-weekly subcutaneous recombinant human erythropoietin in children receiving continuous cycling peritoneal dialysis},
   Journal = {Am J Nephrol.},
   Volume = {14},
   Number = {1},
   Pages = {14-18},
   Year = {1994} }



@article{
2819,
   Author = {Lin, F. K. and Suggs, S. and Lin, C. H. and Browne, J. K. and Smalling, R. and Egrie, J. C. and Chen, K. K. and Fox, G. M. and Martin, F. and Stabinsky, Z.},
   Title = {Cloning and expression of the human erythropoietin gene},
   Journal = {Proceedings of the National Academy of Sciences of the United States of America},
   Volume = {82},
   Number = {22},
   Pages = {7580-7584},
   Year = {1985} }



@article{
2818,
   Author = {Jacobs, K. and Shoemaker, C. and Rudersdorf, R. and Neill, S. D. and Kaufman, R. J. and Mufson, A. and Seehra, J. and Jones, S. S. and Hewick, R. and Fritsch, E. F.},
   Title = {Isolation and characterization of genomic and cDNA clones of human erythropoietin},
   Journal = {Nature},
   Volume = {313},
   Number = {6005},
   Pages = {806-810},
   Year = {1985} }



@article{
2817,
   Author = {Jabs, K. and Harmon, W. E.},
   Title = {Recombinant human erythropoietin therapy in children on dialysis},
   Journal = {Adv.Ren Replace.Ther.},
   Volume = {3},
   Number = {1},
   Pages = {24-36},
   Year = {1996} }



@book{
2816,
   Title = {Investigational Drug Brochure. HMR4396 (Gene-Activated)},
   Year = {2000} }



@book{
2815,
   Author = {Johns Hopkins, Hospital and Gunn, V. L. and Nechyba, C. and Barone, M. A.},
   Title = {The harriet lane handbook. A manual for pediatric house officers},
   Publisher = {C.V. Mosby},
   Address = {Baltimore},
   Year = {2006} }



@article{
2814,
   Author = {Anemia Work, Group},
   Title = {Clinical practices guidelines for the treatment of anemia of chronic renal failure. IV. Administration of epoetin},
   Journal = {American Journal of Kidney Diseases: the official journal of the National Kidney Foundation},
   Volume = {30},
   Number = {4, suppl 3},
   Pages = {S213-S217},
   Year = {1997} }



@article{
2813,
   Author = {Anemia Work, Group},
   Title = {Clinical practices guidelines for the treatment of anemia of chronic renal failure. III. Iron support},
   Journal = {Am J Kidney},
   Volume = {30},
   Number = {4, suppl 3},
   Pages = {S202-S212},
   Year = {1997} }



@techreport{
2812,
   Title = {Federal Register. International conference on harmonisation: E11: Clinical investigation of medicinal products in the pediatric population},
   Number = {No. 71:19777-19781},
   Year = {2000} }



@article{
2811,
   Author = {Brandt, J. R. and Avner, E. D. and Hickman, R. O. and Watkins, S. L.},
   Title = {Safety and efficacy of erythropoietin in children with chronic renal failure},
   Journal = {Pediatr.Nephrol.},
   Volume = {13},
   Number = {2},
   Pages = {143-147},
   Year = {1999} }



@article{
2810,
   Author = {Ramakrishnan, R. and Cheung, W. K. and Wacholtz, M. C. and Minton, N. and Jusko, W. J.},
   Title = {Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers},
   Journal = {J Clin.Pharmacol.},
   Volume = {44},
   Number = {9},
   Pages = {991-1002},
   Year = {2004} }



@article{
2809,
   Author = {Bijlsma, S. and Bobeldijk, I. and Verheij, E. R. and Ramaker, R. and Kochhar, S. and Macdonald, I. A. and van, Ommen B. and Smilde, A. K.},
   Title = {Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation},
   Journal = {Anal.Chem.},
   Volume = {78},
   Number = {2},
   Pages = {567-574},
   Year = {2006} }



@article{
2808,
   Author = {Yee, J. Y. and Duffull, S. B.},
   Title = {The effect of body weight on dalteparin pharmacokinetics. A preliminary study},
   Journal = {Eur.J Clin.Pharmacol.},
   Volume = {56},
   Number = {4},
   Pages = {293-297},
   Year = {2000} }



@article{
2807,
   Author = {Green, B. and Duffull, S. B.},
   Title = {What is the best size descriptor to use for pharmacokinetic studies in the obese?},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {58},
   Number = {2},
   Pages = {119-133},
   Year = {2004} }



@article{
2806,
   Author = {Green, B. and Duffull, S.},
   Title = {Caution when lean body weight is used as a size descriptor for obese subjects},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {72},
   Number = {6},
   Pages = {743-744},
   Year = {2002} }



@article{
2805,
   Author = {Duffull, S. B. and Dooley, M. J. and Green, B. and Poole, S. G. and Kirkpatrick, C. M.},
   Title = {A standard weight descriptor for dose adjustment in the obese patient},
   Journal = {Clinical Pharmacokinetics},
   Volume = {43},
   Number = {15},
   Pages = {1167-1178},
   Year = {2004} }



@article{
2804,
   Author = {Janmahasatian, S. and Duffull, S. B. and Ash, S. and Ward, L. C. and Byrne, N. M. and Green, B.},
   Title = {Quantification of lean bodyweight},
   Journal = {Clinical Pharmacokinetics},
   Volume = {44},
   Number = {10},
   Pages = {1051-1065},
   Year = {2005} }



@article{
2803,
   Author = {Feng, Y. and Green, B. and Duffull, S. B. and Kane-Gill, S. L. and Bobek, M. B. and Bies, R. R.},
   Title = {Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation},
   Journal = {Br.J Clin.Pharmacol.},
   Volume = {62},
   Number = {2},
   Pages = {165-176},
   Year = {2006} }



@article{
2802,
   Author = {Thall, P. F. and Wathen, J. K.},
   Title = {Covariate-adjusted adaptive randomization in a sarcoma trial with multi-stage treatments},
   Journal = {Statistics in Medicine},
   Volume = {24},
   Number = {13},
   Pages = {1947-1964},
   Year = {2005} }



@article{
2801,
   Author = {Thall, P. F. and Cook, J. D.},
   Title = {Dose-finding based on efficacy-toxicity trade-offs},
   Journal = {Biometrics},
   Volume = {60},
   Number = {3},
   Pages = {684-693},
   Year = {2004} }



@article{
2800,
   Author = {Cheung, Y. K. and Inoue, L. Y. and Wathen, J. K. and Thall, P. F.},
   Title = {Continuous Bayesian adaptive randomization based on event times with covariates},
   Journal = {Statistics in Medicine},
   Volume = {25},
   Number = {1},
   Pages = {55-70},
   Year = {2006} }



@article{
2798,
   Author = {Piotrovskij, V.},
   Title = {Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc elongation},
   Journal = {The AAPS Journal},
   Volume = {7},
   Number = {3},
   Pages = {E609-E624},
   Year = {2005} }



@article{
2797,
   Author = {Heaney, R. P.},
   Title = {Estrogen-calcium interactions in the postmenopause: a quantitative description},
   Journal = {Bone Miner.},
   Volume = {11},
   Number = {1},
   Pages = {67-84},
   Year = {1990} }



@article{
2796,
   Author = {Hauser, R. A. and Friedlander, J. and Zesiewicz, T. A. and Adler, C. H. and Seeberger, L. C. and O'Brien, C. F. and Molho, E. S. and Factor, S. A.},
   Title = {A home diary to assess functional status in patients with Parkinson's disease with motor fluctuations and dyskinesia},
   Journal = {Clin.Neuropharmacol.},
   Volume = {23},
   Number = {2},
   Pages = {75-81},
   Year = {2000} }



@book{
2795,
   Author = {Agresti, A.},
   Title = {Categorical Data Analysis},
   Publisher = {John Wiley & Sons Inc.},
   Address = {New York},
   Year = {1990} }



@techreport{
2794,
   Title = {Study 6002-US-06: Positron Emission Tomography study using [ 11 C]KW-6002 to detrmine adenosine A2A receptor occupancy in human brain},
   Number = {Final Report},
   Year = {2006} }



@article{
2793,
   Author = {Bara-Jimenez, W. and Sherzai, A. and Dimitrova, T. and Favit, A. and Bibbiani, F. and Gillespie, M. and Morris, M. J. and Mouradian, M. M. and Chase, T. N.},
   Title = {Adenosine A(2A) receptor antagonist treatment of Parkinson's disease},
   Journal = {Neurology},
   Volume = {61},
   Number = {3},
   Pages = {293-296},
   Year = {2003} }



@article{
2792,
   Author = {Hauser, R. A. and Hubble, J. P. and Truong, D. D.},
   Title = {Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD},
   Journal = {Neurology},
   Volume = {61},
   Number = {3},
   Pages = {297-303},
   Year = {2003} }



@article{
2791,
   Author = {Ochi, M. and Shiozaki, S. and Kase, H.},
   Title = {Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease},
   Journal = {Neuroscience},
   Volume = {127},
   Number = {1},
   Pages = {223-231},
   Year = {2004} }



@article{
2790,
   Author = {Aoyama, S. and Koga, K. and Mori, A. and Miyaji, H. and Sekine, S. and Kase, H. and Uchimura, T. and Kobayashi, H. and Kuwana, Y.},
   Title = {Distribution of adenosine A(2A) receptor antagonist KW-6002 and its effect on gene expression in the rat brain},
   Journal = {Brain Res.},
   Volume = {953},
   Number = {1-2},
   Pages = {119-125},
   Year = {2002} }



@article{
2789,
   Author = {Ikeda, K. and Kurokawa, M. and Aoyama, S. and Kuwana, Y.},
   Title = {Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease},
   Journal = {J Neurochem.},
   Volume = {80},
   Number = {2},
   Pages = {262-270},
   Year = {2002} }



@article{
2788,
   Author = {Lundblad, M. and Vaudano, E. and Cenci, M. A.},
   Title = {Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia},
   Journal = {J Neurochem.},
   Volume = {84},
   Number = {6},
   Pages = {1398-1410},
   Year = {2003} }



@article{
2787,
   Author = {Pueyo, E. and Smetana, P. and Laguna, P. and Malik, M.},
   Title = {Estimation of the QT/RR hysteresis lag},
   Journal = {J Electrocardiol.},
   Volume = {36 Suppl},
   Pages = {187-190},
   Year = {2003} }



@article{
2786,
   Author = {Hu, C. and Moore, K. H. and Kim, Y. H. and Sale, M. E.},
   Title = {Statistical issues in a modeling approach to assessing bioequivalence or PK similarity with presence of sparsely sampled subjects},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {31},
   Number = {4},
   Pages = {321-339},
   Year = {2004} }



@article{
2785,
   Author = {Maeda, S. and Dean, D. D. and Gomez, R. and Schwartz, Z. and Boyan, B. D.},
   Title = {The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3)},
   Journal = {Calcif.Tissue Int.},
   Volume = {70},
   Number = {1},
   Pages = {54-65},
   Year = {2002} }



@book{
2784,
   Author = {Boyd, E.},
   Title = {The growth of the surface area of the human body},
   Publisher = {University of Minnesota Press},
   Address = {Minneapolis},
   Year = {1935} }



@book{
2783,
   Title = {Tenex package insert. A.H. Robbins Company},
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@techreport{
2782,
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@book{
2781,
   Author = {Burhham, K. P. and Anderson, D. R.},
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@article{
2780,
   Author = {Arnsten, A. F. and Cai, J. X. and Goldman-Rakic, P. S.},
   Title = {The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes},
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@article{
2779,
   Author = {Horrigan, J. P. and Barnhill, L. J.},
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   Year = {1995} }



@article{
2778,
   Author = {Riddle, M. A. and Bernstein, G. A. and Cook, E. H. and Leonard, H. L. and March, J. S. and Swanson, J. M.},
   Title = {Anxiolytics, adrenergic agents, and naltrexone},
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   Volume = {38},
   Number = {5},
   Pages = {546-556},
   Year = {1999} }



@article{
2777,
   Author = {Casat, C. D. and Pleasants, D. Z. and Van Wyck, Fleet J.},
   Title = {A double-blind trial of bupropion in children with attention deficit disorder},
   Journal = {Psychopharmacol.Bull.},
   Volume = {23},
   Number = {1},
   Pages = {120-122},
   Year = {1987} }



@article{
2776,
   Author = {Garfinkel, B. D. and Wender, P. H. and Sloman, L. and O'Neill, I.},
   Title = {Tricyclic antidepressant and methylphenidate treatment of attention deficit disorder in children},
   Journal = {J.Am.Acad.Child Psychiatry},
   Volume = {22},
   Number = {4},
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   Year = {1983} }



@article{
2775,
   Author = {Newcorn, J. H. and Schulz, K. and Harrison, M. and DeBellis, M. D. and Udarbe, J. K. and Halperin, J. M.},
   Title = {Alpha 2 adrenergic agonists. Neurochemistry, efficacy, and clinical guidelines for use in children},
   Journal = {Pediatric Clinics of North America},
   Volume = {45},
   Number = {5},
   Pages = {1099-22, viii},
   Year = {1998} }



@article{
2774,
   Author = {Kiechel, J. R.},
   Title = {Pharmacokinetics and metabolism of guanfacine in man: a review},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {10 Suppl 1},
   Pages = {25S-32S},
   Year = {1980} }



@article{
2773,
   Author = {Carchman, S. H. and Crowe, J. T., Jr. and Wright, G. J.},
   Title = {The bioavailability and pharmacokinetics of guanfacine after oral and intravenous administration to healthy volunteers},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {27},
   Number = {10},
   Pages = {762-767},
   Year = {1987} }



@techreport{
2772,
   Title = {Diagnosis and treatment of attention deficit hyperactivity disorder (ADHD)},
   Number = {16},
   Year = {1998} }



@article{
2771,
   Author = {Sridhar, A. V. and Rao, N. K. and Chakraborty, S.},
   Title = {A six-year old with fatal pulmonary embolism},
   Journal = {Acta Paediatr.},
   Volume = {94},
   Number = {7},
   Pages = {977-979},
   Year = {2005} }



@article{
2770,
   Author = {Morris, T. A.},
   Title = {Heparin and low molecular weight heparin: background and pharmacology},
   Journal = {Clin.Chest Med.},
   Volume = {24},
   Number = {1},
   Pages = {39-47},
   Year = {2003} }



@article{
2769,
   Author = {Morris, T. A. and Jacobson, A. and Marsh, J. J. and Lane, J. R.},
   Title = {Pharmacokinetics of UH and LMWH are similar with respect to antithrombin activity},
   Journal = {Thrombosis Research},
   Volume = {115},
   Number = {1-2},
   Pages = {45-51},
   Year = {2005} }



@article{
2768,
   Author = {Pautas, E. and Gouin, I. and Bellot, O. and Andreux, J. P. and Siguret, V.},
   Title = {Safety profile of tinzaparin administered once daily at a standard curative dose in two hundred very elderly patients},
   Journal = {Drug Saf},
   Volume = {25},
   Number = {10},
   Pages = {725-733},
   Year = {2002} }



@article{
2767,
   Author = {Mousa, S. A. and Bozarth, J. and Barrett, J. S.},
   Title = {Pharmacodynamic properties of the low molecular weight heparin, tinzaparin: effect of molecular weight distribution on plasma tissue factor pathway inhibitor in healthy human subjects},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {43},
   Number = {7},
   Pages = {727-734},
   Year = {2003} }



@article{
2766,
   Author = {Nutescu, E. A. and Shapiro, N. L. and Feinstein, H. and Rivers, C. W.},
   Title = {Tinzaparin: considerations for use in clinical practice},
   Journal = {The Annals of Pharmacotherapy},
   Volume = {37},
   Number = {12},
   Pages = {1831-1840},
   Year = {2003} }



@article{
2765,
   Author = {Dager, W. E. and King, J. H. and Branch, J. M. and Chow, S. L. and Ferrer, R. E. and Pak, S. and Togioka, P. Y. and White, R. H.},
   Title = {Tinzaparin in outpatients with pulmonary embolism or deep vein thrombosis},
   Journal = {The Annals of Pharmacotherapy},
   Volume = {39},
   Number = {7-8},
   Pages = {1182-1187},
   Year = {2005} }



@article{
2764,
   Author = {Cheer, S. M. and Dunn, C. J. and Foster, R.},
   Title = {Tinzaparin sodium: a review of its pharmacology and clinical use in the prophylaxis and treatment of thromboembolic disease},
   Journal = {Drugs},
   Volume = {64},
   Number = {13},
   Pages = {1479-1502},
   Year = {2004} }



@article{
2763,
   Author = {Jacobs, R. F. and Maples, H. D. and Aranda, J. V. and Espinoza, G. M. and Knirsch, C. and Chandra, R. and Fisher, J. M. and Kearns, G. L.},
   Title = {Pharmacokinetics of intravenously administered azithromycin in pediatric patients},
   Journal = {The Pediatric Infectious Disease Journal},
   Volume = {24},
   Number = {1},
   Pages = {34-39},
   Year = {2005} }



@article{
2762,
   Author = {Hofbauer, L. C. and Schoppet, M. and Schuller, P. and Viereck, V. and Christ, M.},
   Title = {Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women},
   Journal = {Clin.Endocrinol.(Oxf)},
   Volume = {60},
   Number = {2},
   Pages = {214-219},
   Year = {2004} }



@article{
2761,
   Author = {Pulsatelli, L. and Dolzani, P. and Silvestri, T. and Caraceni, P. and Facchini, A. and Ravaglia, G. and Salvarani, C. and Meliconi, R. and Mariani, E.},
   Title = {Soluble receptor activator of nuclear factor- kappaB Ligand (sRANKL)/osteoprotegerin balance in ageing and age-associated diseases},
   Journal = {Biogerontology.},
   Volume = {5},
   Number = {2},
   Pages = {119-127},
   Year = {2004} }



@article{
2760,
   Author = {Oh, K. W. and Rhee, E. J. and Lee, W. Y. and Kim, S. W. and Baek, K. H. and Kang, M. I. and Yun, E. J. and Park, C. Y. and Ihm, S. H. and Choi, M. G. and Yoo, H. J. and Park, S. W.},
   Title = {Circulating osteoprotegerin and receptor activator of NF-kappaB ligand system are associated with bone metabolism in middle-aged males},
   Journal = {Clin.Endocrinol.(Oxf)},
   Volume = {62},
   Number = {1},
   Pages = {92-98},
   Year = {2005} }



@article{
2759,
   Author = {Abrahamsen, B. and Hjelmborg, J. V. and Kostenuik, P. and Stilgren, L. S. and Kyvik, K. and Adamu, S. and Brixen, K. and Langdahl, B. L.},
   Title = {Circulating amounts of osteoprotegerin and RANK ligand: genetic influence and relationship with BMD assessed in female twins},
   Journal = {Bone},
   Volume = {36},
   Number = {4},
   Pages = {727-735},
   Year = {2005} }



@article{
2758,
   Author = {Fabrega, E. and Orive, A. and Garcia-Suarez, C. and Garcia-Unzueta, M. and Antonio, Amado J. and Pons-Romero, F.},
   Title = {Osteoprotegerin and RANKL in alcoholic liver cirrhosis},
   Journal = {Liver Int.},
   Volume = {25},
   Number = {2},
   Pages = {305-310},
   Year = {2005} }



@article{
2757,
   Author = {Buzi, F. and Maccarinelli, G. and Guaragni, B. and Ruggeri, F. and Radetti, G. and Meini, A. and Mazzolari, E. and Cocchi, D.},
   Title = {Serum osteoprotegerin and receptor activator of nuclear factors kB (RANKL) concentrations in normal children and in children with pubertal precocity, Turner's syndrome and rheumatoid arthritis},
   Journal = {Clin.Endocrinol.(Oxf)},
   Volume = {60},
   Number = {1},
   Pages = {87-91},
   Year = {2004} }



@techreport{
2756,
   Author = {Yuen, G.},
   Title = {Steady-state amprenavir population pharmacokinetic modeling and validation analysis following administration of GW433908 and GW433908 + ritonavir to healthy and HIV-Infected subjects},
   Year = {2002} }



@article{
2755,
   Author = {Goujard, C. and Vincent, I. and Meynard, J. L. and Choudet, N. and Bollens, D. and Rousseau, C. and Demarles, D. and Gillotin, C. and Bidault, R. and Taburet, A. M.},
   Title = {Steady-state pharmacokinetics of amprenavir coadministered with ritonavir in human immunodeficiency virus type 1-infected patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {47},
   Number = {1},
   Pages = {118-123},
   Year = {2003} }



@article{
2754,
   Author = {Bouillon, T. and Bruhn, J. and Radu-Radulescu, L. and Bertaccini, E. and Park, S. and Shafer, S.},
   Title = {Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil},
   Journal = {Anesthesiology},
   Volume = {97},
   Number = {6},
   Pages = {1350-1362},
   Year = {2002} }



@article{
2753,
   Author = {Callies, S. and de Alwis, D. P. and Wright, J. G. and Sandler, A. and Burgess, M. and Aarons, L.},
   Title = {A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {51},
   Number = {2},
   Pages = {107-118},
   Year = {2003} }



@article{
2752,
   Author = {Martin-Suarez, A. and Atencio, D. R. and Lopez, F. G. and Santos, M. and Zarzuelo, A. and Mendez, M. E. and Alberca, I. and Lanao, J. M.},
   Title = {Pharmacokinetic study of the digoxin-acenocoumarol interaction in rabbits},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {26},
   Number = {6},
   Pages = {813-817},
   Year = {2003} }



@article{
2751,
   Author = {Yukawa, E. and Nonaka, T. and Yukawa, M. and Higuchi, S. and Kuroda, T. and Goto, Y.},
   Title = {Pharmacoepidemiologic investigation of a clonazepam-valproic acid interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {28},
   Number = {6},
   Pages = {497-504},
   Year = {2003} }



@article{
2750,
   Author = {Joel, S. P. and Papamichael, D. and Richards, F. and Davis, T. and Aslanis, V. and Chatelut, E. and Locke, K. and Slevin, M. L. and Seymour, M. T.},
   Title = {Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {76},
   Number = {1},
   Pages = {45-54},
   Year = {2004} }



@article{
2749,
   Author = {de Jonge, M. E. and Huitema, A. D. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {31},
   Number = {2},
   Pages = {135-156},
   Year = {2004} }



@article{
2748,
   Author = {Gordi, T. and Xie, R. and Huong, N. V. and Huong, D. X. and Karlsson, M. O. and Ashton, M.},
   Title = {A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {59},
   Number = {2},
   Pages = {189-198},
   Year = {2005} }



@article{
2747,
   Author = {Brophy, D. F. and Israel, D. S. and Pastor, A. and Gillotin, C. and Chittick, G. E. and Symonds, W. T. and Lou, Y. and Sadler, B. M. and Polk, R. E.},
   Title = {Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {44},
   Number = {4},
   Pages = {978-984},
   Year = {2000} }



@article{
2746,
   Author = {Veronese, L. and Rautaureau, J. and Sadler, B. M. and Gillotin, C. and Petite, J. P. and Pillegand, B. and Delvaux, M. and Masliah, C. and Fosse, S. and Lou, Y. and Stein, D. S.},
   Title = {Single-dose pharmacokinetics of amprenavir, a human immunodeficiency virus type 1 protease inhibitor, in subjects with normal or impaired hepatic function},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {44},
   Number = {4},
   Pages = {821-826},
   Year = {2000} }



@article{
2745,
   Author = {Sadler, B. M. and Gillotin, C. and Lou, Y. and Stein, D. S.},
   Title = {Pharmacokinetic and pharmacodynamic study of the human immunodeficiency virus protease inhibitor amprenavir after multiple oral dosing},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {45},
   Number = {1},
   Pages = {30-37},
   Year = {2001} }



@article{
2744,
   Author = {Polk, R. E. and Brophy, D. F. and Israel, D. S. and Patron, R. and Sadler, B. M. and Chittick, G. E. and Symonds, W. T. and Lou, Y. and Kristoff, D. and Stein, D. S.},
   Title = {Pharmacokinetic Interaction between amprenavir and rifabutin or rifampin in healthy males},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {45},
   Number = {2},
   Pages = {502-508},
   Year = {2001} }



@article{
2743,
   Author = {Polk, R. E. and Crouch, M. A. and Israel, D. S. and Pastor, A. and Sadler, B. M. and Chittick, G. E. and Symonds, W. T. and Gouldin, W. and Lou, Y.},
   Title = {Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men},
   Journal = {Pharmacotherapy},
   Volume = {19},
   Number = {12},
   Pages = {1378-1384},
   Year = {1999} }



@article{
2742,
   Author = {Sadler, B. M. and Gillotin, C. and Lou, Y. and Eron, J. J. and Lang, W. and Haubrich, R. and Stein, D. S.},
   Title = {Pharmacokinetic study of human immunodeficiency virus protease inhibitors used in combination with amprenavir},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {45},
   Number = {12},
   Pages = {3663-3668},
   Year = {2001} }



@article{
2741,
   Author = {Sadler, B. M. and Piliero, P. J. and Preston, S. L. and Lloyd, P. P. and Lou, Y. and Stein, D. S.},
   Title = {Pharmacokinetics and safety of amprenavir and ritonavir following multiple-dose, co-administration to healthy volunteers},
   Journal = {AIDS},
   Volume = {15},
   Number = {8},
   Pages = {1009-1018},
   Year = {2001} }



@article{
2740,
   Author = {Sadler, B. M. and Chittick, G. E. and Polk, R. E. and Slain, D. and Kerkering, T. M. and Studenberg, S. D. and Lou, Y. and Moore, K. H. and Woolley, J. L. and Stein, D. S.},
   Title = {Metabolic disposition and pharmacokinetics of [14C]-amprenavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, administered as a single oral dose to healthy male subjects},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {41},
   Number = {4},
   Pages = {386-396},
   Year = {2001} }



@article{
2739,
   Author = {Sadler, B. M. and Gillotin, C. and Lou, Y. and Stein, D. S.},
   Title = {In vivo effect of alpha(1)-acid glycoprotein on pharmacokinetics of amprenavir, a human immunodeficiency virus protease inhibitor},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {45},
   Number = {3},
   Pages = {852-856},
   Year = {2001} }



@article{
2738,
   Author = {Sadler, B. M. and Hanson, C. D. and Chittick, G. E. and Symonds, W. T. and Roskell, N. S.},
   Title = {Safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus (HIV) type 1 protease inhibitor, following oral administration of single doses to HIV-infected adults},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {43},
   Number = {7},
   Pages = {1686-1692},
   Year = {1999} }



@article{
2737,
   Author = {Pasternak, G. W.},
   Title = {Pharmacological mechanisms of opioid analgesics},
   Journal = {Clin.Neuropharmacol.},
   Volume = {16},
   Number = {1},
   Pages = {1-18},
   Year = {1993} }



@article{
2736,
   Author = {Sarhill, N. and Walsh, D. and Nelson, K. A.},
   Title = {Hydromorphone: pharmacology and clinical applications in cancer patients},
   Journal = {Support.Care Cancer},
   Volume = {9},
   Number = {2},
   Pages = {84-96},
   Year = {2001} }



@article{
2735,
   Author = {Bruera, E. and Sloan, P. and Mount, B. and Scott, J. and Suarez-Almazor, M.},
   Title = {A randomized, double-blind, double-dummy, crossover trial comparing the safety and efficacy of oral sustained-release hydromorphone with immediate-release hydromorphone in patients with cancer pain. Canadian Palliative Care Clinical Trials Group},
   Journal = {J Clin.Oncol.},
   Volume = {14},
   Number = {5},
   Pages = {1713-1717},
   Year = {1996} }



@book{
2734,
   Title = {LEXIVA (fosamprenavir calcium) Tablets package insert. NDA 21-548/S-008},
   Publisher = {GlaxoSmithKline},
   Address = {Research Triangle Park, NC 27709},
   Year = {2006} }



@article{
2733,
   Author = {Magni, P. and Bellazzi, R.},
   Title = {A stochastic model to assess the variability of blood glucose time series in diabetic patients self-monitoring},
   Journal = {IEEE Trans.Biomed.Eng},
   Volume = {53},
   Number = {6},
   Pages = {977-985},
   Year = {2006} }



@article{
2732,
   Author = {Claret, L. and Cox, E. H. and McFadyen, L. and Pidgen, A. and Johnson, P. J. and Haughie, S. and Boolell, M. and Bruno, R.},
   Title = {Modeling and simulation of sexual activity daily diary data of patients with female sexual arousal disorder treated with sildenafil citrate (Viagra(R))},
   Journal = {Pharmaceutical Research},
   Volume = {Online First},
   Year = {2006} }



@article{
2731,
   Author = {Cortinez, L. I. and Munoz, H. R. and Lopez, R.},
   Title = {[Pharmacodynamics of propofol in children and adults: comparison based on the auditory evoked potentials index]},
   Journal = {Rev.Esp.Anestesiol.Reanim.},
   Volume = {53},
   Number = {5},
   Pages = {289-296},
   Year = {2006} }



@article{
2730,
   Author = {El-Tahtawy, A. and Gastonguay, M. R.},
   Title = {Development and evaluation of a population pharmacokinetic model for hydromorphone following different routes of administration},
   Journal = {Journal of Clinical Pharmacology},
   Year = {2006} }



@article{
2728,
   Author = {Vashi, V. and Harris, S. and El-Tahtawy, A. and Wu, D. and Cipriano, A.},
   Title = {Clinical pharmacology and pharmacokinetics of once-daily hydromorphone hydrochloride extended-release capsules},
   Journal = {J Clin.Pharmacol.},
   Volume = {45},
   Number = {5},
   Pages = {547-554},
   Year = {2005} }



@article{
2727,
   Author = {Fung, H. B. and Kirschenbaum, H. L. and Hameed, R.},
   Title = {Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor},
   Journal = {Clinical Therapeutics},
   Volume = {22},
   Number = {5},
   Pages = {549-572},
   Year = {2000} }



@article{
2726,
   Author = {Pedneault, L. and Brothers, C. and Pagano, G. and Tymkewycz, P. and Yeo, J. and Millard, J. and Fetter, A.},
   Title = {Safety profile and tolerability of amprenavir in the treatment of adult and pediatric patients with HIV infection},
   Journal = {Clinical Therapeutics},
   Volume = {22},
   Number = {12},
   Pages = {1378-1394},
   Year = {2000} }



@article{
2725,
   Author = {Yogev, R. and Kovacs, A. and Chadwick, E. G. and Homans, J. D. and Lou, Y. and Symonds, W. T.},
   Title = {Single-dose safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, in HIV-infected children},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {1},
   Pages = {336-341},
   Year = {2005} }



@article{
2724,
   Author = {Sadler, B. M. and Stein, D. S.},
   Title = {Clinical pharmacology and pharmacokinetics of amprenavir},
   Journal = {The Annals of Pharmacotherapy},
   Volume = {36},
   Number = {1},
   Pages = {102-118},
   Year = {2002} }



@article{
2723,
   Author = {Miller, S. L.},
   Title = {Amprenavir approved for HIV treatment},
   Journal = {Am.J Health Syst.Pharm.},
   Volume = {56},
   Number = {11},
   Pages = {1057-1058},
   Year = {1999} }



@article{
2722,
   Author = {Paccaly, A. and Frick, A. and Rohatagi, S. and Liu, J. and Shukla, U. and Rosenburg, R. and Hinder, M. and Jensen, B. K.},
   Title = {Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for phase 2/3 simulation of exposure},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {1},
   Pages = {37-44},
   Year = {2006} }



@article{
2721,
   Author = {Buerger, C. and Plock, N. and Dehghanyar, P. and Joukhadar, C. and Kloft, C.},
   Title = {Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {7},
   Pages = {2455-2463},
   Year = {2006} }



@article{
2720,
   Author = {Gueorguieva, I. and Aarons, L. and Rowland, M.},
   Title = {Diazepam Pharamacokinetics from Preclinical to Phase I Using a Bayesian Population Physiologically Based Pharmacokinetic Model with Informative Prior Distributions in Winbugs},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {5},
   Pages = {571-594},
   Year = {2006} }



@article{
2719,
   Author = {Troconiz, I. F. and Wolters, J. M. and Tillmann, C. and Schaefer, H. G. and Roth, W.},
   Title = {Modelling the anti-migraine effects of BIBN 4096 BS : A new calcitonin gene-related peptide receptor antagonist},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {7},
   Pages = {715-728},
   Year = {2006} }



@article{
2718,
   Author = {Hsu, C. H. and Taylor, J. M. and Murray, S. and Commenges, D.},
   Title = {Multiple imputation for interval censored data with auxiliary variables},
   Journal = {Stat Med.},
   Year = {2006} }



@article{
2717,
   Author = {Yang, F. and Tong, X. and McCarver, D. G. and Hines, R. N. and Beard, D. A.},
   Title = {Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {33},
   Number = {4},
   Pages = {485-518},
   Year = {2006} }



@article{
2716,
   Author = {Kuti, J. L. and Ong, C. and Lo, M. and Melnick, D. and Soto, N. and Nicolau, D. P.},
   Title = {Comparison of probability of target attainment calculated by Monte Carlo simulation with meropenem clinical and microbiological response for the treatment of complicated skin and skin structure infections},
   Journal = {Int.J Antimicrob.Agents},
   Volume = {28},
   Number = {1},
   Pages = {62-68},
   Year = {2006} }



@article{
2715,
   Author = {Bostrom, E. and Simonsson, U. and Hammarlund-Udenaes, M.},
   Title = {In vivo blood-brain barrier transport of oxycodone in the rat - indications for active influx and implications for PK/PD},
   Journal = {Drug Metab Dispos.},
   Year = {2006} }



@article{
2714,
   Author = {Dailly, E. and Tribut, O. and Tattevin, P. and Arvieux, C. and Perre, P. and Raffi, F. and Jolliet, P.},
   Title = {Influence of tenofovir, nevirapine and efavirenz on ritonavir-boosted atazanavir pharmacokinetics in HIV-infected patients},
   Journal = {Eur.J Clin.Pharmacol.},
   Year = {2006} }



@article{
2713,
   Author = {Nie, L. and Chu, H. and Cole, S. R.},
   Title = {A general approach for sample size and statistical power calculations assessing the effects of interventions using a mixture model in the presence of detection limits},
   Journal = {Contemp.Clin.Trials},
   Volume = {in press},
   Year = {2006} }



@article{
2712,
   Author = {van, Kesteren C. and Benders, M. J. and Groenendaal, F. and van, Bel F. and Ververs, F. F. and Rademaker, C. M.},
   Title = {Population pharmacokinetics of allopurinol in full-term neonates with perinatal asphyxia},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {3},
   Pages = {339-344},
   Year = {2006} }



@article{
2711,
   Author = {Pullen, J. and de, Rozario L. and Stolk, L. M. and Degraeuwe, P. L. and van Tiel, F. H. and Zimmermann, L. J.},
   Title = {Population pharmacokinetics and dosing of flucloxacillin in preterm and term neonates},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {3},
   Pages = {351-358},
   Year = {2006} }



@article{
2710,
   Author = {Auret, K. and Roger, Goucke C. and Ilett, K. F. and Page-Sharp, M. and Boyd, F. and Oh, T. E.},
   Title = {Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {3},
   Pages = {359-366},
   Year = {2006} }



@article{
2709,
   Author = {Lotrich, F. E. and Bies, R. R. and Smith, G. S. and Pollock, B. G.},
   Title = {Relevance of assessing drug concentration exposure in pharmacogenetic and imaging studies},
   Journal = {J Psychopharmacol.},
   Volume = {20},
   Number = {4 Suppl},
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   Year = {2006} }



@article{
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   Title = {Population pharmacokinetic modelling of carbamazepine in epileptic elderly patients: implications for dosage},
   Journal = {J Clin.Pharm.Ther.},
   Volume = {31},
   Number = {3},
   Pages = {211-221},
   Year = {2006} }



@article{
2707,
   Author = {Bouvet, Y. and Bouissou, F. and Coulais, Y. and Seronie-Vivien, S. and Tafani, M. and Decramer, S. and Chatelut, E.},
   Title = {GFR is better estimated by considering both serum cystatin C and creatinine levels},
   Journal = {Pediatr.Nephrol.},
   Volume = {In press},
   Year = {2006} }



@book{
2706,
   Title = {OXYCONTINr (Oxycodone HCl Controlled-Release) Tablets package insert. OT00367 065570-0F-001},
   Publisher = {Purdue Pharma L.P.},
   Address = {Stamford, CT 06901-3431},
   Year = {2001} }



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   Title = {Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo},
   Journal = {Clinical Pharmacology and Therapeutics},
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   Year = {2005} }



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   Author = {Rodan, G. A.},
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2703,
   Author = {Costa, E.},
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   Pages = {321-350},
   Year = {1998} }



@article{
2702,
   Author = {Thummel, K. E. and Wilkinson, G. R.},
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   Volume = {38},
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   Year = {1998} }



@article{
2701,
   Author = {Thummel, K. E.},
   Title = {Does the CYP3A5*3 polymorphism affect in vivo drug elimination?},
   Journal = {Pharmacogenetics},
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   Year = {2003} }



@article{
2700,
   Author = {Amitai, Y. and Almog, S. and Singer, R. and Hammer, R. and Bentur, Y. and Danon, Y. L.},
   Title = {Atropine poisoning in children during the Persian Gulf crisis. A national survey in Israel},
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@article{
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   Journal = {Ann.Emerg.Med.},
   Volume = {40},
   Number = {4},
   Pages = {405-408},
   Year = {2002} }



@article{
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   Title = {Pediatric nerve agent poisoning: medical and operational considerations for emergency medical services in a large American city},
   Journal = {Pediatr.Emerg.Care},
   Volume = {22},
   Number = {4},
   Pages = {239-244},
   Year = {2006} }



@article{
2697,
   Author = {Treluyer, J. M. and Jacqz-Aigrain, E. and Alvarez, F. and Cresteil, T.},
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   Journal = {Eur.J Biochem.},
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   Number = {2},
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   Year = {1991} }



@article{
2696,
   Author = {Bell, B. R. and Bailer, A. J. and Wright, S. E.},
   Title = {A simulation study comparing different experimental designs for estimating uptake and elimination rates},
   Journal = {Environ.Toxicol.Chem.},
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   Number = {1},
   Pages = {248-252},
   Year = {2006} }



@article{
2695,
   Author = {Ng, C. M. and Lum, B. L. and Gimenez, V. and Kelsey, S. and Allison, D.},
   Title = {Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis},
   Journal = {Pharmaceutical Research},
   Year = {2006} }



@article{
2694,
   Author = {Donovan, J. M. and Elliott, M. R. and Heitjan, D. F.},
   Title = {Predicting event times in clinical trials when treatment arm is masked},
   Journal = {J Biopharm.Stat},
   Volume = {16},
   Number = {3},
   Pages = {343-356},
   Year = {2006} }



@article{
2693,
   Author = {Nugroho, A. K. and Romeijn, S. G. and Zwier, R. and de Vries, J. B. and Dijkstra, D. and Wikstrom, H. and la-Pasqua, O. and Danhof, M. and Bouwstra, J. A.},
   Title = {Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: In vitro-in vivo correlation},
   Journal = {J Pharm.Sci.},
   Volume = {95},
   Number = {7},
   Pages = {1570-1585},
   Year = {2006} }



@article{
2692,
   Author = {Yin, O. Q. and Lau, S. K. and Chow, M. S.},
   Title = {Population pharmacokinetics of cyclosporine in chinese cardiac transplant recipients},
   Journal = {Pharmacotherapy},
   Volume = {26},
   Number = {6},
   Pages = {790-797},
   Year = {2006} }



@article{
2691,
   Author = {Hirt, D. and Treluyer, J. M. and Jullien, V. and Firtion, G. and Chappuy, H. and Rey, E. and Pons, G. and Mandelbrot, L. and Urien, S.},
   Title = {Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {6},
   Pages = {2079-2086},
   Year = {2006} }



@article{
2690,
   Author = {Nakade, S. and Ueda, S. and Ohno, T. and Nakayama, K. and Miyata, Y. and Yukawa, E. and Higuchi, S.},
   Title = {Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma},
   Journal = {Drug Metab Pharmacokinet.},
   Volume = {21},
   Number = {2},
   Pages = {133-139},
   Year = {2006} }



@article{
2689,
   Author = {Knorr, B. and Maganti, L. and Ramakrishnan, R. and Tozzi, C. A. and Migoya, E. and Kearns, G.},
   Title = {Pharmacokinetics and safety of montelukast in children aged 3 to 6 months},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {6},
   Pages = {620-627},
   Year = {2006} }



@article{
2688,
   Author = {Amer, M. M.},
   Title = {Mathematical model of chloride concentration in human blood},
   Journal = {J Med.Eng Technol.},
   Volume = {30},
   Number = {1},
   Pages = {25-30},
   Year = {2006} }



@article{
2687,
   Author = {Gao, F. and Manatunga, A. K. and Chen, S.},
   Title = {Non-parametric estimation for baseline hazards function and covariate effects with time-dependent covariates},
   Journal = {Stat Med.},
   Year = {2006} }



@article{
2686,
   Author = {Wilkins, J. J. and Langdon, G. and McIlleron, H. and Pillai, G. C. and Smith, P. J. and Simonsson, U. S.},
   Title = {Variability in the population pharmacokinetics of pyrazinamide in South African tuberculosis patients},
   Journal = {Eur.J Clin.Pharmacol.},
   Year = {2006} }



@article{
2685,
   Author = {Paradisis, M. and Jiang, X. and McLachlan, A. J. and Evans, N. and Kluckow, M. and Osborn, D. A.},
   Title = {Population pharmacokinetics and dosing regimen design of milrinone in preterm infants},
   Journal = {Archives of Disease in Childhood.Fetal and Neonatal Edition},
   Volume = {91},
   Number = {3},
   Year = {2006} }



@article{
2684,
   Author = {Darpo, B. and Agin, M. and Kazierad, D. J. and Layton, G. and Muirhead, G. and Gray, P. and Jorkasky, D. K.},
   Title = {Man versus machine: is there an optimal method for QT measurements in thorough QT studies?},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {6},
   Pages = {598-612},
   Year = {2006} }



@article{
2683,
   Author = {Fromm, M. F. and Busse, D. and Kroemer, H. K. and Eichelbaum, M.},
   Title = {Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin},
   Journal = {Hepatology},
   Volume = {24},
   Number = {4},
   Pages = {796-801},
   Year = {1996} }



@article{
2682,
   Author = {Barrett, J. S. and Joshi, A. S. and Chai, M. and Ludden, T. M. and Fiske, W. D. and Pieniaszek, H. J., Jr.},
   Title = {Population pharmacokinetic meta-analysis with efavirenz},
   Journal = {Int.J Clin.Pharmacol.Ther.},
   Volume = {40},
   Number = {11},
   Pages = {507-519},
   Year = {2002} }



@article{
2681,
   Author = {Chiba, M. and Nshime, J. A. and Lin, J. H.},
   Title = {In vitro metabolism of indinavir in the human fetal liver microsomes},
   Journal = {Drug Metab Dispos.},
   Volume = {25},
   Number = {10},
   Pages = {1219-1222},
   Year = {1997} }



@article{
2680,
   Author = {Treluyer, J. M. and Bowers, G. and Cazali, N. and Sonnier, M. and Rey, E. and Pons, G. and Cresteil, T.},
   Title = {Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation},
   Journal = {Drug Metab Dispos.},
   Volume = {31},
   Number = {3},
   Pages = {275-281},
   Year = {2003} }



@article{
2679,
   Author = {Kanamori, M. and Takahashi, H. and Echizen, H.},
   Title = {Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {40},
   Number = {11},
   Pages = {485-492},
   Year = {2002} }



@article{
2678,
   Author = {Vyhlidal, C. A. and Gaedigk, R. and Leeder, J. S.},
   Title = {Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression},
   Journal = {Drug Metab Dispos.},
   Volume = {34},
   Number = {1},
   Pages = {131-137},
   Year = {2006} }



@article{
2677,
   Author = {Finkelstein, J. S. and Hayes, A. and Hunzelman, J. L. and Wyland, J. J. and Lee, H. and Neer, R. M.},
   Title = {The effects of parathyroid hormone, alendronate, or both in men with osteoporosis},
   Journal = {N.Engl.J Med.},
   Volume = {349},
   Number = {13},
   Pages = {1216-1226},
   Year = {2003} }



@article{
2676,
   Author = {McClung, M. R. and San, Martin J. and Miller, P. D. and Civitelli, R. and Bandeira, F. and Omizo, M. and Donley, D. W. and Dalsky, G. P. and Eriksen, E. F.},
   Title = {Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass},
   Journal = {Arch.Intern.Med.},
   Volume = {165},
   Number = {15},
   Pages = {1762-1768},
   Year = {2005} }



@article{
2675,
   Author = {Greenspan, S. L. and Parker, R. A. and Ferguson, L. and Rosen, H. N. and Maitland-Ramsey, L. and Karpf, D. B.},
   Title = {Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomized clinical trial},
   Journal = {J Bone Miner.Res.},
   Volume = {13},
   Number = {9},
   Pages = {1431-1438},
   Year = {1998} }



@article{
2674,
   Author = {Murphy, M. G. and Weiss, S. and McClung, M. and Schnitzer, T. and Cerchio, K. and Connor, J. and Krupa, D. and Gertz, B. J.},
   Title = {Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women},
   Journal = {J Clin.Endocrinol.Metab},
   Volume = {86},
   Number = {3},
   Pages = {1116-1125},
   Year = {2001} }



@article{
2673,
   Author = {Ettinger, B. and San, Martin J. and Crans, G. and Pavo, I.},
   Title = {Differential effects of teriparatide on BMD after treatment with raloxifene or alendronate},
   Journal = {J Bone Miner.Res.},
   Volume = {19},
   Number = {5},
   Pages = {745-751},
   Year = {2004} }



@article{
2672,
   Author = {Deal, C. and Omizo, M. and Schwartz, E. N. and Eriksen, E. F. and Cantor, P. and Wang, J. and Glass, E. V. and Myers, S. L. and Krege, J. H.},
   Title = {Combination teriparatide and raloxifene therapy for postmenopausal osteoporosis: results from a 6-month double-blind placebo-controlled trial},
   Journal = {J Bone Miner.Res.},
   Volume = {20},
   Number = {11},
   Pages = {1905-1911},
   Year = {2005} }



@article{
2671,
   Author = {von, Knoch F. and Jaquiery, C. and Kowalsky, M. and Schaeren, S. and Alabre, C. and Martin, I. and Rubash, H. E. and Shanbhag, A. S.},
   Title = {Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells},
   Journal = {Biomaterials},
   Volume = {26},
   Number = {34},
   Pages = {6941-6949},
   Year = {2005} }



@article{
2670,
   Author = {Im, G. I. and Qureshi, S. A. and Kenney, J. and Rubash, H. E. and Shanbhag, A. S.},
   Title = {Osteoblast proliferation and maturation by bisphosphonates},
   Journal = {Biomaterials},
   Volume = {25},
   Number = {18},
   Pages = {4105-4115},
   Year = {2004} }



@article{
2669,
   Author = {Rogers, M. J.},
   Title = {New insights into the molecular mechanisms of action of bisphosphonates},
   Journal = {Curr.Pharm.Des},
   Volume = {9},
   Number = {32},
   Pages = {2643-2658},
   Year = {2003} }



@article{
2668,
   Author = {Dobnig, H. and Hofbauer, L. C. and Viereck, V. and Obermayer-Pietsch, B. and Fahrleitner-Pammer, A.},
   Title = {Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients},
   Journal = {Osteoporos.Int.},
   Volume = {17},
   Number = {5},
   Pages = {693-703},
   Year = {2006} }



@article{
2667,
   Author = {Mandema, J. W. and Cox, E. and Alderman, J.},
   Title = {Therapeutic benefit of eletriptan compared to sumatriptan for the acute relief of migraine pain--results of a model-based meta-analysis that accounts for encapsulation},
   Journal = {Cephalalgia},
   Volume = {25},
   Number = {9},
   Pages = {715-725},
   Year = {2005} }



@article{
2666,
   Author = {Leow, K. P. and Smith, M. T. and Williams, B. and Cramond, T.},
   Title = {Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {52},
   Number = {5},
   Pages = {487-495},
   Year = {1992} }



@article{
2665,
   Author = {Poyhia, R. and Vainio, A. and Kalso, E.},
   Title = {A review of oxycodone's clinical pharmacokinetics and pharmacodynamics},
   Journal = {J.Pain Symptom.Manage.},
   Volume = {8},
   Number = {2},
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@article{
2664,
   Author = {Leow, K. P. and Cramond, T. and Smith, M. T.},
   Title = {Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain},
   Journal = {Anesthesia and Analgesia},
   Volume = {80},
   Number = {2},
   Pages = {296-302},
   Year = {1995} }



@article{
2663,
   Author = {Heiskanen, T. and Olkkola, K. T. and Kalso, E.},
   Title = {Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {6},
   Pages = {603-611},
   Year = {1998} }



@article{
2662,
   Author = {Davis, M. P. and Varga, J. and Dickerson, D. and Walsh, D. and LeGrand, S. B. and Lagman, R.},
   Title = {Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy},
   Journal = {Support.Care Cancer},
   Volume = {11},
   Number = {2},
   Pages = {84-92},
   Year = {2003} }



@article{
2661,
   Author = {Lalovic, B. and Kharasch, E. and Hoffer, C. and Risler, L. and Liu-Chen, L. Y. and Shen, D. D.},
   Title = {Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {79},
   Number = {5},
   Pages = {461-479},
   Year = {2006} }



@article{
2660,
   Author = {Lombardo, F. and Obach, R. S. and Dicapua, F. M. and Bakken, G. A. and Lu, J. and Potter, D. M. and Gao, F. and Miller, M. D. and Zhang, Y.},
   Title = {A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human},
   Journal = {J Med.Chem.},
   Volume = {49},
   Number = {7},
   Pages = {2262-2267},
   Year = {2006} }



@article{
2659,
   Author = {Wong, M. and Balleine, R. L. and Blair, E. Y. and McLachlan, A. J. and Ackland, S. P. and Garg, M. B. and Evans, S. and Farlow, D. and Collins, M. and Rivory, L. P. and Hoskins, J. M. and Mann, G. J. and Clarke, C. L. and Gurney, H.},
   Title = {Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer},
   Journal = {J Clin.Oncol.},
   Year = {2006} }



@article{
2658,
   Author = {Feng, Y. and Pollock, B. G. and Ferrell, R. E. and Kimak, M. A. and Reynolds, C. F., III and Bies, R. R.},
   Title = {Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {61},
   Number = {5},
   Pages = {558-569},
   Year = {2006} }



@article{
2657,
   Author = {O'Brien, C. A. and Jilka, R. L. and Fu, Q. and Stewart, S. and Weinstein, R. S. and Manolagas, S. C.},
   Title = {IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice},
   Journal = {Am.J Physiol Endocrinol.Metab},
   Volume = {289},
   Number = {5},
   Pages = {E784-E793},
   Year = {2005} }



@article{
2656,
   Author = {Huang, J. C. and Sakata, T. and Pfleger, L. L. and Bencsik, M. and Halloran, B. P. and Bikle, D. D. and Nissenson, R. A.},
   Title = {PTH differentially regulates expression of RANKL and OPG},
   Journal = {J Bone Miner.Res.},
   Volume = {19},
   Number = {2},
   Pages = {235-244},
   Year = {2004} }



@article{
2655,
   Author = {Simon, N. and Dussol, B. and Sampol, E. and Purgus, R. and Brunet, P. and Lacarelle, B. and Berland, Y. and Bruguerolle, B. and Urien, S.},
   Title = {Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialysed patients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {5},
   Pages = {493-501},
   Year = {2006} }



@article{
2654,
   Author = {Pullen, J. and Stolk, L. M. and Nieman, F. H. and Degraeuwe, P. L. and van Tiel, F. H. and Zimmermann, L. J.},
   Title = {Population Pharmacokinetics and Dosing of Amoxicillin in (Pre)term Neonates},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {2},
   Pages = {226-231},
   Year = {2006} }



@article{
2653,
   Author = {Rosario, M. C. and Poland, B. and Sullivan, J. and Westby, M. and van der, Ryst E.},
   Title = {A pharmacokinetic-pharmacodynamic model to optimize the phase IIa development program of maraviroc},
   Journal = {J Acquir.Immune.Defic.Syndr.},
   Year = {2006} }



@article{
2652,
   Author = {Lambert, R. J. and Lambert, R.},
   Title = {Population distributions of minimum inhibitory concentration - increasing accuracy and utility},
   Journal = {J Appl.Microbiol.},
   Volume = {100},
   Number = {5},
   Pages = {999-1010},
   Year = {2006} }



@article{
2651,
   Author = {Kho, Y. and Jansman, F. G. and Prins, N. H. and Neef, C. and Brouwers, J. R.},
   Title = {Population pharmacokinetics of oxaliplatin (85 mg/m 2 ) in combination with 5-fluorouracil in patients with advanced colorectal cancer},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {2},
   Pages = {206-211},
   Year = {2006} }



@article{
2650,
   Author = {Kastrissios, H. and Rohatagi, S. and Moberly, J. and Truitt, K. and Gao, Y. and Wada, R. and Takahashi, M. and Kawabata, K. and Salazar, D.},
   Title = {Development of a predictive pharmacokinetic model for a novel cyclooxygenase-2 inhibitor},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {5},
   Pages = {537-548},
   Year = {2006} }



@article{
2649,
   Author = {Fedorov, V. V. and Herzberg, A. M. and Leonov, S. L.},
   Title = {Methods of selecting informative variables},
   Journal = {Biom.J},
   Volume = {48},
   Number = {1},
   Pages = {157-173},
   Year = {2006} }



@article{
2648,
   Author = {Darpo, B. and Nebout, T. and Sager, P. T.},
   Title = {Clinical evaluation of QT/QTc prolongation and proarrhythmic potential for nonantiarrhythmic drugs: The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use E14 Guideline},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {5},
   Pages = {498-507},
   Year = {2006} }



@article{
2647,
   Author = {Olofsson, S. K. and Geli, P. and Andersson, D. I. and Cars, O.},
   Title = {Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {12},
   Pages = {5081-5091},
   Year = {2005} }



@article{
2646,
   Author = {Ambrose, P. G.},
   Title = {Monte Carlo simulation in the evaluation of susceptibility breakpoints: predicting the future: insights from the society of infectious diseases pharmacists},
   Journal = {Pharmacotherapy},
   Volume = {26},
   Number = {1},
   Pages = {129-134},
   Year = {2006} }



@article{
2645,
   Author = {Schiller, P. C. and D'Ippolito, G. and Roos, B. A. and Howard, G. A.},
   Title = {Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment},
   Journal = {J Bone Miner.Res.},
   Volume = {14},
   Number = {9},
   Pages = {1504-1512},
   Year = {1999} }



@article{
2644,
   Author = {Poole, K. E. and Reeve, J.},
   Title = {Parathyroid hormone - a bone anabolic and catabolic agent},
   Journal = {Curr.Opin.Pharmacol.},
   Volume = {5},
   Number = {6},
   Pages = {612-617},
   Year = {2005} }



@article{
2642,
   Author = {Gardner, J. C. and van Bezooijen, R. L. and Mervis, B. and Hamdy, N. A. and Lowik, C. W. and Hamersma, H. and Beighton, P. and Papapoulos, S. E.},
   Title = {Bone mineral density in sclerosteosis; affected individuals and gene carriers},
   Journal = {J Clin.Endocrinol.Metab},
   Volume = {90},
   Number = {12},
   Pages = {6392-6395},
   Year = {2005} }



@article{
2641,
   Author = {Bellido, T. and Ali, A. A. and Gubrij, I. and Plotkin, L. I. and Fu, Q. and O'Brien, C. A. and Manolagas, S. C. and Jilka, R. L.},
   Title = {Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis},
   Journal = {Endocrinology},
   Volume = {146},
   Number = {11},
   Pages = {4577-4583},
   Year = {2005} }



@article{
2640,
   Author = {Keller, H. and Kneissel, M.},
   Title = {SOST is a target gene for PTH in bone},
   Journal = {Bone},
   Volume = {37},
   Number = {2},
   Pages = {148-158},
   Year = {2005} }



@article{
2639,
   Author = {Berry, D. A.},
   Title = {Bayesian clinical trials},
   Journal = {Nat.Rev.Drug Discov.},
   Volume = {5},
   Number = {1},
   Pages = {27-36},
   Year = {2006} }



@article{
2638,
   Author = {Vanness, D. J. and Kim, W. R.},
   Title = {Bayesian estimation, simulation and uncertainty analysis: the cost-effectiveness of ganciclovir prophylaxis in liver transplantation},
   Journal = {Health Econ.},
   Volume = {11},
   Number = {6},
   Pages = {551-566},
   Year = {2002} }



@article{
2637,
   Author = {Miyata, M. and Yasuda, K. and Burioka, N. and Takane, H. and Suyama, H. and Shigeoka, Y. and Endo, M. and Kurai, J. and Morita, M. and Igishi, T. and Shimizu, E.},
   Title = {The influence of granisetron on the pharmacokinetics and pharmacodynamics of docetaxel in asian lung cancer patients},
   Journal = {Cancer J},
   Volume = {12},
   Number = {1},
   Pages = {69-72},
   Year = {2006} }



@article{
2636,
   Author = {Lee, C. K. and Rowinsky, E. K. and Li, J. and Giles, F. and Moore, M. J. and Hidalgo, M. and Capparelli, E. and Jolivet, J. and Baker, S. D.},
   Title = {Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue},
   Journal = {Clinical Cancer Research: an official journal of the American Association for Cancer Research},
   Volume = {12},
   Number = {7},
   Pages = {2158-2165},
   Year = {2006} }



@article{
2635,
   Author = {Joerger, M. and Huitema, A. D. and van den Bongard, D. H. and Schellens, J. H. and Beijnen, J. H.},
   Title = {Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors},
   Journal = {Clinical Cancer Research: an official journal of the American Association for Cancer Research},
   Volume = {12},
   Number = {7},
   Pages = {2150-2157},
   Year = {2006} }



@article{
2634,
   Author = {Rattanakul, C. and Lenbury, Y. and Krishnamara, N. and Wollkind, D. J.},
   Title = {Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy},
   Journal = {Biosystems},
   Volume = {70},
   Number = {1},
   Pages = {55-72},
   Year = {2003} }



@article{
2631,
   Author = {Potter, L. K. and Greller, L. D. and Cho, C. R. and Nuttall, M. E. and Stroup, G. B. and Suva, L. J. and Tobin, F. L.},
   Title = {Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kinetics},
   Journal = {Bone},
   Volume = {37},
   Number = {2},
   Pages = {159-169},
   Year = {2005} }



@article{
2630,
   Author = {Rook, E. J. and Huitema, A. D. and van den, Brink W. and van Ree, J. M. and Beijnen, J. H.},
   Title = {Population pharmacokinetics of heroin and its major metabolites},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {4},
   Pages = {401-417},
   Year = {2006} }



@article{
2629,
   Author = {Rauh, M. and Stachel, D. and Kuhlen, M. and Groschl, M. and Holter, W. and Rascher, W.},
   Title = {Quantification of busulfan in saliva and plasma in haematopoietic stem cell transplantation in children : validation of liquid chromatography tandem mass spectrometry method},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {3},
   Pages = {305-316},
   Year = {2006} }



@article{
2628,
   Author = {Perez-Ruixo, J. J. and Zannikos, P. and Ozdemir, V. and Franc, M. A. and Francke, S. and Piotrovsky, V.},
   Title = {Effect of CYP2D6 genetic polymorphism on the population pharmacokinetics of tipifarnib},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Year = {2006} }



@article{
2627,
   Author = {Peeters, M. Y. and Prins, S. A. and Knibbe, C. A. and DeJongh, J. and van Schaik, R. H. and van, Dijk M. and van, der Heiden I. and Tibboel, D. and Danhof, M.},
   Title = {Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery},
   Journal = {Anesthesiology},
   Volume = {104},
   Number = {3},
   Pages = {466-474},
   Year = {2006} }



@article{
2626,
   Author = {Pai, M. P. and Allen, S. E. and Amsden, G. W.},
   Title = {Altered steady state pharmacokinetics of levofloxacin in adult cystic fibrosis patients receiving calcium carbonate},
   Journal = {J Cyst.Fibros.},
   Year = {2006} }



@article{
2625,
   Author = {Marshall, S. and Macintyre, F. and James, I. and Krams, M. and Jonsson, N. E.},
   Title = {Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic protein},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {2},
   Pages = {177-197},
   Year = {2006} }



@article{
2624,
   Author = {Lesaffre, E. and Rizopoulos, D. and Tsonaka, R.},
   Title = {The logistic-transform for bounded outcome scores},
   Journal = {Biostatistics.},
   Year = {2006} }



@article{
2623,
   Author = {Hooker, A. and Vicini, P.},
   Title = {Simultaneous population optimal design for pharmacokinetic-pharmacodynamic experiments},
   Journal = {AAPS J},
   Volume = {7},
   Number = {4},
   Pages = {E759-E785},
   Year = {2005} }



@article{
2622,
   Author = {Hong, Y. and Shaw, P. J. and Nath, C. E. and Yadav, S. P. and Stephen, K. R. and Earl, J. W. and McLachlan, A. J.},
   Title = {Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {3},
   Pages = {935-942},
   Year = {2006} }



@article{
2621,
   Author = {Honda, M. and Ogura, Y. and Toyoda, W. and Taguchi, M. and Nozawa, T. and Inoue, H. and Hashimoto, Y.},
   Title = {Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {29},
   Number = {4},
   Pages = {772-778},
   Year = {2006} }



@article{
2620,
   Author = {Hirt, D. and Urien, S. and Jullien, V. and Firtion, G. and Rey, E. and Pons, G. and Blanche, S. and Treluyer, J. M.},
   Title = {Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with 182 children},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {3},
   Pages = {910-916},
   Year = {2006} }



@article{
2619,
   Author = {Hilsenbeck, S. G. and Osborne, C. K.},
   Title = {Is there a role for adjuvant tamoxifen in progesterone receptor-positive breast cancer? An in silico clinical trial},
   Journal = {Clinical Cancer Research: an official journal of the American Association for Cancer Research},
   Volume = {12},
   Number = {3 Pt 2},
   Pages = {1049s-1055s},
   Year = {2006} }



@article{
2618,
   Author = {Gw, B. and Dr, M. and Pa, T. and M, M.},
   Title = {Population pharmacokinetics and bioavailability of motexafin gadolinium (Xcytrin) in CD1 mice following intravenous and intraperitoneal injection},
   Journal = {Invest New Drugs},
   Year = {2006} }



@article{
2617,
   Author = {Fiaccadori, E. and Maggiore, U. and Rotelli, C. and Giacosa, R. and Parenti, E. and Picetti, E. and Manini, P. and Andreoli, R. and Cabassi, A.},
   Title = {Does haemodialysis significantly affect serum linezolid concentrations in critically ill patients with renal failure? A pilot investigation},
   Journal = {Nephrol.Dial.Transplant.},
   Year = {2006} }



@article{
2616,
   Author = {Dansirikul, C. and Staatz, C. E. and Duffull, S. B. and Taylor, P. J. and Lynch, S. V. and Tett, S. E.},
   Title = {Relationships of tacrolimus pharmacokinetic measures and adverse outcomes in stable adult liver transplant recipients},
   Journal = {J Clin.Pharm.Ther.},
   Volume = {31},
   Number = {1},
   Pages = {17-25},
   Year = {2006} }



@article{
2615,
   Author = {Calvo, R. and Lukas, J. C. and Rodriguez, M. and Leal, N. and Suarez, E.},
   Title = {The role of unbound drug in pharmacokinetics/pharmacodynamics and in therapy},
   Journal = {Curr.Pharm.Des},
   Volume = {12},
   Number = {8},
   Pages = {977-987},
   Year = {2006} }



@article{
2614,
   Author = {Bustad, A. and Terziivanov, D. and Leary, R. and Port, R. and Schumitzky, A. and Jelliffe, R.},
   Title = {Parametric and nonparametric population methods: their comparative performance in analysing a clinical dataset and two monte carlo simulation studies},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {4},
   Pages = {365-383},
   Year = {2006} }



@article{
2613,
   Author = {Bhavnani, S. M. and Passarell, J. A. and Owen, J. S. and Loutit, J. S. and Porter, S. B. and Ambrose, P. G.},
   Title = {Pharmacokinetic-pharmacodynamic relationships describing the efficacy of oritavancin in patients with Staphylococcus aureus bacteremia},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {3},
   Pages = {994-1000},
   Year = {2006} }



@article{
2612,
   Author = {Barthel, F. M. and Babiker, A. and Royston, P. and Parmar, M. K.},
   Title = {Evaluation of sample size and power for multi-arm survival trials allowing for non-uniform accrual, non-proportional hazards, loss to follow-up and cross-over},
   Journal = {Stat Med.},
   Year = {2006} }



@article{
2611,
   Title = {The Therapeutic Orphan--30 Years Later. Proceedings of a joint conference of the Pediatric Pharmacology Research Unit Network, the European Society of Developmental Pharmacology, and the National Institute of Child Health and Human Development. Washington DC, USA, May 2, 1997},
   Journal = {Pediatrics},
   Volume = {104},
   Number = {3 Pt 2},
   Pages = {581-645},
   Year = {1999} }



@article{
2610,
   Author = {Christensen, M. L. and Helms, R. A. and Chesney, R. W.},
   Title = {Is pediatric labeling really necessary?},
   Journal = {Pediatrics},
   Volume = {104},
   Number = {3 Pt 2},
   Pages = {593-597},
   Year = {1999} }



@article{
2609,
   Author = {Schechter, N. L.},
   Title = {The undertreatment of pain in children: an overview},
   Journal = {Pediatric Clinics of North America},
   Volume = {36},
   Number = {4},
   Pages = {781-794},
   Year = {1989} }



@article{
2608,
   Author = {Olkkola, K. T. and Hamunen, K. and Seppala, T. and Maunuksela, E. L.},
   Title = {Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {38},
   Number = {1},
   Pages = {71-76},
   Year = {1994} }



@article{
2607,
   Author = {Blumer, J. L.},
   Title = {Off-label uses of drugs in children},
   Journal = {Pediatrics},
   Volume = {104},
   Number = {3 Pt 2},
   Pages = {598-602},
   Year = {1999} }



@article{
2606,
   Author = {Bjornsson, T. D. and Callaghan, J. T. and Einolf, H. J. and Fischer, V. and Gan, L. and Grimm, S. and Kao, J. and King, S. P. and Miwa, G. and Ni, L. and Kumar, G. and McLeod, J. and Obach, R. S. and Roberts, S. and Roe, A. and Shah, A. and Snikeris, F. and Sullivan, J. T. and Tweedie, D. and Vega, J. M. and Walsh, J. and Wrighton, S. A.},
   Title = {The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective},
   Journal = {Drug Metab Dispos.},
   Volume = {31},
   Number = {7},
   Pages = {815-832},
   Year = {2003} }



@article{
2605,
   Author = {Kokki, H. and Rasanen, I. and Reinikainen, M. and Suhonen, P. and Vanamo, K. and Ojanpera, I.},
   Title = {Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children},
   Journal = {Clinical Pharmacokinetics},
   Volume = {43},
   Number = {9},
   Pages = {613-622},
   Year = {2004} }



@article{
2604,
   Author = {Benet, L. Z. and Cummins, C. L.},
   Title = {The drug efflux-metabolism alliance: biochemical aspects},
   Journal = {Adv.Drug Deliv.Rev.},
   Volume = {50 Suppl 1},
   Pages = {S3-11},
   Year = {2001} }



@article{
2603,
   Author = {Benet, L. Z. and Cummins, C. L. and Wu, C. Y.},
   Title = {Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data},
   Journal = {Curr.Drug Metab},
   Volume = {4},
   Number = {5},
   Pages = {393-398},
   Year = {2003} }



@article{
2602,
   Author = {Lau, Y. Y. and Wu, C. Y. and Okochi, H. and Benet, L. Z.},
   Title = {Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {308},
   Number = {3},
   Pages = {1040-1045},
   Year = {2004} }



@article{
2601,
   Author = {Benet, L. Z. and Cummins, C. L. and Wu, C. Y.},
   Title = {Unmasking the dynamic interplay between efflux transporters and metabolic enzymes},
   Journal = {Int.J.Pharm.},
   Volume = {277},
   Number = {1-2},
   Pages = {3-9},
   Year = {2004} }



@article{
2600,
   Author = {Benet, L. Z.},
   Title = {There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found},
   Journal = {Mol.Interv.},
   Volume = {5},
   Number = {2},
   Pages = {79-83},
   Year = {2005} }



@article{
2599,
   Author = {Sun, H. and Frassetto, L. and Benet, L. Z.},
   Title = {Effects of renal failure on drug transport and metabolism},
   Journal = {Pharmacology and Therapeutics},
   Volume = {109},
   Number = {1-2},
   Pages = {1-11},
   Year = {2006} }



@article{
2598,
   Author = {Lau, Y. Y. and Okochi, H. and Huang, Y. and Benet, L. Z.},
   Title = {Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {316},
   Number = {2},
   Pages = {762-771},
   Year = {2006} }



@article{
2597,
   Author = {Farrington, K. and Varghese, Z. and Newman, S. P. and Ahmed, K. Y. and Fernando, O. N. and Moorhead, J. F.},
   Title = {Dissociation of absorptions of calcium and phosphate after successful cadaveric renal transplantation},
   Journal = {Br Med.J},
   Volume = {1},
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   Year = {1979} }



@article{
2596,
   Author = {Farrington, K. and Mohammed, M. N. and Newman, S. P. and Varghese, Z. and Moorhead, J. F.},
   Title = {Comparison of radioisotope methods for the measurement of phosphate absorption in normal subjects and in patients with chronic renal failure},
   Journal = {Clin.Sci.(Lond)},
   Volume = {60},
   Number = {1},
   Pages = {55-63},
   Year = {1981} }



@article{
2595,
   Author = {Wiegmann, T. B. and Kaye, M.},
   Title = {Malabsorption of calcium and phosphate in chronic renal failure: 32P and 45Ca studies in dialysis patients},
   Journal = {Clin.Nephrol.},
   Volume = {34},
   Number = {1},
   Pages = {35-41},
   Year = {1990} }



@article{
2594,
   Author = {Lemaire, V. and Tobin, F. L. and Greller, L. D. and Cho, C. R. and Suva, L. J.},
   Title = {Modeling the interactions between osteoblast and osteoclast activities in bone remodeling},
   Journal = {J Theor.Biol.},
   Volume = {229},
   Number = {3},
   Pages = {293-309},
   Year = {2004} }



@article{
2593,
   Author = {Reddy, N. P. and Joshi, A. M.},
   Title = {A stochastic compartmental model of bone cells},
   Journal = {Int.J Biomed.Comput.},
   Volume = {21},
   Number = {3-4},
   Pages = {163-174},
   Year = {1987} }



@article{
2592,
   Author = {Lalovic, B. and Phillips, B. and Risler, L. L. and Howald, W. and Shen, D. D.},
   Title = {Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes},
   Journal = {Drug Metab Dispos.},
   Volume = {32},
   Number = {4},
   Pages = {447-454},
   Year = {2004} }



@article{
2591,
   Author = {Sharma, A. and Ebling, W. F. and Jusko, W. J.},
   Title = {Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena},
   Journal = {J Pharm.Sci.},
   Volume = {87},
   Number = {12},
   Pages = {1577-1584},
   Year = {1998} }



@article{
2590,
   Author = {Yao, Z. and Krzyzanski, W. and Jusko, W. J.},
   Title = {Assessment of basic indirect pharmacodynamic response models with physiological limits},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2589,
   Author = {Gueorguieva, I. and Aarons, L. and Ogungbenro, K. and Jorga, K. M. and Rodgers, T. and Rowland, M.},
   Title = {Optimal design for multivariate response pharmacokinetic models},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2588,
   Author = {Winter, W. D. and DeJongh, J. and Post, T. and Ploeger, B. and Urquhart, R. and Moules, I. and Eckland, D. and Danhof, M.},
   Title = {A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Year = {2006} }



@article{
2587,
   Author = {Maas, H. J. and Danhof, M. and la Pasqua, O. E.},
   Title = {Prediction of headache response in migraine treatment},
   Journal = {Cephalalgia},
   Volume = {26},
   Number = {4},
   Pages = {416-422},
   Year = {2006} }



@article{
2586,
   Author = {El-Tahtawy, A. and Kokki, H. and Reidenberg, B. E.},
   Title = {Population pharmacokinetics of oxycodone in children 6 months to 7 years old},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {4},
   Pages = {433-442},
   Year = {2006} }



@article{
2585,
   Author = {Goodisman, J. and Souid, A. K.},
   Title = {Constancy in integrated Cisplatin plasma concentrations among pediatric patients},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {4},
   Pages = {443-448},
   Year = {2006} }



@article{
2584,
   Author = {Whitehead, J. and Zhou, Y. and Stevens, J. and Blakey, G. and Price, J. and Leadbetter, J.},
   Title = {Bayesian decision procedures for dose-escalation based on evidence of undesirable events and therapeutic benefit},
   Journal = {Stat Med.},
   Volume = {25},
   Number = {1},
   Pages = {37-53},
   Year = {2006} }



@article{
2583,
   Author = {Palmer, C. R. and Rosenberger, W. F.},
   Title = {Ethics and practice: alternative designs for phase III randomized clinical trials},
   Journal = {Controlled Clinical Trials},
   Volume = {20},
   Number = {2},
   Pages = {172-186},
   Year = {1999} }



@article{
2582,
   Author = {Krams, M. and Lees, K. R. and Hacke, W. and Grieve, A. P. and Orgogozo, J. M. and Ford, G. A.},
   Title = {Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke},
   Journal = {Stroke},
   Volume = {34},
   Number = {11},
   Pages = {2543-2548},
   Year = {2003} }



@article{
2581,
   Author = {Atkinson, A. C. and Biswas, A.},
   Title = {Bayesian adaptive biased-coin designs for clinical trials with normal responses},
   Journal = {Biometrics},
   Volume = {61},
   Number = {1},
   Pages = {118-125},
   Year = {2005} }



@article{
2580,
   Author = {Chang, M. and Chow, S. C.},
   Title = {A hybrid Bayesian adaptive design for dose response trials},
   Journal = {J Biopharm.Stat},
   Volume = {15},
   Number = {4},
   Pages = {677-691},
   Year = {2005} }



@article{
2579,
   Author = {Grieve, A. P. and Krams, M.},
   Title = {ASTIN: a Bayesian adaptive dose-response trial in acute stroke},
   Journal = {Clin.Trials},
   Volume = {2},
   Number = {4},
   Pages = {340-351},
   Year = {2005} }



@article{
2578,
   Author = {Magnusson, M. O. and Karlsson, M. O. and Sandstrom, R.},
   Title = {A mechanism-based integrated pharmacokinetic enzyme model describing the time course and magnitude of phenobarbital-mediated enzyme induction in the rat},
   Journal = {Pharmaceutical Research},
   Volume = {23},
   Number = {3},
   Pages = {521-532},
   Year = {2006} }



@book{
2577,
   Author = {Gelman, A. and Carlin, J. B. and Stern, H. S. and Rubin, D. B.},
   Title = {Bayesian data analysis},
   Publisher = {Chapman & Hall/CRC},
   Address = {New York},
   Year = {2004} }



@article{
2576,
   Author = {Retout, S. and Duffull, S. and Mentre, F.},
   Title = {Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {65},
   Number = {2},
   Pages = {141-151},
   Year = {2001} }



@book{
2575,
   Author = {Law, A. M. and Kelton, W. D. and Kane, K. T. and Munson, E. M. and Lorkovic, M.},
   Title = {Simulation modeling and analysis},
   Publisher = {Thomas Casson},
   Year = {2000} }



@book{
2574,
   Author = {Kimko, H. and Duffull, S.},
   Title = {Simulation for designing clinical trials},
   Publisher = {Marcel Dekker},
   Address = {New York},
   Year = {2001} }



@article{
2573,
   Author = {Kimko, H. C. and Reele, S. S. and Holford, N. H. and Peck, C. C.},
   Title = {Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {68},
   Number = {5},
   Pages = {568-577},
   Year = {2000} }



@article{
2572,
   Author = {Mentre, F. and Mallet, A. and Baccar, D.},
   Title = {Optimal design in random-effects regression models},
   Journal = {Biometrika},
   Volume = {84},
   Number = {2},
   Pages = {429-442},
   Year = {1997} }



@article{
2571,
   Author = {Foracchia, M. and Hooker, A. and Vicini, P. and Ruggeri, A.},
   Title = {POPED, a software for optimal experiment design in population kinetics},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {74},
   Number = {1},
   Pages = {29-46},
   Year = {2004} }



@article{
2570,
   Author = {Tod, M. and Rocchisani, J. M.},
   Title = {Implementation of OSPOP, an algorithm for the estimation of optimal sampling times in pharmacokinetics by the ED, EID and API criteria},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {50},
   Number = {1},
   Pages = {13-22},
   Year = {1996} }



@article{
2569,
   Author = {Tod, M. and Rocchisani, J. M.},
   Title = {Comparison of ED, EID, and API criteria for the robust optimization of sampling times in pharmacokinetics},
   Journal = {J Pharmacokinet.Biopharm.},
   Volume = {25},
   Number = {4},
   Pages = {515-537},
   Year = {1997} }



@article{
2568,
   Author = {Duffull, S. B. and Retout, S. and Mentre, F.},
   Title = {The use of simulated annealing for finding optimal population designs},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {69},
   Number = {1},
   Pages = {25-35},
   Year = {2002} }



@article{
2567,
   Author = {Retout, S. and Mentre, F. and Bruno, R.},
   Title = {Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics},
   Journal = {Stat Med.},
   Volume = {21},
   Number = {18},
   Pages = {2623-2639},
   Year = {2002} }



@article{
2566,
   Author = {Chen, Y. Q. and Hu, C. and Wang, Y.},
   Title = {Attributable risk function in the proportional hazards model for censored time-to-event},
   Journal = {Biostatistics.},
   Year = {2006} }



@article{
2565,
   Author = {Gordi, T. and Xie, R. and Jusko, W. J.},
   Title = {Semi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of artemisinin},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {60},
   Number = {6},
   Pages = {594-604},
   Year = {2005} }



@article{
2564,
   Author = {Goodwin, J. T. and Clark, D. E.},
   Title = {In silico predictions of blood-brain barrier penetration: considerations to "keep in mind"},
   Journal = {J Pharmacol.Exp.Ther.},
   Volume = {315},
   Number = {2},
   Pages = {477-483},
   Year = {2005} }



@article{
2563,
   Author = {Mager, D. E. and Shirey, J. D. and Cox, D. and Fitzgerald, D. J. and Abernethy, D. R.},
   Title = {Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network},
   Journal = {J Pharm.Sci.},
   Volume = {94},
   Number = {11},
   Pages = {2475-2486},
   Year = {2005} }



@article{
2562,
   Author = {Krzyzanski, W. and Jusko, W. J. and Wacholtz, M. C. and Minton, N. and Cheung, W. K.},
   Title = {Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects},
   Journal = {Eur.J Pharm.Sci.},
   Volume = {26},
   Number = {3-4},
   Pages = {295-306},
   Year = {2005} }



@article{
2561,
   Author = {Rosario, M. C. and Jacqmin, P. and Dorr, P. and van der, Ryst E. and Hitchcock, C.},
   Title = {A pharmacokinetic-pharmacodynamic disease model to predict in vivo antiviral activity of maraviroc},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {78},
   Number = {5},
   Pages = {508-519},
   Year = {2005} }



@article{
2560,
   Author = {Andes, D. and Craig, W. A.},
   Title = {Treatment of infections with ESBL-producing organisms: pharmacokinetic and pharmacodynamic considerations},
   Journal = {Clin.Microbiol.Infect.},
   Volume = {11 Suppl 6},
   Pages = {10-17},
   Year = {2005} }



@article{
2559,
   Author = {Baars, J. H. and Kalisch, D. and Herold, K. F. and Hadzidiakos, D. A. and Rehberg, B.},
   Title = {Concentration-dependent suppression of F-waves by sevoflurane does not predict immobility to painful stimuli in humans},
   Journal = {Br J Anaesth.},
   Volume = {95},
   Number = {6},
   Pages = {789-797},
   Year = {2005} }



@article{
2558,
   Author = {Baars, J. H. and Tas, S. and Herold, K. F. and Hadzidiakos, D. A. and Rehberg, B.},
   Title = {The suppression of spinal F-waves by propofol does not predict immobility to painful stimuli in humans{dagger}},
   Journal = {Br J Anaesth.},
   Volume = {96},
   Number = {1},
   Pages = {118-126},
   Year = {2006} }



@article{
2557,
   Author = {McKay, I. D. and Voss, L. J. and Sleigh, J. W. and Barnard, J. P. and Johannsen, E. K.},
   Title = {Pharmacokinetic-pharmacodynamic modeling the hypnotic effect of sevoflurane using the spectral entropy of the electroencephalogram},
   Journal = {Anesthesia and Analgesia},
   Volume = {102},
   Number = {1},
   Pages = {91-97},
   Year = {2006} }



@article{
2556,
   Author = {Adams, J. C. and Dills, R. L. and Morgan, M. S. and Kalman, D. A. and Pierce, C. H.},
   Title = {A physiologically based toxicokinetic model of inhalation exposure to xylenes in Caucasian men},
   Journal = {Regulatory Toxicology and Pharmacology},
   Volume = {43},
   Number = {2},
   Pages = {203-214},
   Year = {2005} }



@article{
2555,
   Author = {Northam, R. S. and Hernandez, A. W. and Litzinger, M. J. and Minecan, D. N. and Glauser, T. A. and Mangat, S. and Zheng, C. and Souppart, C. and Sturm, Y.},
   Title = {Oxcarbazepine in infants and young children with partial seizures},
   Journal = {Pediatr.Neurol.},
   Volume = {33},
   Number = {5},
   Pages = {337-344},
   Year = {2005} }



@article{
2554,
   Author = {Don, B. R. and Spin, G. and Nestorov, I. and Hutmacher, M. and Rose, A. and Kaysen, G. A.},
   Title = {The pharmacokinetics of etanercept in patients with end-stage renal disease on haemodialysis},
   Journal = {J Pharm.Pharmacol.},
   Volume = {57},
   Number = {11},
   Pages = {1407-1413},
   Year = {2005} }



@article{
2553,
   Author = {Buckwalter, M. and Dowell, J. A.},
   Title = {Population pharmacokinetic analysis of dalbavancin, a novel lipoglycopeptide},
   Journal = {J Clin.Pharmacol.},
   Volume = {45},
   Number = {11},
   Pages = {1279-1287},
   Year = {2005} }



@article{
2552,
   Author = {Jefferson, J. W. and Pradko, J. F. and Muir, K. T.},
   Title = {Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations},
   Journal = {Clinical Therapeutics},
   Volume = {27},
   Number = {11},
   Pages = {1685-1695},
   Year = {2005} }



@article{
2551,
   Author = {van Rij, C. M. and Huitema, A. D. and Swart, E. L. and Greuter, H. N. and Lammertsma, A. A. and van Loenen, A. C. and Franssen, E. J.},
   Title = {Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {60},
   Number = {5},
   Pages = {477-485},
   Year = {2005} }



@article{
2550,
   Author = {Langdon, G. and Wilkins, J. and McFadyen, L. and McIlleron, H. and Smith, P. and Simonsson, U. S.},
   Title = {Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {11},
   Pages = {4429-4436},
   Year = {2005} }



@article{
2549,
   Author = {Sauermann, R. and Karch, R. and Langenberger, H. and Kettenbach, J. and Mayer-Helm, B. and Petsch, M. and Wagner, C. and Sautner, T. and Gattringer, R. and Karanikas, G. and Joukhadar, C.},
   Title = {Antibiotic abscess penetration: fosfomycin levels measured in pus and simulated concentration-time profiles},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {11},
   Pages = {4448-4454},
   Year = {2005} }



@article{
2548,
   Author = {Liefaard, L. C. and Ploeger, B. A. and Molthoff, C. F. and Boellaard, R. and Lammertsma, A. A. and Danhof, M. and Voskuyl, R. A.},
   Title = {Population Pharmacokinetic Analysis for Simultaneous Determination of B (max) and K (D) In Vivo by Positron Emission Tomography},
   Journal = {Mol.Imaging Biol.},
   Pages = {1-11},
   Year = {2005} }



@article{
2547,
   Author = {de Jonge, M. E. and Huitema, A. D. and van Dam, S. M. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {27},
   Number = {6},
   Pages = {756-765},
   Year = {2005} }



@article{
2546,
   Author = {Regazzi, M. B. and Iacona, I. and Avanzini, M. A. and Arcaini, L. and Merlini, G. and Perfetti, V. and Zaja, F. and Montagna, M. and Morra, E. and Lazzarino, M.},
   Title = {Pharmacokinetic behavior of rituximab: a study of different schedules of administration for heterogeneous clinical settings},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {27},
   Number = {6},
   Pages = {785-792},
   Year = {2005} }



@article{
2545,
   Author = {Urien, S. and Rezai, K. and Lokiec, F.},
   Title = {Pharmacokinetic modelling of 5-fu production from capecitabine-a population study in 40 adult patients with metastatic cancer},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {32},
   Number = {5-6},
   Pages = {817-833},
   Year = {2005} }



@article{
2544,
   Author = {Ahn, J. E. and Birnbaum, A. K. and Brundage, R. C.},
   Title = {Inherent correlation between dose and clearance in therapeutic drug monitoring settings: possible misinterpretation in population pharmacokinetic analyses},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Volume = {32},
   Number = {5-6},
   Pages = {703-718},
   Year = {2005} }



@article{
2543,
   Author = {Lukas, J. C. and Suarez, A. M. and Valverde, M. P. and Calvo, M. V. and Lanao, J. M. and Calvo, R. and Suarez, E. and Gil, A. D.},
   Title = {Time-dependent pharmacokinetics of cyclosporine (Neoral) in de novo renal transplant patients},
   Journal = {J Clin.Pharm.Ther.},
   Volume = {30},
   Number = {6},
   Pages = {549-557},
   Year = {2005} }



@article{
2542,
   Author = {Buelga, D. S. and del Mar Fernandez de, Gatta and Herrera, E. V. and Dominguez-Gil, A. and Garcia, M. J.},
   Title = {Population pharmacokinetic analysis of vancomycin in patients with hematological malignancies},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {12},
   Pages = {4934-4941},
   Year = {2005} }



@article{
2541,
   Author = {Wurthwein, G. and Groll, A. H. and Hempel, G. and dler-Shohet, F. C. and Lieberman, J. M. and Walsh, T. J.},
   Title = {Population pharmacokinetics of amphotericin B lipid complex in neonates},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {49},
   Number = {12},
   Pages = {5092-5098},
   Year = {2005} }



@article{
2540,
   Author = {Verstuyft, C. and Marcellin, F. and Morand-Joubert, L. and Launay, O. and Brendel, K. and Mentre, F. and Peytavin, G. and Gerard, L. and Becquemont, L. and Aboulker, J. P.},
   Title = {Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy},
   Journal = {AIDS},
   Volume = {19},
   Number = {18},
   Pages = {2127-2131},
   Year = {2005} }



@article{
2538,
   Author = {Allegaert, K. and Anderson, B. J. and Cossey, V. and Holford, N. H.},
   Title = {Limited predictability of amikacin clearance in extreme premature neonates at birth},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {61},
   Number = {1},
   Pages = {39-48},
   Year = {2006} }



@article{
2537,
   Author = {Shangguan, W. N. and Lian, Q. and Aarons, L. and Matthews, I. and Wang, Z. and Chen, X. and Freemantle, N. and Smith, F. G.},
   Title = {Pharmacokinetics of a Single Bolus of Propofol in Chinese Children of Different Ages},
   Journal = {Anesthesiology},
   Volume = {104},
   Number = {1},
   Pages = {27-32},
   Year = {2006} }



@article{
2536,
   Author = {Hoekstra, M. and Haagsma, C. and Neef, C. and Proost, J. and Knuif, A. and van de, Laar M.},
   Title = {Splitting High-Dose Oral Methotrexate Improves Bioavailability: A Pharmacokinetic Study in Patients with Rheumatoid Arthritis},
   Journal = {J Rheumatol.},
   Year = {2006} }



@article{
2535,
   Author = {Marino, D. J. and Clewell, H. J. and Gentry, P. R. and Covington, T. R. and Hack, C. E. and David, R. M. and Morgott, D. A.},
   Title = {Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose-response modeling in mice},
   Journal = {Regulatory Toxicology and Pharmacology},
   Year = {2006} }



@article{
2534,
   Author = {Stocker, H. and Kloft, C. and Plock, N. and Breske, A. and Kruse, G. and Herzmann, C. and Schulbin, H. and Kreckel, P. and Weber, C. and Goebel, F. and Roeling, J. and Staszewski, S. and Plettenberg, A. and Moecklinghoff, C. and Arasteh, K. and Kurowski, M.},
   Title = {Pharmacokinetics of enfuvirtide in patients treated in typical routine clinical settings},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {50},
   Number = {2},
   Pages = {667-673},
   Year = {2006} }



@article{
2533,
   Author = {Kuhle, S. and Massicotte, P. and Dinyari, M. and Vegh, P. and Mitchell, D. and Marzinotto, V. and Chan, A. and Pieniaszek, H. and Mitchell, L. G.},
   Title = {Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events},
   Journal = {Thromb.Haemost.},
   Volume = {94},
   Number = {6},
   Pages = {1164-1171},
   Year = {2005} }



@article{
2532,
   Author = {Ohnishi, A. and Yano, Y. and Ishibashi, T. and Katsube, T. and Oguma, T.},
   Title = {Evaluation of Bayesian predictability of vancomycin concentration using population pharmacokinetic parameters in pediatric patients},
   Journal = {Drug Metab Pharmacokinet.},
   Volume = {20},
   Number = {6},
   Pages = {415-422},
   Year = {2005} }



@article{
2531,
   Author = {Ogawa, R. and Kishi, R. and Mihara, K. and Takahashi, H. and Takagi, A. and Matsumoto, N. and Masuhara, K. and Nakazawa, K. and Miyake, F. and Kobayashi, S. and Echizen, H.},
   Title = {Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic, Pilsicainide, in Patients With Cardiac Arrhythmias},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {1},
   Pages = {59-68},
   Year = {2006} }



@article{
2530,
   Author = {Du, X. and Li, C. and Kuti, J. L. and Nightingale, C. H. and Nicolau, D. P.},
   Title = {Population pharmacokinetics and pharmacodynamics of meropenem in pediatric patients},
   Journal = {J Clin.Pharmacol.},
   Volume = {46},
   Number = {1},
   Pages = {69-75},
   Year = {2006} }



@article{
2529,
   Author = {Bjorkman, S.},
   Title = {Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods?},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {1},
   Pages = {1-11},
   Year = {2006} }



@article{
2528,
   Author = {Sam, W. J. and Tham, L. S. and Holmes, M. J. and Aw, M. and Quak, S. H. and Lee, K. H. and Lim, S. G. and Prabhakaran, K. and Chan, S. Y. and Ho, P. C.},
   Title = {Population pharmacokinetics of tacrolimus in whole blood and plasma in asian liver transplant patients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {45},
   Number = {1},
   Pages = {59-75},
   Year = {2006} }



@article{
2527,
   Author = {Lai, T. L. and Shih, M. C. and Wong, S. P.},
   Title = {A New Approach to Modeling Covariate Effects and Individualization in Population Pharmacokinetics-Pharmacodynamics},
   Journal = {J Pharmacokinet.Pharmacodyn.},
   Pages = {1-26},
   Year = {2006} }



@article{
2526,
   Author = {Lodise, T. P., Jr. and Rhoney, D. H. and Tam, V. H. and McKinnon, P. S. and Drusano, G. L.},
   Title = {Pharmacodynamic profiling of cefepime in plasma and cerebrospinal fluid of hospitalized patients with external ventriculostomies},
   Journal = {Diagn.Microbiol.Infect.Dis.},
   Year = {2006} }



@article{
2525,
   Author = {Charles, B. and Norris, R. and Xiao, X. and Hague, W.},
   Title = {Population Pharmacokinetics of Metformin in Late Pregnancy},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {28},
   Number = {1},
   Pages = {67-72},
   Year = {2006} }



@article{
2524,
   Author = {Staatz, C. E. and Byrne, C. and Thomson, A. H.},
   Title = {Population pharmacokinetic modelling of gentamicin and vancomycin in patients with unstable renal function following cardiothoracic surgery},
   Journal = {Br J Clin.Pharmacol.},
   Volume = {61},
   Number = {2},
   Pages = {164-176},
   Year = {2006} }



@article{
2523,
   Author = {Takama, H. and Tanaka, H. and Nakashima, D. and Ueda, R. and Takaue, Y.},
   Title = {Population pharmacokinetics of intravenous busulfan in patients undergoing hematopoietic stem cell transplantation},
   Journal = {Bone Marrow Transplantation},
   Volume = {37},
   Number = {4},
   Pages = {345-351},
   Year = {2006} }



@article{
2522,
   Author = {Nong, A. and McCarver, D. G. and Hines, R. N. and Krishnan, K.},
   Title = {Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene},
   Journal = {Toxicology and Applied Pharmacology},
   Year = {2006} }



@article{
2521,
   Author = {Stewart, C. F. and Iacono, L. C. and Panetta, J. C. and Gajjar, A. and Freeman Iii, B. B.},
   Title = {Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma},
   Journal = {Neuro.-oncol.},
   Year = {2006} }



@article{
2520,
   Author = {Sandstrom, M. and Lindman, H. and Nygren, P. and Johansson, M. and Bergh, J. and Karlsson, M. O.},
   Title = {Population analysis of the pharmacokinetics and the haematological toxicity of the fluorouracil-epirubicin-cyclophosphamide regimen in breast cancer patients},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Pages = {1-14},
   Year = {2006} }



@article{
2519,
   Author = {Latz, J. E. and Rusthoven, J. J. and Karlsson, M. O. and Ghosh, A. and Johnson, R. D.},
   Title = {Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {57},
   Number = {4},
   Pages = {427-435},
   Year = {2006} }



@article{
2518,
   Author = {Latz, J. E. and Karlsson, M. O. and Rusthoven, J. J. and Ghosh, A. and Johnson, R. D.},
   Title = {A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {57},
   Number = {4},
   Pages = {412-426},
   Year = {2006} }



@article{
2517,
   Author = {Latz, J. E. and Chaudhary, A. and Ghosh, A. and Johnson, R. D.},
   Title = {Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {57},
   Number = {4},
   Pages = {401-411},
   Year = {2006} }



@article{
2516,
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@article{
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@incollection{
2373,
   Author = {Mould, D. R. and Kimko, H. and Duffull, S.},
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@article{
2372,
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@article{
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@article{
2370,
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@article{
2369,
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@article{
2368,
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@article{
2367,
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@article{
2366,
   Author = {Post, T. M. and Freijer, J. I. and DeJongh, J. and Danhof, M.},
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@article{
2365,
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@article{
2364,
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@article{
2363,
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@article{
2362,
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@article{
2361,
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@article{
2360,
   Author = {Huntjens, D. R. and Danhof, M. and la Pasqua, O. E.},
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@article{
2359,
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@article{
2358,
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@article{
2355,
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2354,
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@article{
2353,
   Author = {Greenblatt, D. J. and Gan, L. and Harmatz, J. S. and Shader, R. I.},
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@article{
2352,
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2351,
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2349,
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@article{
2348,
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@article{
2347,
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2346,
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@article{
2345,
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@article{
2344,
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@article{
2343,
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2342,
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2341,
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@article{
2339,
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   Title = {Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients},
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2338,
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@article{
2337,
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@misc{
2336,
   Author = {Fisher, Jeannine and Riggs, Matthew and Gardner, Mark},
   Title = {Population pharmacokinetic meta-analysis of lasofoxifene in postmenopausal women},
      Year = {2004} }



@article{
2335,
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2334,
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   Title = {Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo},
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@misc{
2332,
   Title = {Clinical Pharmacology Study Report D5130C05267. A single-blind, randomised, placebo-controlled Phase I study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple oral doses of AZD6140 in healthy male Japanese and Caucasian volunteers},
   Publisher = {AstraZeneca Pharmaceuticals LP},
      Year = {2005} }



@misc{
2331,
   Title = {Study D5130C00014. An open, non-randomized, parallel group study to assess the effects of age and gender on the pharmacokinetics, pharmacodynamics, safety and tolerability of a single oral dose (200 mg) of AZD6140 in healthy male and female volunteers},
   Publisher = {AstraZeneca Pharmaceuticals LP},
      Year = {} }



@misc{
2330,
   Title = {Clinical Study Report D5130C00008. A 28-day, randomised, double-blind, double-dummy, parallel group, dose finding study to investigate the pharmacodynamics and pharmacokinetics of AZD6140 plus acetyl salicylic acid (ASA) compared with Clopidogrel plus ASA in subjects with atherosclerosis},
   Publisher = {AstraZeneca Pharmaceuticals LP},
      Year = {2004} }



@misc{
2329,
   Title = {Clinical Pharmacology Study Report D5130C00019. An open-label, single-dose, randomised, two-treatment, two-way crossover study to assess the relative bioavailability of new formulation of AZD6140 immediate release (IR) tablets to the formulation of AZD6140 tablets used in previous studies},
   Publisher = {AstraZeneca Pharmaceuticals LP},
      Year = {2004} }



@misc{
2328,
   Title = {Study D51430C05239. A single-blind, placebo-controlled, parallel group, randomised study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamic properties of multiple ascending doses of AZD6140 compared to Clopidogrel in healthy volunteers},
   Publisher = {AstraZeneca Pharmaceuticals LP},
      Year = {} }



@misc{
2327,
   Title = {Cubist study report. A randomized, double-blind, placebo controlled multiple dose, safety, and pharmacokinetic study of ascending doses of daptomycin in healthy volunteers (DAP-ADT-04-02). July 2005},
      Year = {} }



@techreport{
2326,
   Author = {GloboMaxr, L. L. C.},
   Title = {Final report. Preliminary evaluation of possible Daptomycin exposure - CPK relationship for Cidecin r  (Daptomycin for injection). NDA 21-572},
   Institution = {Sponsor: Cubist Pharmaceuticals, Inc.},
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@article{
2325,
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@misc{
2324,
   Title = {CubicinT (Daptomycin for injection) package insert},
   Publisher = {Cubist Pharmaceuticals, Inc.},
      Year = {2003} }



@techreport{
2323,
   Author = {GloboMaxr, L. L. C.},
   Title = {A population pharmacokinetic analysis of Cidecinr (Daptomycin for injection): Final Report. NDA 21-572},
   Institution = {Sponsor: Cubist Pharmaceuticals, Inc.},
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@article{
2322,
   Author = {Jamali, F. and Kunz-Dober, C. M.},
   Title = {Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery},
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@article{
2321,
   Author = {Wang, D. and Miller, R. and Zheng, J. and Hu, C.},
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@article{
2320,
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@article{
2319,
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@article{
2318,
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   Journal = {Clinical Pharmacology and Therapeutics},
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2317,
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   Title = {The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials},
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@article{
2316,
   Author = {Meshinchi, S. and Woods, W. G. and Stirewalt, D. L. and Sweetser, D. A. and Buckley, J. D. and Tjoa, T. K. and Bernstein, I. D. and Radich, J. P.},
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2315,
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@article{
2314,
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2313,
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@article{
2312,
   Author = {Berry, D. A. and Eick, S. G.},
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@article{
2311,
   Author = {Weir, C. J. and Lees, K. R.},
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@article{
2310,
   Author = {Karrison, T. G. and Huo, D. and Chappell, R.},
   Title = {A group sequential, response-adaptive design for randomized clinical trials},
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   Year = {2003} }



@article{
2309,
   Author = {Morgan, C. C.},
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@article{
2308,
   Author = {Hall, D. B. and Meier, U. and Diener, H. C.},
   Title = {A group sequential adaptive treatment assignment design for proof of concept and dose selection in headache trials},
   Journal = {Contemp.Clin.Trials},
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@article{
2307,
   Author = {Giles, F. J. and Kantarjian, H. M. and Cortes, J. E. and Garcia-Manero, G. and Verstovsek, S. and Faderl, S. and Thomas, D. A. and Ferrajoli, A. and O'Brien, S. and Wathen, J. K. and Xiao, L. C. and Berry, D. A. and Estey, E. H.},
   Title = {Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxacitabine and idarubicin in untreated patients 50 years or older with adverse karyotype acute myeloid leukemia},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
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   Year = {2003} }



@article{
2306,
   Author = {Anthony, M. and Berg, M. J.},
   Title = {Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I},
   Journal = {J.Womens Health Gend.Based.Med.},
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   Year = {2002} }



@article{
2305,
   Author = {Anderson, G. D.},
   Title = {Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase},
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   Year = {2002} }



@article{
2304,
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2301,
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@article{
2300,
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@article{
2299,
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@article{
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@article{
2297,
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@misc{
2296,
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@book{
2295,
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@article{
2291,
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2290,
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@article{
2289,
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@article{
2288,
   Author = {Zhou, H. and Mayer, P. R. and Wajdula, J. and Fatenejad, S.},
   Title = {Unaltered etanercept pharmacokinetics with concurrent methotrexate in patients with rheumatoid arthritis},
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@article{
2287,
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   Title = {Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine},
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@article{
2286,
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   Title = {Population pharmacokinetics and pharmacodynamics of garenoxacin in patients with community-acquired respiratory tract infections},
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@article{
2285,
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@article{
2284,
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   Title = {Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration},
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@article{
2283,
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@article{
2282,
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2281,
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2279,
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2278,
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2276,
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2273,
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2271,
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@misc{
2258,
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2244,
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@article{
2242,
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@article{
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@article{
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@article{
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@article{
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@article{
2228,
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   Title = {Prediction of clinical responses in a simulated phase III trial of Crohn's patients administered the antisense phosphorothioate oligonucleotide ISIS 2302: comparison of proposed dosing regimens},
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@article{
2227,
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@article{
2226,
   Author = {Lodise, T. P., Jr. and Lomaestro, B. and Rodvold, K. A. and Danziger, L. H. and Drusano, G. L.},
   Title = {Pharmacodynamic profiling of piperacillin in the presence of tazobactam in patients through the use of population pharmacokinetic models and Monte Carlo simulation},
   Journal = {Antimicrobial Agents and Chemotherapy},
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@article{
2225,
   Author = {Doufas, A. G. and Bakhshandeh, M. and Bjorksten, A. R. and Shafer, S. L. and Sessler, D. I.},
   Title = {Induction Speed Is Not a Determinant of Propofol Pharmacodynamics},
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@article{
2224,
   Author = {Zingmark, P. H. and Edenius, C. and Karlsson, M. O.},
   Title = {Pharmacokinetic/pharmacodynamic models for the depletion of Vbeta5.2/5.3 T cells by the monoclonal antibody ATM-027 in patients with multiple sclerosis, as measured by FACS},
   Journal = {British Journal of Clinical Pharmacology},
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@article{
2223,
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   Title = {Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients},
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@article{
2222,
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   Title = {The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients},
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@article{
2221,
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@article{
2220,
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   Title = {Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships},
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@article{
2219,
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   Title = {Intravenous indometacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study},
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@article{
2218,
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@article{
2217,
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@article{
2216,
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@article{
2215,
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@article{
2214,
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   Title = {Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia},
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@article{
2213,
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   Title = {Population pharmacokinetics of ciprofloxacin in pediatric and adolescent patients with acute infections},
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@article{
2212,
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   Title = {Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors},
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@article{
2211,
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@article{
2210,
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@article{
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@article{
2208,
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@article{
2207,
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@article{
2206,
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@article{
2205,
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@article{
2204,
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2203,
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@article{
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2196,
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2182,
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@misc{
2181,
   Title = {Briefing document for meeting 5 June 00: Pharmacodynamic modeling of rosiglitazone (BRL 49653C) as monotherapy in Type 2 Diabetes Mellitus patients},
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2180,
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@article{
2172,
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@article{
2169,
   Author = {Rockwell, S. and Kelley, M.},
   Title = {RSR13, a synthetic allosteric modifier of hemoglobin, as an adjunct to radiotherapy: preliminary studies with EMT6 cells and tumors and normal tissues in mice},
   Journal = {Radiat.Oncol.Investig.},
   Volume = {6},
   Number = {5},
   Pages = {199-208},
   Year = {1998} }



@article{
2168,
   Author = {Pagel, P. S. and Hettrick, D. A. and Montgomery, M. W. and Kersten, J. R. and Warltier, D. C.},
   Title = {RSR13, a synthetic allosteric modifier of hemoglobin, enhances recovery of stunned myocardium in dogs},
   Journal = {Adv.Exp.Med.Biol.},
   Volume = {454},
   Pages = {527-531},
   Year = {1998} }



@article{
2167,
   Author = {Steffen, R. P.},
   Title = {Effect of RSR13 on temperature-dependent changes in hemoglobin oxygen affinity of human whole blood},
   Journal = {Adv.Exp.Med.Biol.},
   Volume = {454},
   Pages = {653-661},
   Year = {1998} }



@article{
2166,
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   Title = {RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice},
   Journal = {British Journal of Cancer},
   Volume = {79},
   Number = {5-6},
   Pages = {814-820},
   Year = {1999} }



@article{
2165,
   Author = {Sarraf-Yazdi, S. and Sheng, H. and Grocott, H. P. and Bart, R. D. and Pearlstein, R. D. and Steffen, R. P. and Warner, D. S.},
   Title = {Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat},
   Journal = {Brain Res.},
   Volume = {826},
   Number = {2},
   Pages = {172-180},
   Year = {1999} }



@article{
2164,
   Author = {Eichelbronner, O. and Sielenkamper, A. and D'Almeida, M. and Ellis, C. G. and Sibbald, W. J. and Chin-Yee, I. H.},
   Title = {Effects of FI(O(2)) on hemodynamic responses and O(2) transport during RSR13-induced reduction in P(50)},
   Journal = {American Journal of Physiology},
   Volume = {277},
   Number = {1 Pt 2},
   Pages = {H290-H298},
   Year = {1999} }



@article{
2163,
   Author = {Kleinberg, L. and Grossman, S. A. and Piantadosi, S. and Pearlman, J. and Engelhard, H. and Lesser, G. and Ruffer, J. and Gerber, M.},
   Title = {Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {17},
   Number = {8},
   Pages = {2593-2603},
   Year = {1999} }



@article{
2162,
   Author = {Kilgore, K. S. and Shwartz, C. F. and Gallagher, M. A. and Steffen, R. P. and Mosca, R. S. and Bolling, S. F.},
   Title = {RSR13, a synthetic allosteric modifier of hemoglobin, improves myocardial recovery following hypothermic cardiopulmonary bypass},
   Journal = {Circulation},
   Volume = {100},
   Number = {19 Suppl},
   Pages = {II351-II356},
   Year = {1999} }



@article{
2161,
   Author = {Mackensen, G. B. and Nellgard, B. and Sarraf-Yazdi, S. and Dexter, F. and Steffen, R. P. and Grocott, H. P. and Warner, D. S.},
   Title = {Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat},
   Journal = {Brain Res.},
   Volume = {853},
   Number = {1},
   Pages = {15-21},
   Year = {2000} }



@article{
2160,
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   Title = {A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics},
   Journal = {Int.J.Radiat.Oncol.Biol.Phys.},
   Volume = {49},
   Number = {4},
   Pages = {1133-1139},
   Year = {2001} }



@article{
2159,
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   Title = {Enhancement of tumor oxygenation and radiation response by the allosteric effector of hemoglobin, RSR13},
   Journal = {Radiat.Res.},
   Volume = {156},
   Number = {3},
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   Year = {2001} }



@article{
2158,
   Author = {Burke, T. J. and Malhotra, D. and Shapiro, J. I.},
   Title = {Effects of enhanced oxygen release from hemoglobin by RSR13 in an acute renal failure model},
   Journal = {Kidney Int.},
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   Number = {4},
   Pages = {1407-1414},
   Year = {2001} }



@article{
2157,
   Author = {Breidbach, A. and Catlin, D. H.},
   Title = {RSR13, a potential athletic performance enhancement agent: detection in urine by gas chromatography/mass spectrometry},
   Journal = {Rapid Commun.Mass Spectrom.},
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   Number = {24},
   Pages = {2379-2382},
   Year = {2001} }



@article{
2156,
   Author = {Shaw, E. and Scott, C. and Suh, J. and Kadish, S. and Stea, B. and Hackman, J. and Pearlman, A. and Murray, K. and Gaspar, L. and Mehta, M. and Curran, W. and Gerber, M.},
   Title = {RSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {21},
   Number = {12},
   Pages = {2364-2371},
   Year = {2003} }



@article{
2155,
   Author = {Kleinberg, L. and Grossman, S. A. and Carson, K. and Lesser, G. and O'Neill, A. and Pearlman, J. and Phillips, P. and Herman, T. and Gerber, M.},
   Title = {Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II new approaches to brain tumor therapy CNS consortium safety and efficacy study},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {20},
   Number = {14},
   Pages = {3149-3155},
   Year = {2002} }



@article{
2154,
   Author = {Kolman, A.},
   Title = {Efaproxiral (allos therapeutics)},
   Journal = {IDrugs.},
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   Number = {8},
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   Year = {2003} }



@article{
2153,
   Author = {Bayard, D. S. and Jelliffe, R. W.},
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   Year = {2004} }



@article{
2152,
   Author = {Wahlby, U. and Matolcsi, K. and Karlsson, M. O. and Jonsson, E. N.},
   Title = {Evaluation of type 1 error rates when modeling ordered categorical data in NONMEM},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
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   Year = {2004} }



@article{
2151,
   Author = {Bailey, J. M. and Levy, J. H. and Kikura, M. and Szlam, F. and Hug, C. C., Jr.},
   Title = {Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery},
   Journal = {Anesthesiology},
   Volume = {81},
   Number = {3},
   Pages = {616-622},
   Year = {1994} }



@article{
2150,
   Author = {Retout, S. and Mentre, F.},
   Title = {Optimization of individual and population designs using Splus},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {6},
   Pages = {417-443},
   Year = {2003} }



@article{
2149,
   Author = {Kowalski, K. G. and McFadyen, L. and Hutmacher, M. M. and Frame, B. and Miller, R.},
   Title = {A two-part mixture model for longitudinal adverse event severity data},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {5},
   Pages = {315-336},
   Year = {2003} }



@article{
2148,
   Author = {Bjorkman, S.},
   Title = {Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified models},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {4},
   Pages = {285-307},
   Year = {2003} }



@article{
2147,
   Author = {Xu, L. and Eiseman, J. L. and Egorin, M. J. and D'Argenio, D. Z.},
   Title = {Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {3},
   Pages = {185-219},
   Year = {2003} }



@article{
2146,
   Author = {Frame, B. and Miller, R. and Lalonde, R. L.},
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   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
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   Number = {3},
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   Year = {2003} }



@article{
2145,
   Author = {Green, B. and Duffull, S. B.},
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   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {2},
   Pages = {145-161},
   Year = {2003} }



@techreport{
2144,
   Author = {Boeckmann, A. J. and Beal, S. L. and Sheiner, L. B.},
   Title = {NONMEM Users Guide - Part III NONMEM Installation Guide},
   Year = {1998} }



@article{
2143,
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   Journal = {European Journal of Clinical Pharmacology},
   Volume = {59},
   Number = {10},
   Pages = {775-778},
   Year = {2003} }



@article{
2142,
   Author = {AbuTarif, M. A. and Taft, D. R.},
   Title = {Simulation of the pharmacokinetic profile of methazolamide in blood: effect of erythrocyte carbonic anhydrase binding on drug disposition},
   Journal = {Pharmaceutical Research},
   Volume = {19},
   Number = {4},
   Pages = {551-555},
   Year = {2002} }



@article{
2141,
   Author = {Zhang, L. and Beal, S. L. and Sheiner, L. B.},
   Title = {Simultaneous vs. sequential analysis for population PK/PD data II: Robustness of methods},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {30},
   Number = {6},
   Pages = {405-416},
   Year = {2003} }



@article{
2140,
   Author = {Zhang, L. and Beal, S. L. and Sheiner, L. B.},
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   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
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   Year = {2003} }



@article{
2139,
   Author = {Everson, P. J. and Morris, C. N.},
   Title = {Simulation From  Wishart   Distributions With Eigenvalue Constraints},
   Journal = {Journal of Computational and Graphical Statistics},
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   Number = {2},
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   Year = {2000} }



@article{
2138,
   Author = {Nolin, T. D. and Gastonguay, M. R. and Bies, R. R. and Matzke, G. R. and Frye, R. F.},
   Title = {Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {74},
   Number = {6},
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   Year = {2003} }



@article{
2137,
   Author = {Gillespie, W. R. and Sale, M. and Gastonguay, M. R.},
   Title = {Modeling uncertainty in clinical trial simulation: A Bayesian approach},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65  },
   Number = {2},
   Pages = {PIII-21},
   Year = {1999} }



@article{
2136,
   Author = {Bois, F. Y. and Woodruff, T. J. and Spear, R. C.},
   Title = {Comparison of three physiologically based pharmacokinetic models of benzene disposition},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {110},
   Number = {1},
   Pages = {79-88},
   Year = {1991} }



@article{
2135,
   Author = {Hinderling, P. H.},
   Title = {Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics},
   Journal = {Pharmacological Reviews},
   Volume = {49},
   Number = {3},
   Pages = {279-295},
   Year = {1997} }



@article{
2134,
   Author = {Krzyzanski, W. and Jusko, W. J.},
   Title = {Multiple-pool cell lifespan model of hematologic effects of anticancer agents},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {29},
   Number = {4},
   Pages = {311-337},
   Year = {2002} }



@article{
2133,
   Author = {Ball, R. and Schwartz, S. L.},
   Title = {Kinetic and dynamic models of diving gases in decompression sickness prevention},
   Journal = {Clinical Pharmacokinetics},
   Volume = {41},
   Number = {6},
   Pages = {389-402},
   Year = {2002} }



@article{
2132,
   Author = {Sheiner, L. B.},
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   Journal = {British Journal of Clinical Pharmacology},
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   Year = {2002} }



@article{
2131,
   Author = {Beddhu, S. and Samore, M. H. and Roberts, M. S. and Stoddard, G. J. and Pappas, L. M. and Cheung, A. K.},
   Title = {Creatinine production, nutrition, and glomerular filtration rate estimation},
   Journal = {J.Am.Soc.Nephrol.},
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   Number = {4},
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   Year = {2003} }



@article{
2130,
   Author = {Hopke, P. K. and Liu, C. and Rubin, D. B.},
   Title = {Multiple imputation for multivariate data with missing and below-threshold measurements: time-series concentrations of pollutants in the Arctic},
   Journal = {Biometrics},
   Volume = {57},
   Number = {1},
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   Year = {2001} }



@article{
2129,
   Author = {Brooks, S. P. and Gelman, A.},
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   Journal = {J.Comput.Graph.Stat.},
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@article{
2128,
   Author = {Eberly, L. E. and Carlin, B. P.},
   Title = {Identifiability and convergence issues for Markov chain Monte Carlo fitting of spatial models},
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   Number = {17-18},
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   Year = {2000} }



@article{
2127,
   Author = {Meyer, R. and Christensen, N.},
   Title = {Fast Bayesian reconstruction of chaotic dynamical systems via extended Kalman filtering},
   Journal = {Phys.Rev.E.Stat.Nonlin.Soft.Matter Phys.},
   Volume = {65},
   Number = {1 Pt 2},
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   Year = {2002} }



@article{
2126,
   Author = {Bonetta, L.},
   Title = {Pediatric study of medicines becomes mandatory},
   Journal = {Nat.Med.},
   Volume = {6},
   Number = {10},
   Pages = {1069},
   Year = {2000} }



@article{
2125,
   Author = {Dove, A.},
   Title = {FDA in a quandary over Pediatric Rule},
   Journal = {Nat.Med.},
   Volume = {8},
   Number = {6},
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   Year = {2002} }



@article{
2124,
   Author = {Somberg, J. C.},
   Title = {Pediatric drug development},
   Journal = {American Journal of Therapeutics},
   Volume = {10},
   Number = {1},
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   Year = {2003} }



@article{
2123,
   Author = {Hattis, D. and Ginsberg, G. and Sonawane, B. and Smolenski, S. and Russ, A. and Kozlak, M. and Goble, R.},
   Title = {Differences in pharmacokinetics between children and adults--II. Children's variability in drug elimination half-lives and in some parameters needed for physiologically-based pharmacokinetic modeling},
   Journal = {Risk Anal.},
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   Number = {1},
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   Year = {2003} }



@article{
2122,
   Author = {Bolch, W. E. and Huston, T. E. and Farfan, E. B. and Vernetson, W. G.},
   Title = {Influences of parameter uncertainties within the ICRP-66 respiratory tract model: particle clearance},
   Journal = {Health Physics},
   Volume = {84},
   Number = {4},
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   Year = {2003} }



@article{
2121,
   Author = {Farfan, E. B. and Huston, T. E. and Bolch, W. E. and Vernetson, W. G.},
   Title = {Influences of parameter uncertainties within the ICRP-66 respiratory tract model: regional tissue doses for 239PuO2 and 238UO2/238U3O8},
   Journal = {Health Physics},
   Volume = {84},
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   Year = {2003} }



@article{
2120,
   Author = {Aden, J. and Scott, B. R.},
   Title = {Modeling variability and uncertainty associated with inhaled weapons-grade PuO2},
   Journal = {Health Physics},
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   Number = {6},
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   Year = {2003} }



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2119,
   Author = {Cox, L. A., Jr.},
   Title = {Reassessing benzene risks using internal doses and Monte-Carlo uncertainty analysis},
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@article{
2118,
   Author = {Bois, F. Y.},
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   Pages = {275-282},
   Year = {2000} }



@article{
2117,
   Author = {Bois, F. Y.},
   Title = {Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics},
   Journal = {Environ.Health Perspect.},
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   Pages = {307-316},
   Year = {2000} }



@article{
2116,
   Author = {Jonsson, F. and Bois, F. and Johanson, G.},
   Title = {Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise},
   Journal = {Toxicol.Sci.},
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   Number = {2},
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   Year = {2001} }



@article{
2115,
   Author = {Jonsson, F. and Johanson, G.},
   Title = {Bayesian estimation of variability in adipose tissue blood flow in man by physiologically based pharmacokinetic modeling of inhalation exposure to toluene},
   Journal = {Toxicology},
   Volume = {157},
   Number = {3},
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   Year = {2001} }



@article{
2114,
   Author = {Smith, T. J. and Lin, Y. S. and Mezzetti, M. and Bois, F. Y. and Kelsey, K. and Ibrahim, J.},
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   Year = {2001} }



@article{
2113,
   Author = {Jonsson, F. and Johanson, G.},
   Title = {A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane},
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   Number = {2},
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   Year = {2001} }



@article{
2112,
   Author = {Jonsson, F. and Bois, F. Y. and Johanson, G.},
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   Year = {2001} }



@article{
2111,
   Author = {Jonsson, F. and Johanson, G.},
   Title = {Physiologically based modeling of the inhalation kinetics of styrene in humans using a bayesian population approach},
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   Number = {1},
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   Year = {2002} }



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2110,
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   Title = {Bayesian cost-effectiveness analysis. An example using the GUSTO trial},
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2109,
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   Title = {An elementary introduction to Bayesian computing using WinBUGS},
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@article{
2108,
   Author = {Raab, G. M. and Parpia, T.},
   Title = {Random effects models for HIV marker data: practical approaches with currently available software},
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2107,
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2106,
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2105,
   Author = {Tucker, G. T. and Rostami-Hodjegan, A. and Jackson, P. R.},
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2104,
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@article{
2103,
   Author = {van Leeuwen, P. and Bettermann, H.},
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@article{
2102,
   Author = {Wahlby, U. and Jonsson, E. N. and Karlsson, M. O.},
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   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
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@article{
2101,
   Author = {Tanaka, C. and Kawai, R. and Rowland, M.},
   Title = {Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats},
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@article{
2100,
   Author = {Chung, H. C. and Kim, S. H. and Lee, M. G. and Kim, S. G.},
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1966,
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1965,
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1964,
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1963,
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1962,
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1961,
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1960,
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1959,
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1958,
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1957,
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1956,
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1955,
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1954,
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1953,
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1952,
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1951,
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1950,
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1949,
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1948,
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1947,
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1946,
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1945,
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1944,
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1943,
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@techreport{
1942,
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@misc{
1941,
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@misc{
1940,
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1939,
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1938,
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@techreport{
1937,
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1935,
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1934,
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@techreport{
1933,
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1932,
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1931,
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1930,
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1928,
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1927,
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1914,
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1909,
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1908,
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1907,
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1906,
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1903,
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1900,
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1899,
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@article{
1898,
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@article{
1897,
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@article{
1896,
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@article{
1895,
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@article{
1894,
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@article{
1893,
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@article{
1892,
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   Title = {Population pharmacokinetics of caffeine in premature neonates},
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@article{
1891,
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@article{
1889,
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@article{
1888,
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@article{
1887,
   Author = {International Conference on, Harmonization},
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@techreport{
1886,
   Author = {Group, F. D. A. Ethics Working},
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   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
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@techreport{
1885,
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1884,
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   Title = {Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia},
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   Year = {2001} }



@article{
1882,
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   Title = {Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group},
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1870,
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1869,
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1868,
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1863,
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1860,
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@article{
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@book{
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   Journal = {Clinical Pharmacology and Therapeutics},
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@article{
1855,
   Author = {Kaiko, R. F.},
   Title = {Pharmacokinetics and pharmacodynamics of controlled-release opioids},
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@article{
1854,
   Author = {Gourlay, G. K. and Cherry, D. A. and Onley, M. M. and Tordoff, S. G. and Conn, D. A. and Hood, G. M. and Plummer, J. L.},
   Title = {Pharmacokinetics and pharmacodynamics of twenty-four-hourly Kapanol compared to twelve-hourly MS Contin in the treatment of severe cancer pain},
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@article{
1853,
   Author = {Eliot, L. and Loewen, G. and Butler, J. and Tembe, E. and Devane, J.},
   Title = {Steady-state pharmacokinetic comparison of Morphelan TM  ROER (Morphine Sulfate Rapid Onset Extended Release) once-a-day and morphine oral solution administered q4h around-the-clock in healthy volunteers. Abstract no. 205},
   Journal = {American Academy of Pain Medicine (AAPM)},
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1852,
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1851,
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1850,
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@techreport{
1849,
   Title = {Draft Guideline on statistical principles for clinical trials},
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@techreport{
1848,
   Author = {Stroud, J. R. and Muller, P. and Rosner, G. L.},
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@techreport{
1847,
   Title = {Interim guidance for documentation of  in vivo  bioequivalence of albuterol inhalation aerosols (metered dose inhalers) (Draft guidance - withdrawn)},
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@article{
1846,
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@article{
1845,
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@article{
1844,
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@article{
1843,
   Author = {Goldberger, A. L.},
   Title = {Fractal mechanisms in the electrophysiology of the heart},
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1842,
   Author = {Garfinkel, A. and Spano, M. L. and Ditto, W. L. and Weiss, J. N.},
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@article{
1841,
   Author = {Malik, M.},
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@article{
1840,
   Author = {El Dajani, R. and Miquel, M. and Rubel, P. and Maison-Blanche, P. and Fayn, J. and Forlini, M. C.},
   Title = {A neural network approach for predicting and modelling the dynamical behaviour of cardiac ventricular repolarisation},
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@article{
1839,
   Author = {Castellanos, A. and Moleiro, F. and Lopera, G. and Huikuri, H. and Interian, A., Jr. and Myerburg, R. J.},
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1838,
   Author = {Sosnowski, M. and Czyz, Z. and Tendera, M.},
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   Journal = {Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of},
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@article{
1837,
   Author = {Skinner, J. E. and Wolf, S. G. and Kresh, J. Y. and Izrailtyan, I. and Armour, J. A. and Huang, M. H.},
   Title = {Application of chaos theory to a model biological system: evidence of self-organization in the intrinsic cardiac nervous system},
   Journal = {Integrative Physiological and Behavioral Science : the official journal of the Pavlovian Society},
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@article{
1836,
   Author = {Meyer, M. and Marconi, C. and Ferretti, G. and Fiocchi, R. and Cerretelli, P. and Skinner, J. E.},
   Title = {Heart rate variability in the human transplanted heart: nonlinear dynamics and QT vs RR-QT alterations during exercise suggest a return of neurocardiac regulation in long-term recovery},
   Journal = {Integrative Physiological and Behavioral Science : the official journal of the Pavlovian Society},
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@article{
1835,
   Author = {Hnatkova, K. and Malik, M.},
   Title = {"Optimum" formulae for heart rate correction of the QT interval},
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@article{
1834,
   Author = {Baranowski, R. and Zebrowski, J. J.},
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@techreport{
1833,
   Title = {Guidance for Industry. Guideline for the clinical evaluation of analgesic drugs},
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@techreport{
1832,
   Title = {Reviewer Guidance. Conducting a clinical safety review of a new product application and preparing a report on the review. (Draft Guidance)},
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   Year = {1996} }



@techreport{
1831,
   Title = {Guidance for Industry. Food-Effect bioavailability and fed bioequivalence studies: Study design, data analysis, and labeling (Draft Guidance)},
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   Year = {2001} }



@techreport{
1830,
   Title = {Guidance for Industry. Average, population, and individual approaches to establishing bioequivalence (Draft Guidance)},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
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   Year = {1999} }



@techreport{
1829,
   Title = {Guidance for Industry. Waiver of  in vivo  bioavailability and bioequivalence studies for immediate-release solid oral dosage forms based on a biopharmaceutics classification system},
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   Year = {2002} }



@techreport{
1828,
   Title = {Guidance for Industry.  In vivo  drug metabolism/drug interaction studies -- Study design, data analysis, and recommendations for dosing and labeling},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research},
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   Year = {1999} }



@techreport{
1827,
   Title = {FDA's policy statement for the development of new stereoisomeric drugs},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
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   Year = {1992} }



@techreport{
1826,
   Title = {Guidance for Industry. E 10 Choice of control group and related issues in clinical trials},
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@techreport{
1825,
   Title = {Guidline for Industry. S3B Pharmacokinetics: Guidance for repeated dose tissue distribution studies},
   Institution = {International Conference on Harmonization},
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@article{
1824,
   Author = {International Conference on, Harmonization},
   Title = {Guidline for Industry. S3A Toxicokinetics: The assessment of systemic exposure in toxicity studies},
   Journal = {Federal Register},
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   Year = {1995} }



@techreport{
1823,
   Title = {Guidance for Industry. Guideline for the format and content of the nonclinical pharmacology/toxicology section of an application},
   Institution = {Food and Drug Administration, Center for Drugs and Biologics},
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   Year = {1987} }



@techreport{
1822,
   Title = {Guidance for Industry. Single dose acute toxicity testing for pharmaceuticals},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
   Month= {August},
   Year = {1996} }



@techreport{
1821,
   Title = {Guidance for Industry. Qualifying for pediatric exclusivity under Section 505A of the Federal Food, Drug, and Cosmetic Act (Procedural)},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research},
   Month= {September},
   Year = {1999} }



@techreport{
1820,
   Title = {Guidance for Industry. Population pharmacokinetics},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research},
   Month= {February},
   Year = {1999} }



@techreport{
1819,
   Title = {Guidance for Industry. M3 nonclinical safety studies for the conduct of human clinical trials for pharmaceuticals},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research},
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   Year = {1997} }



@techreport{
1818,
   Title = {Guidance for Industry. Drug metabolism/drug interaction studies in the drug development process: Studies  in vitro  },
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research},
   Month= {April},
   Year = {1997} }



@techreport{
1817,
   Author = {Senn, S. and Hale, M.},
   Title = {Moving forward: applying computer-assisted trial design to current practices in drug development. A round table discussion between biostatisticians},
   Institution = {Pharsight Corporation},
   Month= {August},
   Year = {1997} }



@techreport{
1816,
   Author = {Breiman, L.},
   Title = {Bagging Predictors},
   Institution = {Department of Statistics, University of California},
   Number = {421  },
   Type = {Technical Report},
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   Year = {1994} }



@techreport{
1815,
   Author = {Huang, M. and Chou, J. and Beaulieu, N.},
   Title = {Highly scalable, rule-based recommendations in real-time},
   Institution = {Modify Technologies, Inc.},
   Type = {White Paper},
   Month= {September},
   Year = {1999} }



@article{
1814,
   Author = {Schumitzky, A.},
   Title = {The nonparametric maximum likelihood approach to pharmacokinetic population analysis},
   Journal = {Proc.1993 Wester Simulation Multiconference - Simulation for Health Care},
   Year = {1993} }



@article{
1813,
   Author = {Gunter, B.},
   Title = {Bootstrapping: how to make something from almost nothing and get statistically valid answers. Part 4: Bias-corrected intervals},
   Journal = {Quality Progress},
   Pages = {79-83},
   Year = {1992} }



@article{
1812,
   Author = {Gunter, B.},
   Title = {Bootstrapping: how to make something from almost nothing and get statistically valid answers. Part 3: Examples and enhancements},
   Journal = {Quality Progress},
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   Year = {1992} }



@article{
1811,
   Author = {Gunter, B.},
   Title = {Bootstrapping: how to make something from almost nothing and get statistically valid answers. Part 2: The confidence game},
   Journal = {Quality Progress},
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 -86},
   Year = {1992} }



@article{
1810,
   Author = {Gunter, B.},
   Title = {Bootstrapping: how to make something from almost nothing and get statistically valid answers. Part 1: Brave new world},
   Journal = {Quality Progress},
   Pages = {97 
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   Year = {1991} }



@incollection{
1809,
   Author = {Kubota, K. and Maibach, H. I.},
   Title = {Finite dose  in vitro  percutaneous permeation based on the diffusion model: estimation of pharmacokinetic parameters and prediction of the pharmacokinetic profiles},
   BookTitle = { In Vitro  Percutaneous Absorption: Principles, Fundamentals, and Applications},
   Publisher = {CRC Press},
   Address = {Boca Raton},
   Pages = {243-264},
   Year = {1991} }



@article{
1808,
   Author = {Thompson, B.},
   Title = {The use of statistical significance tests in research: bootstrap and other alternatives},
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@article{
1807,
   Author = {Benet, L. Z.},
   Title = {Mathematical treatment of linear mammillary models using inverse Laplace transforms: a reply},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {68  },
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@article{
1806,
   Author = {Haborak, G. E. and Benmaman, J. D. and Warren, J. W., Jr.},
   Title = {Mathematical treatment of linear mammillary models using inverse Laplace transforms},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {68  },
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   Year = {1979} }



@incollection{
1805,
   Author = {Gibaldi, M. and Perrier, D.},
   Title = {Physiological pharmacokinetic models},
   BookTitle = {Pharmacokinetics},
   Series = {Drugs and the Pharmaceutical Sciences},
   Publisher = {Marcel Dekker, Inc.},
   Address = {New York},
   Volume = {2nd Rev. Ex. Ed.  },
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@article{
1804,
   Author = {Dixon, R. L.},
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   Journal = {Federation Proceedings},
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@article{
1803,
   Author = {Roughton, F. J. W. and Forster, R. E.},
   Title = {Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries},
   Journal = {Journal of Applied Physiology},
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   Number = {2},
   Pages = {290-302},
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@incollection{
1802,
   Author = {Chiou, W. L. and D'Argenio, D. Z.},
   Title = {The significance of marked "universal" dependence of drug concentration on blood sampling site in pharmacokinetics and pharmacodynamics},
   BookTitle = {Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis},
   Publisher = {Plenum Press},
   Address = {New York},
   Pages = {37 
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   Year = {1991} }



@article{
1801,
   Author = {Jacobs, J. R.},
   Title = {Analytical solution to the three-compartment pharmacokinetic model},
   Journal = {IEEE Transactions on Bio-medical Engineering},
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@article{
1800,
   Author = {Sargent, D. J.},
   Title = {A general framework for random effects survival analysis in the Cox proportional hazards setting},
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@article{
1799,
   Author = {Therneau, T. M. and Grambsch, P. M. and Fleming, T. R.},
   Title = {Martingale-based residuals for survival models},
   Journal = {Biometrika},
   Volume = {77  },
   Number = {1},
   Pages = {147-160},
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@incollection{
1798,
   Author = {Ross, S. M.},
   Title = {The Poisson Process},
   BookTitle = {Stochastic Processes},
   Publisher = {John Wiley & Sons},
   Address = {New York},
   Pages = {31-54},
   Year = {1982} }



@incollection{
1797,
   Author = {Ross, S. M.},
   Title = {Preliminaries},
   BookTitle = {Stochastic Processes},
   Publisher = {John Wiley & Sons},
   Address = {New York},
   Pages = {1-30},
   Year = {1982} }



@article{
1796,
   Author = {Koch, G. G. and Landis, J. R. and Freeman, J. L. and Freeman, D. H., Jr. and Lehnen, R. C.},
   Title = {A general methodology for the analysis of experiments with repeated measurement of categorical data},
   Journal = {Biometrics},
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@article{
1795,
   Author = {Louis, T. A.},
   Title = {General methods for analysing repeated measures},
   Journal = {Statistics in Medicine},
   Volume = {7},
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   Year = {1988} }



@article{
1794,
   Author = {Ten Have, T. R. and Kunselman, A. R. and Tran, L.},
   Title = {A comparison of mixed effects logistic regression models for binary response data with two nested levels of clustering},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {8},
   Pages = {947-960},
   Year = {1999} }



@article{
1793,
   Author = {Liu, C. Y. and Sambol, N. C.},
   Title = {Pharmacodynamic analysis of analgesic clinical trials: nonlinear mixed-effects logistic models},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {9},
   Number = {2},
   Pages = {253-270},
   Year = {1999} }



@article{
1792,
   Author = {Ware, J. H. and Lipsitz, S. and Speizer, F. E.},
   Title = {Issues in the analysis of repeated categorical outcomes},
   Journal = {Statistics in Medicine},
   Volume = {7},
   Number = {1-2},
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   Year = {1988} }



@article{
1791,
   Author = {Stukel, T. A.},
   Title = {Comparison of methods for the analysis of longitudinal interval count data},
   Journal = {Statistics in Medicine},
   Volume = {12},
   Number = {14},
   Pages = {1339-1351},
   Year = {1993} }



@article{
1790,
   Author = {Thall, P. F.},
   Title = {Mixed Poisson likelihood regression models for longitudinal interval count data},
   Journal = {Biometrics},
   Volume = {44},
   Number = {1},
   Pages = {197-209},
   Year = {1988} }



@article{
1789,
   Author = {Lawless, J. F.},
   Title = {Regression methods for Poisson process data},
   Journal = {Journal of the American Statistical Association},
   Volume = {82  },
   Number = {399},
   Pages = {808-815},
   Year = {1987} }



@article{
1788,
   Author = {Nelson, J. F.},
   Title = {Multivariate gamma-Poisson models},
   Journal = {Journal of the American Statistical Association},
   Volume = {80  },
   Number = {392},
   Pages = {828-834},
   Year = {1985} }



@article{
1787,
   Author = {Zeger, S. L. and Liang, K. Y.},
   Title = {Longitudinal data analysis for discrete and continuous outcomes},
   Journal = {Biometrics},
   Volume = {42},
   Number = {1},
   Pages = {121-130},
   Year = {1986} }



@article{
1786,
   Author = {Zeger, S. L. and Karim, M. R.},
   Title = {Generalized linear models with random effects; a Gibbs sampling approach},
   Journal = {Journal of the American Statistical Association},
   Volume = {86  },
   Number = {413},
   Pages = {79-86},
   Year = {1991} }



@article{
1785,
   Author = {Lalonde, R. L. and Ouellet, D. and Kimanani, E. K. and Potvin, D. and Vaughan, L. M. and Hill, M. R.},
   Title = {Comparison of different methods to evaluate population dose-response and relative potency: importance of interoccasion variability},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {67-83},
   Year = {1999} }



@article{
1784,
   Author = {Huitema, A. D. and Mathot, R. A. and Tibben, M. M. and Schellens, J. H. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {6},
   Pages = {621-630},
   Year = {2000} }



@article{
1783,
   Author = {Treluyer, J. M. and Merle, Y. and Semlali, A. and Pons, G.},
   Title = {Population pharmacokinetic analysis of netilmicin in neonates and infants with use of a nonparametric method},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {6},
   Pages = {600-609},
   Year = {2000} }



@article{
1782,
   Author = {Metzler, C. M.},
   Title = {Extended least squares (ELS) for pharmacokinetic models},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {76},
   Number = {7},
   Pages = {565-571},
   Year = {1987} }



@article{
1781,
   Author = {Davidian, M. and Gallant, A. R.},
   Title = {Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {5},
   Pages = {529-556},
   Year = {1992} }



@article{
1780,
   Author = {Brown, R. P. and Delp, M. D. and Lindstedt, S. L. and Rhomberg, L. R. and Beliles, R. P.},
   Title = {Physiological parameter values for physiologically based pharmacokinetic models},
   Journal = {Toxicology and Industrial Health},
   Volume = {13},
   Number = {4},
   Pages = {407-484},
   Year = {1997} }



@article{
1779,
   Author = {Naranjo, C. A. and Kwok, M. C. and Lanctot, K. L. and Zhao, H. P. and Spielberg, S. P. and Shear, N. H.},
   Title = {Enhanced differential diagnosis of anticonvulsant hypersensitivity reactions by an integrated Bayesian and biochemical approach},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {56},
   Number = {5},
   Pages = {564-575},
   Year = {1994} }



@article{
1778,
   Author = {Hussain, A. S. and Johnson, R. D. and Vachharajani, N. N. and Ritschel, W. A.},
   Title = {Feasibility of developing a neural network for prediction of human pharmacokinetic parameters from animal data},
   Journal = {Pharmaceutical Research},
   Volume = {10},
   Number = {3},
   Pages = {466-469},
   Year = {1993} }



@article{
1777,
   Author = {Maddalena, D. J. and Johnston, G. A.},
   Title = {Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks},
   Journal = {Journal of Medicinal Chemistry},
   Volume = {38},
   Number = {4},
   Pages = {715-724},
   Year = {1995} }



@article{
1776,
   Author = {Gobburu, J. V. and Shelver, W. H.},
   Title = {Quantitative structure-pharmacokinetic relationships (QSPR) of beta blockers derived using neural networks},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {84},
   Number = {7},
   Pages = {862-865},
   Year = {1995} }



@article{
1775,
   Author = {Ritschel, W. A. and Akileswaran, R. and Hussain, A. S.},
   Title = {Application of neural networks for the prediction of human pharmacokinetic parameters},
   Journal = {Methods and Findings in Experimental and Clinical Pharmacology},
   Volume = {17},
   Number = {9},
   Pages = {629-643},
   Year = {1995} }



@article{
1774,
   Author = {Guh, J. Y. and Yang, C. Y. and Yang, J. M. and Chen, L. M. and Lai, Y. H.},
   Title = {Prediction of equilibrated postdialysis BUN by an artificial neural network in high-efficiency hemodialysis},
   Journal = {American Journal of Kidney Diseases: the official journal of the National Kidney Foundation},
   Volume = {31},
   Number = {4},
   Pages = {638-646},
   Year = {1998} }



@article{
1773,
   Author = {Wessel, M. D. and Jurs, P. C. and Tolan, J. W. and Muskal, S. M.},
   Title = {Prediction of human intestinal absorption of drug compounds from molecular structure},
   Journal = {Journal of Chemical Information and Computer Sciences},
   Volume = {38},
   Number = {4},
   Pages = {726-735},
   Year = {1998} }



@article{
1772,
   Author = {Zernikow, B. and Holtmannspoetter, K. and Michel, E. and Pielemeier, W. and Hornschuh, F. and Westermann, A. and Hennecke, K. H.},
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   Title = {The pharmacokinetic-pharmacodynamic relationship for mycophenolate mofetil in renal transplantation},
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1737,
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1735,
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   Title = {Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo},
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1732,
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1729,
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   Title = {Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking},
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1728,
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@article{
1727,
   Author = {The Childhood Asthma Management Program Research, Group},
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   Title = {Model of complications of NIDDM. I. Model construction and assumptions},
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@article{
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   Title = {Model of complications of NIDDM. II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia},
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@article{
1723,
   Author = {Jackson, R. C.},
   Title = {A pharmacokinetic-pharmacodynamic model of chemotherapy of human immunodeficiency virus infection that relates development of drug resistance to treatment intensity},
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   Title = {A comparison of likelihood-based and marginal estimating equation methods for analysing repeated ordered categorical responses with missing data: application to an intervention trial of vitamin prophylaxis for oesophageal dysplasia},
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   Title = {Simulation as a design tool for phase I/II clinical trials: an example from bone marrow transplantation},
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@article{
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@article{
1703,
   Author = {Schentag, J. J. and Nix, D. E. and Adelman, M. H.},
   Title = {Mathematical examination of dual individualization principles (I): Relationships between AUC above MIC and area under the inhibitory curve for cefmenoxime, ciprofloxacin, and tobramycin},
   Journal = {DICP: The Annals of Pharmacotherapy},
   Volume = {25},
   Number = {10},
   Pages = {1050-1057},
   Year = {1991} }



@article{
1702,
   Author = {Elashoff, J. D. and Koch, G. G. and Chi, G. Y.},
   Title = {Designing a clinical trial to demonstrate prevention of ulcer recurrence: modelling simulation approaches},
   Journal = {Statistics in Medicine},
   Volume = {7},
   Number = {8},
   Pages = {877-888},
   Year = {1988} }



@article{
1701,
   Author = {Kodlin, D. and Cohn, I., Jr.},
   Title = {Simulation experiments of tumor measurement in clinical trials},
   Journal = {Cancer Treat.Rep.},
   Volume = {62},
   Number = {12},
   Pages = {2077-2083},
   Year = {1978} }



@article{
1700,
   Author = {Hale, M. and Gillespie, W. R. and Gupta, S. K. and Tuk, B. and Holford, N. H.},
   Title = {Clinical trial simulation: streamlining your drug development process},
   Journal = {Applied Clinical Trials},
   Volume = {5  },
   Number = {8},
   Pages = {35-40},
   Year = {1996} }



@article{
1699,
   Author = {Chakraborty, A. and Krzyzanski, W. and Jusko, W. J.},
   Title = {Mathematical modeling of circadian cortisol concentrations using indirect response models: comparison of several methods},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {23-43},
   Year = {1999} }



@article{
1698,
   Author = {Kendrick, M. and Johnson, K. I.},
   Title = {Long-term treatment of multiple sclerosis with interferon-beta may be cost effective},
   Journal = {Pharmacoeconomics},
   Volume = {18},
   Number = {1},
   Pages = {45-53},
   Year = {2000} }



@article{
1697,
   Author = {Sendi, P. P. and Craig, B. A. and Pfluger, D. and Gafni, A. and Bucher, H. C.},
   Title = {Systematic validation of disease models for pharmacoeconomic evaluations. Swiss HIV Cohort Study},
   Journal = {Journal of Evaluation in Clinical Practice},
   Volume = {5},
   Number = {3},
   Pages = {283-295},
   Year = {1999} }



@article{
1696,
   Author = {Kirschner, D. and Webb, G. F. and Cloyd, M.},
   Title = {Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes},
   Journal = {Journal of Acquired Immune Deficiency Syndromes},
   Volume = {24},
   Number = {4},
   Pages = {352-362},
   Year = {2000} }



@article{
1695,
   Author = {Armon, C. and Graves, M. C. and Moses, D. and Forte, D. K. and Sepulveda, L. and Darby, S. M. and Smith, R. A.},
   Title = {Linear estimates of disease progression predict survival in patients with amyotrophic lateral sclerosis},
   Journal = {Muscle Nerve},
   Volume = {23},
   Number = {6},
   Pages = {874-882},
   Year = {2000} }



@article{
1694,
   Author = {Hauber, A. B. and Gnanasakthy, A. and Snyder, E. H. and Bala, M. V. and Richter, A. and Mauskopf, J. A.},
   Title = {Potential savings in the cost of caring for Alzheimer's disease. Treatment with rivastigmine},
   Journal = {Pharmacoeconomics},
   Volume = {17},
   Number = {4},
   Pages = {351-360},
   Year = {2000} }



@article{
1693,
   Author = {Weiner, M.},
   Title = {Targeting oral anticoagulation},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {68},
   Number = {1},
   Pages = {4-5},
   Year = {2000} }



@article{
1692,
   Author = {Merle, Y. and Mentre, F.},
   Title = {Bayesian design criteria: computation, comparison, and application to a pharmacokinetic and a pharmacodynamic model},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {1},
   Pages = {101-125},
   Year = {1995} }



@article{
1691,
   Author = {D'Argenio, D. Z.},
   Title = {Optimal sampling times for pharmacokinetic experiments},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {9},
   Number = {6},
   Pages = {739-756},
   Year = {1981} }



@article{
1690,
   Author = {Tod, M. and Mentre, F. and Merle, Y. and Mallet, A.},
   Title = {Robust optimal design for the estimation of hyperparameters in population pharmacokinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {26},
   Number = {6},
   Pages = {689-716},
   Year = {1998} }



@article{
1689,
   Author = {Klotz, I. M.},
   Title = {Numbers of receptor sites from Scatchard graphs: facts and fantasies},
   Journal = {Science},
   Volume = {217},
   Number = {4566},
   Pages = {1247-1249},
   Year = {1982} }



@book{
1688,
   Author = {Kalbfleisch, J. G.},
   Title = {Probability and Statistical Inference, Volume 1: Probability},
   Publisher = {Springer-Verlag},
   Address = {New York},
   Year = {1985} }



@misc{
1687,
   Title = {SPLUS 6.1 Professional for Windows, Insightful, Corp},
      Year = {} }



@techreport{
1686,
   Author = {Boeckmann, A. J. and Sheiner, L. B. and Beal, S. L.},
   Title = {NONMEM Users Guide - Part V: Introductory Guide},
   Year = {1994} }



@book{
1685,
   Editor = {Beal, S. L. and Sheiner, L. B. and Boeckmann, A. J.},
   Title = {NONMEM Users Guide: Part I-VII, (1989-2006)},
   Publisher = {Icon Development Solutions},
   Address = {Ellicott City, Maryland, USA},
   Year = {} }



@techreport{
1684,
   Author = {Beal, S. L. and Sheiner, L. B.},
   Title = {NONMEM Users Guide - Part VII: Conditional Estimation Methods},
   Month= {March},
   Year = {1998} }



@article{
1683,
   Author = {Tatton, W. G. and Chalmers-Redman, R. M.},
   Title = {Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration},
   Journal = {Neurology},
   Volume = {47},
   Number = {6 Suppl 3},
   Pages = {S171-S183},
   Year = {1996} }



@article{
1682,
   Author = {Yoshida, T. and Yamada, Y. and Yamamoto, T. and Kuroiwa, Y.},
   Title = {Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency},
   Journal = {Xenobiotica},
   Volume = {16},
   Number = {2},
   Pages = {129-136},
   Year = {1986} }



@article{
1681,
   Author = {Gourlay, G. K.},
   Title = {Sustained relief of chronic pain. Pharmacokinetics of sustained release morphine},
   Journal = {Clinical Pharmacokinetics},
   Volume = {35},
   Number = {3},
   Pages = {173-190},
   Year = {1998} }



@article{
1680,
   Author = {Lotsch, J. and Weiss, M. and Kobal, G. and Geisslinger, G.},
   Title = {Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {63},
   Number = {6},
   Pages = {629-639},
   Year = {1998} }



@article{
1679,
   Author = {Hasselstrom, J. and Sawe, J.},
   Title = {Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations},
   Journal = {Clinical Pharmacokinetics},
   Volume = {24},
   Number = {4},
   Pages = {344-354},
   Year = {1993} }



@article{
1678,
   Author = {Westerling, D. and Persson, C. and Hoglund, P.},
   Title = {Plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide after intravenous and oral administration to healthy volunteers: relationship to nonanalgesic actions},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {17},
   Number = {3},
   Pages = {287-301},
   Year = {1995} }



@article{
1677,
   Author = {Hunt, A. and Joel, S. and Dick, G. and Goldman, A.},
   Title = {Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain},
   Journal = {Journal of Pediatrics},
   Volume = {135},
   Number = {1},
   Pages = {47-55},
   Year = {1999} }



@article{
1676,
   Author = {Lotsch, J. and Stockmann, A. and Kobal, G. and Brune, K. and Waibel, R. and Schmidt, N. and Geisslinger, G.},
   Title = {Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {60},
   Number = {3},
   Pages = {316-325},
   Year = {1996} }



@article{
1675,
   Author = {Lotsch, J. and Kobal, G. and Stockmann, A. and Brune, K. and Geisslinger, G.},
   Title = {Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers},
   Journal = {Anesthesiology},
   Volume = {87},
   Number = {6},
   Pages = {1348-1358},
   Year = {1997} }



@article{
1674,
   Author = {Lotsch, J. and Weiss, M. and Ahne, G. and Kobal, G. and Geisslinger, G.},
   Title = {Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {4},
   Pages = {1026-1038},
   Year = {1999} }



@article{
1673,
   Author = {Gibson, T. P.},
   Title = {Pharmacokinetics, efficacy, and safety of analgesia with a focus on tramadol HCl},
   Journal = {The American Journal of Medicine},
   Volume = {101},
   Number = {1A},
   Pages = {47S-53S},
   Year = {1996} }



@article{
1672,
   Author = {Liao, S. and Li, X. and Larson, K.},
   Title = {Population pharmacokinetics of tramadol and acetaminophen given orally as a single dose combination tablet in healthy volunteers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65  },
   Number = {2},
   Pages = {122},
   Year = {1999} }



@article{
1671,
   Author = {Heinonen, E. H. and Lammintausta, R.},
   Title = {A review of the pharmacology of selegiline},
   Journal = {Acta Neurologica Scandinavica Supplementum},
   Volume = {136},
   Pages = {44-59},
   Year = {1991} }



@article{
1670,
   Author = {Glavin, G. B. and Dugani, A. M. and Pinsky, C.},
   Title = {L-deprenyl attenuates stress ulcer formation in rats},
   Journal = {Neuroscience Letters},
   Volume = {70},
   Number = {3},
   Pages = {379-381},
   Year = {1986} }



@article{
1669,
   Author = {Fahn, S.},
   Title = {Is levodopa toxic?},
   Journal = {Neurology},
   Volume = {47},
   Number = {6 Suppl 3},
   Pages = {S184-S195},
   Year = {1996} }



@article{
1668,
   Author = {Ariens, E. J.},
   Title = {Stereochemistry: a source of problems in medicinal chemistry},
   Journal = {Medicinal Research Reviews},
   Volume = {6},
   Number = {4},
   Pages = {451-466},
   Year = {1986} }



@article{
1667,
   Author = {Chiou, W. L.},
   Title = {The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II)},
   Journal = {Clinical Pharmacokinetics},
   Volume = {17},
   Number = {4},
   Pages = {275-290},
   Year = {1989} }



@techreport{
1666,
   Title = {Guidance for Industry. Bioavailability and bioequivalence studies for orally administered drug products -- general considerations},
   Institution = {Food and Drug Administration, Center for Drug Evaluation and Research},
   Month= {October},
   Year = {2000} }



@article{
1665,
   Author = {Beal, S. L. and Sheiner, L. B.},
   Title = {Heteroscedastic nonlinear regression},
   Journal = {Technometrics},
   Volume = {30  },
   Number = {3},
   Pages = {327-338},
   Year = {1988} }



@article{
1664,
   Author = {Sanchez, M. J. G. and Manzanares, C. and Santos-Buelga, D. and Blazquez, A. and Manzanares, J. and Urruzuno, P. and Medina, E.},
   Title = {Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy},
   Journal = {Clinical Pharmacokinetics},
   Volume = {40  },
   Pages = {63-71},
   Year = {2001} }



@article{
1663,
   Author = {Gisleskog, P. O. and Hermann, D. and Hammarlund-Udenaes, M. and Karlsson, M. O.},
   Title = {Validation of a population pharmacokinetic/pharmacodynamic model for 5alpha-reductase inhibitors},
   Journal = {European Journal of Pharmaceutical Sciences: official journal of the European Federation for Pharmaceutical Sciences},
   Volume = {8  },
   Pages = {291-299},
   Year = {1999} }



@article{
1662,
   Author = {Luks, A. M. and Zwass, M. S. and Brown, R. C. and Lau, M. and Chari, G. and Fisher, D. M.},
   Title = {Opioid-induced analgesic in neonatal dogs: pharmacodynamic differences between morphine and fenytyl},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {284  },
   Pages = {136-141},
   Year = {1998} }



@article{
1661,
   Author = {Iribarnegaray, M. F. D. and Buelga, D. S. and Sanchez, M. J. G. and Otero, M. J. and Falcao, A. C. and Dominguez-Gil, A.},
   Title = {Carbamazepine population pharmacokinetics in children: mixed-effect models},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {19  },
   Pages = {132-139},
   Year = {1997} }



@incollection{
1660,
   Author = {Laveille, C. and Frey, N. and Lerebours, G. and Resplandy, G. and Jochemsen, R. and Aarons, L. and Vozeh, S.},
   Title = {Population pharmacokinetics-pharmacodynamics of a new specific bradycardic agent (S 16257) and its metabolite (S18982): evaluation of the drug/metabolite potency ratio},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {348 
 },
   Year = {1997} }



@incollection{
1659,
   Author = {Pobel, C. and Tranchand, B. and Ardiet, C. J. and Parola, J. N. and Menard, G. and Aarons, L. and Vozeh, S.},
   Title = {Population analysis of neutropenic effect of melphalan},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {343 
 -346},
   Year = {1997} }



@incollection{
1658,
   Author = {Sambol, N. C. and Liu, C. Y. and Williams, P. V. and Baker, J. and Aarons, L. and Vozeh, S.},
   Title = {Population method can be critical to dose-response assessment of a bronchodilator studied with a bronchoprovocation design},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {337 
 -341},
   Year = {1997} }



@incollection{
1657,
   Author = {Schadeli, F. and Uehlinger, D. E. and Aarons, L. and Vozeh, S.},
   Title = {Dosing guidelines for vancomycin in patients of high-flux hemodialysis: a population based approach},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {311 
 },
   Year = {1997} }



@incollection{
1656,
   Author = {Khan, A. Z. and Pitsiu, M. and Aarons, L. and Parivar, K. and Widman, M. and Vozeh, S.},
   Title = {Population pharmacokinetic analysis of eltanolone},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {289 
 -292},
   Year = {1997} }



@incollection{
1655,
   Author = {Piotrovskij, V. and Peer, A. V. and Huang, M. L. and Woestenborghs, R. and Langenaecken, C. and Aarons, L. and Vozeh, S.},
   Title = {A population analysis of vorozole pharmacokinetics in healthy volunteers and breast cancer patients},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {279 
 -282},
   Year = {1997} }



@incollection{
1654,
   Author = {Jen, J. F. and Cutler, D. and Pai, S. and Batra, V. and Affrime, M. and Hajian, G. and Heft, S. and Aarons, L. and Vozeh, S.},
   Title = {Population pharmacokinetic analysis of temozolomide},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {277 
 -278},
   Year = {1997} }



@incollection{
1653,
   Author = {Bruno, R. and Aarons, L. and Vozeh, S.},
   Title = {Integration of population pharmacokinetics/pharmacodynamics in the clinical development and the registration dossier of docetaxel},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {253 
 -262},
   Year = {1997} }



@incollection{
1652,
   Author = {Jorga, K. and Banken, L. and Fotteler, B. and Aarons, L. and Vozeh, S.},
   Title = {Prospective pharmacokinetic/pharmacodynamic population analysis in the clinical development of tolcapone, a COMT inhibitor for the treatment of Parkinson's disease},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {245 
 -252},
   Year = {1997} }



@incollection{
1651,
   Author = {Weber, W. and Harnisch, L. and Aarons, L. and Vozeh, S.},
   Title = {Use of a population approach to the development of leflunomide: a disease-modifying drug in the treatment of rheumatoid arthritis},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {238 
 -244},
   Year = {1997} }



@incollection{
1650,
   Author = {Fuseau, E. and Kempsford, R. and Winter, P. and Asgharnejad, M. and Sambol, N. and Liu, C. Y. and Aarons, L. and Vozeh, S.},
   Title = {The integration of the population approach into drug development: a case study, naratriptan},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {201 
 -214},
   Year = {1997} }



@incollection{
1649,
   Author = {Shafer, S. L. and Hu, C. and Aarons, L. and Vozeh, S.},
   Title = {Managing pharmacodynamic variability in anesthesia: integrating the EEG, effect site, anesthetic concentrations and measures of anesthetic depth},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {83 
 -94},
   Year = {1997} }



@incollection{
1648,
   Author = {Tanigawara, Y. and Aarons, L. and Vozeh, S.},
   Title = {Recent applications of the population pharmacokinetic approach: pre-marketing and post-marketing},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {25 
 -37},
   Year = {1997} }



@article{
1647,
   Author = {Sheiner, L. B. and Beal, S. L. and Dunne, A.},
   Title = {Analysis of nonrandomly censored ordered categorical longitudinal data from analgesic trials},
   Journal = {Journal of the American Statistical Association},
   Volume = {92  },
   Number = {440},
   Pages = {1235-1244},
   Year = {1997} }



@article{
1646,
   Author = {Hallen, I. P. and Jonsson, S. and Karlsson, M. O. and Oskarsson, A.},
   Title = {Kinetic observations in neonatal mice exposed to lead via milk},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {140  },
   Pages = {13-18},
   Year = {1996} }



@article{
1645,
   Author = {Bachman, W. J. and DeLap, R. J.},
   Title = {Population pharmacokinetics of high-dose zidovudine in a phase I cancer study},
   Journal = {Drug Investigation},
   Volume = {8  },
   Number = {3},
   Pages = {134-142},
   Year = {1994} }



@article{
1644,
   Author = {Holford, N. H. and Peace, K. E.},
   Title = {Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine},
   Journal = {Proceedings of the National Academy of Sciences of the United States of America},
   Volume = {89},
   Number = {23},
   Pages = {11466-11470},
   Year = {1992} }



@article{
1643,
   Author = {Sambol, N. C. and Clementi, W. A. and Sheiner, L. B.},
   Title = {Population dose-response relationships determined from efficacy trials: the antihypertensive effect of atenolol and betaxolol},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19  },
   Pages = {79S-91S},
   Year = {1991} }



@article{
1642,
   Author = {Olson, S. C.},
   Title = {A population pharmacokinetic profile of imazodan in congestive heart failure patients},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19  },
   Pages = {47S-58S},
   Year = {1991} }



@article{
1641,
   Author = {Martin, E. S.},
   Title = {The population pharmacokinetics of theophylline during the early post-natal period},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19  },
   Pages = {59S-77S},
   Year = {1991} }



@incollection{
1640,
   Author = {Jonsson, E. N. and Karlsson, M. O. and Aarons, L. and Vozeh, S.},
   Title = {XPOSE - an Splus based model building aid for population analysis with NONMEM},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {411-413},
   Year = {1997} }



@incollection{
1639,
   Author = {Fotteler, B. and Jorga, K. and Steimer, J. L. and Aarons, L. and Vozeh, S.},
   Title = {From blood flow to data flow: how to build a data set for NONMEM evaluation. an industrial experience},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {397 
 -406},
   Year = {1997} }



@incollection{
1638,
   Author = {derGraaf, P. H. V. and Shaick, E. A. V. and Danhof, M. and Aarons, L. and Vozeh, S.},
   Title = {Mechanism-based modelling of drug-receptor interactions in vivo: a population approach},
   BookTitle = {The population approach: measuring and managing variability in response, concentration and dose},
   Publisher = {European Commission},
   Address = {Brussels},
   Pages = {329 
 -335},
   Year = {1997} }



@article{
1637,
   Author = {Lindsay, C. and Grasela, T. H. and Antal, E. J. and Miller, R. L.},
   Title = {Evaluation of population pharmacokinetics in therapeutic trials. IV application to postmarketing surveillance},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {53},
   Pages = {521-528},
   Year = {1993} }



@incollection{
1636,
   Author = {Tanigawara, Y. and Rowland, M. and Aarons, L.},
   Title = {Population approach in post-marketing dose adjustment},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {223 
 -231},
   Year = {1992} }



@incollection{
1635,
   Author = {Holford, N. G. and Rowland, M. and Aarons, L.},
   Title = {Parametric models for the time course of drug action: the population approach},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {193 
 -206},
   Year = {1992} }



@incollection{
1634,
   Author = {Sambol, N. C. and Rowland, M. and Aarons, L.},
   Title = {The population approach: applications to experimental data},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {183 
 -191},
   Year = {1992} }



@incollection{
1633,
   Author = {Olson, S. C. and Rowland, M. and Aarons, L.},
   Title = {Population pharmacokinetics during drug development: esperience within Parke-Davis},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {143 
 -152},
   Year = {1992} }



@incollection{
1632,
   Author = {Vozeh, S. and Rowland, M. and Aarons, L.},
   Title = {Applications of the population approach to clinical pharmacokinetics and validation of the results},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {107 
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   Year = {1992} }



@article{
1631,
   Author = {Grasela, T. H. and Sheiner, L. B.},
   Title = {Pharmacostatistical modeling for observational data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19  },
   Pages = {25S-35S},
   Year = {1991} }



@article{
1630,
   Author = {Beal, S. L.},
   Title = {Computing initial estimates with mixed effects models: a general method of moments},
   Journal = {Biometrika},
   Volume = {78  },
   Pages = {217-220},
   Year = {1991} }



@article{
1629,
   Author = {McArthur, R. D.},
   Title = {Parameter estimation in a two-compartmental population pharmacokinetic model with destructive sampling},
   Journal = {Mathematical Biosciences},
   Volume = {91  },
   Pages = {157-173},
   Year = {1988} }



@article{
1628,
   Author = {Lindstrom, F. T. and Birkes, D. S.},
   Title = {Estimation of population pharmacokinetic parameters using destructively obtained experimental data: a simulation study of the one-compartment open model},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {195-264},
   Year = {1984} }



@techreport{
1627,
   Author = {Beal, S.},
   Title = {Asymptotic properties of optimization estimators for the independent not identically distributed case with application to extended least squares estimators},
   Institution = {University of California at San Francisco},
   Year = {1984} }



@incollection{
1626,
   Author = {Whiting, B. and Rowland, M. and Aarons, L.},
   Title = {The population approach: applications to date. An overview},
   BookTitle = {New strategies in drug development and clinical evaluation: the population approach},
   Publisher = {Commission of the European Communities},
   Address = {Brussels},
   Pages = {41 
 -58},
   Year = {1992} }



@incollection{
1625,
   Author = {Whiting, B. and Kelman, A. and Grevel, J. and Taylor, J. B.},
   Title = {Population pharmacokinetics},
   BookTitle = {Comprehensive medicinal chemistry},
   Publisher = {Pergamon Press},
   Address = {Oxford},
   Pages = {297 
 -304},
   Year = {1990} }



@incollection{
1624,
   Author = {Beal, S. and Sheiner, L. B. and Garrett, E. R. and Hirtz, J.},
   Title = {Methodology of population pharmacokinetics},
   BookTitle = {Drug fate and metabolism: methods and techniques},
   Publisher = {Marcel Decker},
   Address = {New York},
   Pages = {135 
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   Year = {1985} }



@article{
1623,
   Author = {Spector, R. and Park, G. D. and Johnson, G. F. and Vesell, E. S.},
   Title = {Therapeutic drug monitoring},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {43},
   Number = {4},
   Pages = {345-353},
   Year = {1988} }



@article{
1622,
   Author = {Messori, A. and Bosi, A. and Guidi, S. and Longo, G. and Pistolesi, C. and Saccardi, R. and Valenza, T. and Vannucchi, A. M.},
   Title = {PKRD: a pharmacokinetic program for least-squares and bayesian analysis of repeated-dose pharmacokinetic curves},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {38},
   Number = {1},
   Pages = {27-35},
   Year = {1992} }



@article{
1621,
   Author = {Dodge, W. F. and Jelliffe, R. W. and Richardson, C. J. and McCleery, R. A. and Hokanson, J. A. and Snodgrass, W. R.},
   Title = {Gentamicin population pharmacokinetic models for low birth weight infants using a new nonparametric method},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {50},
   Number = {1},
   Pages = {25-31},
   Year = {1991} }



@article{
1620,
   Author = {Katz, D. and D'Argenio, D. Z.},
   Title = {Implementation and evaluation of control strategies for individualizing dosage regimens, with application to the aminoglycoside antibiotics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {14},
   Number = {5},
   Pages = {523-537},
   Year = {1986} }



@article{
1619,
   Author = {D'Argenio, D. Z. and Khakmahd, K.},
   Title = {Adaptive control of theophylline therapy: importance of blood sampling times},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {11},
   Number = {5},
   Pages = {547-559},
   Year = {1983} }



@incollection{
1618,
   Author = {Jelliffe, R. W. and Maronde, R.},
   Title = {Clinical applications of pharmacokinetics and control theory: planning, monitoring, and adjusting dosage regimens of aminoglycosides, lidocaine, digitoxin, and digoxin},
   BookTitle = {Selected topics in clinical pharmacology},
   Publisher = {Springer-Verlag},
   Address = {New York},
   Pages = {26-82},
   Year = {1986} }



@article{
1617,
   Author = {Bellazzi, R.},
   Title = {Drug delivery optimization through Bayesian networks: an application to erythropoietin therapy in uremic anemia},
   Journal = {Computers and Biomedical Research, an international journal},
   Volume = {26},
   Number = {3},
   Pages = {274-293},
   Year = {1993} }



@article{
1616,
   Author = {Singh, G. J. and Adams, W. P. and Lesko, L. J. and Shah, V. P. and Molzon, J. A. and Williams, R. L. and Pershing, L. K.},
   Title = {Development of in vivo bioequivalence methodology for dermatologic corticosteroids based on pharmacodynamic modeling},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {66},
   Number = {4},
   Pages = {346-357},
   Year = {1999} }



@article{
1615,
   Author = {Yamano, K. and Yamamoto, K. and Kotaki, H. and Takedomi, S. and Matsuo, H. and Sawada, Y. and Iga, T.},
   Title = {Quantitative prediction of metabolic inhibition of midazolam by erythromycin, diltiazem, and verapamil in rats: implication of concentrative uptake of inhibitors into liver},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {292},
   Number = {3},
   Pages = {1118-1126},
   Year = {2000} }



@article{
1614,
   Author = {Warrington, J. S. and Poku, J. W. and von Moltke, L. L. and Shader, R. I. and Harmatz, J. S. and Greenblatt, D. J.},
   Title = {Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {292},
   Number = {3},
   Pages = {1024-1031},
   Year = {2000} }



@article{
1613,
   Author = {Gozzi, P. and Pahlman, I. and Palmer, L. and Gronberg, A. and Persson, S.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of the immunomodulating agent susalimod and experimentally induced tumor necrosis factor-alpha levels in the mouse},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {291},
   Number = {1},
   Pages = {199-203},
   Year = {1999} }



@article{
1612,
   Author = {Lin, J. H. and Chiba, M. and Baillie, T. A.},
   Title = {Is the role of the small intestine in first-pass metabolism overemphasized?},
   Journal = {Pharmacological Reviews},
   Volume = {51},
   Number = {2},
   Pages = {135-158},
   Year = {1999} }



@article{
1611,
   Author = {Upton, R. N. and Huang, Y. F. and Mather, L. E. and Doolette, D. J.},
   Title = {The relationship between the myocardial kinetics of meperidine and its effect on myocardial contractility: model-independent analysis and optimal regional model},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {290},
   Number = {2},
   Pages = {694-701},
   Year = {1999} }



@article{
1610,
   Author = {Amisaki, T. and Eguchi, S.},
   Title = {A comparison of methods for estimating individual pharmacokinetic parameters},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {103-121},
   Year = {1999} }



@article{
1609,
   Author = {Ferron, G. M. and Pyszczynski, N. A. and Jusko, W. J.},
   Title = {Pharmacokinetic and pharmacoimmunodynamic interactions between prednisolone and sirolimus in adrenalectomized rats},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {1-21},
   Year = {1999} }



@article{
1608,
   Author = {Psaty, B. M. and Weiss, N. S. and Furberg, C. D. and Koepsell, T. D. and Siscovick, D. S. and Rosendaal, F. R. and Smith, N. L. and Heckbert, S. R. and Kaplan, R. C. and Lin, D. and Fleming, T. R. and Wagner, E. H.},
   Title = {Surrogate end points, health outcomes, and the drug-approval process for the treatment of risk factors for cardiovascular disease},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {282},
   Number = {8},
   Pages = {786-790},
   Year = {1999} }



@article{
1607,
   Author = {Iyer, G. R. and Bellantone, R. A. and Taft, D. R.},
   Title = {In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {45-66},
   Year = {1999} }



@article{
1606,
   Author = {Albert, P. S.},
   Title = {Longitudinal data analysis (repeated measures) in clinical trials},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {13},
   Pages = {1707-1732},
   Year = {1999} }



@article{
1605,
   Author = {Knatterud, G. L. and Rockhold, F. W. and George, S. L. and Barton, F. B. and Davis, C. E. and Fairweather, W. R. and Honohan, T. and Mowery, R. and O'Neill, R.},
   Title = {Guidelines for quality assurance in multicenter trials: a position paper},
   Journal = {Controlled Clinical Trials},
   Volume = {19},
   Number = {5},
   Pages = {477-493},
   Year = {1998} }



@article{
1604,
   Author = {Kramar, A. and Lebecq, A. and Candalh, E.},
   Title = {Continual reassessment methods in phase I trials of the combination of two drugs in oncology},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {14},
   Pages = {1849-1864},
   Year = {1999} }



@article{
1603,
   Author = {Mathot, R. A. and Geus, W. P.},
   Title = {Pharmacodynamic modeling of the acid inhibitory effect of ranitidine in patients in an intensive care unit during prolonged dosing: characterization of tolerance},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {66},
   Number = {2},
   Pages = {140-151},
   Year = {1999} }



@article{
1602,
   Author = {Chakraborty, A. and Blum, R. A. and Cutler, D. L. and Jusko, W. J.},
   Title = {Pharmacoimmunodynamic interactions of interleukin-10 and prednisone in healthy volunteers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {3},
   Pages = {304-318},
   Year = {1999} }



@article{
1601,
   Author = {Sviri, S. and Shpizen, S. and Leitersdorf, E. and Levy, M. and Caraco, Y.},
   Title = {Phenotypic-genotypic analysis of CYP2C19 in the Jewish Israeli population},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {3},
   Pages = {275-282},
   Year = {1999} }



@article{
1600,
   Author = {Edwards, D. J. and Fitzsimmons, M. E. and Schuetz, E. G. and Yasuda, K. and Ducharme, M. P. and Warbasse, L. H. and Woster, P. M. and Schuetz, J. D. and Watkins, P.},
   Title = {6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {3},
   Pages = {237-244},
   Year = {1999} }



@article{
1599,
   Author = {Yafune, A. and Ishiguro, M.},
   Title = {Bootstrap approach for constructing confidence intervals for population pharmacokinetic parameters. II: A bootstrap modification of standard two-stage (STS) method for phase I trial},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {5},
   Pages = {601-612},
   Year = {1999} }



@article{
1598,
   Author = {Yafune, A. and Ishiguro, M.},
   Title = {Bootstrap approach for constructing confidence intervals for population pharmacokinetic parameters. I: A use of bootstrap standard error},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {5},
   Pages = {581-599},
   Year = {1999} }



@article{
1597,
   Author = {Meyer, M. C. and Straughn, A. B. and Jarvi, E. J. and Patrick, K. S. and Pelsor, F. R. and Williams, R. L. and Patnaik, R. and Chen, M. L. and Shah, V. P.},
   Title = {Bioequivalence of methylphenidate immediate-release tablets using a replicated study design to characterize intrasubject variability},
   Journal = {Pharmaceutical Research},
   Volume = {17},
   Number = {4},
   Pages = {381-384},
   Year = {2000} }



@article{
1596,
   Author = {Hauck, W. W. and Hyslop, T. and Chen, M. L. and Patnaik, R. and Williams, R. L.},
   Title = {Subject-by-formulation interaction in bioequivalence: conceptual and statistical issues. FDA Population/Individual Bioequivalence Working Group. Food and Drug Administration},
   Journal = {Pharmaceutical Research},
   Volume = {17},
   Number = {4},
   Pages = {375-380},
   Year = {2000} }



@article{
1595,
   Author = {Kasai, H. and Ueno, K. and Kusumoto, M. and Shibakawa, M.},
   Title = {Population pharmacokinetic analysis of pirmenol in healthy volunteers and patients with arrhythmia},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {55},
   Number = {1},
   Pages = {77-78},
   Year = {1999} }



@techreport{
1594,
   Author = {Lai, T. L. and Shih, M. and Zhu, G.},
   Title = {Statistics in pharmacology and pre-clinical studies},
   Institution = {Department of Statistics, Stanford University},
   Number = {2000-30  },
   Month= {September},
   Year = {2000} }



@article{
1593,
   Author = {Lai, T. L. and Zhang, L.},
   Title = {Statistical analysis of ligand-binding experiments},
   Journal = {Biometrics},
   Volume = {50},
   Number = {3},
   Pages = {782-797},
   Year = {1994} }



@article{
1592,
   Author = {Lai, T. L.},
   Title = {Regression analysis of compartmental models},
   Journal = {Journal of Research of the National Bureau of Standards},
   Volume = {90  },
   Number = {6},
   Pages = {525-530},
   Year = {1985} }



@article{
1591,
   Author = {Gu, M. and Lai, T. L.},
   Title = {Repeated significance testing with censored rank statistics in interim analysis of clinical trials},
   Journal = {Statistica Sinica},
   Volume = {8  },
   Pages = {411-428},
   Year = {1998} }



@article{
1590,
   Author = {Gu, M. and Lai, T. L.},
   Title = {Determination of power and sample size in the design of clinical trials with failure-time endpoints and interim analyses},
   Journal = {Controlled Clinical Trials},
   Volume = {20  },
   Pages = {423-438},
   Year = {1999} }



@techreport{
1589,
   Author = {Lai, T. L.},
   Title = {Sequential analysis: some classical problems and new challenges},
   Institution = {Department of Statistics, Stanford University},
   Number = {2000-33  },
   Month= {September},
   Year = {2000} }



@techreport{
1588,
   Author = {Arms, A. D. and Travis, C. C.},
   Title = {EPA Final Report: reference physiological parameters in pharmacokinetic modeling},
   Number = {EPA/600/6-88/004  },
   Month= {February},
   Year = {1988} }



@article{
1587,
   Author = {Leggett, R. W. and Williams, L. R.},
   Title = {Suggested reference values for regional blood volumes in humans},
   Journal = {Health Physics},
   Volume = {60},
   Number = {2},
   Pages = {139-154},
   Year = {1991} }



@article{
1586,
   Author = {Williams, L. R. and Leggett, R. W.},
   Title = {Reference values for resting blood flow to organs of man},
   Journal = {Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association},
   Volume = {10},
   Number = {3},
   Pages = {187-217},
   Year = {1989} }



@article{
1585,
   Author = {Davies, B. and Morris, T.},
   Title = {Physiological parameters in laboratory animals and humans},
   Journal = {Pharmaceutical Research},
   Volume = {10},
   Number = {7},
   Pages = {1093-1095},
   Year = {1993} }



@article{
1584,
   Author = {Lam, G. and Chen, M. L. and Chiou, W. L.},
   Title = {Determination of tissue to blood partition coefficients in physiologically-based pharmacokinetic studies},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {71},
   Number = {4},
   Pages = {454-456},
   Year = {1982} }



@article{
1583,
   Author = {Khor, S. P. and Mayersohn, M.},
   Title = {Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations},
   Journal = {Drug Metabolism and Disposition: The Biological Fate of Chemicals},
   Volume = {19},
   Number = {2},
   Pages = {478-485},
   Year = {1991} }



@article{
1582,
   Author = {Khor, S. P. and Bozigian, H. and Mayersohn, M.},
   Title = {Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat},
   Journal = {Drug Metabolism and Disposition: The Biological Fate of Chemicals},
   Volume = {19},
   Number = {2},
   Pages = {486-490},
   Year = {1991} }



@article{
1581,
   Author = {Scott, D. O. and Sorenson, L. R. and Steele, K. L. and Puckett, D. L. and Lunte, C. E.},
   Title = {In vivo microdialysis sampling for pharmacokinetic investigations},
   Journal = {Pharmaceutical Research},
   Volume = {8},
   Number = {3},
   Pages = {389-392},
   Year = {1991} }



@article{
1580,
   Author = {Stahle, L.},
   Title = {Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline},
   Journal = {Life Sciences},
   Volume = {49},
   Number = {24},
   Pages = {1835-1842},
   Year = {1991} }



@article{
1579,
   Author = {Stahle, L. and Segersvard, S. and Ungerstedt, U.},
   Title = {Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain and other tissues in rats},
   Journal = {Life Sciences},
   Volume = {49},
   Number = {24},
   Pages = {1843-1852},
   Year = {1991} }



@article{
1578,
   Author = {Stahle, L. and Arner, P. and Ungerstedt, U.},
   Title = {Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man},
   Journal = {Life Sciences},
   Volume = {49},
   Number = {24},
   Pages = {1853-1858},
   Year = {1991} }



@article{
1577,
   Author = {Bungay, P. M. and Morrison, P. F. and Dedrick, R. L.},
   Title = {Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro},
   Journal = {Life Sciences},
   Volume = {46},
   Number = {2},
   Pages = {105-119},
   Year = {1990} }



@article{
1576,
   Author = {Herbette, L. G. and Trumbore, M. and Chester, D. W. and Katz, A. M.},
   Title = {Possible molecular basis for the pharmacokinetics and pharmacodynamics of three membrane-active drugs: propranolol, nimodipine and amiodarone},
   Journal = {Journal of Molecular and Cellular Cardiology},
   Volume = {20},
   Number = {5},
   Pages = {373-378},
   Year = {1988} }



@article{
1575,
   Author = {Kates, R. E. and Jaillon, P.},
   Title = {A model to describe myocardial drug disposition in the dog},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {214},
   Number = {1},
   Pages = {31-36},
   Year = {1980} }



@article{
1574,
   Author = {Ito, K. and Sawada, Y. and Sugiyama, Y. and Hanano, M. and Iga, T.},
   Title = {Kinetic evaluation for measurement of in vivo receptor occupancy by psychotropic drug in brain: implication for human studies},
   Journal = {Chemical and Pharmaceutical Bulletin},
   Volume = {39},
   Number = {7},
   Pages = {1813-1819},
   Year = {1991} }



@article{
1573,
   Author = {Ben David, J. and Zipes, D. P.},
   Title = {Torsades de pointes and proarrhythmia},
   Journal = {Lancet},
   Volume = {341},
   Number = {8860},
   Pages = {1578-1582},
   Year = {1993} }



@article{
1572,
   Author = {Atkinson, A. J., Jr. and Ruo, T. I. and Frederiksen, M. C.},
   Title = {Physiological basis of multicompartmental models of drug distribution},
   Journal = {Trends in Pharmacological Sciences},
   Volume = {12},
   Number = {3},
   Pages = {96-101},
   Year = {1991} }



@article{
1571,
   Author = {Mackay, D.},
   Title = {Concentration-response curves and receptor classification: null method or operational model?},
   Journal = {Trends in Pharmacological Sciences},
   Volume = {9},
   Number = {6},
   Pages = {202-205},
   Year = {1988} }



@article{
1570,
   Author = {Smith, D. A.},
   Title = {Species differences in metabolism and pharmacokinetics: are we close to an understanding?},
   Journal = {Drug Metabolism Reviews},
   Volume = {23  },
   Number = {3-4},
   Pages = {355-373},
   Year = {1991} }



@article{
1569,
   Author = {Medina, R. L. and Albanese, R. A.},
   Title = {Animal-to-human extrapolation using compartmental models},
   Journal = {Neuroscience and Biobehavioral Reviews},
   Volume = {15},
   Number = {1},
   Pages = {57-61},
   Year = {1991} }



@article{
1568,
   Author = {Dedrick, R. L.},
   Title = {Animal scale-up},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {1},
   Number = {5},
   Pages = {435-461},
   Year = {1973} }



@article{
1567,
   Author = {Adolph, E. F.},
   Title = {Quantitative relations in the physiological constitutions of mammals},
   Journal = {Science},
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   Pages = {579-585},
   Year = {1949} }



@article{
1566,
   Author = {Gerlowski, L. E. and Jain, R. K.},
   Title = {Physiologically based pharmacokinetic modeling: principles and applications},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {72},
   Number = {10},
   Pages = {1103-1127},
   Year = {1983} }



@article{
1565,
   Author = {Andersen, M. E.},
   Title = {Tissue dosimetry, physiologically-based pharmacokinetic modeling, and cancer risk assessment},
   Journal = {Cell Biology and Toxicology},
   Volume = {5},
   Number = {4},
   Pages = {405-415},
   Year = {1989} }



@article{
1564,
   Author = {Frederick, C. B. and Potter, D. W. and Chang-Mateu, M. I. and Andersen, M. E.},
   Title = {A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {114},
   Number = {2},
   Pages = {246-260},
   Year = {1992} }



@article{
1563,
   Author = {Bjorkman, S. and Stanski, D. R. and Harashima, H. and Dowrie, R. and Harapat, S. R. and Wada, D. R. and Ebling, W. F.},
   Title = {Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {21},
   Number = {3},
   Pages = {255-279},
   Year = {1993} }



@article{
1562,
   Author = {Bernareggi, A. and Rowland, M.},
   Title = {Physiologic modeling of cyclosporin kinetics in rat and man},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {1},
   Pages = {21-50},
   Year = {1991} }



@article{
1561,
   Author = {Gearhart, J. M. and Jepson, G. W. and Clewell, H. J., III and Andersen, M. E. and Conolly, R. B.},
   Title = {Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {106},
   Number = {2},
   Pages = {295-310},
   Year = {1990} }



@incollection{
1560,
   Author = {Schwartz, S. L. and Gastonguay, M. and Robinson, D. E. and Balter, N. J. and Gorrod, J. W. and Wahren, J.},
   Title = {Physiologically based pharmacokinetic modelling of nicotine},
   BookTitle = {Nicotine and related alkaloids: absorption, distribution, metabolism and excretion},
   Publisher = {Chapman and Hall},
   Address = {London},
   Pages = {267-286},
   Year = {1993} }



@article{
1559,
   Author = {Ludden, T. and Allerheiligen, S. and Burk, R.},
   Title = {Application of population analysis to physiological pharmacokinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19  },
   Number = {3},
   Pages = {101S-113S},
   Year = {1991} }



@article{
1558,
   Author = {Young, J. D. and Braun, W. H. and Rampy, L. W. and Chenoweth, M. B. and Blau, G. E.},
   Title = {Pharmacokinetics of 1,4-dioxane in humans},
   Journal = {Journal of Toxicology and Environmental Health},
   Volume = {3},
   Number = {3},
   Pages = {507-520},
   Year = {1977} }



@article{
1557,
   Author = {Young, J. D. and Braun, W. H. and Gehring, P. J.},
   Title = {The dose-dependent fate of 1,4-dioxane in rats},
   Journal = {Journal of Environmental Pathology and Toxicology},
   Volume = {2},
   Number = {2},
   Pages = {263-282},
   Year = {1978} }



@article{
1556,
   Author = {Leung, H. W. and Paustenbach, D. J.},
   Title = {Cancer risk assessment for dioxane based upon a physiologically-based pharmacokinetic approach},
   Journal = {Toxicology Letters},
   Volume = {51},
   Number = {2},
   Pages = {147-162},
   Year = {1990} }



@article{
1555,
   Author = {Conolly, R. B. and Andersen, M. E.},
   Title = {Biologically based pharmacodynamic models: tools for toxicological research and risk assessment},
   Journal = {Annual Review of Pharmacology and Toxicology},
   Volume = {31},
   Pages = {503-523},
   Year = {1991} }



@article{
1554,
   Author = {Somani, S. M. and Gupta, S. K. and Khalique, A. and Unni, L. K.},
   Title = {Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat},
   Journal = {Drug Metabolism and Disposition: The Biological Fate of Chemicals},
   Volume = {19},
   Number = {3},
   Pages = {655-660},
   Year = {1991} }



@article{
1553,
   Author = {Colburn, W. A.},
   Title = {Physiologic pharmacokinetic modeling},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {28},
   Number = {8},
   Pages = {673-677},
   Year = {1988} }



@article{
1552,
   Author = {Boxenbaum, H.},
   Title = {Time concepts in physics, biology, and pharmacokinetics},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {75},
   Number = {11},
   Pages = {1053-1062},
   Year = {1986} }



@article{
1551,
   Author = {Yates, F. E. and Kugler, P. N.},
   Title = {Similarity principles and intrinsic geometries: contrasting approaches to interspecies scaling},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {75},
   Number = {11},
   Pages = {1019-1027},
   Year = {1986} }



@article{
1550,
   Author = {Boxenbaum, H. and Ronfeld, R.},
   Title = {Interspecies pharmacokinetic scaling and the Dedrick plots},
   Journal = {American Journal of Physiology},
   Volume = {245},
   Number = {6},
   Pages = {R768-R775},
   Year = {1983} }



@article{
1549,
   Author = {Ruelius, H. W.},
   Title = {Extrapolation from animals to man: predictions, pitfalls and perspectives},
   Journal = {Xenobiotica},
   Volume = {17},
   Number = {3},
   Pages = {255-265},
   Year = {1987} }



@article{
1548,
   Author = {Dedrick, R. L. and Bischoff, K. B.},
   Title = {Species similarities in pharmacokinetics},
   Journal = {Federation Proceedings},
   Volume = {39},
   Number = {1},
   Pages = {54-59},
   Year = {1980} }



@article{
1547,
   Author = {Sawada, Y. and Hanano, M. and Sugiyama, Y. and Iga, T.},
   Title = {Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {12},
   Number = {3},
   Pages = {241-261},
   Year = {1984} }



@article{
1546,
   Author = {Riond, J. L. and Riviere, J. E.},
   Title = {Allometric analysis of doxycycline pharmacokinetic parameters},
   Journal = {Journal of Veterinary Pharmacology and Therapeutics},
   Volume = {13},
   Number = {4},
   Pages = {404-407},
   Year = {1990} }



@article{
1545,
   Author = {Boxenbaum, H.},
   Title = {Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {10},
   Number = {2},
   Pages = {201-227},
   Year = {1982} }



@article{
1544,
   Author = {Monro, A. M.},
   Title = {Interspecies comparisons in toxicology: the utility and futility of plasma concentrations of the test substance},
   Journal = {Regulatory Toxicology and Pharmacology},
   Volume = {12},
   Number = {2},
   Pages = {137-160},
   Year = {1990} }



@article{
1543,
   Author = {Ings, R. M.},
   Title = {Interspecies scaling and comparisons in drug development and toxicokinetics},
   Journal = {Xenobiotica},
   Volume = {20},
   Number = {11},
   Pages = {1201-1231},
   Year = {1990} }



@article{
1542,
   Author = {Boxenbaum, H.},
   Title = {Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {5-6},
   Pages = {1071-1121},
   Year = {1984} }



@article{
1541,
   Author = {Travis, C. C. and Bowers, J. C.},
   Title = {Interspecies scaling of anesthetic potency},
   Journal = {Toxicology and Industrial Health},
   Volume = {7},
   Number = {4},
   Pages = {249-260},
   Year = {1991} }



@article{
1540,
   Author = {Patel, B. A. and Boudinot, F. D. and Schinazi, R. F. and Gallo, J. M. and Chu, C. K.},
   Title = {Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species},
   Journal = {Journal of Pharmacobio-dynamics},
   Volume = {13},
   Number = {3},
   Pages = {206-211},
   Year = {1990} }



@article{
1539,
   Author = {Mordenti, J.},
   Title = {Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {74},
   Number = {10},
   Pages = {1097-1099},
   Year = {1985} }



@article{
1538,
   Author = {Dedrick, R. L.},
   Title = {Interspecies scaling of regional drug delivery},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {75},
   Number = {11},
   Pages = {1047-1052},
   Year = {1986} }



@article{
1537,
   Author = {Calabrese, E. J.},
   Title = {Animal extrapolation and the challenge of human heterogeneity},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {75},
   Number = {11},
   Pages = {1041-1046},
   Year = {1986} }



@article{
1536,
   Author = {Mordenti, J. and Chen, S. A. and Moore, J. A. and Ferraiolo, B. L. and Green, J. D.},
   Title = {Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins},
   Journal = {Pharmaceutical Research},
   Volume = {8},
   Number = {11},
   Pages = {1351-1359},
   Year = {1991} }



@article{
1535,
   Author = {Mordenti, J.},
   Title = {Man versus beast: pharmacokinetic scaling in mammals},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {75},
   Number = {11},
   Pages = {1028-1040},
   Year = {1986} }



@article{
1534,
   Author = {Cleek, R. L. and Bunge, A. L.},
   Title = {A new method for estimating dermal absorption from chemical exposure. 1. General approach},
   Journal = {Pharmaceutical Research},
   Volume = {10},
   Number = {4},
   Pages = {497-506},
   Year = {1993} }



@article{
1533,
   Author = {Conner, D. P. and Almirez, R. G. and Rhyne, P. and Zamani, K. and Bolden, B. J. and Peck, C. C.},
   Title = {Transcutaneous collection of theophylline: constancy and linearity of skin permeability},
   Journal = {Skin Pharmacology},
   Volume = {2},
   Number = {3},
   Pages = {155-161},
   Year = {1989} }



@article{
1532,
   Author = {Zatz, J.},
   Title = {Simulation studies of skin permeation},
   Journal = {Journal of the Society of Cosmetic Chemists},
   Volume = {43  },
   Pages = {37-48},
   Year = {1992} }



@article{
1531,
   Author = {Williams, P. L. and Carver, M. P. and Riviere, J. E.},
   Title = {A physiologically relevant pharmacokinetic model of xenobiotic percutaneous absorption utilizing the isolated perfused porcine skin flap},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {79},
   Number = {4},
   Pages = {305-311},
   Year = {1990} }



@article{
1530,
   Author = {Efron, B.},
   Title = {Missing data, imputation, and the bootstrap},
   Journal = {Journal of the American Statistical Association},
   Volume = {89  },
   Number = {426},
   Pages = {463-479},
   Year = {1994} }



@article{
1529,
   Author = {Efron, B.},
   Title = {Estimating the error rate of a prediction rule: improvement on cross-validation},
   Journal = {Journal of the American Statistical Association},
   Volume = {78  },
   Number = {382},
   Pages = {316-331},
   Year = {1983} }



@article{
1528,
   Author = {Lindley, C. M. and Sawyer, W. T. and Macik, B. G. and Lusher, J. and Harrison, J. F. and Baird-Cox, K. and Birch, K. and Glazer, S. and Roberts, H. R.},
   Title = {Pharmacokinetics and pharmacodynamics of recombinant factor VIIa},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {55},
   Number = {6},
   Pages = {638-648},
   Year = {1994} }



@article{
1527,
   Author = {Leff, P.},
   Title = {Analysis of agonist action using the operational model},
   Journal = {Trends in Pharmacological Sciences},
   Volume = {9},
   Number = {11},
   Pages = {395-398},
   Year = {1988} }



@article{
1526,
   Author = {Karnes, H. T. and Shiu, G. and Shah, V. P.},
   Title = {Validation of bioanalytical methods},
   Journal = {Pharmaceutical Research},
   Volume = {8},
   Number = {4},
   Pages = {421-426},
   Year = {1991} }



@article{
1525,
   Author = {Wilkinson, G. R.},
   Title = {Clearance approaches in pharmacology},
   Journal = {Pharmacological Reviews},
   Volume = {39},
   Number = {1},
   Pages = {1-47},
   Year = {1987} }



@article{
1524,
   Author = {Yamaoka, K. and Nakagawa, T. and Uno, T.},
   Title = {Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {6},
   Number = {2},
   Pages = {165-175},
   Year = {1978} }



@article{
1523,
   Author = {Selz, K. and Mandell, A.},
   Title = {Bernoulli partition-equivalence of intermittent neuronal discharge patterns},
   Journal = {International Journal of Bifurcation and Chaos},
   Volume = {1  },
   Number = {3},
   Pages = {717-722},
   Year = {1991} }



@article{
1522,
   Author = {Chan, G. L. and Matzke, G. R.},
   Title = {Effects of renal insufficiency on the pharmacokinetics and pharmacodynamics of opioid analgesics},
   Journal = {Drug Intelligence & Clinical Pharmacy},
   Volume = {21},
   Number = {10},
   Pages = {773-783},
   Year = {1987} }



@article{
1521,
   Author = {Fitzgerald, J.},
   Title = {Narcotic analgesics in renal failure},
   Journal = {Connecticut Medicine},
   Volume = {55},
   Number = {12},
   Pages = {701-704},
   Year = {1991} }



@article{
1520,
   Author = {Chiou, W. L.},
   Title = {The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I)},
   Journal = {Clinical Pharmacokinetics},
   Volume = {17},
   Number = {3},
   Pages = {175-199},
   Year = {1989} }



@article{
1519,
   Author = {Cook, R. D. and Critchley, F.},
   Title = {Identifying regression outliers and mixtures graphically},
   Journal = {Journal of the American Statistical Association},
   Volume = {95  },
   Number = {451},
   Pages = {781-794},
   Year = {2000} }



@article{
1518,
   Author = {Poulin, P. and Theil, F. P.},
   Title = {A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {89},
   Number = {1},
   Pages = {16-35},
   Year = {2000} }



@article{
1517,
   Author = {Darby, J. K. and Pasta, D. J. and Elfand, L. and Dabiri, L. and Clark, L. and Herbert, J.},
   Title = {Risperidone dose and blood level variability: accumulation effects and interindividual and intraindividual variability in the nonresponder patient in the clinical practice setting},
   Journal = {Journal of Clinical Psychopharmacology},
   Volume = {17},
   Number = {6},
   Pages = {478-484},
   Year = {1997} }



@article{
1516,
   Author = {Flores, C. M. and Wilson, S. G. and Mogil, J. S.},
   Title = {Pharmacogenetic variability in neuronal nicotinic receptor-mediated antinociception},
   Journal = {Pharmacogenetics},
   Volume = {9},
   Number = {5},
   Pages = {619-625},
   Year = {1999} }



@article{
1515,
   Author = {Clewell, H. J., III and Andersen, M. E. and Wills, R. J. and Latriano, L.},
   Title = {A physiologically based pharmacokinetic model for retinoic acid and its metabolites},
   Journal = {Journal of the American Academy of Dermatology},
   Volume = {36},
   Number = {3 Pt 2},
   Pages = {S77-S85},
   Year = {1997} }



@article{
1514,
   Author = {Nestorov, I. A.},
   Title = {Sensitivity analysis of pharmacokinetic and pharmacodynamic systems: I. A structural approach to sensitivity analysis of physiologically based pharmacokinetic models},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {6},
   Pages = {577-596},
   Year = {1999} }



@article{
1513,
   Author = {Hinkley, D. V.},
   Title = {Jackknife confidence limits using student t approximations},
   Journal = {Biometrika},
   Volume = {64  },
   Number = {1},
   Pages = {21-28},
   Year = {1977} }



@article{
1512,
   Author = {Landaw, E. M. and DiStefano, J. J., III},
   Title = {Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations},
   Journal = {American Journal of Physiology},
   Volume = {246},
   Number = {5 Pt 2},
   Pages = {R665-R677},
   Year = {1984} }



@article{
1511,
   Author = {Lemmens, H. J. and Dyck, J. B. and Shafer, S. L. and Stanski, D. R.},
   Title = {Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {56},
   Number = {3},
   Pages = {261-271},
   Year = {1994} }



@article{
1510,
   Author = {Breslow, N. E. and Clayton, D. G.},
   Title = {Approximate inference in generalized linear mixed models},
   Journal = {Journal of the American Statistical Association},
   Volume = {88  },
   Number = {421},
   Pages = {9-25},
   Year = {1993} }



@article{
1509,
   Author = {Laird, N. M. and Ware, J. H.},
   Title = {Random-effects models for longitudinal data},
   Journal = {Biometrics},
   Volume = {38},
   Number = {4},
   Pages = {963-974},
   Year = {1982} }



@incollection{
1508,
   Author = {de Bruijn, N. G. and Bruijn, N. G. and de Groot, J. and Zaanen, A.},
   Title = {The Laplace method for integrals},
   BookTitle = {Asymptotic methods in analysis},
   Series = {Bibliotheca Mathematica: A series of monographs on pure and applied mathematics},
   Publisher = {North-Holland Publishing Co.},
   Address = {Amsterdam},
   Volume = {second  },
   Pages = {60-76},
   Year = {1961} }



@incollection{
1507,
   Author = {de Bruijn, N. G. and de Groot, J. and Zaanen, A.},
   Title = {Introduction},
   BookTitle = {Asymptotic methods in analysis},
   Series = {Bibliotheca Mathematica: A series of monographs on pure and applied mathematics},
   Publisher = {North-Holland Publishing Co.},
   Address = {Amsterdam},
   Volume = {second  },
   Pages = {1-20},
   Year = {1961} }



@article{
1506,
   Author = {Tierney, L. and Kadane, J.},
   Title = {Accurate Approximations for Posterior Moments and Marginal Densities},
   Journal = {Journal of the American Statistical Association},
   Volume = {81  },
   Number = {393},
   Pages = {82-86},
   Year = {1986} }



@article{
1505,
   Author = {Wolfinger, R.},
   Title = {Laplace's approximation for nonlinear mixed models},
   Journal = {Biometrika},
   Volume = {80  },
   Number = {4},
   Pages = {791-795},
   Year = {1993} }



@techreport{
1504,
   Author = {Pinheiro, Jose C. and Bates, Douglas M.},
   Title = {Model building for nonlinear mixed effects models},
   Institution = {University of Wisconsin, Dept. of Biostatistics},
   Number = {91},
   Type = {11 p},
   Month= {May},
   Year = {1995} }



@article{
1503,
   Author = {Pinheiro, J. and Bates, D. M.},
   Title = {Approximations to the log-likelihood function in the nonlinear mixed-effects model},
   Journal = {Journal of Computational and Graphical Statistics},
   Volume = {4  },
   Number = {1},
   Pages = {12-35},
   Year = {1995} }



@article{
1502,
   Author = {Yu, D. K. and Hutcheson, S. J. and Wei, G. and Bhargava, V. O. and Weir, S. J.},
   Title = {A comparison of population and standard two-stage pharmacokinetic analyses of vigabatrin data},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {15},
   Number = {6},
   Pages = {473-484},
   Year = {1994} }



@incollection{
1501,
   Author = {Sheiner, L. B. and Beal, S. L. and Albert, K. S.},
   Title = {Analysis of Nonexperimental Pharmacokinetic Data},
   BookTitle = {Drug absorption and disposition: statistical considerations},
   Publisher = {American Pharmaceutical Association},
   Address = {Washington D.C.},
   Pages = {31 
 -49},
   Year = {1983} }



@article{
1500,
   Author = {Gelman, A. and Rubin, D. B.},
   Title = {Inference from iterative simulation using multiple sequences},
   Journal = {Statistical Science},
   Volume = {7  },
   Number = {4},
   Pages = {457-511},
   Year = {1992} }



@article{
1499,
   Author = {Gelfand, A. E. and Smith, A. F. and Lee, T.},
   Title = {Bayesian analysis of constrained parameter and truncated data problems using Gibbs sampling},
   Journal = {Journal of the American Statistical Association},
   Volume = {87},
   Number = {418},
   Pages = {523-532},
   Year = {1992} }



@article{
1498,
   Author = {Gelfand, A. E. and Smith, A. F.},
   Title = {Sampling-Based approaches to calculating marginal densities},
   Journal = {Journal of the American Statistical Association},
   Volume = {85  },
   Number = {410},
   Pages = {398-409},
   Year = {1990} }



@article{
1497,
   Author = {Wolfinger, R.},
   Title = {Tolerance intervals for variance component models using bayesian simulation},
   Journal = {Journal of Quality Technology},
   Volume = {30},
   Number = {1},
   Pages = {18-32},
   Year = {1998} }



@article{
1496,
   Author = {Merle, Y. and Mentre, F.},
   Title = {Optimal sampling times for Bayesian estimation of the pharmacokinetic parameters of nortriptyline during therapeutic drug monitoring},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {27},
   Number = {1},
   Pages = {85-101},
   Year = {1999} }



@article{
1495,
   Author = {Zhou, X. H. and Gao, S.},
   Title = {Confidence intervals for the log-normal mean},
   Journal = {Statistics in Medicine},
   Volume = {16},
   Number = {7},
   Pages = {783-790},
   Year = {1997} }



@article{
1494,
   Author = {Aarons, L. and Balant, L. P. and Mentre, F. and Morselli, P. L. and Rowland, M. and Steimer, J. L. and Vozeh, S.},
   Title = {Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {5},
   Pages = {389-391},
   Year = {1994} }



@article{
1493,
   Author = {Ten Have, T. R. and Localio, A. R.},
   Title = {Empirical Bayes estimation of random effects parameters in mixed effects logistic regression models},
   Journal = {Biometrics},
   Volume = {55},
   Number = {4},
   Pages = {1022-1029},
   Year = {1999} }



@article{
1492,
   Author = {Chouquet, C. and Richardson, S. and Burgard, M. and Blanche, S. and Mayaux, M. J. and Rouzioux, C. and Costagliola, D.},
   Title = {Timing of human immunodeficiency virus type 1 (HIV-1) transmission from mother to child: bayesian estimation using a mixture},
   Journal = {Statistics in Medicine},
   Volume = {18},
   Number = {7},
   Pages = {815-833},
   Year = {1999} }



@article{
1491,
   Author = {Rosner, G. L. and Muller, P.},
   Title = {Bayesian population pharmacokinetic and pharmacodynamic analyses using mixture models},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {25},
   Number = {2},
   Pages = {209-233},
   Year = {1997} }



@article{
1490,
   Author = {Royston, P. and Ferreira, A.},
   Title = {A new approach to modeling daily probabilities of conception},
   Journal = {Biometrics},
   Volume = {55},
   Number = {4},
   Pages = {1005-1013},
   Year = {1999} }



@article{
1489,
   Author = {Mallick, B. K. and Denison, D. G. and Smith, A. F.},
   Title = {Bayesian survival analysis using a MARS model},
   Journal = {Biometrics},
   Volume = {55},
   Number = {4},
   Pages = {1071-1077},
   Year = {1999} }



@article{
1488,
   Author = {Belin, T. R. and Rubin, D. B.},
   Title = {The analysis of repeated-measures data on schizophrenic reaction times using mixture models},
   Journal = {Statistics in Medicine},
   Volume = {14},
   Number = {8},
   Pages = {747-768},
   Year = {1995} }



@article{
1487,
   Author = {Rosner, G. L. and Muller, P.},
   Title = {Pharmacodynamic analysis of hematologic profiles},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {22},
   Number = {6},
   Pages = {499-524},
   Year = {1994} }



@article{
1486,
   Author = {Wakefield, J. and Walker, S.},
   Title = {A population approach to initial dose selection},
   Journal = {Statistics in Medicine},
   Volume = {16},
   Number = {10},
   Pages = {1135-1149},
   Year = {1997} }



@article{
1485,
   Author = {Rahman, N. J. and Wakefield, J. C. and Stephens, D. A. and Falcoz, C.},
   Title = {The Bayesian analysis of a pivotal pharmacokinetic study},
   Journal = {Statistical Methods in Medical Research},
   Volume = {8},
   Number = {3},
   Pages = {195-216},
   Year = {1999} }



@article{
1484,
   Author = {Jen, J. F. and Glue, P. and Ezzet, F. and Chung, C. and Gupta, S. K. and Jacobs, S. and Hajian, G.},
   Title = {Population pharmacokinetic analysis of pegylated interferon alfa-2b and interferon alfa-2b in patients with chronic hepatitis C},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {69},
   Number = {6},
   Pages = {407-421},
   Year = {2001} }



@article{
1483,
   Author = {Huitema, A. D. and Mathot, R. A. and Tibben, M. M. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {3},
   Pages = {211-230},
   Year = {2001} }



@article{
1482,
   Author = {van Zuylen, L. and Karlsson, M. O. and Verweij, J. and Brouwer, E. and de Bruijn, P. and Nooter, K. and Stoter, G. and Sparreboom, A.},
   Title = {Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {47},
   Number = {4},
   Pages = {309-318},
   Year = {2001} }



@article{
1481,
   Author = {Ploeger, B. and Mensinga, T. and Sips, A. and Deerenberg, C. and Meulenbelt, J. and DeJongh, J.},
   Title = {A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {170},
   Number = {1},
   Pages = {46-55},
   Year = {2001} }



@article{
1480,
   Author = {Mould, D. and Chapelsky, M. and Aluri, J. and Swagzdis, J. and Samuels, R. and Granett, J.},
   Title = {A population pharmacokinetic-pharmacodynamic and logistic regression analysis of lotrafiban in patients},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {69},
   Number = {4},
   Pages = {210-222},
   Year = {2001} }



@article{
1479,
   Author = {Kovarik, J. M. and Nashan, B. and Neuhaus, P. and Clavien, P. A. and Gerbeau, C. and Hall, M. L. and Korn, A.},
   Title = {A population pharmacokinetic screen to identify demographic-clinical covariates of basiliximab in liver transplantation},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {69},
   Number = {4},
   Pages = {201-209},
   Year = {2001} }



@article{
1478,
   Author = {Cullberg, M. and Eriksson, U. G. and Larsson, M. and Karlsson, M. O.},
   Title = {Population modelling of the effect of inogatran, at thrombin inhibitor, on ex vivo coagulation time (APTT) in healthy subjects and patients with coronary artery disease},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {1},
   Pages = {71-79},
   Year = {2001} }



@article{
1477,
   Author = {Brynne, L. and McNay, J. L. and Schaefer, H. G. and Swedberg, K. and Wiltse, C. G. and Karlsson, M. O.},
   Title = {Pharmacodynamic models for the cardiovascular effects of moxonidine in patients with congestive heart failure},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {1},
   Pages = {35-43},
   Year = {2001} }



@article{
1476,
   Author = {Frame, B. and Koup, J. and Miller, R. and Lalonde, R.},
   Title = {Population pharmacokinetics of clinafloxacin in healthy volunteers and patients with infections: experience with heterogeneous pharmacokinetic data},
   Journal = {Clinical Pharmacokinetics},
   Volume = {40},
   Number = {4},
   Pages = {307-315},
   Year = {2001} }



@article{
1475,
   Author = {Brynne, L. and Paalzow, L. K. and Karlsson, M. O.},
   Title = {Consequence of exercise on the cardiovascular effects of l-propranolol in spontaneously hypertensive rats},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {294},
   Number = {3},
   Pages = {1201-1208},
   Year = {2000} }



@article{
1474,
   Author = {Friberg, L. E. and Brindley, C. J. and Karlsson, M. O. and Devlin, A. J.},
   Title = {Models of schedule dependent haematological toxicity of 2'-deoxy-2'-methylidenecytidine (DMDC)},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {56},
   Number = {8},
   Pages = {567-574},
   Year = {2000} }



@article{
1473,
   Author = {Terret, C. and Erdociain, E. and Guimbaud, R. and Boisdron-Celle, M. and McLeod, H. L. and Fety-Deporte, R. and Lafont, T. and Gamelin, E. and Bugat, R. and Canal, P. and Chatelut, E.},
   Title = {Dose and time dependencies of 5-fluorouracil pharmacokinetics},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {68},
   Number = {3},
   Pages = {270-279},
   Year = {2000} }



@article{
1472,
   Author = {Karlsson, M. O. and Schoemaker, R. C. and Kemp, B. and Cohen, A. F. and van Gerven, J. M. and Tuk, B. and Peck, C. C. and Danhof, M.},
   Title = {A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {68},
   Number = {2},
   Pages = {175-188},
   Year = {2000} }



@article{
1471,
   Author = {Krecic-Shepard, M. E. and Park, K. and Barnas, C. and Slimko, J. and Kerwin, D. R. and Schwartz, J. B.},
   Title = {Race and sex influence clearance of nifedipine: results of a population study},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {68},
   Number = {2},
   Pages = {130-142},
   Year = {2000} }



@article{
1470,
   Author = {Kemme, M. J. and Burggraaf, J. and Schoemaker, R. C. and Paulson, S. and Karim, A. and Lentjes, E. G. and Childs, A. and Braeckman, R. A. and Cohen, A. F.},
   Title = {The influence of reduced liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue factor pathway inhibitor.PG},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {5},
   Year = {2000} }



@article{
1469,
   Author = {Karlsson, M. O. and Molnar, V. and Freijs, A. and Nygren, P. and Bergh, J. and Larsson, R.},
   Title = {Pharmacokinetic models for the saturable distribution of paclitaxel},
   Journal = {Drug Metabolism and Disposition: The Biological Fate of Chemicals},
   Volume = {27},
   Number = {10},
   Pages = {1220-1223},
   Year = {1999} }



@article{
1468,
   Author = {Romson, J. L. and Leung, J. M. and Bellows, W. H. and Bronstein, M. and Keith, F. and Moores, W. and Flachsbart, K. and Richter, R. and Pastor, D. and Fisher, D. M.},
   Title = {Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients},
   Journal = {Anesthesiology},
   Volume = {91},
   Number = {5},
   Pages = {1318-1328},
   Year = {1999} }



@article{
1467,
   Author = {Fisher, D. M. and Reynolds, K. S. and Schmith, V. D. and Hsu, J. and Sokoll, M. D. and Lennon, R. L. and Caldwell, J. E.},
   Title = {The influence of renal function on the pharmacokinetics and pharmacodynamics and simulated time course of doxacurium},
   Journal = {Anesthesia and Analgesia},
   Volume = {89},
   Number = {3},
   Pages = {786-795},
   Year = {1999} }



@article{
1466,
   Author = {Fisher, D. M. and Kahwaji, R. and Bevan, D. and Bikhazi, G. and Fragen, R. J. and Angst, M. S. and Ornstein, E. and Matteo, R. S.},
   Title = {Factors affecting the pharmacokinetic characteristics of rapacuronium},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {4},
   Pages = {993-1000},
   Year = {1999} }



@article{
1465,
   Author = {Mould, D. R. and Davis, C. B. and Minthorn, E. A. and Kwok, D. C. and Elliott, M. J. and Luggen, M. E. and Totoritis, M. C.},
   Title = {A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {66},
   Number = {3},
   Pages = {246-257},
   Year = {1999} }



@article{
1464,
   Author = {Funaki, T.},
   Title = {Enterohepatic circulation model for population pharmacokinetic analysis},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {51},
   Number = {10},
   Pages = {1143-1148},
   Year = {1999} }



@article{
1463,
   Author = {Albrecht, S. and Ihmsen, H. and Hering, W. and Geisslinger, G. and Dingemanse, J. and Schwilden, H. and Schuttler, J.},
   Title = {The effect of age on the pharmacokinetics and pharmacodynamics of midazolam},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {6},
   Pages = {630-639},
   Year = {1999} }



@article{
1462,
   Author = {Lalonde, R. L. and Gaudreault, J. and Karhu, D. A. and Marriott, T. B.},
   Title = {Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {1},
   Pages = {40-49},
   Year = {1999} }



@article{
1461,
   Author = {Tegeder, I. and Lotsch, J. and Krebs, S. and Muth-Selbach, U. and Brune, K. and Geisslinger, G.},
   Title = {Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state.PG},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {65},
   Number = {5},
   Year = {1999} }



@article{
1460,
   Author = {Szenohradszky, J. and Caldwell, J. E. and Wright, P. M. and Brown, R. and Lau, M. and Luks, A. M. and Fisher, D. M.},
   Title = {Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {1},
   Pages = {24-35},
   Year = {1999} }



@article{
1459,
   Author = {Wong, S. L. and Drajesk, J. and Chang, M. and Lanni, C. and Witt, G. and Hansen, R. and Awni, W. M.},
   Title = {Pharmacokinetics and pharmacodynamics of single and multiple oral doses of a novel 5-lipoxygenase inhibitor (ABT-761) in healthy volunteers.PG},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {63},
   Number = {3},
   Year = {1998} }



@article{
1458,
   Author = {Weiskopf, R. B. and Viele, M. K. and Feiner, J. and Kelley, S. and Lieberman, J. and Noorani, M. and Leung, J. M. and Fisher, D. M. and Murray, W. R. and Toy, P. and Moore, M. A.},
   Title = {Human cardiovascular and metabolic response to acute, severe isovolemic anemia},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {279},
   Number = {3},
   Pages = {217-221},
   Year = {1998} }



@article{
1457,
   Author = {Port, R. E. and Ding, R. W. and Fies, T. and Scharer, K.},
   Title = {Predicting the time course of haemoglobin in children treated with erythropoietin for renal anaemia},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {5},
   Pages = {461-466},
   Year = {1998} }



@article{
1456,
   Author = {Sundberg, J. and Jonsson, S. and Karlsson, M. O. and Hallen, I. P. and Oskarsson, A.},
   Title = {Kinetics of methylmercury and inorganic mercury in lactating and nonlactating mice},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {151},
   Number = {2},
   Pages = {319-329},
   Year = {1998} }



@article{
1455,
   Author = {Brynne, L. and Karlsson, M. O. and Paalzow, L. K.},
   Title = {Concentration-effect relationship of l-propranolol and metoprolol in spontaneous hypertensive rats after exercise-induced tachycardia.PG},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {286},
   Number = {3},
   Year = {1998} }



@article{
1454,
   Author = {Karlsson, M. O. and Molnar, V. and Bergh, J. and Freijs, A. and Larsson, R.},
   Title = {A general model for time-dissociated pharmacokinetic-pharmacodynamic relationship exemplified by paclitaxel myelosuppression},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {63},
   Number = {1},
   Pages = {11-25},
   Year = {1998} }



@article{
1453,
   Author = {Gardmark, M. and Karlsson, M. O. and Jonsson, F. and Hammarlund-Udenaes, M.},
   Title = {Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {87},
   Number = {7},
   Pages = {813-820},
   Year = {1998} }



@article{
1452,
   Author = {Karlsson, M. O. and Wade, J. R. and Loumaye, E. and Munafo, A.},
   Title = {The population pharmacokinetics of recombinant- and urinary-human follicle stimulating hormone in women},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {45},
   Number = {1},
   Pages = {13-20},
   Year = {1998} }



@article{
1451,
   Author = {Hempel, G. and Karlsson, M. O. and de Alwis, D. P. and Toublanc, N. and McNay, J. and Schaefer, H. G.},
   Title = {Population pharmacokinetic-pharmacodynamic modeling of moxonidine using 24-hour ambulatory blood pressure measurements},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {6},
   Pages = {622-635},
   Year = {1998} }



@article{
1450,
   Author = {Troconiz, I. F. and Garrido, M. J. and Garcia, E. and Suarez, E. and Calvo, R.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of mivacurium in rats},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {86},
   Number = {2},
   Pages = {252-256},
   Year = {1997} }



@article{
1449,
   Author = {Talke, P. and Richardson, C. A. and Scheinin, M. and Fisher, D. M.},
   Title = {Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine},
   Journal = {Anesthesia and Analgesia},
   Volume = {85},
   Number = {5},
   Pages = {1136-1142},
   Year = {1997} }



@article{
1448,
   Author = {Fisher, D. M. and Wright, P. M.},
   Title = {Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants?},
   Journal = {Anesthesiology},
   Volume = {86},
   Number = {3},
   Pages = {567-575},
   Year = {1997} }



@article{
1447,
   Author = {Fisher, D. M. and Ramsay, M. A. and Hein, H. A. and Marcel, R. J. and Sharma, M. and Ramsay, K. J. and Miller, R. D.},
   Title = {Pharmacokinetics of rocuronium during the three stages of liver transplantation},
   Journal = {Anesthesiology},
   Volume = {86},
   Number = {6},
   Pages = {1306-1316},
   Year = {1997} }



@article{
1446,
   Author = {Reynolds, L. M. and Lau, M. and Brown, R. and Luks, A. and Sharma, M. and Fisher, D. M.},
   Title = {Bioavailability of intramuscular rocuronium in infants and children},
   Journal = {Anesthesiology},
   Volume = {87},
   Number = {5},
   Pages = {1096-1105},
   Year = {1997} }



@article{
1445,
   Author = {Piotrovskij, V. and Van Peer, A.},
   Title = {A model with separate hepato-portal compartment ("first-pass" model): fitting to plasma concentration-time profiles in humans},
   Journal = {Pharmaceutical Research},
   Volume = {14},
   Number = {2},
   Pages = {230-237},
   Year = {1997} }



@article{
1444,
   Author = {Viele, M. K. and Weiskopf, R. B. and Fisher, D.},
   Title = {Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics},
   Journal = {Anesthesiology},
   Volume = {86},
   Number = {4},
   Pages = {848-858},
   Year = {1997} }



@article{
1443,
   Author = {Rydberg, T. and Jonsson, A. and Karlsson, M. O. and Melander, A.},
   Title = {Concentration-effect relations of glibenclamide and its active metabolites in man: modelling of pharmacokinetics and pharmacodynamics},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {43},
   Number = {4},
   Pages = {373-381},
   Year = {1997} }



@article{
1442,
   Author = {Samara, E. and Cao, G. and Locke, C. and Granneman, G. R. and Dean, R. and Killian, A.},
   Title = {Population analysis of the pharmacokinetics and pharmacodynamics of seratrodast in patients with mild to moderate asthma},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {4},
   Pages = {426-435},
   Year = {1997} }



@article{
1441,
   Author = {de Hoog, M. and Schoemaker, R. C. and Mouton, J. W. and van den Anker, J. N.},
   Title = {Tobramycin population pharmacokinetics in neonates},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {4},
   Pages = {392-399},
   Year = {1997} }



@article{
1440,
   Author = {Tuk, B. and Oberye, J. J. and Pieters, M. S. and Schoemaker, R. C. and Kemp, B. and van Gerven, J. and Danhof, M. and Kamphuisen, H. A. and Cohen, A. F. and Breimer, D. D. and Peck, C. C.},
   Title = {Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {4},
   Pages = {444-452},
   Year = {1997} }



@article{
1439,
   Author = {Karlsson, M. O. and Wade, J. R. and Loumaye, E. and Munafo, A.},
   Title = {A population model for the follicular growth in women treated with follicle stimulating hormone},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {6},
   Pages = {665-674},
   Year = {1997} }



@article{
1438,
   Author = {Racine-Poon, A. and Botta, L. and Chang, T. W. and Davis, F. M. and Gygax, D. and Liou, R. S. and Rohane, P. and Staehelin, T. and van Steijn, A. M. and Frank, W.},
   Title = {Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {6},
   Pages = {675-690},
   Year = {1997} }



@article{
1437,
   Author = {Hussein, Z. and Eaves, J. and Hutchinson, D. B. and Canfield, C. J.},
   Title = {Population pharmacokinetics of atovaquone in patients with acute malaria caused by Plasmodium falciparum},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {61},
   Number = {5},
   Pages = {518-530},
   Year = {1997} }



@article{
1436,
   Author = {Shangraw, R. E. and Fisher, D. M.},
   Title = {Pharmacokinetics of dichloroacetate in patients undergoing liver transplantation},
   Journal = {Anesthesiology},
   Volume = {84},
   Number = {4},
   Pages = {851-858},
   Year = {1996} }



@article{
1435,
   Author = {Murat, I. and Billard, V. and Vernois, J. and Zaouter, M. and Marsol, P. and Souron, R. and Farinotti, R.},
   Title = {Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches.PG},
   Journal = {Anesthesiology},
   Volume = {84},
   Number = {3},
   Year = {1996} }



@article{
1434,
   Author = {Hallen, I. P. and Jonsson, S. and Karlsson, M. O. and Oskarsson, A.},
   Title = {Toxicokinetics of lead in lactating and nonlactating mice},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {136},
   Number = {2},
   Pages = {342-347},
   Year = {1996} }



@article{
1433,
   Author = {Zhou, X. J. and Gruber, W. and Demmler, G. and Jacobs, R. and Reuman, P. and Adler, S. and Shelton, M. and Pass, R. and Britt, B. and Trang, J. M. and Whitley, R. J. and Sommadossi, J. P.},
   Title = {Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections. NIAID Collaborative Antiviral Study Group.PG},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {40},
   Number = {9},
   Year = {1996} }



@article{
1432,
   Author = {Gatti, G. and Merighi, M. and Hossein, J. and Travaini, S. and Casazza, R. and Karlsson, M. and Cruciani, M. and Bassetti, D.},
   Title = {Population pharmacokinetics of dapsone administered biweekly to human immunodeficiency virus-infected patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {40},
   Number = {12},
   Pages = {2743-2748},
   Year = {1996} }



@article{
1431,
   Author = {Korth-Bradley, J. M. and Rose, G. M. and de Vane, P. J. and Peters, J. and Chiang, S. T.},
   Title = {Population pharmacokinetics of intravenous amiodarone in patients with refractory ventricular tachycardia/fibrillation},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {36},
   Number = {8},
   Pages = {715-719},
   Year = {1996} }



@article{
1430,
   Author = {Thomson, A. H. and Kerr, S. and Wright, S.},
   Title = {Population pharmacokinetics of caffeine in neonates and young infants},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {18},
   Number = {3},
   Pages = {245-253},
   Year = {1996} }



@article{
1429,
   Author = {Troconiz, I. F. and Lopez-Bustamante, L. G. and Fos, D.},
   Title = {Tenoxicam pharmacokinetics in rats: a population model},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {84},
   Number = {12},
   Pages = {1482-1487},
   Year = {1995} }



@article{
1428,
   Author = {Bragg, P. and Zwass, M. S. and Lau, M. and Fisher, D. M.},
   Title = {Opioid pharmacodynamics in neonatal dogs: differences between morphine and fentanyl},
   Journal = {Journal of Applied Physiology},
   Volume = {79},
   Number = {5},
   Pages = {1519-1524},
   Year = {1995} }



@article{
1427,
   Author = {Holford, N. H. and Williams, P. E. and Muirhead, G. J. and Mitchell, A. and York, A.},
   Title = {Population pharmacodynamics of romazarit},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {39},
   Number = {3},
   Pages = {313-320},
   Year = {1995} }



@article{
1426,
   Author = {Liu, C. Y. and Sambol, N. C.},
   Title = {Pharmacodynamic analysis of analgesic clinical trials using empirical methods},
   Journal = {Pharmaceutical Research},
   Volume = {12},
   Number = {3},
   Pages = {438-445},
   Year = {1995} }



@article{
1425,
   Author = {Holford, N. H. and Peace, K.},
   Title = {The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {47},
   Number = {1},
   Pages = {17-23},
   Year = {1994} }



@article{
1424,
   Author = {Fisher, D. M.},
   Title = {Propofol in pediatrics. Lessons in pharmacokinetic modeling},
   Journal = {Anesthesiology},
   Volume = {80},
   Number = {1},
   Pages = {2-5},
   Year = {1994} }



@article{
1423,
   Author = {Grasela, T. H. and Fiedler-Kelly, J. B. and Salvadori, C. and Marey, C. and Jochemsen, R. and Loo, H.},
   Title = {Predictive performance of population pharmacokinetic parameters of tianeptine as applied to plasma concentrations from a post-marketing study},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {45},
   Number = {2},
   Pages = {123-128},
   Year = {1993} }



@article{
1422,
   Author = {Ganes, D. and Bansal, S. and Johnson, D. and Leal, M. and Nicolau, G. and Yacobi, A.},
   Title = {Population pharmacodynamic modeling of drug-induced anemia},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {82},
   Number = {5},
   Pages = {546-549},
   Year = {1993} }



@article{
1421,
   Author = {Grevel, J. and Post, B. K. and Kahan, B. D.},
   Title = {Michaelis-Menten kinetics determine cyclosporine steady-state concentrations: a population analysis in kidney transplant patients},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {53},
   Number = {6},
   Pages = {651-660},
   Year = {1993} }



@article{
1420,
   Author = {Kleinbloesem, C. H. and Weber, C. and Fahrner, E. and Dellenbach, M. and Welker, H. and Schroter, V. and Belz, G. G.},
   Title = {Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {53},
   Number = {5},
   Pages = {585-592},
   Year = {1993} }



@article{
1419,
   Author = {Holford, N. H. and Ambros, R. J. and Stoeckel, K.},
   Title = {Models for describing absorption rate and estimating extent of bioavailability: application to cefetamet pivoxil},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {5},
   Pages = {421-442},
   Year = {1992} }



@article{
1418,
   Author = {Schmitt, R. and Kleinbloesem, C. H. and Belz, G. G. and Schroeter, V. and Feifel, U. and Pozenel, H. and Kirch, W. and Halabi, A. and Woittiez, A. J. and Welker, H. A.},
   Title = {Hemodynamic and humoral effects of the novel calcium antagonist Ro 40- 5967 in patients with hypertension},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {52},
   Number = {3},
   Pages = {314-323},
   Year = {1992} }



@article{
1417,
   Author = {Aarons, L. and Mandema, J. W. and Danhof, M.},
   Title = {A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {5},
   Pages = {485-496},
   Year = {1991} }



@article{
1416,
   Author = {Wiest, D. B. and Pinson, J. B. and Gal, P. S. and Brundage, R. C. and Schall, S. and Ransom, J. L. and Weaver, R. L. and Purohit, D. and Brown, Y.},
   Title = {Population pharmacokinetics of intravenous indomethacin in neonates with symptomatic patent ductus arteriosus},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {49},
   Number = {5},
   Pages = {550-557},
   Year = {1991} }



@article{
1415,
   Author = {Fattinger, K. and Vozeh, S. and Olafsson, A. and Vlcek, J. and Wenk, M. and Follath, F.},
   Title = {Netilmicin in the neonate: population pharmacokinetic analysis and dosing recommendations},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {50},
   Number = {1},
   Pages = {55-65},
   Year = {1991} }



@article{
1414,
   Author = {Fattinger, K. and Vozeh, S. and Ha, H. R. and Borner, M. and Follath, F.},
   Title = {Population pharmacokinetics of quinidine},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {31},
   Number = {3},
   Pages = {279-286},
   Year = {1991} }



@article{
1413,
   Author = {Tanigawara, Y. and Hori, R. and Okumura, K. and Tsuji, J. and Shimizu, N. and Noma, S. and Suzuki, J. and Livingston, D. J. and Richards, S. M. and Keyes, L. D.},
   Title = {Pharmacokinetics in chimpanzees of recombinant human tissue-type plasminogen activator produced in mouse C127 and Chinese hamster ovary cells},
   Journal = {Chemical and Pharmaceutical Bulletin},
   Volume = {38},
   Number = {2},
   Pages = {517-522},
   Year = {1990} }



@article{
1412,
   Author = {Cohen, P. and Collart, L. and Prober, C. G. and Fischer, A. F. and Blaschke, T. F.},
   Title = {Gentamicin pharmacokinetics in neonates undergoing extracorporal membrane oxygenation},
   Journal = {The Pediatric Infectious Disease Journal},
   Volume = {9},
   Number = {8},
   Pages = {562-566},
   Year = {1990} }



@article{
1411,
   Author = {Aarons, L. and Vozeh, S. and Wenk, M. and Weiss, P. and Follath, F.},
   Title = {Population pharmacokinetics of tobramycin},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {28},
   Number = {3},
   Pages = {305-314},
   Year = {1989} }



@article{
1410,
   Author = {Moore, E. S. and Faix, R. G. and Banagale, R. C. and Grasela, T. H.},
   Title = {The population pharmacokinetics of theophylline in neonates and young infants},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {17},
   Number = {1},
   Pages = {47-66},
   Year = {1989} }



@article{
1409,
   Author = {Bach, V. and Carl, P. and Ravlo, O. and Crawford, M. E. and Jensen, A. G. and Mikkelsen, B. O. and Crevoisier, C. and Heizmann, P. and Fattinger, K.},
   Title = {A randomized comparison between midazolam and thiopental for elective cesarean section anesthesia: III. Placental transfer and elimination in neonates},
   Journal = {Anesthesia and Analgesia},
   Volume = {68},
   Number = {3},
   Pages = {238-242},
   Year = {1989} }



@article{
1408,
   Author = {Thomson, A. H. and Kelman, A. W. and de Vane, P. J. and Hillis, W. S. and Whiting, B.},
   Title = {Changes in lignocaine disposition during long-term infusion in patients with acute ventricular arrhythmias},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {9},
   Number = {3},
   Pages = {283-291},
   Year = {1987} }



@article{
1407,
   Author = {Maitre, P. O. and Vozeh, S. and Heykants, J. and Thomson, D. A. and Stanski, D. R.},
   Title = {Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients},
   Journal = {Anesthesiology},
   Volume = {66},
   Number = {1},
   Pages = {3-12},
   Year = {1987} }



@article{
1406,
   Author = {Miller, R. and Rheeders, M. and Klein, C. and Suchet, I.},
   Title = {Population pharmacokinetics of phenytoin in South African black patients},
   Journal = {South African Medical Journal},
   Volume = {72},
   Number = {3},
   Pages = {188-190},
   Year = {1987} }



@article{
1405,
   Author = {Ajayi, A. A. and Campbell, B. C. and Kelman, A. W. and Howie, C. and Meredith, P. A. and Reid, J. L.},
   Title = {Pharmacodynamics and population pharmacokinetics of enalapril and lisinopril},
   Journal = {International Journal of Clinical Pharmacology Research},
   Volume = {5},
   Number = {6},
   Pages = {419-427},
   Year = {1985} }



@article{
1404,
   Author = {Mungall, D. R. and Ludden, T. M. and Marshall, J. and Hawkins, D. W. and Talbert, R. L. and Crawford, M. H.},
   Title = {Population pharmacokinetics of racemic warfarin in adult patients},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {13},
   Number = {3},
   Pages = {213-227},
   Year = {1985} }



@article{
1403,
   Author = {Beal, S. L.},
   Title = {Ways to fit a PK model with some data below the quantification limit},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {5},
   Pages = {481-504},
   Year = {2001} }



@article{
1402,
   Author = {Laporte-Simitsidis, S. and Girard, P. and Mismetti, P. and Chabaud, S. and Decousus, H. and Boissel, J. P.},
   Title = {Inter-study variability in population pharmacokinetic meta-analysis: when and how to estimate it?},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {89},
   Number = {2},
   Pages = {155-167},
   Year = {2000} }



@article{
1401,
   Author = {Gardmark, M. and Brynne, L. and Hammarlund-Udenaes, M. and Karlsson, M. O.},
   Title = {Interchangeability and predictive performance of empirical tolerance models},
   Journal = {Clinical Pharmacokinetics},
   Volume = {36},
   Number = {2},
   Pages = {145-167},
   Year = {1999} }



@article{
1400,
   Author = {Sadray, S. and Jonsson, E. N. and Karlsson, M. O.},
   Title = {Likelihood-based diagnostics for influential individuals in non-linear mixed effects model selection},
   Journal = {Pharmaceutical Research},
   Volume = {16},
   Number = {8},
   Pages = {1260-1265},
   Year = {1999} }



@article{
1399,
   Author = {Karlsson, M. O. and Jonsson, E. N. and Wiltse, C. G. and Wade, J. R.},
   Title = {Assumption testing in population pharmacokinetic models: illustrated with an analysis of moxonidine data from congestive heart failure patients},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {26},
   Number = {2},
   Pages = {207-246},
   Year = {1998} }



@article{
1398,
   Author = {Jonsson, E. N. and Wade, J. R. and Almqvist, G. and Karlsson, M. O.},
   Title = {Discrimination between rival dosing histories},
   Journal = {Pharmaceutical Research},
   Volume = {14},
   Number = {8},
   Pages = {984-991},
   Year = {1997} }



@article{
1397,
   Author = {Jonsson, E. N. and Wade, J. R. and Karlsson, M. O.},
   Title = {Comparison of some practical sampling strategies for population pharmacokinetic studies},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {2},
   Pages = {245-263},
   Year = {1996} }



@article{
1396,
   Author = {Hashimoto, Y. and Koue, T. and Otsuki, Y. and Yasuhara, M. and Hori, R. and Inui, K.},
   Title = {Simulation for population analysis of Michaelis-Menten elimination kinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {2},
   Pages = {205-216},
   Year = {1995} }



@article{
1395,
   Author = {al Banna, M. K. and Kelman, A. W. and Whiting, B.},
   Title = {Experimental design and efficient parameter estimation in population pharmacokinetics},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {18},
   Number = {4},
   Pages = {347-360},
   Year = {1990} }



@article{
1394,
   Author = {Antal, E. J. and Grasela, T. H., Jr. and Smith, R. B.},
   Title = {An evaluation of population pharmacokinetics in therapeutic trials. Part III. Prospective data collection versus retrospective data assembly},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {46},
   Number = {5},
   Pages = {552-559},
   Year = {1989} }



@article{
1393,
   Author = {Grasela, T. H., Jr. and Antal, E. J. and Ereshefsky, L. and Wells, B. G. and Evans, R. L. and Smith, R. B.},
   Title = {An evaluation of population pharmacokinetics in therapeutic trials. Part II. Detection of a drug-drug interaction},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {42},
   Number = {4},
   Pages = {433-441},
   Year = {1987} }



@article{
1392,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model: routine clinical pharmacokinetic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {8},
   Number = {6},
   Pages = {553-571},
   Year = {1980} }



@article{
1391,
   Author = {Samara, E. and Granneman, R.},
   Title = {Role of population pharmacokinetics in drug development. A pharmaceutical industry perspective},
   Journal = {Clinical Pharmacokinetics},
   Volume = {32},
   Number = {4},
   Pages = {294-312},
   Year = {1997} }



@article{
1390,
   Author = {Yuh, L. and Beal, S. and Davidian, M. and Harrison, F. and Hester, A. and Kowalski, K. and Vonesh, E. and Wolfinger, R.},
   Title = {Population pharmacokinetic/pharmacodynamic methodology and applications: a bibliography},
   Journal = {Biometrics},
   Volume = {50},
   Number = {2},
   Pages = {566-575},
   Year = {1994} }



@article{
1389,
   Author = {Ludden, T. M.},
   Title = {Population pharmacokinetics},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {28},
   Number = {12},
   Pages = {1059-1063},
   Year = {1988} }



@article{
1388,
   Author = {Aarons, L.},
   Title = {The kinetics of flurbiprofen in synovial fluid},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {3},
   Pages = {265-269},
   Year = {1991} }



@article{
1369,
   Author = {Thomson, A. H. and Way, S. and Bryson, S. M. and McGovern, E. M. and Kelman, A. W. and Whiting, B.},
   Title = {Population pharmacokinetics of gentamicin in neonates},
   Journal = {Developmental Pharmacology and Therapeutics},
   Volume = {11},
   Number = {3},
   Pages = {173-179},
   Year = {1988} }



@article{
1364,
   Author = {Thomson, A. H. and Kelly, J. G. and Whiting, B.},
   Title = {Lisinopril population pharmacokinetics in elderly and renal disease patients with hypertension},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {27},
   Number = {1},
   Pages = {57-65},
   Year = {1989} }



@article{
1332,
   Author = {Uehlinger, D. E. and Gotch, F. A. and Sheiner, L. B.},
   Title = {A pharmacodynamic model of erythropoietin therapy for uremic anemia},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {51},
   Number = {1},
   Pages = {76-89},
   Year = {1992} }



@article{
1328,
   Author = {Verme, C. N. and Ludden, T. M. and Clementi, W. A. and Harris, S. C.},
   Title = {Pharmacokinetics of quinidine in male patients. A population analysis},
   Journal = {Clinical Pharmacokinetics},
   Volume = {22},
   Number = {6},
   Pages = {468-480},
   Year = {1992} }



@article{
1317,
   Author = {Kobayashi, K. and Jodrell, D. I. and Ratain, M. J.},
   Title = {Pharmacodynamic-pharmacokinetic relationships and therapeutic drug monitoring},
   Journal = {Cancer Surveys},
   Volume = {17},
   Pages = {51-78},
   Year = {1993} }



@article{
1298,
   Author = {Vielhaber, J. P. and Kuhlman, J. V. and Barrett, J. S.},
   Title = {Updating NONMEM IV installation and execution on the VAX 9000: DCL procedure for single-step execution},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {42},
   Number = {1},
   Pages = {71-72},
   Year = {1994} }



@article{
1297,
   Author = {De Gaetano, A. and Castagneto, M. and Mingrone, G. and Coleman, W. P. and Sganga, G. and Tataranni, P. A. and Gangeri, G. and Greco, A. V.},
   Title = {PC-based differential model fitting as a support for clinical research},
   Journal = {International Journal of Clinical Monitoring and Computing},
   Volume = {11},
   Number = {1},
   Pages = {35-41},
   Year = {1994} }



@article{
1291,
   Author = {Vielhaber, J. P. and Barrett, J. S.},
   Title = {NM-Win: a personal computer-based Microsoft Windows front-end to NONMEM IV},
   Journal = {Pharmaceutical Research},
   Volume = {11},
   Number = {5},
   Pages = {709-714},
   Year = {1994} }



@article{
1281,
   Author = {Tracewell, W. G. and Trump, D. L. and Vaughan, W. P. and Smith, D. C. and Gwilt, P. R.},
   Title = {Population pharmacokinetics of hydroxyurea in cancer patients},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {35},
   Number = {5},
   Pages = {417-422},
   Year = {1995} }



@article{
1279,
   Author = {Tanigawara, Y. and Nomura, H. and Kagimoto, N. and Okumura, K. and Hori, R.},
   Title = {Premarketing population pharmacokinetic study of levofloxacin in normal subjects and patients with infectious diseases},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {18},
   Number = {2},
   Pages = {315-320},
   Year = {1995} }



@article{
1261,
   Author = {Tanigawara, Y. and Komada, F. and Shimizu, T. and Iwakawa, S. and Iwai, T. and Maekawa, H. and Hori, R. and Okumura, K.},
   Title = {Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {18},
   Number = {11},
   Pages = {1590-1598},
   Year = {1995} }



@article{
1254,
   Author = {Triggs, E. J. and Charles, B. G. and Contin, M. and Martinelli, P. and Cortelli, P. and Riva, R. and Albani, F. and Baruzzi, A.},
   Title = {Population pharmacokinetics and pharmacodynamics of oral levodopa in parkinsonian patients},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {1},
   Pages = {59-67},
   Year = {1996} }



@article{
1251,
   Author = {Banfield, C. R. and Zhu, G. R. and Jen, J. F. and Jensen, P. K. and Schumaker, R. C. and Perhach, J. L. and Affrime, M. B. and Glue, P.},
   Title = {The effect of age on the apparent clearance of felbamate: a retrospective analysis using nonlinear mixed-effects modeling},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {18},
   Number = {1},
   Pages = {19-29},
   Year = {1996} }



@article{
1250,
   Author = {Bauer, L. A. and Horn, J. R. and Pettit, H.},
   Title = {Mixed-effect modeling for detection and evaluation of drug interactions: digoxin-quinidine and digoxin-verapamil combinations},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {18},
   Number = {1},
   Pages = {46-52},
   Year = {1996} }



@article{
1229,
   Author = {De Gaetano, A. and Mingrone, G. and Castageneto, M.},
   Title = {NONMEM improves group parameter estimation for the minimal model of glucose kinetics},
   Journal = {American Journal of Physiology},
   Volume = {271},
   Number = {5 Pt 1},
   Pages = {E932-E937},
   Year = {1996} }



@article{
1197,
   Author = {Tracewell, W. G. and Stalker, D. J. and Maloley, P. A. and Gallagher, T. F. and Gwilt, P. R.},
   Title = {Population pharmacokinetics of glyburide in patients with well- controlled diabetes},
   Journal = {Pharmacotherapy},
   Volume = {18},
   Number = {1},
   Pages = {51-56},
   Year = {1998} }



@article{
1190,
   Author = {Tod, M. and Lortholary, O. and Seytre, D. and Semaoun, R. and Uzzan, B. and Guillevin, L. and Casassus, P. and Petitjean, O.},
   Title = {Population pharmacokinetic study of amikacin administered once or twice daily to febrile, severely neutropenic adults},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {42},
   Number = {4},
   Pages = {849-856},
   Year = {1998} }



@article{
1185,
   Author = {Yano, I. and Takayama, A. and Takano, M. and Inatani, M. and Tanihara, H. and Ogura, Y. and Honda, Y. and Inui, K.},
   Title = {Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {54},
   Number = {1},
   Pages = {63-68},
   Year = {1998} }



@article{
1183,
   Author = {Cox, E. H. and Langemeijer, M. W. and Danhof, M.},
   Title = {Pharmacokinetic-pharmacodynamic modelling of the analgesic effect of alfentanil in the rat using tooth pulp evoked potentials},
   Journal = {Journal of Pharmacological and Toxicological Methods},
   Volume = {39},
   Number = {1},
   Pages = {19-27},
   Year = {1998} }



@article{
1174,
   Author = {Troconiz, I. F. and Naukkarinen, T. H. and Ruottinen, H. M. and Rinne, U. K. and Gordin, A. and Karlsson, M. O.},
   Title = {Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {1},
   Pages = {106-116},
   Year = {1998} }



@article{
1171,
   Author = {de Alwis, D. P. and Aarons, L. and Palmer, J. L.},
   Title = {Population pharmacokinetics of ondansetron: a covariate analysis},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {2},
   Pages = {117-125},
   Year = {1998} }



@article{
1169,
   Author = {Tanikawa, K. and Matsumoto, Y. and Matsumoto, M. and Fukuoka, M.},
   Title = {Development of a computer program, MDGP, for population pharmacokinetic analysis written using ANSI C language on wide platforms},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {21},
   Number = {8},
   Pages = {847-852},
   Year = {1998} }



@article{
1152,
   Author = {Chu, X. M. and Rui, J. Z. and Zhou, Y. G. and Dai, Y. J. and Cai, W. M. and Ling, S. S.},
   Title = {[Analysis of population pharmacokinetics with NONMEM in clinical patients treated with amikacin by intravenous infusion]},
   Journal = {Yao Xue Xue Bao - Acta Pharmaceutica Sinica},
   Volume = {31},
   Number = {12},
   Pages = {881-885},
   Year = {1996} }



@article{
1139,
   Author = {Bailey, J. M. and Miller, B. E. and Lu, W. and Tosone, S. R. and Kanter, K. R. and Tam, V. K.},
   Title = {The pharmacokinetics of milrinone in pediatric patients after cardiac surgery},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {4},
   Pages = {1012-1018},
   Year = {1999} }



@article{
1098,
   Author = {de Hoog, M. and Schoemaker, R. C. and Mouton, J. W. and van den Anker, J. N.},
   Title = {Vancomycin population pharmacokinetics in neonates},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {4},
   Pages = {360-367},
   Year = {2000} }



@article{
1055,
   Author = {Chan, E. and Lee, H. S. and Hue, S. S.},
   Title = {Population pharmacokinetics of carbamazepine in Singapore epileptic patients},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {6},
   Pages = {567-576},
   Year = {2001} }



@article{
1054,
   Author = {Baas, H. and Zehrden, F. and Selzer, R. and Kohnen, R. and Loetsch, J. and Harder, S.},
   Title = {Pharmacokinetic-pharmacodynamic relationship of levodopa with and without tolcapone in patients with Parkinson's disease},
   Journal = {Clinical Pharmacokinetics},
   Volume = {40},
   Number = {5},
   Pages = {383-393},
   Year = {2001} }



@article{
1048,
   Author = {Deleu, D. and Aarons, L. and Ahmed, I. A.},
   Title = {Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {57},
   Number = {3},
   Pages = {243-248},
   Year = {2001} }



@article{
1039,
   Author = {Fukatsu, S. and Yano, I. and Igarashi, T. and Hashida, T. and Takayanagi, K. and Saito, H. and Uemoto, S. and Kiuchi, T. and Tanaka, K. and Inui, K.},
   Title = {Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {57},
   Number = {6-7},
   Pages = {479-484},
   Year = {2001} }



@article{
1038,
   Author = {Yukawa, E. and Suematu, F. and Yukawa, M. and Minemoto, M. and Ohdo, S. and Higuchi, S. and Goto, Y. and Aoyama, T.},
   Title = {Population pharmacokinetics of digoxin in Japanese patients: a 2- compartment pharmacokinetic model},
   Journal = {Clinical Pharmacokinetics},
   Volume = {40},
   Number = {10},
   Pages = {773-781},
   Year = {2001} }



@article{
1037,
   Author = {Comets, E. and Mentre, F.},
   Title = {Evaluation of tests based on individual versus population modeling to compare dissolution curves},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {11},
   Number = {3},
   Pages = {107-123},
   Year = {2001} }



@article{
1036,
   Author = {Edstein, M. D. and Kocisko, D. A. and Brewer, T. G. and Walsh, D. S. and Eamsila, C. and Charles, B. G.},
   Title = {Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {52},
   Number = {6},
   Pages = {663-670},
   Year = {2001} }



@article{
1035,
   Author = {Ouellet, D. and Bockbrader, H. N. and Wesche, D. L. and Shapiro, D. Y. and Garofalo, E.},
   Title = {Population pharmacokinetics of gabapentin in infants and children},
   Journal = {Epilepsy Research},
   Volume = {47},
   Number = {3},
   Pages = {229-241},
   Year = {2001} }



@article{
1034,
   Author = {Jonsson, E. N. and Wade, J. R. and Karlsson, M. O.},
   Title = {Nonlinearity detection: advantages of nonlinear mixed-effects modeling},
   Journal = {AAPS PharmSci},
   Volume = {2},
   Number = {3},
   Pages = {E32},
   Year = {2000} }



@article{
1033,
   Author = {Lalezari, J. P. and Friedberg, D. N. and Bissett, J. and Giordano, M. F. and Hardy, W. D. and Drew, W. L. and Hubbard, L. D. and Buhles, W. C. and Stempien, M. J. and Georgiou, P. and Jung, D. T. and Robinson, C. A.},
   Title = {High dose oral ganciclovir treatment for cytomegalovirus retinitis},
   Journal = {Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology},
   Volume = {24},
   Number = {1-2},
   Pages = {67-77},
   Year = {2002} }



@article{
1032,
   Author = {Leger, F. and Seronie-Vivien, S. and Makdessi, J. and Lochon, I. and Delord, J. P. and Sarda, C. and Canal, P. and Chatelut, E.},
   Title = {Impact of the biochemical assay for serum creatinine measurement on the individual carboplatin dosing: a prospective study},
   Journal = {European Journal of Cancer},
   Volume = {38},
   Number = {1},
   Pages = {52-56},
   Year = {2002} }



@article{
1031,
   Author = {Hing, J. P. and Woolfrey, S. G. and Greenslade, D. and Wright, P. M.},
   Title = {Analysis of toxicokinetic data using NONMEM: impact of quantification limit and replacement strategies for censored data},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {5},
   Pages = {465-479},
   Year = {2001} }



@article{
1030,
   Author = {Ririe, D. G. and James, R. L. and O'Brien, J. J. and Lin, Y. A. and Bennett, J. and Barclay, D. and Hines, M. H. and Butterworth, J. F.},
   Title = {The pharmacokinetics of epsilon-aminocaproic acid in children undergoing surgical repair of congenital heart defects},
   Journal = {Anesthesia and Analgesia},
   Volume = {94},
   Number = {1},
   Pages = {44-9, table},
   Year = {2002} }



@article{
1029,
   Author = {Jacobson, P. and Ng, J. and Ratanatharathorn, V. and Uberti, J. and Brundage, R. C.},
   Title = {Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients},
   Journal = {Bone Marrow Transplantation},
   Volume = {28},
   Number = {8},
   Pages = {753-758},
   Year = {2001} }



@article{
1028,
   Author = {Hussein, R. and Charles, B. G. and Morris, R. G. and Rasiah, R. L.},
   Title = {Population pharmacokinetics of perhexiline from very sparse, routine monitoring data},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {23},
   Number = {6},
   Pages = {636-643},
   Year = {2001} }



@article{
1027,
   Author = {Huitema, A. D. and Mathot, R. A. and Tibben, M. M. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {Validation of a therapeutic drug monitoring strategy for thiotepa in a high-dose chemotherapy regimen},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {23},
   Number = {6},
   Pages = {650-657},
   Year = {2001} }



@article{
1026,
   Author = {Yukawa, E. and Satou, M. and Nonaka, T. and Yukawa, M. and Ohdo, S. and Higuchi, S. and Kuroda, T. and Goto, Y.},
   Title = {Pharmacoepidemiologic investigation of clonazepam relative clearance by mixed-effect modeling using routine clinical pharmacokinetic data in Japanese patients},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {42},
   Number = {1},
   Pages = {81-88},
   Year = {2002} }



@article{
1025,
   Author = {Schadeli, F. and Marti, H. P. and Frey, F. J. and Uehlinger, D. E.},
   Title = {Population pharmacokinetic model to predict steady-state exposure to once-daily cyclosporin microemulsion in renal transplant recipients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {41},
   Number = {1},
   Pages = {59-69},
   Year = {2002} }



@article{
1024,
   Author = {Xuan, D. and Ye, M. and Kim, M. and Nightingale, C. H. and Nicolau, D. P.},
   Title = {Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: a population approach},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {54},
   Number = {1},
   Pages = {71-75},
   Year = {2002} }



@article{
1023,
   Author = {Tateishi, M. and Ebihara, A.},
   Title = {Population Pharmacokinetics of Digoxin in Duchenne Muscular Dystrophy (DMD) Patients},
   Journal = {American Journal of Therapeutics},
   Volume = {1},
   Number = {2},
   Pages = {144-149},
   Year = {1994} }



@article{
1022,
   Author = {Gobburu, J. V. and Lawrence, J.},
   Title = {Application of resampling techniques to estimate exact significance levels for covariate selection during nonlinear mixed effects model building: some inferences},
   Journal = {Pharmaceutical Research},
   Volume = {19},
   Number = {1},
   Pages = {92-98},
   Year = {2002} }



@article{
1021,
   Author = {Sale, M. and Sadler, B. M. and Stein, D. S.},
   Title = {Pharmacokinetic modeling and simulations of interaction of amprenavir and ritonavir},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {46},
   Number = {3},
   Pages = {746-754},
   Year = {2002} }



@article{
1020,
   Author = {Olofsen, E. and Sleigh, J. W. and Dahan, A.},
   Title = {The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG},
   Journal = {Anesthesiology},
   Volume = {96},
   Number = {3},
   Pages = {555-564},
   Year = {2002} }



@article{
1019,
   Author = {Avramis, V. I. and Sencer, S. and Periclou, A. P. and Sather, H. and Bostrom, B. C. and Cohen, L. J. and Ettinger, A. G. and Ettinger, L. J. and Franklin, J. and Gaynon, P. S. and Hilden, J. M. and Lange, B. and Majlessipour, F. and Mathew, P. and Needle, M. and Neglia, J. and Reaman, G. and Holcenberg, J. S.},
   Title = {A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study},
   Journal = {Blood},
   Volume = {99},
   Number = {6},
   Pages = {1986-1994},
   Year = {2002} }



@article{
1018,
   Author = {Yukawa, E. and Hokazono, T. and Yukawa, M. and Ichimaru, R. and Maki, T. and Matsunaga, K. and Ohdo, S. and Anai, M. and Higuchi, S. and Goto, Y.},
   Title = {Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {41},
   Number = {2},
   Pages = {153-159},
   Year = {2002} }



@article{
1017,
   Author = {Koprowski, S. P., Jr. and Barrett, J. S.},
   Title = {Data warehouse implementation with clinical pharmacokinetic/pharmacodynamic data},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {40},
   Number = {3},
   Pages = {S14-S29},
   Year = {2002} }



@article{
1016,
   Author = {Crul, M. and Mathot, R. A. and Giaccone, G. and Punt, C. A. and Rosing, H. and Hillebrand, M. X. and Ando, Y. and Nishi, N. and Tanaka, H. and Schellens, J. M. and Beijnen, J. H.},
   Title = {Population pharmacokinetics of the novel anticancer agent KRN7000},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {49},
   Number = {4},
   Pages = {287-293},
   Year = {2002} }



@article{
1015,
   Author = {Kirchheiner, J. and Brockmoller, J. and Meineke, I. and Bauer, S. and Rohde, W. and Meisel, C. and Roots, I.},
   Title = {Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {71},
   Number = {4},
   Pages = {286-296},
   Year = {2002} }



@article{
1014,
   Author = {De Maat, M. M. and Huitema, A. D. and Mulder, J. W. and Meenhorst, P. L. and Van Gorp, E. C. and Beijnen, J. H.},
   Title = {Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {53},
   Number = {5},
   Pages = {552P},
   Year = {2002} }



@article{
1013,
   Author = {Van Den Bongard, H. J. and Mathot, R. A. and Van Tellingen, O. and Schellens, J. H. and Beijnen, J. H.},
   Title = {A population pharmacokinetic model for Cremophor EL using nonlinear mixed-effect modeling: model building and validation},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {53},
   Number = {5},
   Pages = {552P-553P},
   Year = {2002} }



@article{
1012,
   Author = {Shi, J. and Ludden, T. M. and Melikian, A. P. and Gastonguay, M. R. and Hinderling, P. H.},
   Title = {Population pharmacokinetics and pharmacodynamics of sotalol in pediatric patients with supraventricular or ventricular tachyarrhythmia},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {6},
   Pages = {555-575},
   Year = {2001} }



@article{
1011,
   Author = {Batey, M. A. and Wright, J. G. and Azzabi, A. and Newell, D. R. and Lind, M. J. and Calvert, A. H. and Boddy, A. V.},
   Title = {Population pharmacokinetics of adjuvant cyclophosphamide, methotrexate and 5-fluorouracil (CMF)},
   Journal = {European Journal of Cancer},
   Volume = {38},
   Number = {8},
   Pages = {1081-1089},
   Year = {2002} }



@article{
1010,
   Author = {de Hoog, M. and Schoemaker, R. C. and van den Anker, J. N. and Vinks, A. A.},
   Title = {NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {24},
   Number = {3},
   Pages = {359-365},
   Year = {2002} }



@article{
1009,
   Author = {Aso, R. and Ohashi, K. and Katoh, T. and Ogata, H.},
   Title = {Population pharmacokinetics, protein binding and antiarrhythmic effects of disopyramide enantiomers in arrhythmic patients},
   Journal = {International Journal of Clinical Pharmacology Research},
   Volume = {21},
   Number = {3-4},
   Pages = {137-146},
   Year = {2001} }



@article{
1008,
   Author = {Van Den Bongard, H. J. and Mathot, R. A. and Van Tellingen, O. and Schellens, J. H. and Beijnen, J. H.},
   Title = {A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {50},
   Number = {1},
   Pages = {16-24},
   Year = {2002} }



@article{
1007,
   Author = {Rodriguez, M. and Carlos, M. A. and Ortega, I. and Suarez, E. and Calvo, R. and Lukas, J. C.},
   Title = {Sex specificity in methadone analgesia in the rat: a population pharmacokinetic and pharmacodynamic approach},
   Journal = {Pharmaceutical Research},
   Volume = {19},
   Number = {6},
   Pages = {858-867},
   Year = {2002} }



@article{
1006,
   Author = {Meyer-Barner, M. and Meineke, I. and Schreeb, K. H. and Gleiter, C. H.},
   Title = {Pharmacokinetics of doxepin and desmethyldoxepin: an evaluation with the population approach},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {58},
   Number = {4},
   Pages = {253-257},
   Year = {2002} }



@article{
1005,
   Author = {Xie, R. and Mathijssen, R. H. and Sparreboom, A. and Verweij, J. and Karlsson, M. O.},
   Title = {Clinical pharmacokinetics of irinotecan and its metabolites: a population analysis},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {20},
   Number = {15},
   Pages = {3293-3301},
   Year = {2002} }



@article{
1004,
   Author = {Furuya, A. and Nozawa, M. and Gotoh, J. and Jingu, S. and Akimoto, M. and Higuchi, S. and Suwa, T. and Ogata, H.},
   Title = {Pharmacokinetic and pharmacodynamic analysis of TS-943, a selective non- peptide platelet glycoprotein-IIb/IIIa (GPIIb/IIIa) receptor antagonist, using a nonlinear mixed effect model in dogs},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {54},
   Number = {7},
   Pages = {921-927},
   Year = {2002} }



@article{
1003,
   Author = {Panteix, G. and Beaujard, A. and Garbit, F. and Chaduiron-Faye, C. and Guillaumont, M. and Gilly, F. and Baltassat, P. and Bressolle, F.},
   Title = {Population pharmacokinetics of cisplatin in patients with advanced ovarian cancer during intraperitoneal hyperthermia chemotherapy},
   Journal = {Anticancer Research},
   Volume = {22},
   Number = {2B},
   Pages = {1329-1336},
   Year = {2002} }



@article{
1002,
   Author = {Rouits, E. and Guichard, S. and Canal, P. and Chatelut, E.},
   Title = {Non-linear pharmacokinetics of irinotecan in mice},
   Journal = {Anticancer Drugs},
   Volume = {13},
   Number = {6},
   Pages = {631-635},
   Year = {2002} }



@article{
1001,
   Author = {Svensson, U. S. and Alin, H. and Karlsson, M. O. and Bergqvist, Y. and Ashton, M.},
   Title = {Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {58},
   Number = {5},
   Pages = {339-351},
   Year = {2002} }



@article{
973,
   Author = {Yano, I. and Tanigawara, Y. and Yasuhara, M. and Mikawa, H. and Hori, R.},
   Title = {Population pharmacokinetics of theophylline. I: Intravenous infusion to children in the acute episode of asthma},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {16},
   Number = {1},
   Pages = {59-62},
   Year = {1993} }



@article{
972,
   Author = {Yano, I. and Tanigawara, Y. and Yasuhara, M. and Okumura, K. and Kawakatsu, K. and Nishimura, K. and Hori, R.},
   Title = {Population pharmacokinetics of theophylline. II: Intravenous infusion to patients with stable chronic airway obstruction},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {16},
   Number = {5},
   Pages = {501-505},
   Year = {1993} }



@article{
970,
   Author = {Yamamoto, N. and Tamura, T. and Karato, A. and Uenaka, K. and Eguchi, K. and Shinkai, T. and Ohe, Y. and Oshita, F. and Arioka, H. and Nakashima, H.},
   Title = {CPT-11: population pharmacokinetic model and estimation of pharmacokinetics using the Bayesian method in patients with lung cancer},
   Journal = {Japanese Journal of Cancer Research},
   Volume = {85},
   Number = {9},
   Pages = {972-977},
   Year = {1994} }



@article{
967,
   Author = {Wu, H. and Ding, A. A.},
   Title = {Population HIV-1 dynamics in vivo: applicable models and inferential tools for virological data from AIDS clinical trials},
   Journal = {Biometrics},
   Volume = {55},
   Number = {2},
   Pages = {410-418},
   Year = {1999} }



@article{
954,
   Author = {Wheeler, L. A. and Sheiner, L. B.},
   Title = {Delta check tables for the Technicon SMA 6 continuous-flow analyzer},
   Journal = {Clinical Chemistry},
   Volume = {23},
   Number = {2 PT. 1},
   Pages = {216-219},
   Year = {1977} }



@article{
947,
   Author = {Wang, B. and Ludden, T. M. and Cheung, E. N. and Schwab, G. G. and Roskos, L. K.},
   Title = {Population pharmacokinetic-pharmacodynamic modeling of filgrastim (r- metHuG-CSF) in healthy volunteers},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {4},
   Pages = {321-342},
   Year = {2001} }



@article{
945,
   Author = {Wahlby, U. and Jonsson, E. N. and Karlsson, M. O.},
   Title = {Assessment of actual significance levels for covariate effects in NONMEM},
   Journal = {Journal of Pharmacokinetics and Pharmacodynamics},
   Volume = {28},
   Number = {3},
   Pages = {231-252},
   Year = {2001} }



@article{
935,
   Author = {Vozeh, S. and Muir, K. T. and Sheiner, L. B. and Follath, F.},
   Title = {Predicting individual phenytoin dosage},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {9},
   Number = {2},
   Pages = {131-146},
   Year = {1981} }



@article{
934,
   Author = {Vozeh, S. and Powell, J. R. and Cupit, G. C. and Riegelman, S. and Sheiner, L. B.},
   Title = {Influence of allopurinol on theophylline disposition in adults},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {27},
   Number = {2},
   Pages = {194-197},
   Year = {1980} }



@article{
933,
   Author = {Vozeh, S. and Powell, J. R. and Riegelman, S. and Costello, J. F. and Sheiner, L. B. and Hopewell, P. C.},
   Title = {Changes in theophylline clearance during acute illness},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {240},
   Number = {17},
   Pages = {1882-1884},
   Year = {1978} }



@article{
932,
   Author = {Vonesh, E. F. and Carter, R. L.},
   Title = {Mixed-effects nonlinear regression for unbalanced repeated measures},
   Journal = {Biometrics},
   Volume = {48},
   Number = {1},
   Pages = {1-17},
   Year = {1992} }



@article{
927,
   Author = {Verotta, D. and Sheiner, L. B.},
   Title = {Comparing responses when each response is a curve},
   Journal = {American Journal of Physiology},
   Volume = {263},
   Number = {1 Pt 2},
   Pages = {R206-R214},
   Year = {1992} }



@article{
926,
   Author = {Verotta, D. and Sheiner, L. B. and Beal, S. L.},
   Title = {Mean time parameters for generalized physiological flow models (semihomogeneous linear systems)},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {3},
   Pages = {319-331},
   Year = {1991} }



@article{
925,
   Author = {Verotta, D. and Kitts, J. and Rodriguez, R. and Coldwell, J. and Miller, R. D. and Sheiner, L. B.},
   Title = {Reversal of neuromuscular blockade in humans by neostigmine and edrophonium: a mathematical model},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {6},
   Pages = {713-729},
   Year = {1991} }



@article{
924,
   Author = {Verotta, D. and Sheiner, L. B.},
   Title = {Semiparametric analysis of non-steady-state pharmacodynamic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {6},
   Pages = {691-712},
   Year = {1991} }



@article{
918,
   Author = {Vanhove, G. F. and Kastrissios, H. and Gries, J. M. and Verotta, D. and Park, K. and Collier, A. C. and Squires, K. and Sheiner, L. B. and Blaschke, T. F.},
   Title = {Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {41},
   Number = {11},
   Pages = {2428-2432},
   Year = {1997} }



@article{
917,
   Author = {Vanhove, G. F. and Gries, J. M. and Verotta, D. and Sheiner, L. B. and Coombs, R. and Collier, A. C. and Blaschke, T. F.},
   Title = {Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {41},
   Number = {11},
   Pages = {2433-2438},
   Year = {1997} }



@article{
908,
   Author = {Troconiz, I. F. and Sheiner, L. B. and Verotta, D.},
   Title = {Semiparametric models for antagonistic drug interactions},
   Journal = {Journal of Applied Physiology},
   Volume = {76},
   Number = {5},
   Pages = {2224-2233},
   Year = {1994} }



@article{
903,
   Author = {Tod, M. and Padoin, C. and Minozzi, C. and Cougnard, J. and Petitjean, O.},
   Title = {Population pharmacokinetic study of isepamicin with intensive care unit patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {40},
   Number = {4},
   Pages = {983-987},
   Year = {1996} }



@article{
902,
   Author = {Tod, M. and Pobel, C. and Le, Gros V. and Louchahi, K. and Petitjean, O. and Brion, N. and Garcia-Mace, J. L.},
   Title = {A population pharmacokinetic study of alminoprofen penetration into synovial fluid},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {16},
   Number = {8},
   Pages = {627-634},
   Year = {1995} }



@article{
899,
   Author = {Taright, N. and Mentre, F. and Mallet, A. and Jouvent, R.},
   Title = {Nonparametric estimation of population characteristics of the kinetics of lithium from observational and experimental data: individualization of chronic dosing regimen using a new Bayesian approach},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {16},
   Number = {3},
   Pages = {258-269},
   Year = {1994} }



@article{
895,
   Author = {Takama, H. and Tanaka, H. and Sudo, T. and Tamura, T. and Tanigawara, Y.},
   Title = {Population pharmacokinetic modeling and model validation of a spicamycin derivative, KRN5500, in phase 1 study},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {47},
   Number = {5},
   Pages = {404-410},
   Year = {2001} }



@article{
886,
   Author = {Staatz, C. E. and Taylor, P. J. and Lynch, S. V. and Willis, C. and Charles, B. G. and Tett, S. E.},
   Title = {Population pharmacokinetics of tacrolimus in children who receive cut- down or full liver transplants},
   Journal = {Transplantation},
   Volume = {72},
   Number = {6},
   Pages = {1056-1061},
   Year = {2001} }



@article{
879,
   Author = {Shi, J. and Benowitz, N. L. and Denaro, C. P. and Sheiner, L. B.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of caffeine: tolerance to pressor effects},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {53},
   Number = {1},
   Pages = {6-14},
   Year = {1993} }



@article{
876,
   Author = {Sheiner, L. B.},
   Title = {Learning versus confirming in clinical drug development},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {61},
   Number = {3},
   Pages = {275-291},
   Year = {1997} }



@article{
867,
   Author = {Sheiner, L. B.},
   Title = {Implications of an alternative approach to dose-response trials},
   Journal = {Journal of Acquired Immune Deficiency Syndromes},
   Volume = {3 Suppl 2},
   Pages = {S20-S26},
   Year = {1990} }



@article{
862,
   Author = {Sheiner, L. B.},
   Title = {Analysis of pharmacokinetic data using parametric models. III. Hypothesis tests and confidence intervals},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {14},
   Number = {5},
   Pages = {539-555},
   Year = {1986} }



@article{
812,
   Author = {Ruggeri, A. and Martinelli, M.},
   Title = {A program for the optimization of cyclosporine therapy using population kinetics modeling},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {61},
   Number = {1},
   Pages = {61-69},
   Year = {2000} }



@article{
811,
   Author = {Ross, R. A. and Lee, M. L. and Delaney, M. L. and Onderdonk, A. B.},
   Title = {Mixed-effect models for predicting microbial interactions in the vaginal ecosystem},
   Journal = {Journal of Clinical Microbiology},
   Volume = {32},
   Number = {4},
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470,
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   Title = {[Individualization of drug dosage by therapeutic monitoring in plasma and the application of pharmacokinetic principles]},
   Journal = {Journal of Clinical Chemistry and Clinical Biochemistry},
   Volume = {21},
   Number = {11},
   Pages = {649-658},
   Year = {1983} }



@article{
468,
   Author = {Vozeh, S. and Wenk, M. and Follath, F.},
   Title = {Experience with NONMEM: analysis of serum concentration data in patients treated with mexiletine and lidocaine},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {305-315},
   Year = {1984} }



@article{
467,
   Author = {Fluhler, H. and Huber, H. and Widmer, E. and Brechbuhler, S.},
   Title = {Experiences in the application of NONMEM to pharmacokinetic data analysis},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {317-339},
   Year = {1984} }



@article{
466,
   Author = {Beal, S. L.},
   Title = {Population pharmacokinetic data and parameter estimation based on their first two statistical moments},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {173-193},
   Year = {1984} }



@article{
465,
   Author = {Steimer, J. L. and Mallet, A. and Golmard, J. L. and Boisvieux, J. F.},
   Title = {Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {265-292},
   Year = {1984} }



@article{
464,
   Author = {Kelman, A. W. and Thomson, A. H. and Whiting, B. and Bryson, S. M. and Steedman, D. A. and Mawer, G. E. and Samba-Donga, L. A.},
   Title = {Estimation of gentamicin clearance and volume of distribution in neonates and young children},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {18},
   Number = {5},
   Pages = {685-692},
   Year = {1984} }



@article{
462,
   Author = {Grasela, T. H., Jr. and Donn, S. M.},
   Title = {Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data},
   Journal = {Developmental Pharmacology and Therapeutics},
   Volume = {8},
   Number = {6},
   Pages = {374-383},
   Year = {1985} }



@article{
461,
   Author = {Yamaoka, K. and Tanaka, H. and Okumura, K. and Yasuhara, M. and Hori, R.},
   Title = {An analysis program MULTI(ELS) based on extended nonlinear least squares method for microcomputers},
   Journal = {Journal of Pharmacobio-dynamics},
   Volume = {9},
   Number = {2},
   Pages = {161-173},
   Year = {1986} }



@article{
460,
   Author = {Grasela, T. H., Jr. and Antal, E. J. and Townsend, R. J. and Smith, R. B.},
   Title = {An evaluation of population pharmacokinetics in therapeutic trials. Part I. Comparison of methodologies},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {39},
   Number = {6},
   Pages = {605-612},
   Year = {1986} }



@article{
459,
   Author = {Whiting, B. and Kelman, A. W. and Grevel, J.},
   Title = {Population pharmacokinetics. Theory and clinical application},
   Journal = {Clinical Pharmacokinetics},
   Volume = {11},
   Number = {5},
   Pages = {387-401},
   Year = {1986} }



@article{
458,
   Author = {Maitre, P. O. and Ausems, M. E. and Vozeh, S. and Stanski, D. R.},
   Title = {Evaluating the accuracy of using population pharmacokinetic data to predict plasma concentrations of alfentanil},
   Journal = {Anesthesiology},
   Volume = {68},
   Number = {1},
   Pages = {59-67},
   Year = {1988} }



@article{
456,
   Author = {Grevel, J. and Whiting, B. and Kelman, A. W. and Taylor, W. B. and Bateman, D. N.},
   Title = {Population analysis of the pharmacokinetic variability of high-dose metoclopramide in cancer patients},
   Journal = {Clinical Pharmacokinetics},
   Volume = {14},
   Number = {1},
   Pages = {52-63},
   Year = {1988} }



@article{
455,
   Author = {Vozeh, S. and Uematsu, T. and Aarons, L. and Maitre, P. and Landolt, H. and Gratzl, O.},
   Title = {Intravenous phenytoin loading in patients after neurosurgery and in status epilepticus. A population pharmacokinetic study},
   Journal = {Clinical Pharmacokinetics},
   Volume = {14},
   Number = {2},
   Pages = {122-128},
   Year = {1988} }



@article{
454,
   Author = {Amisaki, T. and Tatsuhara, T.},
   Title = {An alternative two stage method via the EM-algorithm for the estimation of population pharmacokinetic parameters},
   Journal = {Journal of Pharmacobio-dynamics},
   Volume = {11},
   Number = {5},
   Pages = {335-348},
   Year = {1988} }



@article{
453,
   Author = {Mentre, F. and Mallet, A. and Steimer, J. L.},
   Title = {Hyperparameter estimation using stochastic approximation with application to population pharmacokinetics},
   Journal = {Biometrics},
   Volume = {44},
   Number = {3},
   Pages = {673-683},
   Year = {1988} }



@article{
451,
   Author = {Graves, N. M. and Ludden, T. M. and Holmes, G. B. and Fuerst, R. H. and Leppik, I. E.},
   Title = {Pharmacokinetics of felbamate, a novel antiepileptic drug: application of mixed-effect modeling to clinical trials},
   Journal = {Pharmacotherapy},
   Volume = {9},
   Number = {6},
   Pages = {372-376},
   Year = {1989} }



@article{
450,
   Author = {Colburn, W. A.},
   Title = {Controversy. IV: Population pharmacokinetics, NONMEM and the pharmacokinetic screen; academic, industrial and regulatory perspectives},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {29},
   Number = {1},
   Pages = {1-6},
   Year = {1989} }



@article{
449,
   Author = {Maitre, P. O. and Funk, B. and Crevoisier, C. and Ha, H. R.},
   Title = {Pharmacokinetics of midazolam in patients recovering from cardiac surgery},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {2},
   Pages = {161-166},
   Year = {1989} }



@article{
448,
   Author = {Yukawa, E. and Higuchi, S. and Aoyama, T.},
   Title = {Population pharmacokinetics of phenytoin from routine clinical data in Japan},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {14},
   Number = {1},
   Pages = {71-77},
   Year = {1989} }



@article{
447,
   Author = {Driscoll, M. S. and Ludden, T. M. and Casto, D. T. and Littlefield, L. C.},
   Title = {Evaluation of theophylline pharmacokinetics in a pediatric population using mixed effects models},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {17},
   Number = {2},
   Pages = {141-168},
   Year = {1989} }



@article{
446,
   Author = {Grevel, J. and Thomas, P. and Whiting, B.},
   Title = {Population pharmacokinetic analysis of bisoprolol},
   Journal = {Clinical Pharmacokinetics},
   Volume = {17},
   Number = {1},
   Pages = {53-63},
   Year = {1989} }



@article{
445,
   Author = {Launay, M. C. and Iliadis, A. and Richard, B.},
   Title = {Population pharmacokinetics of mitoxantrone performed by a NONMEM method},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {78},
   Number = {10},
   Pages = {877-880},
   Year = {1989} }



@article{
444,
   Author = {Graves, D. A. and Locke, C. S., Jr. and Muir, K. T. and Miller, R. P.},
   Title = {The influence of assay variability on pharmacokinetic parameter estimation},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {17},
   Number = {5},
   Pages = {571-592},
   Year = {1989} }



@article{
443,
   Author = {Stanski, D. R. and Maitre, P. O.},
   Title = {Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited},
   Journal = {Anesthesiology},
   Volume = {72},
   Number = {3},
   Pages = {412-422},
   Year = {1990} }



@article{
442,
   Author = {Graves, D. A. and Chang, I.},
   Title = {Application of NONMEM to routine bioavailability data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {18},
   Number = {2},
   Pages = {145-160},
   Year = {1990} }



@article{
441,
   Author = {Vozeh, S. and Maitre, P. O. and Stanski, D. R.},
   Title = {Evaluation of population (NONMEM) pharmacokinetic parameter estimates},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {18},
   Number = {2},
   Pages = {161-173},
   Year = {1990} }



@article{
440,
   Author = {Yukawa, E. and Higuchi, S. and Aoyama, T.},
   Title = {Population pharmacokinetics of phenytoin from routine clinical data in Japan: an update},
   Journal = {Chemical and Pharmaceutical Bulletin},
   Volume = {38},
   Number = {7},
   Pages = {1973-1976},
   Year = {1990} }



@article{
439,
   Author = {Gitterman, S. R. and Drusano, G. L. and Egorin, M. J. and Standiford, H. C.},
   Title = {Population pharmacokinetics of zidovudine. The Veterans Administration Cooperative Studies Group},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {48},
   Number = {2},
   Pages = {161-167},
   Year = {1990} }



@article{
438,
   Author = {Graves, D. A. and Muir, K. T. and Richards, W. and Steiger, B. W. and Chang, I. and Patel, B.},
   Title = {Hydralazine dose-response curve analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {18},
   Number = {4},
   Pages = {279-291},
   Year = {1990} }



@article{
437,
   Author = {Kaniwa, N. and Aoyagi, N. and Ogata, H. and Ishii, M.},
   Title = {Application of the NONMEM method to evaluation of the bioavailability of drug products},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {79},
   Number = {12},
   Pages = {1116-1120},
   Year = {1990} }



@article{
436,
   Author = {Martin, E. S., III and Crismon, M. L. and Godley, P. J.},
   Title = {Postinduction carbamazepine clearance in an adult psychiatric population},
   Journal = {Pharmacotherapy},
   Volume = {11},
   Number = {4},
   Pages = {296-302},
   Year = {1991} }



@article{
434,
   Author = {White, D. B. and Walawander, C. A. and Tung, Y. and Grasela, T. H.},
   Title = {An evaluation of point and interval estimates in population pharmacokinetics using NONMEM analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {1},
   Pages = {87-112},
   Year = {1991} }



@article{
433,
   Author = {Karlsson, M. O. and Thomson, A. H. and McGovern, E. M. and Chow, P. and Evans, T. J. and Kelman, A. W.},
   Title = {Population pharmacokinetics of rectal theophylline in neonates},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {13},
   Number = {3},
   Pages = {195-200},
   Year = {1991} }



@article{
432,
   Author = {Jermain, D. M. and Crismon, M. L. and Martin, E. S., III},
   Title = {Population pharmacokinetics of lithium},
   Journal = {Clinical Pharmacology},
   Volume = {10},
   Number = {5},
   Pages = {376-381},
   Year = {1991} }



@article{
430,
   Author = {Yukawa, E. and Higuchi, S. and Aoyama, T.},
   Title = {One-point feedback control method for phenytoin dosage adjustment},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {43},
   Number = {7},
   Pages = {499-503},
   Year = {1991} }



@article{
429,
   Author = {Maitre, P. O. and Buhrer, M. and Thomson, D. and Stanski, D. R.},
   Title = {A three-step approach combining Bayesian regression and NONMEM population analysis: application to midazolam},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {4},
   Pages = {377-384},
   Year = {1991} }



@article{
428,
   Author = {Drusano, G. L.},
   Title = {Optimal sampling theory and population modelling: application to determination of the influence of the microgravity environment on drug distribution and elimination},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {31},
   Number = {10},
   Pages = {962-967},
   Year = {1991} }



@article{
426,
   Author = {Peverini, R. L. and Sale, M. and Rhine, W. D. and Fagan, L. M. and Lenert, L. A.},
   Title = {Anticoagulation therapy advisor: a decision-support system for heparin therapy during ECMO},
   Journal = {Proc.Annu.Symp.Comput.Appl.Med.Care},
   Pages = {567-571},
   Year = {1992} }



@article{
425,
   Author = {Collart, L. and Blaschke, T. F. and Boucher, F. and Prober, C. G.},
   Title = {Potential of population pharmacokinetics to reduce the frequency of blood sampling required for estimating kinetic parameters in neonates},
   Journal = {Developmental Pharmacology and Therapeutics},
   Volume = {18},
   Number = {1-2},
   Pages = {71-80},
   Year = {1992} }



@article{
424,
   Author = {Wade, J. R. and Kelman, A. W. and Kerr, D. J. and Robert, J. and Whiting, B.},
   Title = {Variability in the pharmacokinetics of epirubicin: a population analysis},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {29},
   Number = {5},
   Pages = {391-395},
   Year = {1992} }



@article{
423,
   Author = {Williams, P. J. and Lane, J. and Murray, W. and Mergener, M. A. and Kamigaki, M.},
   Title = {Pharmacokinetics of the digoxin-quinidine interaction via mixed-effect modelling},
   Journal = {Clinical Pharmacokinetics},
   Volume = {22},
   Number = {1},
   Pages = {66-74},
   Year = {1992} }



@article{
422,
   Author = {Yuen, G. J. and Drusano, G. L. and Brooks, J. and Flor, S.},
   Title = {Use of nonlinear, mixed-effects modeling for population analysis of ofloxacin: effects of age on oral drug pharmacokinetics},
   Journal = {Pharmacotherapy},
   Volume = {12},
   Number = {2},
   Pages = {88-92},
   Year = {1992} }



@article{
421,
   Author = {Jensen, P. D. and Edgren, B. E. and Brundage, R. C.},
   Title = {Population pharmacokinetics of gentamicin in neonates using a nonlinear, mixed-effects model},
   Journal = {Pharmacotherapy},
   Volume = {12},
   Number = {3},
   Pages = {178-182},
   Year = {1992} }



@article{
419,
   Author = {Pai, S. M. and Shukla, U. A. and Grasela, T. H. and Knupp, C. A. and Dolin, R. and Valentine, F. T. and McLaren, C. and Liebman, H. A. and Martin, R. R. and Pittman, K. A.},
   Title = {Population pharmacokinetic analysis of didanosine (2',3'- dideoxyinosine) plasma concentrations obtained in phase I clinical trials in patients with AIDS or AIDS-related complex},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {32},
   Number = {3},
   Pages = {242-247},
   Year = {1992} }



@article{
418,
   Author = {Wang, J. and Endrenyi, L.},
   Title = {A computationally efficient approach for the design of population pharmacokinetic studies},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {3},
   Pages = {279-294},
   Year = {1992} }



@article{
417,
   Author = {White, D. B. and Walawander, C. A. and Liu, D. Y. and Grasela, T. H.},
   Title = {Evaluation of hypothesis testing for comparing two populations using NONMEM analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {3},
   Pages = {295-313},
   Year = {1992} }



@article{
416,
   Author = {Kay, J. D. and Colan, S. D. and Graham, T. P., Jr.},
   Title = {Congestive heart failure in pediatric patients},
   Journal = {Am.Heart J},
   Volume = {142},
   Number = {5},
   Pages = {923-928},
   Year = {2001} }



@article{
415,
   Author = {Kauffman, R. E. and Kearns, G. L.},
   Title = {Pharmacokinetic studies in paediatric patients. Clinical and ethical considerations},
   Journal = {Clinical Pharmacokinetics},
   Volume = {23},
   Number = {1},
   Pages = {10-29},
   Year = {1992} }



@article{
414,
   Author = {Phillips, K. F.},
   Title = {Response to "An evaluation of point and interval estimates in population pharmacokinetics using NONMEM analysis" by White et al},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {4},
   Pages = {389-395},
   Year = {1992} }



@article{
413,
   Author = {Yukawa, E. and Higuchi, S. and Aoyama, T.},
   Title = {Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {44},
   Number = {9},
   Pages = {755-760},
   Year = {1992} }



@article{
412,
   Author = {Yukawa, E. and Mine, H. and Higuchi, S. and Aoyama, T.},
   Title = {Digoxin population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {44},
   Number = {9},
   Pages = {761-765},
   Year = {1992} }



@article{
410,
   Author = {Szenohradszky, J. and Fisher, D. M. and Segredo, V. and Caldwell, J. E. and Bragg, P. and Sharma, M. L. and Gruenke, L. D. and Miller, R. D.},
   Title = {Pharmacokinetics of rocuronium bromide (ORG 9426) in patients with normal renal function or patients undergoing cadaver renal transplantation},
   Journal = {Anesthesiology},
   Volume = {77},
   Number = {5},
   Pages = {899-904},
   Year = {1992} }



@article{
409,
   Author = {Schmith, V. D. and Fiedler-Kelly, J. and Abou-Donia, M. and Huffman, C. S. and Grasela, T. H., Jr.},
   Title = {Population pharmacodynamics of doxacurium},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {52},
   Number = {5},
   Pages = {528-536},
   Year = {1992} }



@article{
408,
   Author = {Bruno, R. and Iliadis, M. C. and Lacarelle, B. and Cosson, V. and Mandema, J. W. and Le Roux, Y. and Montay, G. and Durand, A. and Ballereau, M. and Alasia, M.},
   Title = {Evaluation of Bayesian estimation in comparison to NONMEM for population pharmacokinetic data analysis: application to pefloxacin in intensive care unit patients},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {6},
   Pages = {653-669},
   Year = {1992} }



@article{
407,
   Author = {Holford, N. H. and Peace, K. E.},
   Title = {Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine},
   Journal = {Proceedings of the National Academy of Sciences of the United States of America},
   Volume = {89},
   Number = {23},
   Pages = {11471-11475},
   Year = {1992} }



@article{
405,
   Author = {Grasela, T. H. and Fiedler-Kelly, J. B. and Salvadori, C. and Marey, C. and Jochemsen, R.},
   Title = {Development of a population pharmacokinetic database for tianeptine},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {45},
   Number = {2},
   Pages = {173-179},
   Year = {1993} }



@article{
404,
   Author = {Ritschel, W. A.},
   Title = {Identification of populations at risk in drug testing and therapy: application to elderly patients},
   Journal = {European Journal of Drug Metabolism and Pharmacokinetics},
   Volume = {18},
   Number = {1},
   Pages = {101-111},
   Year = {1993} }



@article{
403,
   Author = {Miller, R. and Ludden, T. M.},
   Title = {Bioavailability of controlled release carbamazepine estimated by mixed effect modelling},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {44},
   Number = {3},
   Pages = {231-235},
   Year = {1993} }



@article{
402,
   Author = {Botha, J. H. and Tyrannes, I. and Miller, R. and Wesley, A.},
   Title = {Determination of theophylline clearance in South African children},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {44},
   Number = {4},
   Pages = {369-375},
   Year = {1993} }



@article{
401,
   Author = {Karna, P. and Lee, C. and Kumar, A. and Dyke, J. and Gooch, W. M., III},
   Title = {Population pharmacokinetics of ceftizoxime in premature newborns},
   Journal = {Developmental Pharmacology and Therapeutics},
   Volume = {20},
   Number = {3-4},
   Pages = {135-143},
   Year = {1993} }



@article{
400,
   Author = {Wade, J. R. and Kelman, A. W. and Howie, C. A. and Whiting, B.},
   Title = {Effect of misspecification of the absorption process on subsequent parameter estimation in population analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {21},
   Number = {2},
   Pages = {209-222},
   Year = {1993} }



@article{
399,
   Author = {Yukawa, E. and Nomiyama, N. and Higuchi, S. and Aoyama, T.},
   Title = {Lithium population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {15},
   Number = {2},
   Pages = {75-82},
   Year = {1993} }



@article{
398,
   Author = {Powers, J. D.},
   Title = {Statistical considerations in pharmacokinetic study design},
   Journal = {Clinical Pharmacokinetics},
   Volume = {24},
   Number = {5},
   Pages = {380-387},
   Year = {1993} }



@article{
397,
   Author = {Vielhaber, J. P. and Kuhlman, J. V. and Barrett, J. S.},
   Title = {NONMEM version III implementation on a VAX 9000: a DCL procedure for single-step execution and the unrealized advantage of a vectorizing FORTRAN compiler},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {40},
   Number = {2},
   Pages = {103-115},
   Year = {1993} }



@article{
396,
   Author = {Ette, E. I. and Kelman, A. W. and Howie, C. A. and Whiting, B.},
   Title = {Interpretation of simulation studies for efficient estimation of population pharmacokinetic parameters},
   Journal = {The Annals of Pharmacotherapy},
   Volume = {27},
   Number = {9},
   Pages = {1034-1039},
   Year = {1993} }



@article{
395,
   Author = {Egan, T. D. and Lemmens, H. J. and Fiset, P. and Hermann, D. J. and Muir, K. T. and Stanski, D. R. and Shafer, S. L.},
   Title = {The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers},
   Journal = {Anesthesiology},
   Volume = {79},
   Number = {5},
   Pages = {881-892},
   Year = {1993} }



@article{
393,
   Author = {Uematsu, T.},
   Title = {Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug},
   Journal = {International Journal of Clinical Pharmacology, Therapy, and Toxicology},
   Volume = {31},
   Number = {12},
   Pages = {606-610},
   Year = {1993} }



@article{
392,
   Author = {Port, R. E. and Schlemmer, H. P. and Bachert, P.},
   Title = {Pharmacokinetic analysis of sparse in vivo NMR spectroscopy data using relative parameters and the population approach},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {47},
   Number = {2},
   Pages = {187-193},
   Year = {1994} }



@article{
391,
   Author = {Chetty, M. and Miller, R. and Moodley, S. V.},
   Title = {Smoking and body weight influence the clearance of chlorpromazine},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {6},
   Pages = {523-526},
   Year = {1994} }



@article{
390,
   Author = {Li, Z. and Chen, G. and Zhuo, H. T.},
   Title = {Application of NONMEM method for evaluation of relative biological availability of ofloxacin},
   Journal = {Zhongguo Yao Li Xue.Bao.},
   Volume = {15},
   Number = {1},
   Pages = {39-42},
   Year = {1994} }



@article{
389,
   Author = {Lindberg-Freijs, A. and Karlsson, M. O.},
   Title = {Dose dependent absorption and linear disposition of cyclosporin A in rat},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {15},
   Number = {1},
   Pages = {75-86},
   Year = {1994} }



@article{
388,
   Author = {Keller, F. and Horstensmeyer, C. and Looby, M. and Borner, K. and Pommer, W. and Erdmann, K. and Giehl, M.},
   Title = {Vancomycin dosing in haemodialysis patients and Bayesian estimate of individual pharmacokinetic parameters},
   Journal = {The International Journal of Artificial Organs},
   Volume = {17},
   Number = {1},
   Pages = {19-26},
   Year = {1994} }



@article{
387,
   Author = {Kataria, B. K. and Ved, S. A. and Nicodemus, H. F. and Hoy, G. R. and Lea, D. and Dubois, M. Y. and Mandema, J. W. and Shafer, S. L.},
   Title = {The pharmacokinetics of propofol in children using three different data analysis approaches},
   Journal = {Anesthesiology},
   Volume = {80},
   Number = {1},
   Pages = {104-122},
   Year = {1994} }



@article{
384,
   Author = {Hashimoto, Y. and Odani, A. and Tanigawara, Y. and Yasuhara, M. and Okuno, T. and Hori, R.},
   Title = {Population analysis of the dose-dependent pharmacokinetics of zonisamide in epileptic patients},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {17},
   Number = {2},
   Pages = {323-326},
   Year = {1994} }



@article{
383,
   Author = {Wade, J. R. and Beal, S. L. and Sambol, N. C.},
   Title = {Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {22},
   Number = {2},
   Pages = {165-177},
   Year = {1994} }



@article{
382,
   Author = {Hashimoto, Y. and Ozaki, J. and Koue, T. and Odani, A. and Yasuhara, M. and Hori, R.},
   Title = {Simulation for the analysis of distorted pharmacodynamic data},
   Journal = {Pharmaceutical Research},
   Volume = {11},
   Number = {4},
   Pages = {545-548},
   Year = {1994} }



@article{
381,
   Author = {Hussein, Z. and Samara, E. and Locke, C. S. and Orchard, M. A. and Ringham, G. L. and Granneman, G. R.},
   Title = {Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {55},
   Number = {4},
   Pages = {441-450},
   Year = {1994} }



@article{
380,
   Author = {Li, Z. and Chen, G.},
   Title = {[Evaluation of theophylline population pharmacokinetics in adult hospitalized patients using NONMEM analysis]},
   Journal = {Zhongguo Yao Li Xue.Bao.},
   Volume = {15},
   Number = {3},
   Pages = {267-270},
   Year = {1994} }



@article{
378,
   Author = {Eisenach, J. C. and Shafer, S. L. and Bucklin, B. A. and Jackson, C. and Kallio, A.},
   Title = {Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep},
   Journal = {Anesthesiology},
   Volume = {80},
   Number = {6},
   Pages = {1349-1359},
   Year = {1994} }



@article{
377,
   Author = {Maire, P. and Barbaut, X. and Girard, P. and Mallet, A. and Jelliffe, R. W. and Berod, T.},
   Title = {Preliminary results of three methods for population pharmacokinetic analysis (NONMEM, NPML, NPEM) of amikacin in geriatric and general medicine patients},
   Journal = {International Journal of Bio-medical Computing},
   Volume = {36},
   Number = {1-2},
   Pages = {139-141},
   Year = {1994} }



@article{
376,
   Author = {Seay, R. E. and Brundage, R. C. and Jensen, P. D. and Schilling, C. G. and Edgren, B. E.},
   Title = {Population pharmacokinetics of vancomycin in neonates},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {56},
   Number = {2},
   Pages = {169-175},
   Year = {1994} }



@article{
375,
   Author = {Burtin, P. and Jacqz-Aigrain, E. and Girard, P. and Lenclen, R. and Magny, J. F. and Betremieux, P. and Tehiry, C. and Desplanques, L. and Mussat, P.},
   Title = {Population pharmacokinetics of midazolam in neonates},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {56},
   Number = {6 Pt 1},
   Pages = {615-625},
   Year = {1994} }



@article{
374,
   Author = {Launay-Iliadis, M. C. and Bruno, R. and Cosson, V. and Vergniol, J. C. and Oulid-Aissa, D. and Marty, M. and Clavel, M. and Aapro, M. and Le Bail, N. and Iliadis, A.},
   Title = {Population pharmacokinetics of docetaxel during phase I studies using nonlinear mixed-effect modeling and nonparametric maximum-likelihood estimation},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {37},
   Number = {1-2},
   Pages = {47-54},
   Year = {1995} }



@article{
373,
   Author = {Awni, W. M. and Granneman, G. R. and Locke, C. S. and Brandwein, S. R. and Dube, L. M.},
   Title = {Population pharmacokinetics of zileution, a selective 5-lipoxygenase inhibitor, in patients with rheumatoid arthritis},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {48},
   Number = {2},
   Pages = {155-160},
   Year = {1995} }



@article{
372,
   Author = {Rui, J. Z. and Cai, M. H. and Chu, X. M. and Chen, G.},
   Title = {[NONMEM approach for estimating population pharmacokinetic parameters of phenytoin in Chinese epileptics]},
   Journal = {Yao Xue Xue Bao - Acta Pharmaceutica Sinica},
   Volume = {30},
   Number = {3},
   Pages = {172-178},
   Year = {1995} }



@article{
371,
   Author = {Rui, J. Z. and Zhuo, H. T. and Jiang, G. H. and Chen, G.},
   Title = {[Evaluation of population pharmacokinetics of cyclosporin A in renal transplantation patients with NONMEM]},
   Journal = {Yao Xue Xue Bao - Acta Pharmaceutica Sinica},
   Volume = {30},
   Number = {4},
   Pages = {241-247},
   Year = {1995} }



@article{
370,
   Author = {Shah, A. K. and Brundage, R. C. and Lake, K. D. and Sawchuk, R. J.},
   Title = {The estimation of the plasma free fraction of cyclosporine in rabbits and heart transplant patients: the application of a physiological model of renal clearance},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {16},
   Number = {1},
   Pages = {59-70},
   Year = {1995} }



@article{
365,
   Author = {Magorian, T. and Wood, P. and Caldwell, J. and Fisher, D. and Segredo, V. and Szenohradszky, J. and Sharma, M. and Gruenke, L. and Miller, R.},
   Title = {The pharmacokinetics and neuromuscular effects of rocuronium bromide in patients with liver disease},
   Journal = {Anesthesia and Analgesia},
   Volume = {80},
   Number = {4},
   Pages = {754-759},
   Year = {1995} }



@article{
364,
   Author = {Chatelut, E. and Canal, P. and Brunner, V. and Chevreau, C. and Pujol, A. and Boneu, A. and Roche, H. and Houin, G. and Bugat, R.},
   Title = {Prediction of carboplatin clearance from standard morphological and biological patient characteristics},
   Journal = {Journal of the National Cancer Institute},
   Volume = {87},
   Number = {8},
   Pages = {573-580},
   Year = {1995} }



@article{
363,
   Author = {Schaefer, H. G. and Ahr, G. and Kuhlmann, J.},
   Title = {Pharmacokinetic development of quinolone antibiotics},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {33},
   Number = {5},
   Pages = {266-276},
   Year = {1995} }



@article{
362,
   Author = {Rietbrock, S. and Merz, P. G. and Fuhr, U. and Harder, S. and Marschner, J. P. and Loew, D. and Biehl, J.},
   Title = {Absorption behavior of sulpiride described using Weibull functions},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {33},
   Number = {5},
   Pages = {299-303},
   Year = {1995} }



@article{
361,
   Author = {Leslie, K. and Sessler, D. I. and Bjorksten, A. R. and Moayeri, A.},
   Title = {Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium},
   Journal = {Anesthesia and Analgesia},
   Volume = {80},
   Number = {5},
   Pages = {1007-1014},
   Year = {1995} }



@article{
360,
   Author = {Wade, J. R. and Sambol, N. C.},
   Title = {Felodipine population dose-response and concentration-response relationships in patients with essential hypertension},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {57},
   Number = {5},
   Pages = {569-581},
   Year = {1995} }



@article{
359,
   Author = {Brier, M. E. and Sloan, R. S. and Aronoff, G. R.},
   Title = {Population pharmacokinetics of the active metabolite of nabumetone in renal dysfunction},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {57},
   Number = {6},
   Pages = {622-627},
   Year = {1995} }



@article{
358,
   Author = {Mentre, F. and Gomeni, R.},
   Title = {A two-step iterative algorithm for estimation in nonlinear mixed-effect models with an evaluation in population pharmacokinetics},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {5},
   Number = {2},
   Pages = {141-158},
   Year = {1995} }



@article{
357,
   Author = {Parker, E. M. and Hutchison, M. and Blumer, J. L.},
   Title = {The pharmacokinetics of meropenem in infants and children: a population analysis},
   Journal = {The Journal of Antimicrobial Chemotherapy},
   Volume = {36 Suppl A},
   Pages = {63-71},
   Year = {1995} }



@article{
356,
   Author = {Best, N. G. and Tan, K. K. and Gilks, W. R. and Spiegelhalter, D. J.},
   Title = {Estimation of population pharmacokinetics using the Gibbs sampler},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {4},
   Pages = {407-435},
   Year = {1995} }



@article{
355,
   Author = {Albrecht, C. F. and Kruger, P. B. and Smit, B. J. and Freestone, M. and Gouws, L. and Miller, R. and van Jaarsveld, P. P.},
   Title = {The pharmacokinetic behaviour of hypoxoside taken orally by patients with lung cancer in a phase I trial},
   Journal = {South African Medical Journal},
   Volume = {85},
   Number = {9},
   Pages = {861-865},
   Year = {1995} }



@article{
354,
   Author = {Eastwood, N. B. and Boyd, A. H. and Parker, C. J. and Hunter, J. M.},
   Title = {Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure},
   Journal = {British Journal of Anaesthesia},
   Volume = {75},
   Number = {4},
   Pages = {431-435},
   Year = {1995} }



@article{
353,
   Author = {Billard, V. and Gambus, P. L. and Barr, J. and Minto, C. F. and Corash, L. and Tessman, J. W. and Stickney, J. L. and Shafer, S. L.},
   Title = {The pharmacokinetics of 8-methoxypsoralen following i.v. administration in humans},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {40},
   Number = {4},
   Pages = {347-360},
   Year = {1995} }



@article{
351,
   Author = {Weber, W. and Harnisch, L. and Zimmer, M. and Rokitta, C. and Mendes, P.},
   Title = {NONMEM analysis in determining the tri-exponential disposition of cefotaxime: a method of evaluating serum and urinary phase I data},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {33},
   Number = {10},
   Pages = {560-564},
   Year = {1995} }



@article{
348,
   Author = {Yukawa, E.},
   Title = {New and simple method for estimating metildigoxin dosing regimens by multiple trough screen analysis},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {33},
   Number = {11},
   Pages = {605-611},
   Year = {1995} }



@article{
347,
   Author = {Ette, E. I. and Kelman, A. W. and Howie, C. A. and Whiting, B.},
   Title = {Analysis of animal pharmacokinetic data: performance of the one point per animal design},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {6},
   Pages = {551-566},
   Year = {1995} }



@article{
346,
   Author = {Ette, E. I. and Ludden, T. M.},
   Title = {Population pharmacokinetic modeling: the importance of informative graphics},
   Journal = {Pharmaceutical Research},
   Volume = {12},
   Number = {12},
   Pages = {1845-1855},
   Year = {1995} }



@article{
345,
   Author = {Yukawa, E.},
   Title = {A feasibility study of the multiple-peak approach for pharmacokinetic screening: population-based investigation of valproic acid relative clearance using routine clinical pharmacokinetic data},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {47},
   Number = {12A},
   Pages = {1048-1052},
   Year = {1995} }



@article{
344,
   Author = {Rui, J. Z. and Yang, Y. C. and Wang, Y. N. and Chen, G.},
   Title = {[Population pharmacokinetics/pharmacodynamics of magnesium sulfate in pregnancy induced hypertensive gravidas treated with the drug]},
   Journal = {Yao Xue Xue Bao - Acta Pharmaceutica Sinica},
   Volume = {31},
   Number = {2},
   Pages = {81-85},
   Year = {1996} }



@article{
343,
   Author = {Schaefer, H. G. and Stass, H. and Wedgwood, J. and Hampel, B. and Fischer, C. and Kuhlmann, J. and Schaad, U. B.},
   Title = {Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {40},
   Number = {1},
   Pages = {29-34},
   Year = {1996} }



@article{
341,
   Author = {Bouillon, T. and Meineke, I. and Port, R. and Hildebrandt, R. and Gunther, K. and Gundert-Remy, U.},
   Title = {Concentration-effect relationship of the positive chronotropic and hypokalaemic effects of fenoterol in healthy women of childbearing age},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {2},
   Pages = {153-160},
   Year = {1996} }



@article{
340,
   Author = {Periclou, A. P. and Avramis, V. I.},
   Title = {NONMEM population pharmacokinetic studies of cytosine arabinoside after high-dose and after loading bolus followed by continuous infusion of the drug in pediatric patients with leukemias},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {39},
   Number = {1-2},
   Pages = {42-50},
   Year = {1996} }



@article{
337,
   Author = {Vozeh, S. and Steimer, J. L. and Rowland, M. and Morselli, P. and Mentre, F. and Balant, L. P. and Aarons, L.},
   Title = {The use of population pharmacokinetics in drug development},
   Journal = {Clinical Pharmacokinetics},
   Volume = {30},
   Number = {2},
   Pages = {81-93},
   Year = {1996} }



@article{
336,
   Author = {Carlton, L. D. and Patterson, J. H. and Mattson, C. N. and Schmith, V. D.},
   Title = {The effects of epoprostenol on drug disposition. II: A pilot study of the pharmacokinetics of furosemide with and without epoprostenol in patients with congestive heart failure},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {36},
   Number = {3},
   Pages = {257-264},
   Year = {1996} }



@article{
335,
   Author = {Boyd, A. H. and Eastwood, N. B. and Parker, C. J. and Hunter, J. M.},
   Title = {Comparison of the pharmacodynamics and pharmacokinetics of an infusion of cis-atracurium (51W89) or atracurium in critically ill patients undergoing mechanical ventilation in an intensive therapy unit},
   Journal = {British Journal of Anaesthesia},
   Volume = {76},
   Number = {3},
   Pages = {382-388},
   Year = {1996} }



@article{
334,
   Author = {Lee, T. C. and Charles, B. G. and Steer, P. A. and Flenady, V. J. and Grant, T. C.},
   Title = {Theophylline population pharmacokinetics from routine monitoring data in very premature infants with apnoea},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {41},
   Number = {3},
   Pages = {191-200},
   Year = {1996} }



@article{
333,
   Author = {Odani, A. and Hashimoto, Y. and Takayanagi, K. and Otsuki, Y. and Koue, T. and Takano, M. and Yasuhara, M. and Hattori, H. and Furusho, K. and Inui, K.},
   Title = {Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model},
   Journal = {Biological and Pharmaceutical Bulletin},
   Volume = {19},
   Number = {3},
   Pages = {444-448},
   Year = {1996} }



@article{
332,
   Author = {Chatelut, E. and Boddy, A. V. and Peng, B. and Rubie, H. and Lavit, M. and Dezeuze, A. and Pearson, A. D. and Roche, H. and Robert, A. and Newell, D. R. and Canal, P.},
   Title = {Population pharmacokinetics of carboplatin in children},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {59},
   Number = {4},
   Pages = {436-443},
   Year = {1996} }



@article{
331,
   Author = {Egan, T. D. and Minto, C. F. and Hermann, D. J. and Barr, J. and Muir, K. T. and Shafer, S. L.},
   Title = {Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers},
   Journal = {Anesthesiology},
   Volume = {84},
   Number = {4},
   Pages = {821-833},
   Year = {1996} }



@article{
330,
   Author = {McLachlan, A. J. and Tett, S. E.},
   Title = {Pharmacokinetics of fluconazole in people with HIV infection: a population analysis},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {41},
   Number = {4},
   Pages = {291-298},
   Year = {1996} }



@article{
329,
   Author = {Burtin, P. and Mentre, F. and van Bree, J. and Steimer, J. L.},
   Title = {Sparse sampling for assessment of drug exposure in toxicological studies},
   Journal = {European Journal of Drug Metabolism and Pharmacokinetics},
   Volume = {21},
   Number = {2},
   Pages = {105-111},
   Year = {1996} }



@article{
327,
   Author = {Sandstrom, M. and Freijs, A. and Larsson, R. and Nygren, P. and Fjallskog, M. L. and Bergh, J. and Karlsson, M. O.},
   Title = {Lack of relationship between systemic exposure for the component drug of the fluorouracil, epirubicin, and 4-hydroxycyclophosphamide regimen in breast cancer patients},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {14},
   Number = {5},
   Pages = {1581-1588},
   Year = {1996} }



@article{
326,
   Author = {Lalonde, R. L. and Lessard, D. and Gaudreault, J.},
   Title = {Population pharmacokinetics of terfenadine},
   Journal = {Pharmaceutical Research},
   Volume = {13},
   Number = {6},
   Pages = {832-838},
   Year = {1996} }



@article{
325,
   Author = {Jacquez, J. A.},
   Title = {Parameter identifiability is required in pooled data methods},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {3},
   Pages = {301-305},
   Year = {1996} }



@article{
324,
   Author = {Pentikis, H. S. and Henderson, J. D. and Tran, N. L. and Ludden, T. M.},
   Title = {Bioequivalence: individual and population compartmental modeling compared to the noncompartmental approach},
   Journal = {Pharmaceutical Research},
   Volume = {13},
   Number = {7},
   Pages = {1116-1121},
   Year = {1996} }



@article{
323,
   Author = {Jia, X. and Nedelman, J. R.},
   Title = {Errors in time in pharmacokinetic studies},
   Journal = {Journal of Biopharmaceutical Statistics},
   Volume = {6},
   Number = {3},
   Pages = {303-318},
   Year = {1996} }



@article{
322,
   Author = {Yukawa, E. and Aoyama, T.},
   Title = {Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {36},
   Number = {8},
   Pages = {752-759},
   Year = {1996} }



@article{
321,
   Author = {Bennett, J. E. and Wakefield, J. C.},
   Title = {A comparison of a Bayesian population method with two methods as implemented in commercially available software},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {4},
   Pages = {403-432},
   Year = {1996} }



@article{
320,
   Author = {Schnider, T. W. and Minto, C. F. and Bruckert, H. and Mandema, J. W.},
   Title = {Population pharmacodynamic modeling and covariate detection for central neural blockade},
   Journal = {Anesthesiology},
   Volume = {85},
   Number = {3},
   Pages = {502-512},
   Year = {1996} }



@article{
319,
   Author = {Schoemaker, R. C. and Cohen, A. F.},
   Title = {Estimating impossible curves using NONMEM},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {42},
   Number = {3},
   Pages = {283-290},
   Year = {1996} }



@article{
318,
   Author = {Brier, M. E. and Aronoff, G. R.},
   Title = {Application of artificial neural networks to clinical pharmacology},
   Journal = {International Journal of Clinical Pharmacology and Therapeutics},
   Volume = {34},
   Number = {11},
   Pages = {510-514},
   Year = {1996} }



@article{
316,
   Author = {Williams, P. J. and Lane, J. R. and Capparelli, E. V. and Kim, Y. H. and Coleman, R.},
   Title = {Direct comparison of three methods for predicting digoxin concentrations},
   Journal = {Pharmacotherapy},
   Volume = {16},
   Number = {6},
   Pages = {1085-1092},
   Year = {1996} }



@article{
315,
   Author = {Hussein, Z. and Eaves, C. J. and Hutchinson, D. B. and Canfield, C. J.},
   Title = {Population pharmacokinetics of proguanil in patients with acute P. falciparum malaria after combined therapy with atovaquone},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {42},
   Number = {5},
   Pages = {589-597},
   Year = {1996} }



@article{
314,
   Author = {Mandema, J. W. and Kaiko, R. F. and Oshlack, B. and Reder, R. F. and Stanski, D. R.},
   Title = {Characterization and validation of a pharmacokinetic model for controlled-release oxycodone},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {42},
   Number = {6},
   Pages = {747-756},
   Year = {1996} }



@article{
313,
   Author = {Mandema, J. W. and Stanski, D. R.},
   Title = {Population pharmacodynamic model for ketorolac analgesia},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {60},
   Number = {6},
   Pages = {619-635},
   Year = {1996} }



@article{
312,
   Author = {Hering, W. and Ihmsen, H. and Uhrlau, C. and Schuttler, J.},
   Title = {[Concentration-effect relationship, hemodynamics and respiration after infusion of the steroid anesthetic eltanolone in healthy subjects]},
   Journal = {Anaesthesist},
   Volume = {45},
   Number = {12},
   Pages = {1142-1150},
   Year = {1996} }



@article{
309,
   Author = {Looby, M. and Linke, R. and Weiss, M.},
   Title = {Pharmacokinetics and tissue distribution of idarubicin and its active metabolite idarubicinol in the rabbit},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {39},
   Number = {6},
   Pages = {554-556},
   Year = {1997} }



@article{
308,
   Author = {Falcao, A. C. and Fernandez de Gatta, M. M. and Delgado Iribarnegaray, M. F. and Santos, Buelga D. and Garcia, M. J. and Dominguez-Gil, A. and Lanao, J. M.},
   Title = {Population pharmacokinetics of caffeine in premature neonates},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {52},
   Number = {3},
   Pages = {211-217},
   Year = {1997} }



@article{
307,
   Author = {McFadyen, M. L. and Miller, R. and Ludden, T. M.},
   Title = {Ketotifen pharmacokinetics in children with atopic perennial asthma},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {52},
   Number = {5},
   Pages = {383-386},
   Year = {1997} }



@article{
306,
   Author = {Schmith, V. D. and Fiedler-Kelly, J. and Phillips, L. and Grasela, T. H., Jr.},
   Title = {Prospective use of population pharmacokinetics/pharmacodynamics in the development of cisatracurium},
   Journal = {Pharmaceutical Research},
   Volume = {14},
   Number = {1},
   Pages = {91-97},
   Year = {1997} }



@article{
305,
   Author = {Kelley, M. T. and Walson, P. D. and Cox, S. and Dusci, L. J.},
   Title = {Population pharmacokinetics of felbamate in children},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {19},
   Number = {1},
   Pages = {29-36},
   Year = {1997} }



@article{
304,
   Author = {Yukawa, E. and Honda, T. and Ohdo, S. and Higuchi, S. and Aoyama, T.},
   Title = {Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: an update},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {2},
   Pages = {92-100},
   Year = {1997} }



@article{
303,
   Author = {Hossain, M. and Wright, E. and Baweja, R. and Ludden, T. and Miller, R.},
   Title = {Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam},
   Journal = {Pharmaceutical Research},
   Volume = {14},
   Number = {3},
   Pages = {309-315},
   Year = {1997} }



@article{
302,
   Author = {Delgado Iribarnegaray, M. F. and Santo, Bueldga D. and Garcia Sanchez, M. J. and Otero, M. J. and Falcao, A. C. and Dominguez-Gil, A.},
   Title = {Carbamazepine population pharmacokinetics in children: mixed-effect models},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {19},
   Number = {2},
   Pages = {132-139},
   Year = {1997} }



@article{
301,
   Author = {Hussein, Z. and Posner, J.},
   Title = {Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {43},
   Number = {5},
   Pages = {457-465},
   Year = {1997} }



@article{
300,
   Author = {Ette, E. I.},
   Title = {Stability and performance of a population pharmacokinetic model},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {6},
   Pages = {486-495},
   Year = {1997} }



@article{
299,
   Author = {Lee, T. C. and Charles, B. and Steer, P. and Flenady, V. and Shearman, A.},
   Title = {Population pharmacokinetics of intravenous caffeine in neonates with apnea of prematurity},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {61},
   Number = {6},
   Pages = {628-640},
   Year = {1997} }



@article{
298,
   Author = {Benezet, S. and Guimbaud, R. and Chatelut, E. and Chevreau, C. and Bugat, R. and Canal, P.},
   Title = {How to predict carboplatin clearance from standard morphological and biological characteristics in obese patients},
   Journal = {Annals of Oncology: Official Journal of the European Society for Medical Oncology},
   Volume = {8},
   Number = {6},
   Pages = {607-609},
   Year = {1997} }



@article{
297,
   Author = {Chow, H. H. and Tolle, K. M. and Roe, D. J. and Elsberry, V. and Chen, H.},
   Title = {Application of neural networks to population pharmacokinetic data analysis},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {86},
   Number = {7},
   Pages = {840-845},
   Year = {1997} }



@article{
296,
   Author = {Vadiei, K. and Troy, S. and Korth-Bradley, J. and Chiang, S. T. and Zimmerman, J. J.},
   Title = {Population pharmacokinetics of intravenous amiodarone and comparison with two-stage pharmacokinetic analysis},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {7},
   Pages = {610-617},
   Year = {1997} }



@article{
295,
   Author = {Combrink, M. and McFadyen, M. L. and Miller, R.},
   Title = {A comparison of the standard approach and the NONMEM approach in the estimation of bioavailability in man},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {49},
   Number = {7},
   Pages = {731-733},
   Year = {1997} }



@article{
294,
   Author = {Schmith, V. D. and Fiedler-Kelly, J. and Phillips, L. and Grasela, T. H., Jr.},
   Title = {Dose proportionality of cisatracurium},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {7},
   Pages = {625-629},
   Year = {1997} }



@article{
293,
   Author = {Birmingham, P. K. and Tobin, M. J. and Henthorn, T. K. and Fisher, D. M. and Berkelhamer, M. C. and Smith, F. A. and Fanta, K. B. and Cote, C. J.},
   Title = {Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations},
   Journal = {Anesthesiology},
   Volume = {87},
   Number = {2},
   Pages = {244-252},
   Year = {1997} }



@article{
292,
   Author = {Yukawa, E. and Honda, T. and Ohdo, S. and Higuchi, S. and Aoyama, T.},
   Title = {Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening},
   Journal = {The Journal of Pharmacy and Pharmacology},
   Volume = {49},
   Number = {8},
   Pages = {751-756},
   Year = {1997} }



@article{
291,
   Author = {Sun, H. and Ette, E. I. and Ludden, T. M.},
   Title = {On the recording of sample times and parameter estimation from repeated measures pharmacokinetic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {6},
   Pages = {637-650},
   Year = {1996} }



@article{
290,
   Author = {Snoeck, E. and Piotrovskij, V. and Jacqmin, P. and Lins, R. L. and Van Peer, A. and Danhof, M. and Woestenborghs, R. and Van Gool, R. and Dupont, A. G. and Heykants, J.},
   Title = {Population analysis of the non-linear red blood cell partitioning of draflazine following various infusion durations},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {53},
   Number = {1},
   Pages = {57-63},
   Year = {1997} }



@article{
288,
   Author = {Bruno, R. and Vivier, N. and Montay, G. and Le Liboux, A. and Powe, L. K. and Delumeau, J. C. and Rhodes, G. R.},
   Title = {Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {62},
   Number = {5},
   Pages = {518-526},
   Year = {1997} }



@article{
287,
   Author = {Nguyen, L. and Chatelut, E. and Chevreau, C. and Tranchand, B. and Lochon, I. and Bachaud, J. M. and Pujol, A. and Houin, G. and Bugat, R. and Canal, P.},
   Title = {Population pharmacokinetics of total and unbound etoposide},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {41},
   Number = {2},
   Pages = {125-132},
   Year = {1998} }



@article{
286,
   Author = {Schaedeli, F. and Uehlinger, D. E.},
   Title = {Urea kinetics and dialysis treatment time predict vancomycin elimination during high-flux hemodialysis},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {63},
   Number = {1},
   Pages = {26-38},
   Year = {1998} }



@article{
284,
   Author = {Yukawa, E. and To, H. and Ohdo, S. and Higuchi, S. and Aoyama, T.},
   Title = {Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {37},
   Number = {12},
   Pages = {1160-1167},
   Year = {1997} }



@article{
283,
   Author = {Botha, J. H. and du Preez, M. J. and Miller, R. and Adhikari, M.},
   Title = {Determination of population pharmacokinetic parameters for amikacin in neonates using mixed-effect models},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {53},
   Number = {5},
   Pages = {337-341},
   Year = {1998} }



@article{
281,
   Author = {Marino, M. T. and Schuster, B. G. and Brueckner, R. P. and Lin, E. and Kaminskis, A. and Lasseter, K. C.},
   Title = {Population pharmacokinetics and pharmacodynamics of pyridostigmine bromide for prophylaxis against nerve agents in humans},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {38},
   Number = {3},
   Pages = {227-235},
   Year = {1998} }



@article{
280,
   Author = {Yasuhara, M. and Iga, T. and Zenda, H. and Okumura, K. and Oguma, T. and Yano, Y. and Hori, R.},
   Title = {Population pharmacokinetics of vancomycin in Japanese adult patients},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {20},
   Number = {2},
   Pages = {139-148},
   Year = {1998} }



@article{
277,
   Author = {Idkaidek, N. M. and Amidon, G. L. and Smith, D. E. and Najib, N. M. and Hassan, M. M.},
   Title = {Determination of the population pharmacokinetic parameters of sustained- release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {19},
   Number = {3},
   Pages = {169-174},
   Year = {1998} }



@article{
276,
   Author = {Sidhu, J. S. and Ashton, M. and Huong, N. V. and Hai, T. N. and Karlsson, M. O. and Sy, N. D. and Jonsson, E. N. and Cong, L. D.},
   Title = {Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {45},
   Number = {4},
   Pages = {347-354},
   Year = {1998} }



@article{
275,
   Author = {Wright, P. M. and Fisher, D. M.},
   Title = {Can bioavailability of low-variance drugs be estimated with an unpaired, sparse sampling design?},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {63},
   Number = {4},
   Pages = {437-443},
   Year = {1998} }



@article{
274,
   Author = {Laveille, C. and Lachaud-Pettiti, V. and Neuman, E. and Jochemsen, R.},
   Title = {Application of population pharmacokinetics to the phase II development of an anti-Alzheimer's disease compound, S12024},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {38},
   Number = {4},
   Pages = {315-323},
   Year = {1998} }



@article{
272,
   Author = {Yukawa, E. and To, H. and Ohdo, S. and Higuchi, S. and Aoyama, T.},
   Title = {Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {54},
   Number = {1},
   Pages = {69-74},
   Year = {1998} }



@article{
270,
   Author = {Ette, E. I. and Sun, H. and Ludden, T. M.},
   Title = {Balanced designs in longitudinal population pharmacokinetic studies},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {38},
   Number = {5},
   Pages = {417-423},
   Year = {1998} }



@article{
269,
   Author = {Etienne, M. C. and Chatelut, E. and Pivot, X. and Lavit, M. and Pujol, A. and Canal, P. and Milano, G.},
   Title = {Co-variables influencing 5-fluorouracil clearance during continuous venous infusion. A NONMEM analysis},
   Journal = {European Journal of Cancer},
   Volume = {34},
   Number = {1},
   Pages = {92-97},
   Year = {1998} }



@article{
268,
   Author = {Parke, J. and Charles, B. G.},
   Title = {NONMEM population pharmacokinetic modeling of orally administered cyclosporine from routine drug monitoring data after heart transplantation},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {20},
   Number = {3},
   Pages = {284-293},
   Year = {1998} }



@article{
267,
   Author = {Facca, B. and Frame, B. and Triesenberg, S.},
   Title = {Population pharmacokinetics of ceftizoxime administered by continuous infusion in clinically ill adult patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {42},
   Number = {7},
   Pages = {1783-1787},
   Year = {1998} }



@article{
266,
   Author = {Welker, H. A. and Banken, L.},
   Title = {Mibefradil pharmacokinetic and pharmacodynamic population analysis},
   Journal = {International Journal of Clinical Pharmacology Research},
   Volume = {18},
   Number = {2},
   Pages = {63-71},
   Year = {1998} }



@article{
265,
   Author = {Piotrovsky, V. K. and Huang, M. L. and Van Peer, A. and Langenaecken, C.},
   Title = {Effects of demographic variables on vorozole pharmacokinetics in healthy volunteers and in breast cancer patients},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {42},
   Number = {3},
   Pages = {221-228},
   Year = {1998} }



@article{
264,
   Author = {Gatti, G. and Papa, P. and Torre, D. and Andreoni, M. and Poggio, A. and Bassetti, M. and Marone, P.},
   Title = {Population pharmacokinetics of rifabutin in human immunodeficiency virus-infected patients},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {42},
   Number = {8},
   Pages = {2017-2023},
   Year = {1998} }



@article{
263,
   Author = {Hayashi, N. and Kinoshita, H. and Yukawa, E. and Higuchi, S.},
   Title = {Pharmacokinetic analysis of subcutaneous erythropoietin administration with nonlinear mixed effect model including endogenous production},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {1},
   Pages = {11-19},
   Year = {1998} }



@article{
261,
   Author = {Gray, A. L. and Botha, J. H. and Miller, R.},
   Title = {A model for the determination of carbamazepine clearance in children on mono- and polytherapy},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {54},
   Number = {4},
   Pages = {359-362},
   Year = {1998} }



@article{
260,
   Author = {Frame, B. and Beal, S. L.},
   Title = {Non-steady state population kinetics of intravenous phenytoin},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {20},
   Number = {4},
   Pages = {408-416},
   Year = {1998} }



@article{
258,
   Author = {Ragueneau, I. and Laveille, C. and Jochemsen, R. and Resplandy, G. and Funck-Brentano, C. and Jaillon, P.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {2},
   Pages = {192-203},
   Year = {1998} }



@article{
256,
   Author = {Martin, L. and Chatelut, E. and Boneu, A. and Rostaing, L. and Roussilhes, C. and Caselles, O. and Canal, P.},
   Title = {Improvement of the Cockcroft-Gault equation for predicting glomerular filtration in cancer patients},
   Journal = {Bulletin du Cancer},
   Volume = {85},
   Number = {7},
   Pages = {631-636},
   Year = {1998} }



@article{
255,
   Author = {Smith, B. P. and Ward, R. A. and Brier, M. E.},
   Title = {Prediction of anticoagulation during hemodialysis by population kinetics and an artificial neural network},
   Journal = {Artificial Organs},
   Volume = {22},
   Number = {9},
   Pages = {731-739},
   Year = {1998} }



@article{
254,
   Author = {Jonsson, E. N. and Karlsson, M. O.},
   Title = {Automated covariate model building within NONMEM},
   Journal = {Pharmaceutical Research},
   Volume = {15},
   Number = {9},
   Pages = {1463-1468},
   Year = {1998} }



@article{
253,
   Author = {Rosario, M. C. and Thomson, A. H. and Jodrell, D. I. and Sharp, C. A. and Elliott, H. L.},
   Title = {Population pharmacokinetics of gentamicin in patients with cancer},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {3},
   Pages = {229-236},
   Year = {1998} }



@article{
252,
   Author = {Anderson, B. J. and Holford, N. H. and Woollard, G. A. and Chan, P. L.},
   Title = {Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {3},
   Pages = {237-243},
   Year = {1998} }



@article{
251,
   Author = {Drover, D. R. and Lemmens, H. J.},
   Title = {Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery},
   Journal = {Anesthesiology},
   Volume = {89},
   Number = {4},
   Pages = {869-877},
   Year = {1998} }



@article{
250,
   Author = {Romano, S. and Gonzalez, P. and Tejada, P. and Anton, J. and Aguado, J. M. and Lanao, J. M.},
   Title = {Influence of diagnostic and treatment factors in the population pharmacokinetics of gentamicin},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {23},
   Number = {2},
   Pages = {141-148},
   Year = {1998} }



@article{
249,
   Author = {Godfrey, C. and Sweeney, K. and Miller, K. and Hamilton, R. and Kremer, J.},
   Title = {The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {46},
   Number = {4},
   Pages = {369-376},
   Year = {1998} }



@article{
248,
   Author = {Gwilt, P. R. and Radick, L. E. and Li, X. Y. and Whalen, J. J. and Leaf, C. D.},
   Title = {Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {38},
   Number = {10},
   Pages = {945-950},
   Year = {1998} }



@article{
247,
   Author = {Shafer, S. L. and Eisenach, J. C. and Hood, D. D. and Tong, C.},
   Title = {Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans},
   Journal = {Anesthesiology},
   Volume = {89},
   Number = {5},
   Pages = {1074-1088},
   Year = {1998} }



@article{
246,
   Author = {Nagai, N. and Ogata, H. and Wada, Y. and Tsujino, D. and Someya, K. and Ohno, T. and Masuhara, K. and Tanaka, Y. and Takahashi, H. and Nagai, H. and Kato, K. and Koshiba, Y. and Igarashi, T. and Yokoyama, A. and Kinameri, K. and Kato, T. and Kurita, Y.},
   Title = {Population pharmacokinetics and pharmacodynamics of cisplatin in patients with cancer: analysis with the NONMEM program},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {38},
   Number = {11},
   Pages = {1025-1034},
   Year = {1998} }



@article{
245,
   Author = {Lee, K. L. and Lee, K. T. and Chung, H. M. and Lin, Y. P.},
   Title = {Estimation of mean relative bioavailability of cyclosporine Sandimmune and Neoral using NONMEM in renal transplant recipients},
   Journal = {Transplantation Proceedings},
   Volume = {30},
   Number = {7},
   Pages = {3526-3529},
   Year = {1998} }



@article{
244,
   Author = {Yasuhara, M. and Iga, T. and Zenda, H. and Okumura, K. and Oguma, T. and Yano, Y. and Hori, R.},
   Title = {Population pharmacokinetics of vancomycin in Japanese pediatric patients},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {20},
   Number = {6},
   Pages = {612-618},
   Year = {1998} }



@article{
243,
   Author = {Zomorodi, K. and Donner, A. and Somma, J. and Barr, J. and Sladen, R. and Ramsay, J. and Geller, E. and Shafer, S. L.},
   Title = {Population pharmacokinetics of midazolam administered by target controlled infusion for sedation following coronary artery bypass grafting},
   Journal = {Anesthesiology},
   Volume = {89},
   Number = {6},
   Pages = {1418-1429},
   Year = {1998} }



@article{
242,
   Author = {Somma, J. and Donner, A. and Zomorodi, K. and Sladen, R. and Ramsay, J. and Geller, E. and Shafer, S. L.},
   Title = {Population pharmacodynamics of midazolam administered by target controlled infusion in SICU patients after CABG surgery},
   Journal = {Anesthesiology},
   Volume = {89},
   Number = {6},
   Pages = {1430-1443},
   Year = {1998} }



@article{
241,
   Author = {Mamiya, K. and Ieiri, I. and Shimamoto, J. and Yukawa, E. and Imai, J. and Ninomiya, H. and Yamada, H. and Otsubo, K. and Higuchi, S. and Tashiro, N.},
   Title = {The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics},
   Journal = {Epilepsia},
   Volume = {39},
   Number = {12},
   Pages = {1317-1323},
   Year = {1998} }



@article{
239,
   Author = {Gisleskog, P. O. and Hermann, D. and Hammarlund-Udenaes, M. and Karlsson, M. O.},
   Title = {A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors GI198745 and finasteride},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {64},
   Number = {6},
   Pages = {636-647},
   Year = {1998} }



@article{
238,
   Author = {Welker, H. A. and Wiltshire, H. and Bullingham, R.},
   Title = {Clinical pharmacokinetics of mibefradil},
   Journal = {Clinical Pharmacokinetics},
   Volume = {35},
   Number = {6},
   Pages = {405-423},
   Year = {1998} }



@article{
237,
   Author = {Perdaems, N. and Bachaud, J. M. and Rouzaud, P. and Murris-Espin, M. and Hermant, C. and Mihura, J. and Lochon, I. and Houin, G. and Canal, P. and Chatelut, E.},
   Title = {Relation between unbound plasma concentrations and toxicity in a prolonged oral etoposide schedule},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {54},
   Number = {9-10},
   Pages = {677-683},
   Year = {1998} }



@article{
236,
   Author = {Meineke, I. and Eisele, J. and Certa, H. and Gundert-Remy, U. M.},
   Title = {Modelling of residual variability in toxicokinetic studies with sparse sampling: the case of tetrahydronaphthalene},
   Journal = {Archives of Toxicology},
   Volume = {72},
   Number = {12},
   Pages = {807-810},
   Year = {1998} }



@article{
234,
   Author = {Lee, T. C. and Charles, B. G. and Harte, G. J. and Gray, P. H. and Steer, P. A. and Flenady, V. J.},
   Title = {Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {2},
   Pages = {451-457},
   Year = {1999} }



@article{
233,
   Author = {Valodia, P. and Seymour, M. A. and Miller, R. and McFadyen, M. L. and Folb, P. I.},
   Title = {Factors influencing the population pharmacokinetic parameters of phenytoin in adult epileptic patients in South Africa},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {21},
   Number = {1},
   Pages = {57-62},
   Year = {1999} }



@article{
232,
   Author = {Jonsson, F. and Sandborgh-Englund, G. and Johanson, G.},
   Title = {A compartmental model for the kinetics of mercury vapor in humans},
   Journal = {Toxicology and Applied Pharmacology},
   Volume = {155},
   Number = {2},
   Pages = {161-168},
   Year = {1999} }



@article{
231,
   Author = {Gisleskog, P. O. and Hermann, D. and Hammarlund-Udenaes, M. and Karlsson, M. O.},
   Title = {The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {47},
   Number = {1},
   Pages = {53-58},
   Year = {1999} }



@article{
230,
   Author = {Bressolle, F. and Gomeni, R.},
   Title = {Predictive performance of a semiparametric method to estimate population pharmacokinetic parameters using NONMEM},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {26},
   Number = {3},
   Pages = {349-361},
   Year = {1998} }



@article{
229,
   Author = {Jonsson, E. N. and Karlsson, M. O.},
   Title = {Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {58},
   Number = {1},
   Pages = {51-64},
   Year = {1999} }



@article{
228,
   Author = {Grasela, T. H. and Fiedler-Kelly, J. and Cox, E. and Womble, G. P. and Risner, M. E. and Chen, C.},
   Title = {Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {39},
   Number = {4},
   Pages = {373-384},
   Year = {1999} }



@article{
226,
   Author = {Sakurai, Y. and Hishikawa, T. and Hiramatsu, N. and Sagara, Y. and Kuwahara, M. and Nagasaki, M. and Hujimaki, T. and Fujii, R.},
   Title = {[Pharmacokinetic analysis of cefozopran in neonatal infections-- population pharmacokinetics using nonmem]},
   Journal = {The Japanese Journal of Antibiotics},
   Volume = {52},
   Number = {1},
   Pages = {16-23},
   Year = {1999} }



@article{
225,
   Author = {Flores-Murrieta, F. J. and Ko, H. C. and Flores-Acevedo, D. M. and Lopez-Munoz, F. J. and Jusko, W. J. and Sale, M. E. and Castaneda-Hernandez, G.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of tolmetin antinociceptive effect in the rat using an indirect response model: a population approach},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {26},
   Number = {5},
   Pages = {547-557},
   Year = {1998} }



@article{
224,
   Author = {Laporte, S. and Mismetti, P. and Piquet, P. and Doubine, S. and Touchot, A. and Decousus, H.},
   Title = {Population pharmacokinetic of nadroparin calcium (Fraxipariner) in children hospitalised for open heart surgery},
   Journal = {European Journal of Pharmaceutical Sciences: official journal of the European Federation for Pharmaceutical Sciences},
   Volume = {8},
   Number = {2},
   Pages = {119-125},
   Year = {1999} }



@article{
223,
   Author = {Parke, J. and Holford, N. H. and Charles, B. G.},
   Title = {A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models},
   Journal = {Computer Methods and Programs in Biomedicine},
   Volume = {59},
   Number = {1},
   Pages = {19-29},
   Year = {1999} }



@article{
222,
   Author = {Chatelut, E. and Rostaing, L. and Gregoire, N. and Payen, J. L. and Pujol, A. and Izopet, J. and Houin, G. and Canal, P.},
   Title = {A pharmacokinetic model for alpha interferon administered subcutaneously},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {47},
   Number = {4},
   Pages = {365-371},
   Year = {1999} }



@article{
221,
   Author = {Serrano, B. B. and Garcia Sanchez, M. J. and Otero, M. J. and Buelga, D. S. and Serrano, J. and Dominguez-Gil, A.},
   Title = {Valproate population pharmacokinetics in children},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {24},
   Number = {1},
   Pages = {73-80},
   Year = {1999} }



@article{
220,
   Author = {Bonate, P. L.},
   Title = {The effect of collinearity on parameter estimates in nonlinear mixed effect models},
   Journal = {Pharmaceutical Research},
   Volume = {16},
   Number = {5},
   Pages = {709-717},
   Year = {1999} }



@article{
219,
   Author = {Wallenstein, G. C. and Stangier, J. and Ludden, T. M.},
   Title = {Analyzing rich data using different methods provided by NONMEM: pharmacokinetics of telmisartan following intravenous infusion to healthy volunteers},
   Journal = {Pharmaceutical Research},
   Volume = {16},
   Number = {5},
   Pages = {772-776},
   Year = {1999} }



@article{
218,
   Author = {Gronert, G. A. and Fung, D. L. and Haskins, S. C. and Steffey, E. P.},
   Title = {Deep sedation and mechanical ventilation without paralysis for 3 weeks in normal beagles: exaggerated resistance to metocurine in gastrocnemius muscle},
   Journal = {Anesthesiology},
   Volume = {90},
   Number = {6},
   Pages = {1741-1745},
   Year = {1999} }



@article{
217,
   Author = {Campbell, D. and Thomson, A. H. and Stack, B.},
   Title = {Population pharmacokinetics of aminoglycoside antibiotics in patients with cystic fibrosis},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {21},
   Number = {3},
   Pages = {281-288},
   Year = {1999} }



@article{
216,
   Author = {Yukawa, E.},
   Title = {Population-based investigations of drug relative clearance using nonlinear mixed-effect modelling from information generated during the routine clinical care of patients},
   Journal = {Journal of Clinical Pharmacy and Therapeutics},
   Volume = {24},
   Number = {2},
   Pages = {103-113},
   Year = {1999} }



@article{
215,
   Author = {Pfister, M. and Schaedeli, F. and Frey, F. J. and Uehlinger, D. E.},
   Title = {Pharmacokinetics and haemodynamics of candesartan cilexetil in hypertensive patients on regular haemodialysis},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {47},
   Number = {6},
   Pages = {645-651},
   Year = {1999} }



@article{
214,
   Author = {Boni, J. and Korth-Bradley, J. and McGoldrick, K. and Appel, A. and Cooper, S.},
   Title = {Pharmacokinetic and pharmacodynamic action of etodolac in patients after oral surgery},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {39},
   Number = {7},
   Pages = {729-737},
   Year = {1999} }



@article{
213,
   Author = {Brynne, L. and Paalzow, L. K. and Karlsson, M. O.},
   Title = {Mechanism-based modeling of rebound tachycardia after chronic l- propranolol infusion in spontaneous hypertensive rats},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {290},
   Number = {2},
   Pages = {664-671},
   Year = {1999} }



@article{
212,
   Author = {Joubert, P. and Bressolle, F. and Gouby, A. and Doucot, P. Y. and Saissi, G. and Gomeni, R.},
   Title = {A population approach to the forecasting of amikacin plasma and urinary levels using a prescribed dosage regimen},
   Journal = {European Journal of Drug Metabolism and Pharmacokinetics},
   Volume = {24},
   Number = {1},
   Pages = {39-46},
   Year = {1999} }



@article{
211,
   Author = {Bouillon, T. and Schmidt, C. and Garstka, G. and Heimbach, D. and Stafforst, D. and Schwilden, H. and Hoeft, A.},
   Title = {Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil},
   Journal = {Anesthesiology},
   Volume = {91},
   Number = {1},
   Pages = {144-155},
   Year = {1999} }



@article{
210,
   Author = {Mirochnick, M. and Capparelli, E. and Connor, J.},
   Title = {Pharmacokinetics of zidovudine in infants: a population analysis across studies},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {66},
   Number = {1},
   Pages = {16-24},
   Year = {1999} }



@article{
209,
   Author = {Rehberg, B. and Bouillon, T. and Zinserling, J. and Hoeft, A.},
   Title = {Comparative pharmacodynamic modeling of the electroencephalography- slowing effect of isoflurane, sevoflurane, and desflurane},
   Journal = {Anesthesiology},
   Volume = {91},
   Number = {2},
   Pages = {397-405},
   Year = {1999} }



@article{
208,
   Author = {Bressolle, F. and Joulia, J. M. and Pinguet, F. and Ychou, M. and Astre, C. and Duffour, J. and Gomeni, R.},
   Title = {Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {44},
   Number = {4},
   Pages = {295-302},
   Year = {1999} }



@article{
207,
   Author = {Zhou, H. and Khalilieh, S. and Lau, H. and Guerret, M. and Osborne, S. and Alladina, L. and Laurent, A. L. and McLeod, J. F.},
   Title = {Effect of meal timing not critical for the pharmacokinetics of tegaserod (HTF 919)},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {39},
   Number = {9},
   Pages = {911-919},
   Year = {1999} }



@article{
206,
   Author = {Romano, S. and Fdez de Gatta, M. M. and Calvo, M. V. and Caballero, D. and Dominguez-Gil, A. and Lanao, J. M.},
   Title = {Population pharmacokinetics of amikacin in patients with haematological malignancies},
   Journal = {The Journal of Antimicrobial Chemotherapy},
   Volume = {44},
   Number = {2},
   Pages = {235-242},
   Year = {1999} }



@article{
205,
   Author = {Grimsley, C. and Thomson, A. H.},
   Title = {Pharmacokinetics and dose requirements of vancomycin in neonates},
   Journal = {Archives of Disease in Childhood.Fetal and Neonatal Edition},
   Volume = {81},
   Number = {3},
   Pages = {F221-F227},
   Year = {1999} }



@article{
204,
   Author = {Sandstrom, M. and Simonsen, L. E. and Freijs, A. and Karlsson, M. O.},
   Title = {The pharmacokinetics of epirubicin and docetaxel in combination in rats},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {44},
   Number = {6},
   Pages = {469-474},
   Year = {1999} }



@article{
203,
   Author = {Buchwalder-Csajka, C. and Buclin, T. and Brunner, H. R. and Biollaz, J.},
   Title = {Evaluation of the angiotensin challenge methodology for assessing the pharmacodynamic profile of antihypertensive drugs acting on the renin- angiotensin system},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {48},
   Number = {4},
   Pages = {594-604},
   Year = {1999} }



@article{
202,
   Author = {Moore, K. H. and Yuen, G. J. and Hussey, E. K. and Pakes, G. E. and Eron, J. J., Jr. and Bartlett, J. A.},
   Title = {Population pharmacokinetics of lamivudine in adult human immunodeficiency virus-infected patients enrolled in two phase III clinical trials},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {43},
   Number = {12},
   Pages = {3025-3029},
   Year = {1999} }



@article{
201,
   Author = {Hassan, M. and Svensson, U. S. and Ljungman, P. and Bjorkstrand, B. and Olsson, H. and Bielenstein, M. and Abdel-Rehim, M. and Nilsson, C. and Johansson, M. and Karlsson, M. O.},
   Title = {A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {48},
   Number = {5},
   Pages = {669-677},
   Year = {1999} }



@article{
200,
   Author = {Preechagoon, Y. and Charles, B. and Piotrovskij, V. and Donovan, T. and Van Peer, A.},
   Title = {Population pharmacokinetics of enterally administered cisapride in young infants with gastro-oesophageal reflux disease},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {48},
   Number = {5},
   Pages = {688-693},
   Year = {1999} }



@article{
199,
   Author = {Blanco-Serrano, B. and Otero, M. J. and Santos-Buelga, D. and Garcia-Sanchez, M. J. and Serrano, J. and Dominguez-Gil, A.},
   Title = {Population estimation of valproic acid clearance in adult patients using routine clinical pharmacokinetic data},
   Journal = {Biopharmaceutics and Drug Disposition},
   Volume = {20},
   Number = {5},
   Pages = {233-240},
   Year = {1999} }



@article{
198,
   Author = {Frame, B. C. and Facca, B. F. and Nicolau, D. P. and Triesenberg, S. N.},
   Title = {Population pharmacokinetics of continuous infusion ceftazidime},
   Journal = {Clinical Pharmacokinetics},
   Volume = {37},
   Number = {4},
   Pages = {343-350},
   Year = {1999} }



@article{
197,
   Author = {du Preez, M. J. and Botha, J. H. and McFadyen, M. L. and Holford, N. H.},
   Title = {The pharmacokinetics of theophylline in premature neonates during the first few days after birth},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {21},
   Number = {6},
   Pages = {598-603},
   Year = {1999} }



@article{
196,
   Author = {Jorga, K. and Fotteler, B. and Banken, L. and Snell, P. and Steimer, J. L.},
   Title = {Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {49},
   Number = {1},
   Pages = {39-48},
   Year = {2000} }



@article{
195,
   Author = {Vermes, A. and Math t, R. A. and van, der Sijs I. and Dankert, J. and Guchelaar, H. J.},
   Title = {Population pharmacokinetics of flucytosine: comparison and validation of three models using STS, NPEM, and NONMEM},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {22},
   Number = {6},
   Pages = {676-687},
   Year = {2000} }



@article{
194,
   Author = {Schuitmaker, M. and Anderson, B. J. and Holford, N. H. and Woollard, G. A.},
   Title = {Pharmacokinetics of paracetamol in adults after cardiac surgery},
   Journal = {Anaesthesia and Intensive Care},
   Volume = {27},
   Number = {6},
   Pages = {615-622},
   Year = {1999} }



@article{
193,
   Author = {Gwilt, P. and Tempero, M. and Kremer, A. and Connolly, M. and Ding, C.},
   Title = {Pharmacokinetics of levamisole in cancer patients treated with 5- fluorouracil},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {45},
   Number = {3},
   Pages = {247-251},
   Year = {2000} }



@article{
192,
   Author = {MacGregor, D. A. and Smith, T. E. and Prielipp, R. C. and Butterworth, J. F. and James, R. L. and Scuderi, P. E.},
   Title = {Pharmacokinetics of dopamine in healthy male subjects},
   Journal = {Anesthesiology},
   Volume = {92},
   Number = {2},
   Pages = {338-346},
   Year = {2000} }



@article{
191,
   Author = {Peng, A. W. and Hussey, E. K. and Moore, K. H.},
   Title = {A population pharmacokinetic analysis of zanamivir in subjects with experimental and naturally occurring influenza: effects of formulation and route of administration},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {40},
   Number = {3},
   Pages = {242-249},
   Year = {2000} }



@article{
190,
   Author = {Zhou, H. and Choi, L. and Lau, H. and Bruntsch, U. and Vries, E. E. and Eckhardt, G. and Oosterom, A. T. and Verweij, J. and Schran, H. and Barbet, N. and Linnartz, R. and Capdeville, R.},
   Title = {Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {40},
   Number = {3},
   Pages = {275-283},
   Year = {2000} }



@article{
189,
   Author = {Maier, G. A. and Lockwood, G. F. and Oppermann, J. A. and Wei, G. and Bauer, P. and Fedler-Kelly, J. and Grasela, T.},
   Title = {Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies},
   Journal = {European Journal of Drug Metabolism and Pharmacokinetics},
   Volume = {24},
   Number = {3},
   Pages = {249-254},
   Year = {1999} }



@article{
188,
   Author = {Schuttler, J. and Ihmsen, H.},
   Title = {Population pharmacokinetics of propofol: a multicenter study},
   Journal = {Anesthesiology},
   Volume = {92},
   Number = {3},
   Pages = {727-738},
   Year = {2000} }



@article{
187,
   Author = {Chen, S. A. and Sawchuk, R. J. and Brundage, R. C. and Horvath, C. and Mendenhall, H. V. and Gunther, R. A. and Braeckman, R. A.},
   Title = {Plasma and lymph pharmacokinetics of recombinant human interleukin-2 and polyethylene glycol-modified interleukin-2 in pigs},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {293},
   Number = {1},
   Pages = {248-259},
   Year = {2000} }



@article{
186,
   Author = {Bouzom, F. and Laveille, C. and Merdjan, H. and Jochemsen, R.},
   Title = {Use of nonlinear mixed effect modeling for the meta-analysis of preclinical pharmacokinetic data: application to S 20342 in the rat},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {89},
   Number = {5},
   Pages = {603-613},
   Year = {2000} }



@article{
184,
   Author = {Mamiya, K. and Hadama, A. and Yukawa, E. and Ieiri, I. and Otsubo, K. and Ninomiya, H. and Tashiro, N. and Higuchi, S.},
   Title = {CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {55},
   Number = {11-12},
   Pages = {821-825},
   Year = {2000} }



@article{
183,
   Author = {Furuya, A. and Kato, N. and Jingu, S. and Akimoto, M. and Higuchi, S. and Suwa, T. and Ogata, H.},
   Title = {Population pharmacokinetics and pharmacodynamics of TS-943 for selective nonpeptide platelet glycoprotein IIb/IIIa receptor antagonist in normal healthy subjects},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {5},
   Pages = {489-497},
   Year = {2000} }



@article{
182,
   Author = {Dempsey, D. and Jacob, P., III and Benowitz, N. L.},
   Title = {Nicotine metabolism and elimination kinetics in newborns},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {5},
   Pages = {458-465},
   Year = {2000} }



@article{
181,
   Author = {Duffull, S. B. and Aarons, L.},
   Title = {Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers},
   Journal = {European Journal of Pharmaceutical Sciences: official journal of the European Federation for Pharmaceutical Sciences},
   Volume = {10},
   Number = {4},
   Pages = {275-284},
   Year = {2000} }



@article{
180,
   Author = {Duffull, S. B. and Chabaud, S. and Nony, P. and Laveille, C. and Girard, P. and Aarons, L.},
   Title = {A pharmacokinetic simulation model for ivabradine in healthy volunteers},
   Journal = {European Journal of Pharmaceutical Sciences: official journal of the European Federation for Pharmaceutical Sciences},
   Volume = {10},
   Number = {4},
   Pages = {285-294},
   Year = {2000} }



@article{
179,
   Author = {Kerbusch, T. and Huitema, A. D. and Ouwerkerk, J. and Keizer, H. J. and Mathot, R. A. and Schellens, J. H. and Beijnen, J. H.},
   Title = {Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {49},
   Number = {6},
   Pages = {555-561},
   Year = {2000} }



@article{
178,
   Author = {Valodia, P. N. and Seymour, M. A. and McFadyen, M. L. and Miller, R. and Folb, P. I.},
   Title = {Validation of population pharmacokinetic parameters of phenytoin using the parallel Michaelis-Menten and first-order elimination model},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {22},
   Number = {3},
   Pages = {313-319},
   Year = {2000} }



@article{
177,
   Author = {Jackson, K. A. and Rosenbaum, S. E. and Kerr, B. M. and Pithavala, Y. K. and Yuen, G. and Dudley, M. N.},
   Title = {A population pharmacokinetic analysis of nelfinavir mesylate in human immunodeficiency virus-infected patients enrolled in a phase III clinical trial},
   Journal = {Antimicrobial Agents and Chemotherapy},
   Volume = {44},
   Number = {7},
   Pages = {1832-1837},
   Year = {2000} }



@article{
176,
   Author = {Kimura, T. and Kokubun, H. and Shimada, S. and Nishisako, M. and Nowatari, M. and Oguchi, K. and Matsuura, N. and Nonoyama, M. and Sunakawa, K.},
   Title = {[Pharmacokinetics of panipenem in neonates and dosage recommendation]},
   Journal = {The Japanese Journal of Antibiotics},
   Volume = {53},
   Number = {4},
   Pages = {185-193},
   Year = {2000} }



@article{
175,
   Author = {Jorga, K. and Banken, L. and Fotteler, B. and Snell, P. and Steimer, J. L.},
   Title = {Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {6},
   Pages = {610-620},
   Year = {2000} }



@article{
174,
   Author = {Pollak, P. T. and Bouillon, T. and Shafer, S. L.},
   Title = {Population pharmacokinetics of long-term oral amiodarone therapy},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {67},
   Number = {6},
   Pages = {642-652},
   Year = {2000} }



@article{
173,
   Author = {Gauvin, A. and Pinguet, F. and Culine, S. and Astre, C. and Gomeni, R. and Bressolle, F.},
   Title = {Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer},
   Journal = {Clinical Cancer Research: an official journal of the American Association for Cancer Research},
   Volume = {6},
   Number = {7},
   Pages = {2690-2695},
   Year = {2000} }



@article{
172,
   Author = {Xuan, D. and Lu, J. F. and Nicolau, D. P. and Nightingale, C. H.},
   Title = {Population pharmacokinetics of tobramycin in hospitalized patients receiving once-daily dosing regimen},
   Journal = {International Journal of Antimicrobial Agents},
   Volume = {15},
   Number = {3},
   Pages = {185-191},
   Year = {2000} }



@article{
171,
   Author = {Simonsen, L. E. and Wahlby, U. and Sandstrom, M. and Freijs, A. and Karlsson, M. O.},
   Title = {Haematological toxicity following different dosing schedules of 5- fluorouracil and epirubicin in rats},
   Journal = {Anticancer Research},
   Volume = {20},
   Number = {3A},
   Pages = {1519-1525},
   Year = {2000} }



@article{
170,
   Author = {Lill, J. and Bauer, L. A. and Horn, J. R. and Hansten, P. D.},
   Title = {Cyclosporine-drug interactions and the influence of patient age},
   Journal = {American Journal of Health-System Pharmacy},
   Volume = {57},
   Number = {17},
   Pages = {1579-1584},
   Year = {2000} }



@article{
169,
   Author = {Gidal, B. E. and Anderson, G. D. and Rutecki, P. R. and Shaw, R. and Lanning, A.},
   Title = {Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy},
   Journal = {Epilepsy Research},
   Volume = {42},
   Number = {1},
   Pages = {23-31},
   Year = {2000} }



@article{
168,
   Author = {Freyer, G. and Tranchand, B. and Ligneau, B. and Ardiet, C. and Souquet, P. J. and Court, Fortune and Riou, R. and Rebattu, P. and Boissel, J. P. and Trillet-Lenoir, V. and Girard, P.},
   Title = {Population pharmacokinetics of doxorubicin, etoposide and ifosfamide in small cell lung cancer patients: results of a multicentre study},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {50},
   Number = {4},
   Pages = {315-324},
   Year = {2000} }



@article{
167,
   Author = {Ouellet, D. and Periclou, A. P. and Johnson, R. D. and Woodworth, J. R. and Lalonde, R. L.},
   Title = {Population pharmacokinetics of pemetrexed disodium (ALIMTA) in patients with cancer},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {46},
   Number = {3},
   Pages = {227-234},
   Year = {2000} }



@article{
166,
   Author = {Farenc, C. and Fabreguette, J. R. and Bressolle, F.},
   Title = {Pk-fit: a pharmacokinetic/pharmacodynamic and statistical data analysis software},
   Journal = {Computers and Biomedical Research, an international journal},
   Volume = {33},
   Number = {5},
   Pages = {315-329},
   Year = {2000} }



@article{
165,
   Author = {Zannikos, P. N. and Rohatagi, S. and Jensen, B. K. and DePhillips, S. L. and Rhodes, G. R.},
   Title = {Pharmacokinetics and concentration-effect analysis of intravenous RGD891, a platelet GPIIb/IIIa antagonist, using mixed-effects modeling (NONMEM)},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {40},
   Number = {10},
   Pages = {1129-1140},
   Year = {2000} }



@article{
164,
   Author = {Wrishko, R. E. and Levine, M. and Khoo, D. and Abbott, P. and Hamilton, D.},
   Title = {Vancomycin pharmacokinetics and Bayesian estimation in pediatric patients},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {22},
   Number = {5},
   Pages = {522-531},
   Year = {2000} }



@article{
163,
   Author = {Ingwersen, S. H. and Pedersen, P. C. and Groes, L. and Nielsen, K. K. and Aarons, L.},
   Title = {Population pharmacokinetics of tiagabine in epileptic patients on monotherapy},
   Journal = {European Journal of Pharmaceutical Sciences: official journal of the European Federation for Pharmaceutical Sciences},
   Volume = {11},
   Number = {3},
   Pages = {247-254},
   Year = {2000} }



@article{
162,
   Author = {Friberg, L. E. and Freijs, A. and Sandstrom, M. and Karlsson, M. O.},
   Title = {Semiphysiological model for the time course of leukocytes after varying schedules of 5-fluorouracil in rats},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {295},
   Number = {2},
   Pages = {734-740},
   Year = {2000} }



@article{
161,
   Author = {Parke, J. and Charles, B. G.},
   Title = {Factors affecting oral cyclosporin disposition after heart transplantation: bootstrap validation of a population pharmacokinetic model},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {56},
   Number = {6-7},
   Pages = {481-487},
   Year = {2000} }



@article{
160,
   Author = {Yukawa, E. and Hokazono, T. and Funakoshi, A. and Yukawa, M. and Ohdo, S. and Higuchi, S. and Ichimaru, R. and Makit, T. and Matsunaga, K. and Anai, M. and Goto, Y.},
   Title = {Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in Japanese patients},
   Journal = {Journal of Clinical Psychopharmacology},
   Volume = {20},
   Number = {6},
   Pages = {685-690},
   Year = {2000} }



@article{
159,
   Author = {Sam, W. J. and Aw, M. and Quak, S. H. and Lim, S. M. and Charles, B. G. and Chan, S. Y. and Ho, P. C.},
   Title = {Population pharmacokinetics of tacrolimus in Asian paediatric liver transplant patients},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {50},
   Number = {6},
   Pages = {531-541},
   Year = {2000} }



@article{
158,
   Author = {Jonsson, E. and Friberg, L. E. and Karlsson, M. O. and Hassan, S. B. and Freijs, A. and Hansen, K. and Larsson, R.},
   Title = {Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats},
   Journal = {Cancer Chemotherapy and Pharmacology},
   Volume = {46},
   Number = {6},
   Pages = {493-500},
   Year = {2000} }



@article{
157,
   Author = {Xie, R. and Bouw, M. R. and Hammarlund-Udenaes, M.},
   Title = {Modelling of the blood-brain barrier transport of morphine-3- glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport},
   Journal = {British Journal of Pharmacology},
   Volume = {131},
   Number = {8},
   Pages = {1784-1792},
   Year = {2000} }



@article{
156,
   Author = {Kimura, T. and Kokubun, H. and Nowatari, M. and Matsuura, N. and Sunakawa, K. and Kubo, H.},
   Title = {Population pharmacokinetics of panipenem in neonates and retrospective evaluation of dosage},
   Journal = {The Journal of Antimicrobial Chemotherapy},
   Volume = {47},
   Number = {1},
   Pages = {51-59},
   Year = {2001} }



@article{
155,
   Author = {Parker, T. J. and Della Pasqua, O. E. and Loizillon, E. and Chezaubernard, C. and Jochemsen, R. and Danhof, M.},
   Title = {Pharmacokinetic-pharmacodynamic modelling in the early development phase of anti-psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats},
   Journal = {British Journal of Pharmacology},
   Volume = {132},
   Number = {1},
   Pages = {151-158},
   Year = {2001} }



@article{
154,
   Author = {Huitema, A. D. and Mathot, R. A. and Tibben, M. M. and Schellens, J. H. and Rodenhuis, S. and Beijnen, J. H.},
   Title = {Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {51},
   Number = {1},
   Pages = {61-70},
   Year = {2001} }



@article{
153,
   Author = {Wright, J. G. and Boddy, A. V. and Highley, M. and Fenwick, J. and McGill, A. and Calvert, A. H.},
   Title = {Estimation of glomerular filtration rate in cancer patients},
   Journal = {British Journal of Cancer},
   Volume = {84},
   Number = {4},
   Pages = {452-459},
   Year = {2001} }



@article{
152,
   Author = {Drover, D. and Lemmens, H. and Naidu, S. and Cevallos, W. and Darwish, M. and Stanski, D.},
   Title = {Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/pharmacodynamic profiles of zaleplon and zolpidem},
   Journal = {Clinical Therapeutics},
   Volume = {22},
   Number = {12},
   Pages = {1443-1461},
   Year = {2000} }



@article{
151,
   Author = {Garcia Sanchez, M. J. and Manzanares, C. and Santos-Buelga, D. and Blazquez, A. and Manzanares, J. and Urruzuno, P. and Medina, E.},
   Title = {Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy},
   Journal = {Clinical Pharmacokinetics},
   Volume = {40},
   Number = {1},
   Pages = {63-71},
   Year = {2001} }



@article{
150,
   Author = {Reith, D. M. and Hooper, W. D. and Parke, J. and Charles, B.},
   Title = {Population pharmacokinetic modeling of steady state carbamazepine clearance in children, adolescents, and adults},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {28},
   Number = {1},
   Pages = {79-92},
   Year = {2001} }



@article{
149,
   Author = {Williams, P. J. and Lane, J. R. and Turkel, C. C. and Capparelli, E. V. and Dziewanowska, Z. and Fox, A. W.},
   Title = {Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {41},
   Number = {3},
   Pages = {259-267},
   Year = {2001} }



@article{
148,
   Author = {Breilh, D. and Saux, M. C. and Delaisement, C. and Fratta, A. and Ducint, D. and Velly, J. F. and Couraud, L.},
   Title = {Pharmacokinetic population study to describe cefepime lung concentrations},
   Journal = {Pulmonary Pharmacology and Therapeutics},
   Volume = {14},
   Number = {2},
   Pages = {69-74},
   Year = {2001} }



@article{
147,
   Author = {Yates, C. R. and Vysokanov, A. and Mukherjee, A. and Ludden, T. M. and Tolley, E. and Meduri, G. U. and Dalton, J. T.},
   Title = {Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {41},
   Number = {4},
   Pages = {415-424},
   Year = {2001} }



@article{
146,
   Author = {Falcao, A. C. and Buelga, D. S. and Mendez, M. E. and Garcia, M. J. and Pardo, M.},
   Title = {Population Kinetics of Tobramycin in Neonates},
   Journal = {Therapeutic Drug Monitoring},
   Volume = {23},
   Number = {3},
   Pages = {202-208},
   Year = {2001} }



@article{
145,
   Author = {Suematsu, F. and Yukawa, E. and Yukawa, M. and Minemoto, M. and Ohdo, S. and Higuchi, S. and Goto, Y.},
   Title = {Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis},
   Journal = {European Journal of Clinical Pharmacology},
   Volume = {57},
   Number = {1},
   Pages = {19-24},
   Year = {2001} }



@article{
144,
   Author = {Sheiner, L. B. and Stock, R. J.},
   Title = {Coupled pacing and coupled pacing with concealed conduction. Report of a case describing a new observation},
   Journal = {Circulation},
   Volume = {34},
   Number = {5},
   Pages = {759-766},
   Year = {1966} }



@article{
143,
   Author = {Neelon, F. A. and Molinaro, M. and Ishikura, H. and Sheiner, L. B. and Cantoni, G. L.},
   Title = {Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases},
   Journal = {The Journal of Biological Chemistry},
   Volume = {242},
   Number = {19},
   Pages = {4515-4522},
   Year = {1967} }



@article{
142,
   Author = {Molinaro, M. and Sheiner, L. B. and Neelon, F. A. and Cantoni, G. L.},
   Title = {Effect of chemical modification of dihydrouridine in yeast transfer ribonucleic acid on amino acid acceptor activity and ribosomal binding},
   Journal = {The Journal of Biological Chemistry},
   Volume = {243},
   Number = {6},
   Pages = {1277-1282},
   Year = {1968} }



@article{
141,
   Author = {Sheiner, L. B.},
   Title = {Computer-aided long-term anticoagulation therapy},
   Journal = {Computers and Biomedical Research, an international journal},
   Volume = {2},
   Number = {6},
   Pages = {507-518},
   Year = {1969} }



@article{
140,
   Author = {Sheiner, L. B. and Rosenberg, B. and Melmon, K. L.},
   Title = {Modelling of individual pharmacokinetics for computer-aided drug dosage},
   Journal = {Computers and Biomedical Research, an international journal},
   Volume = {5},
   Number = {5},
   Pages = {411-459},
   Year = {1972} }



@article{
139,
   Author = {Peck, C. C. and Sheiner, L. B. and Martin, C. M. and Combs, D. T. and Melmon, K. L.},
   Title = {Computer-assisted digoxin therapy},
   Journal = {The New England Journal of Medicine},
   Volume = {289},
   Number = {9},
   Pages = {441-446},
   Year = {1973} }



@article{
138,
   Author = {Sanchez, N. and Sheiner, L. B. and Halkin, H. and Melmon, K. L.},
   Title = {Pharmacokinetics of digoxin: interpreting bioavailability},
   Journal = {British Medical Journal},
   Volume = {4},
   Number = {5885},
   Pages = {132-134},
   Year = {1973} }



@article{
137,
   Author = {Sheiner, L. B.},
   Title = {The use of serum concentrations of digitalis for quantitative therapeutic decisions},
   Journal = {Cardiovascular Clinics},
   Volume = {6},
   Number = {2},
   Pages = {141-151},
   Year = {1974} }



@article{
136,
   Author = {Sheiner, L. B. and Rosenberg, B. and Marathe, V. V. and Peck, C.},
   Title = {Differences in serum digoxin concentrations between outpatients and inpatients: an effect of compliance?},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {15},
   Number = {3},
   Pages = {239-246},
   Year = {1974} }



@article{
135,
   Author = {Sheiner, L. B. and Melmon, K. L. and Rosenberg, B.},
   Title = {Instructional goals for physicians in the use of blood level data--and the contribution of computers},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {16},
   Number = {1},
   Pages = {260-271},
   Year = {1974} }



@article{
134,
   Author = {Halkin, H. and Sheiner, L. B. and Peck, C. C. and Melmon, K. L.},
   Title = {Determinants of the renal clearance of digoxin},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {17},
   Number = {4},
   Pages = {385-394},
   Year = {1975} }



@article{
133,
   Author = {Sheiner, L. B. and Halkin, H. and Peck, C. and Rosenberg, B. and Melmon, K. L.},
   Title = {Improved computer-assisted digoxin therapy. A method using feedback of measured serum digoxin concentrations},
   Journal = {Annals of Internal Medicine},
   Volume = {82},
   Number = {5},
   Pages = {619-627},
   Year = {1975} }



@article{
132,
   Author = {Galeazzi, R. L. and Sheiner, L. B. and Lockwood, T. and Benet, L. Z.},
   Title = {The renal elimination of procainamide},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {19},
   Number = {1},
   Pages = {55-62},
   Year = {1976} }



@article{
131,
   Author = {Galeazzi, R. L. and Benet, L. Z. and Sheiner, L. B.},
   Title = {Relationship between the pharmacokinetics and pharmacodynamics of procainamide},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {20},
   Number = {3},
   Pages = {278-289},
   Year = {1976} }



@article{
130,
   Author = {Wheeler, L. A. and Sheiner, L. B.},
   Title = {A general method for optimal drug dose computation},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {4},
   Number = {6},
   Pages = {487-497},
   Year = {1976} }



@article{
128,
   Author = {Holford, N. and Sheiner, L. B.},
   Title = {The digoxin concentration: before and after the fact},
   Journal = {American Heart Journal},
   Volume = {94},
   Number = {4},
   Pages = {529-530},
   Year = {1977} }



@article{
127,
   Author = {Sheiner, L. B. and Rosenberg, B. and Marathe, V. V.},
   Title = {Estimation of population characteristics of pharmacokinetic parameters from routine clinical data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {5},
   Number = {5},
   Pages = {445-479},
   Year = {1977} }



@article{
126,
   Author = {Berman, W., Jr. and Ravenscroft, P. J. and Sheiner, L. B. and Heymann, M. A. and Melmon, K. L. and Rudolph, A. M.},
   Title = {Differential effects of digoxin at comparable concentrations in tissues of fetal and adult sheep},
   Journal = {Circulation Research},
   Volume = {41},
   Number = {5},
   Pages = {635-642},
   Year = {1977} }



@article{
125,
   Author = {Martin, E. and Tozer, T. N. and Sheiner, L. B. and Riegelman, S.},
   Title = {The clinical pharmacokinetics of phenytoin},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {5},
   Number = {6},
   Pages = {579-596},
   Year = {1977} }



@article{
124,
   Author = {Wheeler, L. A. and Brecher, G. and Sheiner, L. B.},
   Title = {Clinical laboratory use in the evaluation of anemia},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {238},
   Number = {25},
   Pages = {2709-2714},
   Year = {1977} }



@article{
123,
   Author = {Sheiner, L. B. and Melmon, K. L.},
   Title = {The utility function of antihypertensive therapy},
   Journal = {Annals of the New York Academy of Sciences},
   Volume = {304},
   Pages = {112-127},
   Year = {1978} }



@article{
122,
   Author = {Sheiner, L. B. and Brecher, G. and Wheeler, L. A.},
   Title = {The algorithm in medicine},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {239},
   Number = {19},
   Pages = {1957-1958},
   Year = {1978} }



@article{
121,
   Author = {Powell, J. R. and Vozeh, S. and Hopewell, P. and Costello, J. and Sheiner, L. B. and Riegelman, S.},
   Title = {Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia},
   Journal = {The American Review of Respiratory Disease},
   Volume = {118},
   Number = {2},
   Pages = {229-238},
   Year = {1978} }



@article{
120,
   Author = {Ravenscroft, P. and Vozeh, S. and Weinstein, M. and Sheiner, L. B.},
   Title = {Saliva lithium concentrations in the management of lithium therapy},
   Journal = {Archives of General Psychiatry},
   Volume = {35},
   Number = {9},
   Pages = {1123-1127},
   Year = {1978} }



@article{
118,
   Author = {Silber, B. and Sheiner, L. B. and Powers, J. L. and Winter, M. E. and Sadee, W.},
   Title = {Spironolactone-associated digoxin radioimmunoassay interference},
   Journal = {Clinical Chemistry},
   Volume = {25},
   Number = {1},
   Pages = {48-50},
   Year = {1979} }



@article{
117,
   Author = {Sheiner, L. B. and Stanski, D. R. and Vozeh, S. and Miller, R. D. and Ham, J.},
   Title = {Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {25},
   Number = {3},
   Pages = {358-371},
   Year = {1979} }



@article{
116,
   Author = {Ham, J. and Miller, R. D. and Sheiner, L. B. and Matteo, R. S.},
   Title = {Dosage-schedule independence of d-tubocurarine pharmacokinetics and pharmacodynamics, and recovery of neuromuscular function},
   Journal = {Anesthesiology},
   Volume = {50},
   Number = {6},
   Pages = {528-533},
   Year = {1979} }



@article{
115,
   Author = {Wheeler, L. A. and Sheiner, L. B.},
   Title = {Clinical estimation of creatinine clearance},
   Journal = {American Journal of Clinical Pathology},
   Volume = {72},
   Number = {1},
   Pages = {27-32},
   Year = {1979} }



@article{
114,
   Author = {Stanski, D. R. and Sheiner, L. B.},
   Title = {Pharmacokinetics and dynamics of muscle relaxants},
   Journal = {Anesthesiology},
   Volume = {51},
   Number = {2},
   Pages = {103-105},
   Year = {1979} }



@article{
113,
   Author = {Bonate, P. L. and Floret, S. and Bentzen, C.},
   Title = {Population pharmacokinetics of APOMINE: a meta-analysis in cancer patients and healthy males},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {58},
   Number = {2},
   Pages = {142-155},
   Year = {2004} }



@article{
112,
   Author = {Sheiner, L. B. and Beal, S. and Rosenberg, B. and Marathe, V. V.},
   Title = {Forecasting individual pharmacokinetics},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {26},
   Number = {3},
   Pages = {294-305},
   Year = {1979} }



@article{
111,
   Author = {Stanski, D. R. and Ham, J. and Miller, R. D. and Sheiner, L. B.},
   Title = {Pharmacokinetics and pharmacodynamics of d-tubocurarine during nitrous oxide-narcotic and halothane anesthesia in man},
   Journal = {Anesthesiology},
   Volume = {51},
   Number = {3},
   Pages = {235-241},
   Year = {1979} }



@article{
110,
   Author = {Sheiner, L. B. and Wheeler, L. A. and Moore, J. K.},
   Title = {The performance of delta check methods},
   Journal = {Clinical Chemistry},
   Volume = {25},
   Number = {12},
   Pages = {2034-2037},
   Year = {1979} }



@article{
109,
   Author = {Whiting, B. and Holford, N. H. and Sheiner, L. B.},
   Title = {Quantitative analysis of the disopyramide concentration-effect relationship},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {9},
   Number = {1},
   Pages = {67-75},
   Year = {1980} }



@article{
108,
   Author = {Iavarone, L. and Gomeni, R.},
   Title = {An application of nonlinear mixed-effects modeling to pharmacokinetic data exhibiting nonlinear and time-dependent behavior},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {92},
   Number = {1},
   Pages = {27-34},
   Year = {2003} }



@article{
107,
   Author = {Stanski, D. R. and Ham, J. and Miller, R. D. and Sheiner, L. B.},
   Title = {Time-dependent increase in sensitivity to d-tubocurarine during enflurane anesthesia in man},
   Journal = {Anesthesiology},
   Volume = {52},
   Number = {6},
   Pages = {483-487},
   Year = {1980} }



@article{
104,
   Author = {Holford, N. H. and Sheiner, L. B.},
   Title = {Pharmacokinetic and pharmacodynamic modeling in vivo},
   Journal = {CRC Critical Reviews in Bioengineering},
   Volume = {5},
   Number = {4},
   Pages = {273-322},
   Year = {1981} }



@article{
103,
   Author = {Wheeler, L. A. and Sheiner, L. B.},
   Title = {A clinical evaluation of various delta check methods},
   Journal = {Clinical Chemistry},
   Volume = {27},
   Number = {1},
   Pages = {5-9},
   Year = {1981} }



@article{
102,
   Author = {Sheiner, L. B. and Benet, L. Z. and Pagliaro, L. A.},
   Title = {A standard approach to compiling clinical pharmacokinetic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {9},
   Number = {1},
   Pages = {59-127},
   Year = {1981} }



@article{
101,
   Author = {Holford, N. H. and Coates, P. E. and Guentert, T. W. and Riegelman, S. and Sheiner, L. B.},
   Title = {The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {11},
   Number = {2},
   Pages = {187-195},
   Year = {1981} }



@article{
99,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Some suggestions for measuring predictive performance},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {9},
   Number = {4},
   Pages = {503-512},
   Year = {1981} }



@article{
98,
   Author = {Holford, N. H. and Sheiner, L. B.},
   Title = {Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models},
   Journal = {Clinical Pharmacokinetics},
   Volume = {6},
   Number = {6},
   Pages = {429-453},
   Year = {1981} }



@article{
97,
   Author = {Holford, N. H. and Sheiner, L. B.},
   Title = {Kinetics of pharmacologic response},
   Journal = {Pharmacology and Therapeutics},
   Volume = {16},
   Number = {2},
   Pages = {143-166},
   Year = {1982} }



@article{
96,
   Author = {Beal, S. L. and Sheiner, L. B.},
   Title = {Estimating population kinetics},
   Journal = {Critical Reviews in Biomedical Engineering},
   Volume = {8},
   Number = {3},
   Pages = {195-222},
   Year = {1982} }



@article{
95,
   Author = {Carlson, C. J. and Meister, W. and Emilson, B. and Sheiner, L. B. and Rapaport, E.},
   Title = {Clearance of serum creatine kinase activity},
   Journal = {Cardiovascular Research},
   Volume = {16},
   Number = {2},
   Pages = {66-70},
   Year = {1982} }



@article{
94,
   Author = {Cahalan, M. K. and Johnson, B. H. and Eger, E. I. and Sheiner, L. B. and Richardson, C. A. and Varner, J. K. and Severinghaus, J. W.},
   Title = {A noninvasive in vivo method of assessing the kinetics of halothane metabolism in humans},
   Journal = {Anesthesiology},
   Volume = {57},
   Number = {4},
   Pages = {298-302},
   Year = {1982} }



@article{
93,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Bayesian individualization of pharmacokinetics: simple implementation and comparison with non-Bayesian methods},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {71},
   Number = {12},
   Pages = {1344-1348},
   Year = {1982} }



@article{
92,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Evaluation of methods for estimating population pharmacokinetic parameters. III. Monoexponential model: routine clinical pharmacokinetic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {11},
   Number = {3},
   Pages = {303-319},
   Year = {1983} }



@article{
91,
   Author = {Grasela, T. H. and Sheiner, L. B. and Rambeck, B. and Boenigk, H. E. and Dunlop, A. and Mullen, P. W. and Wadsworth, J. and Richens, A. and Ishizaki, T. and Chiba, K.},
   Title = {Steady-state pharmacokinetics of phenytoin from routinely collected patient data},
   Journal = {Clinical Pharmacokinetics},
   Volume = {8},
   Number = {4},
   Pages = {355-364},
   Year = {1983} }



@article{
90,
   Author = {Sheiner, L. B. and Grasela, T. H.},
   Title = {Experience with NONMEM: analysis of routine phenytoin clinical pharmacokinetic data},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {293-303},
   Year = {1984} }



@article{
89,
   Author = {Peck, C. C. and Sheiner, L. B. and Nichols, A. I.},
   Title = {The problem of choosing weights in nonlinear regression analysis of pharmacokinetic data},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {133-148},
   Year = {1984} }



@article{
88,
   Author = {Sheiner, L. B.},
   Title = {The population approach to pharmacokinetic data analysis: rationale and standard data analysis methods},
   Journal = {Drug Metabolism Reviews},
   Volume = {15},
   Number = {1-2},
   Pages = {153-171},
   Year = {1984} }



@article{
87,
   Author = {Sheiner, L. B.},
   Title = {Analysis of pharmacokinetic data using parametric models--1: Regression models},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {12},
   Number = {1},
   Pages = {93-117},
   Year = {1984} }



@article{
86,
   Author = {Fuseau, E. and Sheiner, L. B.},
   Title = {Simultaneous modeling of pharmacokinetics and pharmacodynamics with a nonparametric pharmacodynamic model},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {35},
   Number = {6},
   Pages = {733-741},
   Year = {1984} }



@article{
85,
   Author = {Peck, C. C. and Beal, S. L. and Sheiner, L. B. and Nichols, A. I.},
   Title = {Extended least squares nonlinear regression: a possible solution to the "choice of weights" problem in analysis of individual pharmacokinetic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {12},
   Number = {5},
   Pages = {545-558},
   Year = {1984} }



@article{
84,
   Author = {Grasela, T. H. and Sheiner, L. B.},
   Title = {Population pharmacokinetics of procainamide from routine clinical data},
   Journal = {Clinical Pharmacokinetics},
   Volume = {9},
   Number = {6},
   Pages = {545-554},
   Year = {1984} }



@article{
83,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Pharmacokinetic parameter estimates from several least squares procedures: superiority of extended least squares},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {13},
   Number = {2},
   Pages = {185-201},
   Year = {1985} }



@article{
82,
   Author = {Kaplan, E. B. and Sheiner, L. B. and Boeckmann, A. J. and Roizen, M. F. and Beal, S. L. and Cohen, S. N. and Nicoll, C. D.},
   Title = {The usefulness of preoperative laboratory screening},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {253},
   Number = {24},
   Pages = {3576-3581},
   Year = {1985} }



@article{
81,
   Author = {Sheiner, L. B.},
   Title = {Analysis of pharmacokinetic data using parametric models. II. Point estimates of an individual's parameters},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {13},
   Number = {5},
   Pages = {515-540},
   Year = {1985} }



@article{
80,
   Author = {Sheiner, L. B. and Benet, L. Z.},
   Title = {Premarketing observational studies of population pharmacokinetics of new drugs},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {38},
   Number = {5},
   Pages = {481-487},
   Year = {1985} }



@article{
79,
   Author = {Ette, E. I. and Williams, P. J. and Kim, Y. H. and Lane, J. R. and Liu, M. J. and Capparelli, E. V.},
   Title = {Model appropriateness and population pharmacokinetic modeling},
   Journal = {Journal of Clinical Pharmacology},
   Volume = {43},
   Number = {6},
   Pages = {610-623},
   Year = {2003} }



@article{
78,
   Author = {Unadkat, J. D. and Bartha, F. and Sheiner, L. B.},
   Title = {Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {40},
   Number = {1},
   Pages = {86-93},
   Year = {1986} }



@article{
77,
   Author = {Fisher, D. M. and Canfell, P. C. and Fahey, M. R. and Rosen, J. I. and Rupp, S. M. and Sheiner, L. B. and Miller, R. D.},
   Title = {Elimination of atracurium in humans: contribution of Hofmann elimination and ester hydrolysis versus organ-based elimination},
   Journal = {Anesthesiology},
   Volume = {65},
   Number = {1},
   Pages = {6-12},
   Year = {1986} }



@article{
76,
   Author = {Carpenter, R. L. and Eger, E. I. and Johnson, B. H. and Unadkat, J. D. and Sheiner, L. B.},
   Title = {The extent of metabolism of inhaled anesthetics in humans},
   Journal = {Anesthesiology},
   Volume = {65},
   Number = {2},
   Pages = {201-205},
   Year = {1986} }



@article{
75,
   Author = {Unadkat, J. D. and Sheiner, L. B. and Hennis, P. J. and Cronnelly, R. and Miller, R. D. and Sharma, M.},
   Title = {An integrated model for the interaction of muscle relaxants with their antagonists},
   Journal = {Journal of Applied Physiology},
   Volume = {61},
   Number = {4},
   Pages = {1593-1598},
   Year = {1986} }



@article{
74,
   Author = {Thomson, A. H. and Kokwaro, G. O. and Muchohi, S. N. and English, M. and Mohammed, S. and Edwards, G.},
   Title = {Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya},
   Journal = {British Journal of Clinical Pharmacology},
   Volume = {56},
   Number = {1},
   Pages = {25-31},
   Year = {2003} }



@article{
73,
   Author = {Fossa, A. A. and Wisialowski, T. and Magnano, A. and Wolfgang, E. and Winslow, R. and Gorczyca, W. and Crimin, K. and Raunig, D. L.},
   Title = {Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition},
   Journal = {J Pharmacol.Exp.Ther.},
   Volume = {312},
   Number = {1},
   Pages = {1-11},
   Year = {2005} }



@article{
72,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {A note on confidence intervals with extended least squares parameter estimates},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {15},
   Number = {1},
   Pages = {93-98},
   Year = {1987} }



@article{
71,
   Author = {Schuttler, J. and Stanski, D. R. and White, P. F. and Trevor, A. J. and Horai, Y. and Verotta, D. and Sheiner, L. B.},
   Title = {Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {15},
   Number = {3},
   Pages = {241-253},
   Year = {1987} }



@article{
70,
   Author = {Verotta, D. and Sheiner, L. B.},
   Title = {Simultaneous modeling of pharmacokinetics and pharmacodynamics: an improved algorithm},
   Journal = {Computer Applications in the Biosciences : CABIOS},
   Volume = {3},
   Number = {4},
   Pages = {345-349},
   Year = {1987} }



@article{
69,
   Author = {Porchet, H. C. and Benowitz, N. L. and Sheiner, L. B. and Copeland, J. R.},
   Title = {Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics},
   Journal = {The Journal of Clinical Investigation},
   Volume = {80},
   Number = {5},
   Pages = {1466-1471},
   Year = {1987} }



@article{
68,
   Author = {Porchet, H. C. and Benowitz, N. L. and Sheiner, L. B.},
   Title = {Pharmacodynamic model of tolerance: application to nicotine},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {244},
   Number = {1},
   Pages = {231-236},
   Year = {1988} }



@article{
67,
   Author = {Sheiner, L. B. and Beal, S. L.},
   Title = {Commentary on "extended least squares (ELS) for pharmacokinetic models"},
   Journal = {Journal of Pharmaceutical Sciences},
   Volume = {77},
   Number = {8},
   Pages = {731-732},
   Year = {1988} }



@article{
66,
   Author = {Goldman, E. S. and Easterling, M. J. and Sheiner, L. B.},
   Title = {Improving the homogeneity of diagnosis-related groups (DRGs) by using clinical laboratory, demographic, and discharge data},
   Journal = {American Journal of Public Health},
   Volume = {79},
   Number = {4},
   Pages = {441-444},
   Year = {1989} }



@article{
65,
   Author = {Verotta, D. and Beal, S. L. and Sheiner, L. B.},
   Title = {Semiparametric approach to pharmacokinetic-pharmacodynamic data},
   Journal = {American Journal of Physiology},
   Volume = {256},
   Number = {4 Pt 2},
   Pages = {R1005-R1010},
   Year = {1989} }



@article{
64,
   Author = {Sheiner, L. B. and Beal, S. L. and Sambol, N. C.},
   Title = {Study designs for dose-ranging},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {46},
   Number = {1},
   Pages = {63-77},
   Year = {1989} }



@article{
63,
   Author = {Verotta, D. and Sheiner, L. B. and Ebling, W. F. and Stanski, D. R.},
   Title = {A semiparametric approach to physiological flow models},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {17},
   Number = {4},
   Pages = {463-491},
   Year = {1989} }



@article{
62,
   Author = {Boyd, R. A. and Chin, S. K. and Don-Pedro, O. and Verotta, D. and Sheiner, L. B. and Williams, R. L. and Giacomini, K. M.},
   Title = {The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {46},
   Number = {4},
   Pages = {408-419},
   Year = {1989} }



@article{
61,
   Author = {Schwartz, J. B. and Verotta, D. and Sheiner, L. B.},
   Title = {Pharmacodynamic modeling of verapamil effects under steady-state and nonsteady-state conditions},
   Journal = {The Journal of Pharmacology and Experimental Therapeutics},
   Volume = {251},
   Number = {3},
   Pages = {1032-1038},
   Year = {1989} }



@article{
60,
   Author = {Sheiner, L. B.},
   Title = {Clinical pharmacology and the choice between theory and empiricism},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {46},
   Number = {6},
   Pages = {605-615},
   Year = {1989} }



@article{
59,
   Author = {Falloon, J. and Piscitelli, S. and Vogel, S. and Sadler, B. and Mitsuya, H. and Kavlick, M. F. and Yoshimura, K. and Rogers, M. and LaFon, S. and Manion, D. J. and Lane, H. C. and Masur, H.},
   Title = {Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity},
   Journal = {Clin.Infect.Dis.},
   Volume = {30},
   Number = {2},
   Pages = {313-318},
   Year = {2000} }



@article{
58,
   Author = {Sheiner, L. B. and Easterling, M. J. and Mozes, B. and Brown, A.},
   Title = {Laboratory data predicts survival post hospitalization},
   Journal = {Journal of Clinical Epidemiology},
   Volume = {44},
   Number = {12},
   Pages = {1387-1403},
   Year = {1991} }



@article{
57,
   Author = {Sambol, N. C. and Sheiner, L. B.},
   Title = {Population dose versus response of betaxolol and atenolol: a comparison of potency and variability},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {49},
   Number = {1},
   Pages = {24-31},
   Year = {1991} }



@article{
56,
   Author = {Sheiner, L. B. and Hashimoto, Y. and Beal, S. L.},
   Title = {A simulation study comparing designs for dose ranging},
   Journal = {Statistics in Medicine},
   Volume = {10},
   Number = {3},
   Pages = {303-321},
   Year = {1991} }



@article{
54,
   Author = {Hashimoto, Y. and Sheiner, L. B.},
   Title = {Designs for population pharmacodynamics: value of pharmacokinetic data and population analysis},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {3},
   Pages = {333-353},
   Year = {1991} }



@article{
53,
   Author = {Sheiner, L. B.},
   Title = {The intellectual health of clinical drug evaluation},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {50},
   Number = {1},
   Pages = {4-9},
   Year = {1991} }



@article{
52,
   Author = {Kahn, M. G. and Fagan, L. M. and Sheiner, L. B.},
   Title = {Combining physiologic models and symbolic methods to interpret time- varying patient data},
   Journal = {Methods of Information in Medicine},
   Volume = {30},
   Number = {3},
   Pages = {167-178},
   Year = {1991} }



@article{
51,
   Author = {Hale, V. G. and Aizawa, K. and Sheiner, L. B. and Benet, L. Z.},
   Title = {Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {19},
   Number = {5},
   Pages = {597-614},
   Year = {1991} }



@article{
50,
   Author = {Cherkassky, V. and Ma, Y.},
   Title = {Comparison of model selection for regression},
   Journal = {Neural Comput.},
   Volume = {15},
   Number = {7},
   Pages = {1691-1714},
   Year = {2003} }



@article{
48,
   Author = {Sheiner, L. B. and Ludden, T. M.},
   Title = {Population pharmacokinetics/dynamics},
   Journal = {Annual Review of Pharmacology and Toxicology},
   Volume = {32},
   Pages = {185-209},
   Year = {1992} }



@article{
47,
   Author = {Barrett, J. S. and Hainer, J. W. and Kornhauser, D. M. and Gaskill, J. L. and Hua, T. A. and Sprogel, P. and Johansen, K. and van Lier, J. J. and Knebel, W. and Pieniaszek, H. J., Jr.},
   Title = {Anticoagulant pharmacodynamics of tinzaparin following 175 iu/kg subcutaneous administration to healthy volunteers},
   Journal = {Thrombosis Research},
   Volume = {101},
   Number = {4},
   Pages = {243-254},
   Year = {2001} }



@article{
46,
   Author = {Lenert, L. A. and Lurie, J. and Sheiner, L. B. and Coleman, R. and Klostermann, H. and Blaschke, T. F.},
   Title = {Advanced computer programs for drug dosing that combine pharmacokinetic and symbolic modeling of patients},
   Journal = {Computers and Biomedical Research, an international journal},
   Volume = {25},
   Number = {1},
   Pages = {29-42},
   Year = {1992} }



@article{
44,
   Author = {Brown, A. N. and Sheiner, L. B. and Cohen, S. N.},
   Title = {Evaluation of bilirubin in a liver screening panel},
   Journal = {JAMA: The Journal of the American Medical Association},
   Volume = {268},
   Number = {12},
   Pages = {1542},
   Year = {1992} }



@article{
43,
   Author = {Sheiner, L. B.},
   Title = {Bioequivalence revisited},
   Journal = {Statistics in Medicine},
   Volume = {11},
   Number = {13},
   Pages = {1777-1788},
   Year = {1992} }



@article{
42,
   Author = {Mandema, J. W. and Verotta, D. and Sheiner, L. B.},
   Title = {Pharmacometrics: Building population pharmacokinetic--pharmacodynamic models. I. Models for covariate effects},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {20},
   Number = {5},
   Pages = {511-528},
   Year = {1992} }



@article{
41,
   Author = {Lowe, C. U. and Alexander, D. and Mishkin, B.},
   Title = {Nontherapeutic research on children: an ethical dilemma},
   Journal = {J Pediatr.},
   Volume = {84},
   Number = {4},
   Pages = {468-473},
   Year = {1974} }



@article{
40,
   Author = {Rutledge, G. W. and Thomsen, G. E. and Farr, B. R. and Tovar, M. A. and Polaschek, J. X. and Beinlich, I. A. and Sheiner, L. B. and Fagan, L. M.},
   Title = {The design and implementation of a ventilator-management advisor},
   Journal = {Artificial Intelligence in Medicine},
   Volume = {5},
   Number = {1},
   Pages = {67-82},
   Year = {1993} }



@article{
39,
   Author = {Sale, M. and Sheiner, L. B. and Volberding, P. and Blaschke, T. F.},
   Title = {Zidovudine response relationships in early human immunodeficiency virus infection},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {54},
   Number = {5},
   Pages = {556-566},
   Year = {1993} }



@article{
38,
   Author = {Holford, N. and Hashimoto, Y. and Sheiner, L. B.},
   Title = {Time and theophylline concentration help explain the recovery of peak flow following acute airways obstruction. Population analysis of a randomised concentration controlled trial},
   Journal = {Clinical Pharmacokinetics},
   Volume = {25},
   Number = {6},
   Pages = {506-515},
   Year = {1993} }



@article{
37,
   Author = {Karlsson, M. O. and Sheiner, L. B.},
   Title = {The importance of modeling interoccasion variability in population pharmacokinetic analyses},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {21},
   Number = {6},
   Pages = {735-750},
   Year = {1993} }



@article{
36,
   Author = {Bragg, P. and Fisher, D. M. and Shi, J. and Donati, F. and Meistelman, C. and Lau, M. and Sheiner, L. B.},
   Title = {Comparison of twitch depression of the adductor pollicis and the respiratory muscles. Pharmacodynamic modeling without plasma concentrations},
   Journal = {Anesthesiology},
   Volume = {80},
   Number = {2},
   Pages = {310-319},
   Year = {1994} }



@article{
35,
   Author = {Mozes, B. and Easterling, M. J. and Sheiner, L. B. and Melmon, K. L. and Kline, R. and Goldman, E. S. and Brown, A. N.},
   Title = {Case-mix adjustment using objective measures of severity: the case for laboratory data},
   Journal = {Health Services Research},
   Volume = {28},
   Number = {6},
   Pages = {689-712},
   Year = {1994} }



@article{
34,
   Author = {Arvestad, L. and Berglund, A. C. and Lagergren, J. and Sennblad, B.},
   Title = {Bayesian gene/species tree reconciliation and orthology analysis using MCMC},
   Journal = {Bioinformatics.},
   Volume = {19 Suppl 1},
   Pages = {I7-I15},
   Year = {2003} }



@article{
33,
   Author = {Karlsson, M. O. and Sheiner, L. B.},
   Title = {Estimating bioavailability when clearance varies with time},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {55},
   Number = {6},
   Pages = {623-637},
   Year = {1994} }



@article{
32,
   Author = {Sheiner, L. B.},
   Title = {A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {56},
   Number = {3},
   Pages = {309-322},
   Year = {1994} }



@article{
31,
   Author = {Ludden, T. M. and Beal, S. L. and Sheiner, L. B.},
   Title = {Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {22},
   Number = {5},
   Pages = {431-445},
   Year = {1994} }



@article{
30,
   Author = {Sheiner, L. B. and Rubin, D. B.},
   Title = {Intention-to-treat analysis and the goals of clinical trials},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {57},
   Number = {1},
   Pages = {6-15},
   Year = {1995} }



@article{
29,
   Author = {Verotta, D. and Sheiner, L. B.},
   Title = {A general conceptual model for non-steady state pharmacokinetic/pharmacodynamic data},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {1},
   Pages = {1-4},
   Year = {1995} }



@article{
28,
   Author = {Karlsson, M. O. and Port, R. E. and Ratain, M. J. and Sheiner, L. B.},
   Title = {A population model for the leukopenic effect of etoposide},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {57},
   Number = {3},
   Pages = {325-334},
   Year = {1995} }



@article{
27,
   Author = {Sheiner, L. B. and Verotta, D.},
   Title = {Further notes on physiologic indirect response models},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {58},
   Number = {2},
   Pages = {238-240},
   Year = {1995} }



@article{
26,
   Author = {Sallas, W. M. and Nedelman, J. R. and Sheiner, L. B. and Meligeni, J. A. and Robinson, W. T.},
   Title = {A nonlinear mixed-effects pharmacokinetic model comparing two formulations of cyclosporine in stable renal transplant patients},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {5},
   Pages = {495-514},
   Year = {1995} }



@article{
25,
   Author = {Fattinger, K. E. and Sheiner, L. B. and Verotta, D.},
   Title = {A new method to explore the distribution of interindividual random effects in non-linear mixed effects models},
   Journal = {Biometrics},
   Volume = {51},
   Number = {4},
   Pages = {1236-1251},
   Year = {1995} }



@article{
24,
   Author = {Karlsson, M. O. and Beal, S. L. and Sheiner, L. B.},
   Title = {Three new residual error models for population PK/PD analyses},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {23},
   Number = {6},
   Pages = {651-672},
   Year = {1995} }



@article{
23,
   Author = {Harb, G. E. and Mandema, J. W. and Delahunty, T. and Benowitz, N. B. and Coleman, R. and Sheiner, L. B. and Jacobson, M. A.},
   Title = {Population pharmacokinetics of didanosine in patients with human immunodeficiency virus infection},
   Journal = {The Journal of Infectious Diseases},
   Volume = {173},
   Number = {1},
   Pages = {273},
   Year = {1996} }



@article{
22,
   Author = {Bruno, R. and Vivler, N. and Vergniol, J. C. and De Phillips, S. L. and Montay, G. and Sheiner, L. B.},
   Title = {A population pharmacokinetic model for docetaxel (Taxotere): model building and validation},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {2},
   Pages = {153-172},
   Year = {1996} }



@article{
21,
   Author = {Girard, P. and Sheiner, L. B. and Kastrissios, H. and Blaschke, T. F.},
   Title = {Do we need full compliance data for population pharmacokinetic analysis?},
   Journal = {Journal of Pharmacokinetics and Biopharmaceutics},
   Volume = {24},
   Number = {3},
   Pages = {265-282},
   Year = {1996} }



@article{
20,
   Author = {Fattinger, K. E. and Verotta, D. and Porchet, H. C. and Munafo, A. and Le Cotonnec, J. Y. and Sheiner, L. B.},
   Title = {Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide},
   Journal = {American Journal of Physiology},
   Volume = {271},
   Number = {4 Pt 1},
   Pages = {E775-E787},
   Year = {1996} }



@article{
19,
   Author = {Gries, J. M. and Troconiz, I. F. and Verotta, D. and Jacobson, M. and Sheiner, L. B.},
   Title = {A pooled analysis of CD4 response to zidovudine and zalcitabine treatment in patients with AIDS and AIDS-related complex},
   Journal = {Clinical Pharmacology and Therapeutics},
   Volume = {61},
   Number = {1},
   Pages = {70-82},
   Year = {1997} }



@article{
18,
   Author = {Ross, R. and Leger, L. and Guardo, R. and de Guise, J. and Pike, B. G.},
   Title = {Adipose tissue volume measured by magnetic resonance imaging and computerized tomography in rats},
   Journal = {Journal of Applied Physiology},
   Volume = {70},
   Number = {5},
   Pages = {2164-2172},
   Year = {1991} }



@article{
17,
   Author = {Smythe, M. and Hoffman, J. and Kizy, K. and Dmuchowski, C.},
   Title = {Estimating creatinine clearance in elderly patients with low serum creatinine concentrations},
   Journal = {Am.J Hosp.Pharm.},
   Volume = {51},
   Number = {2},
   Pages = {198-204},
   Year = {1994} }



@article{
16,
   Author = {de Martino, M. and Galli, L. and Guarino, Amato A. and Vierucci, A.},
   Title = {Human immunodeficiency virus type 1 infection, clinical trials and ethics in paediatrics},
   Journal = {Acta Paediatr.Suppl},
   Volume = {421},
   Pages = {78-85},
   Year = {1997} }



@article{
15,
   Author = {Bruno, R. and Hille, D. and Riva, A. and Vivier, N. and Bokkel Huinnink, W. W. and van Oosterom, A. T. and Kaye, S. B. and Verweij, J. and Fossella, F. V. and Valero, V. and Rigas, J. R. and Seidman, A. D. and Chevallier, B. and Fumoleau, P. and Burris, H. A. and Ravdin, P. M. and Sheiner, L. B.},
   Title = {Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer},
   Journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
   Volume = {16},
   Number = {1},
   Pages = {187-196},
   Year = {1998} }



@article{
14,
   Author = {Kodish, E. D. and Pentz, R. D. and Noll, R. B. and Ruccione, K. and Buckley, J. and Lange, B. J.},
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@article{
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